Lifestyle Cancer Survival Predictors: Influence of Vegetarian Diet on the Relapse of Endometrial Cancer

Endometrial cancer (EC) is the most common gynecological tumor in high-income countries, and its incidence has increased over time. The most critical risk factor for EC is the long-term unopposed exposure to increased estrogens both exogenous and endogenous. Machine learning can be used as a promising tool to resolve longstanding challenges and support identification of the risk factors and their correlations before the clinical trials and make them more focused. In this paper we present the results of the research of the correlation analysis of Endometrial cancer risk factors. The study was performed with EC patients of the Almazov center in Saint-Petersburg, Russia. All women involved in the current study underwent radical surgical intervention due to EC. After initial cancer treatment, they were referred to the Almazov center outpatient specialists for follow-up visits. Many of them were readmitted of the inpatient clinic due to relapse. We extracted a variety of parameters related to lifestyle, dietary habits, socioeconomic, and reproductive features from the inpatient and outpatient databases of Almazov center. The medical records of the women with enough data were included in the study. Prediction of Progression-free survival (PFS) and overall survival (OS) were analyzed respectively. The AUC of ROC was calculated for PFS = 0.93 and for OS = 0.94.

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The Impact of Diet on Urinary Risk Factors for Cystine Stone Formation

Nutrients ◽

10.3390/nu13020528 ◽

2021 ◽

Vol 13 (2) ◽

pp. 528

Author(s):

Roswitha Siener ◽

Norman Bitterlich ◽

Hubert Birwé ◽

Albrecht Hesse

Keyword(s):

Risk Factors ◽

Dietary Habits ◽

Sodium Intake ◽

Stone Formation ◽

Dietary Treatment ◽

Vegetarian Diet ◽

Dietary Sodium ◽

Urine Ph ◽

Cystine Stone ◽

The Impact

Despite the importance of dietary management of cystinuria, data on the contribution of diet to urinary risk factors for cystine stone formation are limited. Studies on the physiological effects of diet on urinary cystine and cysteine excretion are lacking. Accordingly, 10 healthy men received three standardized diets for a period of five days each and collected daily 24 h urine. The Western-type diet (WD; 95 g/day protein) corresponded to usual dietary habits, whereas the mixed diet (MD; 65 g/day protein) and lacto-ovo-vegetarian diet (VD; 65 g/day protein) were calculated according to dietary reference intakes. With intake of the VD, urinary cystine and cysteine excretion decreased by 22 and 15%, respectively, compared to the WD, although the differences were not statistically significant. Urine pH was significantly highest on the VD. Regression analysis showed that urinary phosphate was significantly associated with cystine excretion, while urinary sulfate was a predictor of cysteine excretion. Neither urinary cystine nor cysteine excretion was affected by dietary sodium intake. A lacto-ovo-vegetarian diet is particularly suitable for the dietary treatment of cystinuria, since the additional alkali load may reduce the amount of required alkalizing agents.

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Multi-trait genome-wide association study identifies novel endometrial cancer risk loci that are associated with obesity or female testosterone levels

10.1101/2021.08.01.21261455 ◽

2021 ◽

Author(s):

Xuemin Wang ◽

Pik Fang Kho ◽

Dhanya Ramachandran ◽

Cemsel Bafligil ◽

Frederic Amant ◽

...

Keyword(s):

Risk Factors ◽

Endometrial Cancer ◽

Cancer Risk ◽

Association Study ◽

Genome Wide Association Study ◽

Cancer Susceptibility ◽

Genome Wide Association ◽

Endometrial Cancer Risk ◽

Cancer Risk Factors ◽

Genome Wide

We have performed genetic correlation and Mendelian randomization analyses using publicly available genome-wide association study (GWAS) data to identify endometrial cancer risk factors. These and previously established risk factors of endometrial cancer were then included in a multi-trait Bayesian GWAS analysis to detect endometrial cancer susceptibility variants, identifying three novel loci (7q22.1, 8q24.3 and 16q12.2); two of which were replicated in an independent endometrial cancer GWAS dataset. These loci are hypothesized to affect endometrial cancer risk through altered sex-hormone levels or through effects on obesity. Consistent with this hypothesis, several genes with established roles in these pathways (CYP11B1, CYP3A7, IRX3 and IRX5) were prioritized as candidate endometrial cancer risk genes by interrogation of quantitative trait loci data and chromatin capture assays in endometrial cell lines. The findings of this study identify additional opportunities for hormone treatment and further support weight loss to reduce the risk of developing endometrial cancer.

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A survey of patient knowledge on contraception and endometrial cancer risk factors

Gynecologic Oncology ◽

10.1016/j.ygyno.2020.05.404 ◽

2020 ◽

Vol 159 ◽

pp. 238-239

Author(s):

S. Patel ◽

O.D. Lara ◽

R. Tsai ◽

M.Y. Williams-Brown

Keyword(s):

Risk Factors ◽

Endometrial Cancer ◽

Cancer Risk ◽

Patient Knowledge ◽

Endometrial Cancer Risk ◽

Cancer Risk Factors

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Knowledge of endometrial cancer risk factors in a general gynecologic population

Gynecologic Oncology ◽

10.1016/j.ygyno.2020.03.032 ◽

2020 ◽

Vol 158 (1) ◽

pp. 137-142 ◽

Cited By ~ 3

Author(s):

Christina R. Washington ◽

Ashley Haggerty ◽

Wanda Ronner ◽

Pamela M. Neff ◽

Emily M. Ko

Keyword(s):

Risk Factors ◽

Endometrial Cancer ◽

Cancer Risk ◽

Endometrial Cancer Risk ◽

Cancer Risk Factors

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Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors

Cancer Causes & Control ◽

10.1007/s10552-016-0751-4 ◽

2016 ◽

Vol 27 (6) ◽

pp. 737-748 ◽

Cited By ~ 18

Author(s):

Melissa A. Merritt ◽

Howard D. Strickler ◽

Mark H. Einstein ◽

Hannah P. Yang ◽

Mark E. Sherman ◽

...

Keyword(s):

Risk Factors ◽

Endometrial Cancer ◽

Cancer Risk ◽

Sex Hormone ◽

Human Endometrium ◽

Endometrial Cancer Risk ◽

Cancer Risk Factors

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Plasma Adiponectin Concentrations in Relation to Endometrial Cancer: A Case-Control Study in Greece

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2002-021209 ◽

2003 ◽

Vol 88 (3) ◽

pp. 993-997 ◽

Cited By ~ 144

Author(s):

Eleni Petridou ◽

Christos Mantzoros ◽

Nick Dessypris ◽

Panagiotis Koukoulomatis ◽

Carol Addy ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Endometrial Cancer ◽

Risk Factor ◽

Body Mass ◽

Inverse Association ◽

Cancer Risk Factors ◽

Established Risk Factor ◽

Igf System ◽

Pelvic Prolapse

Adiponectin is a hormone secreted exclusively by adipocytes, and obesity is an established risk factor for endometrial cancer. We have, thus, evaluated the association of adiponectin with the occurrence of endometrial cancer. Questionnaire information and blood samples were taken before treatment from 84 women with newly diagnosed, histologically confirmed endometrial cancer and 84 control women who were admitted for minor gynecologic problems, mainly pelvic prolapse. Adiponectin levels were measured by immunoassay. The results were analyzed through multiple logistic regression and controlled for known risk factors for endometrial cancer, leptin, as well as major components of the IGF system (IGF-I, IGF-II, and IGF-binding protein 3). Among control women, there was no significant association of adiponectin with age or parity. Although there was no association of adiponectin with endometrial cancer among women 65 yr or older, there was an inverse, fairly strong, and statistically significant inverse association among younger women. Among women younger than 65 yr, an increase of adiponectin by 1 sd was associated with a more than 50% reduction of the risk for endometrial cancer [odds ratio (OR) 0.44; 95% confidence interval (CI) 0.24–0.81], even after controlling for body mass index and other potential confounders. Among all women, the adjusted OR for a 1 sd increase in adiponectin was not significant (OR, 0.78; 95% CI, 0.56–1.10) but was significant for a one quintile increase in adiponectin (OR, 0.74; 95% CI, 0.56–0.97). In women younger than 65 yr, among whom obesity represents a powerful risk factor for endometrial cancer, adiponectin is inversely and significantly related to the risk of this disease. This association is independent of possible effects of major components of the IGF system, leptin, body mass index, sociodemographic variables, and known endometrial cancer risk factors. Future studies are needed to prove causality and provide insight on both the mechanism of action of this hormone and its potential role in endometrial cancer.

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Baseline Assessment of Adult Cohorts Cardiovascular and Metabolic Risk Factors at Community Setting, From Temporal Time Trend to Long-Term Burdens, an Approach to Population Health

Journal of Infectious Diseases & Case Reports ◽

10.47363/jidscr/2020(1)106 ◽

2020 ◽

pp. 1-5

Author(s):

Hamid Yahya Hussain ◽

◽

Mohammed Tuffaha ◽

Keyword(s):

Risk Factors ◽

Time Trend ◽

Dietary Habits ◽

Sedentary Lifestyle ◽

Community Setting ◽

Overweight And Obesity ◽

Modifiable Risk Factors ◽

Metabolic Risk ◽

Baseline Assessment

Unhealthy behaviors include poor dietary habits and a sedentary lifestyle. There are two types of Diabetes Mellitus with a prevalence ranging from 1% in rural Uganda to 12% in urban Kenya. Overweight and obesity have been found to be modifiable risk factors for cardio metabolic and other chronic diseases such as hypertension, diabetes and dyslipidemia.

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Abstract 129: My Unlimited Potential: Multidimensional Workplace Life Style Modification Program Associated With Reduction in Cardiovascular Disease Risk Among Employees With Type 2 Diabetes

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.8.suppl_2.129 ◽

2015 ◽

Vol 8 (suppl_2) ◽

Author(s):

Sankalp Das ◽

Maribeth Rouseff ◽

Henry Guzman ◽

Thinh Tran ◽

Doris Brown ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Cardiovascular Disease ◽

Dietary Habits ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

South Florida ◽

Improvement Program ◽

Short And Long Term

Background: Diabetes mellitus is one of the leading conditions resulting in high health costs and lost productivity. In recent year there is a growing interest for managing these chronic conditions through engagement of workplace wellness programs. In this study we examined the short and long term effects of an ongoing multicomponent lifestyle intervention improvement program (My Unlimited Potential (MyUP), among employees of Baptist Health South Florida (BHSF), a large not-for-profit health care system. Method: The present analysis focuses on the efficacy of an intensive lifestyle workplace intervention among individuals presenting with diabetes mellitus. The intervention provided tools to improve physical activity, stress and dietary habits. A multi-disciplinary team made up of an advanced nurse practitioner (ARNP), registered dietician (RD), exercise physiologist (EP), certified diabetic educator (CDE), and registered nurse (RN) met with participants to provide one-on-one counseling and training. Results: The current study assessed 33 (58 years +/- 8.8, 67% female) employees with diabetes mellitus enrolled in the MyUp wellness program who completed baseline, 12-weeks, 6 months and 1 year assessments. Significant short and long term improvements in cardio-metabolic risk factors were observed (Table1). Positive change in distribution of cardiovascular risk factors was noticed at 3, 6 and 12 months (Fig1). Conclusion: These results suggest that a multi component workplace lifestyle modification program results in both short and long term improvement in cardiovascular disease risk among employees with diabetes mellitus. Further large studies are needed to confirm our study findings.

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