Screening of Eugenia caryophyllus Essential oil and their Fractions against Fungi causing Superficial Skin Infection in Human beings

2019 ◽  
Vol 35 (2) ◽  
pp. 189-195
Author(s):  
Neetu Jain ◽  
Keyword(s):  
Essential Oil ◽  
Skin Infection ◽  
Human Beings ◽  
Superficial Skin

scholarly journals SCREENING OF THYMUS VULGARIS ESSENTIAL OIL AGAINST FUNGI CAUSING DERMATOPHYTOSIS IN HUMAN BEINGS

2017 ◽  
Vol 9 (10) ◽  
pp. 236
Author(s):  
Neetu Jain ◽  
Meenakshi Sharma
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Essential Oil ◽  
Inhibitory Concentration ◽  
Antifungal Susceptibility ◽  
Pathogenic Fungi ◽  
Thymus Vulgaris ◽  
Human Beings ◽  
Solid Agar ◽  
Superficial Skin ◽  
Semi Solid

Objective: The study was designed to determined antidermatophytic activity of Thymus vulgaris essential oil against fungi causing superficial skin infections in human and animal.Methods: Minimum inhibitory concentration (MIC) of essential oil was screened against selected pathogenic fungi namely Trichophyton rubrum (MTCC 296), T. mentagrophytes (MTCC 7687), Microsporum gypseum (MTCC 4524), M. fulvum(MTCC2837), T. soudanense and T. interdigitale through semi solid agar antifungal susceptibility testing method(SAAS). Minimum fungicidal concentration (MFC) was also determined by modified semi solid agar antifungal susceptibility method. T. soudanense and T. interdigitalis were isolated through TO. KA. VA hair bating technique from animal habitats soil of Jaipur district.Results: T. vulgaris essential oil exhibited excellent antideramtophytic activity against all selected dermatophytes. Minimum inhibitory concentration was ranged from 0.020±0.000μl/ml to 0.1±0.033 μl/ml. MFC were found little higher than MIC (0.02±0.000μl/ml to.2±0.000μl/ml). M. gypseum was found to be most susceptible fungus as compared to other test fungi.Conclusion: T. vulgaris was found to be most effective fungicidal agent against human pathogenic fungi. Present findings provide for a rationale basis of a possible utilization of this oil in fields requiring safe and cheap compounds with antiseptic and preservative properties, such as cosmetic, pharmaceutical and food industries.

scholarly journals Complications of Computer Tomography Assisted Radiofrequency Ablation in the Treatment of Osteoid Osteoma

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Yunus Oc ◽  
Bekir Eray Kilinc ◽  
Sahin Cennet ◽  
Mehmet Metin Boyacioglu ◽  
Rodi Ertugrul ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Osteoid Osteoma ◽  
Bone Tumors ◽  
Skin Infection ◽  
Primary Bone Tumors ◽  
Benign Bone Tumors ◽  
Superficial Skin ◽  
Primary Bone ◽  
A Prospective Study

Background. Osteoid osteoma (OO) is one of the most commonly occurring benign bone tumors. It constitutes 10-12% of benign bone tumors and 2-3% of primary bone tumors. In radiofrequency ablation (RFA) treatment, the cells of the tumor are thermally inactivated by the help of electrodes shaped like needles. In our study, we aimed to show the major and minor complications in patients undergoing RFA and to show what should be done to prevent these complications. Methods. The study was carried out as a prospective study on the follow-up of 87 osteoid osteoma patients treated between 2015 and 2017. The youngest of the patients was 1 year old and the oldest was 42 years old. The RFA procedure lasted 10 min on average, excluding anesthesia and preparation. All lesions were ablated at 90 degrees for 7 minutes with the heat increased gradually. All patients were followed up for 1 day in the orthopedics clinic. Results. Complications were observed in 7 patients. The lesions with the most complications were observed to be in the tibia, second-degree burns were seen in 2 patients, and superficial skin infection was observed in 2 patients. In 1 patient, the probe tip was broken and remained within the bone. Intramuscular hematoma was detected in 1 lesion located in the proximal femur. A complaint of numbness in the fingers developed in a lesion located in the metacarpus. Conclusion. Preventive measures should be taken before the procedure in order to prevent minor complications, and, for major complications, close follow-up should be done after the procedure and patients should be kept away from heavy physical activities for the first 3 months.

scholarly journals Evaluation of the potentialities of the essential oil of Ocimum gratissimum Linn. towards environmental and industrial perspectives through microbial exploitation.

2017 ◽  
Vol 8 ◽  
Author(s):  
Pranab Giri
Keyword(s):  
Essential Oil ◽  
Natural Environment ◽  
Abiotic Factors ◽  
Environmental Issues ◽  
Biotic Interaction ◽  
Human Beings ◽  
Ocimum Gratissimum ◽  
Plant Microbe Interaction ◽  
Spontaneous Interaction ◽  
Microbial Resources

Nature has its own machinery to regulate spontaneous interaction between biotic and abiotic factors of its own to provide back up for self stability and sustainability. The plant microbe interaction is a biotic interaction the resultant of which has immense role to resolve different environmental issues. It also has some fruitful effect for welfare of human beings. The present article deals with at what extent the biotic interaction between the essential oil from Ocimum gratissimum and microbial resources from the natural environment could be exploited in respect of environmental as well as industrial perspectives.

scholarly journals Comparison of Antibacterial Activity and Wound Healing in a Superficial Abrasion Mouse Model of Staphylococcus aureus Skin Infection Using Photodynamic Therapy Based on Methylene Blue or Mupirocin or Both

2021 ◽  
Vol 8 ◽  
Author(s):  
Montserrat Pérez ◽  
Pilar Robres ◽  
Bernardino Moreno ◽  
Rosa Bolea ◽  
Maria T. Verde ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Antimicrobial Activity ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Skin Infection ◽  
Infection Model ◽  
Impaired Wound Healing ◽  
Superficial Skin ◽  
Histopathological Studies ◽  
Enhance Wound Healing

Background: Antibiotic resistance and impaired wound healing are major concerns in S. aureus superficial skin infections, and new therapies are needed. Antimicrobial photodynamic therapy (aPDT) is a new therapeutic approach for infections, but it also improves healing in many wound models.Objective: To compare the antimicrobial activity and the effects on wound healing of aPDT based on Methylene Blue (MB-aPDT) with mupirocin treatment, either alone or in combination, in superficial skin wounds of S. aureus-infected mice. Additionally, to evaluate the clinical, microbiological, and cosmetic effects on wound healing.Materials and Methods: A superficial skin infection model of S. aureus was established in SKH-1 mice. Infected wounds were treated with MB-aPDT, MB-aPDT with a daily topical mupirocin or only with mupirocin. No treatment was carried out in control animals. Daily clinical and microbiological examinations were performed until complete clinical wound healing. Histopathological studies and statistical analysis were performed at the end of the study.Results: MB-aPDT treatment induced the best wound healing compared to mupirocin alone or to mupirocin plus MB-aPDT. Superficial contraction at 24 h and a greater reduction in size at 48 h, quicker detachment of the crust, less scaling, and absence of scars were observed. Histopathological studies correlated with clinical and gross findings. By contrast, mupirocin showed the highest logaritmic reduction of S. aureus.Conclusions: MB-aPDT and mupirocin treatments are effective in a murine superficial skin infection model of S. aureus. One session of MB-aPDT was the best option for clinical wound healing and cosmetic results. The addition of mupirocin to MB-aPDT treatment improved antimicrobial activity; however, it did not enhance wound healing. No synergistic antibacterial effects were detected.

Antifungal, Anti-aflatoxigenic, Antioxidant Activity and in vivo Efficacy of Essential Oil of the Aerial Parts of Thymus capitatus (L.) Hoffmanns & Link

2018 ◽  
Vol 17 (6) ◽  
pp. 299-309 ◽  
Author(s):  
Y. Ben Miri ◽  
D. Djenane
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Aspergillus Flavus ◽  
Good Alternative ◽  
Gas Chromatography Mass Spectrometry ◽  
Total Phenolic ◽  
Human Beings ◽  
Thymus Capitatus ◽  
Aflatoxin B

Aspergillus flavus has been reported to be the most common fungus used as food by human beings. This fungus may have the potential to produce aflatoxin B1 (AFB1), which is reported as being the most hepatotoxic, teratogenic, mutagenic, and immunosuppressive to humans and other livestock. Therefore, the objective of this work was to study the chemical profile of Thymus capitatus essential oil (EO) and the inhibition of growth of Aspergillus flavus E73 and AFB1 production by the EO. The antioxidant activity and phytotoxicity were also evaluated. The gas chromatography– mass spectrometry (GC–MS) analysis showed that the major components of Thymus capitatus EO were thymol (25.82%), linalool (23.40%), geraniol (14.22%), pcymen- 3-ol (8.93%), and p-cymene (6.76%). The results showed that the EO could inhibit the growth of Aspergillus flavus E73 in the range of 40.72 to 87.00%. The minimal inhibitory concentration (MIC) of Thymus capitatus EO against Aspergillus flavus E73 was found to be at 1.00 mg/ml. The oil revealed complete inhibition of dry mycelium weight and AFB1 production at 1.00 mg/ml. The EO revealed a broad spectrum of fungitoxicity against some fungi. The antioxidant activity was also assessed where IC50 (when initial concentration is reduced to half) and β- carotene/linoleic acid inhibition percentage of Thymus capitatus EO were 619.16 ± 3.94 μg/ml and 65.55%, respectively, while the total phenolic content was 21.45 μg/mg. The EO showed non-phytotoxicity on two varieties of wheat seeds. These findings demonstrated that EO could be good alternative to protect food.

scholarly journals Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats

2019 ◽  
Vol 48 (2) ◽  
pp. 411-424
Author(s):  
Maria Victoria Acevedo-Estupiñan ◽  
Elena Stashenko ◽  
Fernando Rodríguez-Sanabria
Keyword(s):  
Essential Oil ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Metabolic Effects ◽  
Human Beings ◽  
Lippia Alba ◽  
Obesity And Diabetes ◽  
Lower Glucose ◽  
Elisa Technique ◽  
America South

Introduction: Lippia alba (Mill) N.E. Brown (Verbenaceae) is an aromatic plant from Central America, South America, and the Caribbean, it is traditionally used by the Colombian population to treat various diseases such as diabetes and hypertension. The purpose of this research was to evaluate the metabolic effects of Lippia alba essential oil (EO) oral administration on obesity and diabetes markers in Wistar rats. Methods: control and Streptozotocin (STZ) diabetes induced rats were used to evaluate the EO metabolic effects. Glucose and triglycerides were measured using commercial colorimetric kits, the animals’ weight was followed for 21 days treatment and TNF- and adiponectin concentration was determined with ELISA technique. Results: The consumption of EO shows body weight gain regulation, lower glucose and cholesterol levels in normal rats and lower TNF- in comparison with the Glibenclamide treated rats between the STZ diabetic groups. No toxic effects were founded. Conclusions: The EO exerts a benefical metabolic effect in rats, therefore it is interesting to be evaluate a future in human beings with T2DM or overweight.

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