scholarly journals Care and prevention during the COVID-19 pandemic quarantine: sedentary lifestyle and increased risk of kidney stones

2021 ◽  
pp. 45-50
Keyword(s):  
Physical Activity ◽  
Kidney Stones ◽  
Sedentary Lifestyle ◽  
Stone Formation ◽  
Noncommunicable Diseases ◽  
Major Health Problem ◽  
Major Health ◽  
Increased Risk ◽  
Tract Disease ◽  
Kidney Stone Formation

Currently, the issue of lifestyle combined with lack of physical activity in quarantine conditions during the COVID-19 pandemic has become a major health problem in many countries around the world. Increased inactivity is associated with increased obesity as well as decreased physical activity and general health. Kidney stones are the third most common urinary tract disease. Prevention of non-communicable diseases depends on controlling risk factors such as low levels of physical activity. Kidney stones are also among the noncommunicable diseases that can be prevented by changing behavioral habits. Physical activity is a behavior that has many proven health benefits and is one of the most effective ways to prevent chronic diseases. The aim of this study was to investigate sedentary lifestyle and its relationship with oxidative stress and kidney stone formation, and finally to provide medical solutions and recommendations.

scholarly journals Prevalence of Malnutrition (Overweight and Underweight) in Children Aged 10-13 Years in Schools in Manipal and Utopia, Karnataka

2020 ◽  
Vol 10 (1) ◽  
pp. 94
Author(s):  
Fatemeh Jahani
Keyword(s):  
Physical Activity ◽  
Statistical Analysis ◽  
Activity Level ◽  
Normal Height ◽  
Major Health Problem ◽  
Major Health ◽  
Severe Stunting ◽  
Increased Risk ◽  
Child Eating ◽  
Height For Age

Background. Malnutrition is a major health problem in India. It mostly affects children of school going age with serious health problems putting them at an increased risk for developing chronic diseases later in life. This study aims to study the prevalence of malnutrition (overweight and underweight) in children aged 10-13 years in schools in Manipal and Utopia, Karnataka. Materials and Methods. In this study, a total 400 students were studied. Their anthropometric measurements like height, weight, BMI and MUAC, dietary pattern, physical activity level, and child eating behavior. Questionnaire was used to note the student’s information. The data collected was subjected to statistical analysis using SPSS version 21, Diet Cal, and Anthroplus1.0.4. Results. It was observed that in the childhood category 10-13 years there were 222 (55.5%) male and 178(44.5%) female. According to the BMI for age 53.4% of them falls under the normal category; 22.3% falls under the mild wasting category; About 18.3% falls under the obese category and 8% falls under the moderate wasting category. There is no students falling under the severe wasting and overweight category according to the BAZ classification. When the height for age was done for all the children, about 36.3% falls under normal height; About 35.5% falls under mild stunting; 19.3% falls under the moderate stunting; 8.3% falls under the severe stunting category; and 1% falls under tall category according to the HAZ classification. Conclusions. In conclusion, mild stunting and wasting was observed among children. There are no students falling under the severe wasting and overweight category according to the BAZ classification.

scholarly journals Serial blood lactate levels as a prognostic factor for sepsis mortality

2014 ◽  
Vol 54 (3) ◽  
pp. 168
Author(s):  
Keswari Aji Patriawati ◽  
Nurnaningsih Nurnaningsih ◽  
Purnomo Suryantoro
Keyword(s):  
Blood Lactate ◽  
Lactate Clearance ◽  
Major Health Problem ◽  
Major Health ◽  
Serial Blood ◽  
Factors Associated ◽  
Relative Risks ◽  
Increased Risk ◽  
Lactate Levels ◽  
Blood Lactate Levels

Background Sepsis is a major health problem in children and aleading cause of death. In recent decades, lactate has been studiedas a biomarker for sepsis, and as an indicator of global tissuehypoxia, increased glycolysis, endotoxin effect, and anaerobicmetabolism. Many studies h ave shown both high levels andincreased serial blood lactate level measurements to be associatedwith increased risk of sepsis mortality.Objective To evaluate serial blood lactate levels as a prognosticfactor for sepsis mortality.Methods We performed an observational, prospective study in thePediatric Intensive Care Unit (PICU) at DR. Sardjito Hospital,Yogyakarta from July to November 2012. We collected serialblood lactate specimens of children with sepsis, first at the time ofadmission, followed by 6 and 24 hours later. The outcome measurewas mortality at the end ofintensive care. Relative risks and 95%confidence intervals of the factors associated with mortality werecalculated using univariate and multivariate analyses.Results Sepsis was found in 91 (50.3%) patients admitted tothe PIW , of whom 75 were included in this study. Five patients(6. 7%) died before the 24-hour lactate collection and 39 patients(52.0%) died during the study. Blood lactate levels of ~ 4mmol;Lat the first and 24-hour specimens were associated with mortality(RR 2.9; 95%CI 1.09 to 7 .66 and RR 4.92; 95%CI 1.77 to 13.65,respectively). Lactate clearance of less than 10% at 24 hours(adjusted RR 5.3; 95% CI 1.1 to 24.5) had a significantly greaterrisk fo llowed by septic shock (adjusted RR 1.54; 95%CI 1.36 to6.4 7) due to mortality.Conclusion In children with sepsis there is a greater risk of mortalityin those with increasing or persistently high serial blood lactatelevels, as shown by less than 10% lactate clearance at 24-hours afterPIW admission.

scholarly journals Danske og Internationale tendenser: Idræt og Sundhed

2015 ◽  
Vol 31 ◽  
pp. 99-110
Author(s):  
Thomas Skovgaard
Keyword(s):  
Physical Activity ◽  
Physical Inactivity ◽  
Built Environments ◽  
Environmental Determinants ◽  
Major Health Problem ◽  
Major Health ◽  
Strong Focus ◽  
Environmental Determinants Of Health ◽  
The Social ◽  
Health Enhancing Physical Activity

In the last decades there has been increasing recognition that physical inactivity represents a major health problem. Attention has been directed towards making the population more physical active in everyday life. Strategies have focused on individual, social and environmental determinants of health enhancing physical activity. This article argues that policies on physical activity, on top of addressing individual lifestyle factors, must include a strong focus on and plans for intervention in the social and built environments that influence the ability and interest in being physical active.

Localization and Regulation of Claudin-14 in Experimental Models of Hypercalcemia

2020 ◽  
Author(s):  
Sebastian Frische ◽  
R. Todd Alexander ◽  
Patrícia Ferreira ◽  
Rebecca Tan ◽  
Weidong Wang ◽  
...  
Keyword(s):  
Cellular Localization ◽  
Stone Formation ◽  
Apical Cell ◽  
Experimental Models ◽  
Cell Junctions ◽  
Cell Periphery ◽  
Increased Risk ◽  
Junction Protein ◽  
Lacz Activity ◽  
Kidney Stone Formation

Variations in the CLDN14 gene have been linked to increased risk of hypercalciuria and kidney stone formation. However, the exact cellular localization of CLDN14 and its regulation remain to be fully delineated. To this end, we generated a novel antibody that allowed the detection of CLDN14 in paraffin-embedded renal sections. This showed CLDN14 to be detectable in the kidney only after induction of hypercalcemia in rodent models. Protein expression in kidney is localized exclusively to the thick ascending limbs (TAL), mainly restricted to the cortical and upper medullary portion of the kidney. However not all cells in the TAL expressed the tight junction protein. In fact, CLDN14 was primarily expressed in cells also expressing CLDN16, but devoid of CLDN10. CLDN14 appeared in very superficial apical cell domains and near cell junctions in a belt-like formation along the apical cell periphery. In transgenic mice, Cldn14 promotor-driven LacZ activity did not show complete colocalization with CLDN14 protein nor was it increased by hypercalcemia, suggesting that LacZ activity cannot be used as a marker for CLDN14 localization and regulation in this model. In conclusion, CLDN14, showed a restricted localization pattern in the apical domain of select cells of the TAL.

scholarly journals Physical activity in chronic kidney disease and the EXerCise Introduction To Enhance trial

2020 ◽  
Vol 35 (Supplement_2) ◽  
pp. ii18-ii22 ◽  
Author(s):  
Francesca Mallamaci ◽  
Anna Pisano ◽  
Giovanni Tripepi
Keyword(s):  
Physical Activity ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Clinical Outcomes ◽  
Sedentary Lifestyle ◽  
Public Health Problem ◽  
Epidemiological Studies ◽  
Dialysis Patients ◽  
Increased Risk ◽  
Reduced Physical Activity

Abstract It is well known from observational studies that sedentary lifestyle and reduced physical activity are common in dialysis and chronic kidney disease (CKD) patients and associate with an increased risk of morbidity and mortality in this patient population. Epidemiological studies indicate that CKD patients undergo physical activity ~9 days/month and 43.9% of dialysis patients report not exercising at all. On the basis of awareness about the strong link between sedentary lifestyle and adverse clinical outcomes, the National Kidney Foundation and Kidney Disease: Improving Global Outcomes have provided specific recommendations for physical activity in patients with kidney disease. Given the fact that CKD is a public health problem and it is still debated which type of exercise should be prescribed in these patients, this review focuses on the most robust evidence accumulated so far on the beneficial effect of various types of physical exercise on clinical outcomes in CKD and dialysis patients. This review does not treat this very important topic in another CKD category of patients, such as kidney-transplanted patients, for whom a special issue should be dedicated.

scholarly journals Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells

2019 ◽  
Vol 20 (19) ◽  
pp. 4889 ◽  
Author(s):  
Gamero-Estevez ◽  
Andonian ◽  
Jean-Claude ◽  
Gupta ◽  
Ryan
Keyword(s):  
Tight Junction ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Stone Formation ◽  
Barrier Properties ◽  
Tight Junction Proteins ◽  
Sodium Calcium ◽  
Flavonoid Quercetin ◽  
Kidney Stone Formation ◽  
Junction Proteins

: Kidney stones affect 10% of the population. Yet, there is relatively little known about how they form or how to prevent and treat them. The claudin family of tight junction proteins has been linked to the formation of kidney stones. The flavonoid quercetin has been shown to prevent kidney stone formation and to modify claudin expression in different models. Here we investigate the effect of quercetin on claudin expression and localization in MDCK II cells, a cation-selective cell line, derived from the proximal tubule. For this study, we focused our analyses on claudin family members that confer different tight junction properties: barrier-sealing (Cldn1, -3, and -7), cation-selective (Cldn2) or anion-selective (Cldn4). Our data revealed that quercetin’s effects on the expression and localization of different claudins over time corresponded with changes in transepithelial resistance, which was measured continuously throughout the treatment. In addition, these effects appear to be independent of PI3K/AKT signaling, one of the pathways that is known to act downstream of quercetin. In conclusion, our data suggest that quercetin’s effects on claudins result in a tighter epithelial barrier, which may reduce the reabsorption of sodium, calcium and water, thereby preventing the formation of a kidney stone.

MP03-04 IMPACT OF INSULIN RESISTANCE AND PHYSICAL ACTIVITY ON KIDNEY STONE FORMATION IN THE JAPANESE POPULATION

2020 ◽  
Vol 203 ◽  
pp. e22-e23
Author(s):  
Ryosuke Ando* ◽  
Sadao Suzuki ◽  
Takeshi Nishiyama ◽  
Hiroko Nakagawa ◽  
Akihiro Hosono ◽  
...  
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Kidney Stone ◽  
Japanese Population ◽  
Stone Formation ◽  
Kidney Stone Formation

Demographic Study of Water Hardness with Potential to Predict Formation of Renal Crystals

2012 ◽  
Vol 584 ◽  
pp. 504-508 ◽  
Author(s):  
Deeptiman Chatterjee ◽  
Vishaka Verma ◽  
Amiti ◽  
Sheija Rohil ◽  
Narayanasamy Arunai Nambi Raj ◽  
...  
Keyword(s):  
Kidney Stones ◽  
Kidney Stone ◽  
Stone Formation ◽  
Water Hardness ◽  
Renal Calculi ◽  
Developing Nations ◽  
Preventive Strategy ◽  
Drinking Purposes ◽  
Demographic Study ◽  
Kidney Stone Formation

Kidney stones or renal calculi or Nephrolithiasis is a common health problem in both developed and developing nations [1,2]. Analysis of the chemical and physical properties of renal calculi helps in preventing their formation and treatment. In this study, we evaluated the hardness of water used for drinking purposes, in an attempt to correlate water hardness with an increased incidence of stone formation. Identifying risk factors help to develop a preventive strategy to reduce the risk of renal calculi formation. The incidence of kidney stone formation in Vellore district was correlated with the hardness of water samples taken from different areas in Vellore. The study can be employed at a larger demographic level for effective and economic monitoring of the risk of kidney stone formation.

scholarly journals Body size and risk of kidney stones.

1998 ◽  
Vol 9 (9) ◽  
pp. 1645-1652
Author(s):  
G C Curhan ◽  
W C Willett ◽  
E B Rimm ◽  
F E Speizer ◽  
M J Stampfer
Keyword(s):  
Body Mass Index ◽  
Body Size ◽  
Calcium Oxalate ◽  
Body Mass ◽  
Kidney Stones ◽  
Stone Formation ◽  
Stone Disease ◽  
Kidney Stone Formation ◽  
Risk Of Stone Formation

A variety of factors influence the formation of calcium oxalate kidney stones, including gender, diet, and urinary excretion of calcium, oxalate, and uric acid. Several of these factors may be related to body size. Because men on average have a larger body size and a threefold higher lifetime risk of stone formation than women, body size may be an important risk factor for calcium oxalate stone formation. The association between body size (height, weight, and body mass index) and the risk of kidney stone formation was studied in two large cohorts: the Nurses' Health Study (NHS; n = 89,376 women) and the Health Professionals Follow-up Study (HPFS; n = 51,529 men). Information on body size, kidney stone formation, and other exposures of interest was obtained by mailed questionnaires. A total of 1078 incident cases of kidney stones in NHS during 14 yr of follow-up and a total of 956 cases in HPFS during 8 yr of follow-up were confirmed. In both cohorts, the prevalence of a stone disease history and the incidence of stone disease were directly associated with weight and body mass index. However, the magnitude of the associations was consistently greater among women. Specifically, the age-adjusted prevalence odds ratio for women with body mass index > or = 32 kg/m2 compared with 21 to 22.9 kg/m2 was 1.76 (95% confidence interval, 1.50 to 2.07), but 1.38 (95% confidence interval, 1.16 to 1.65) for the same comparison in men. For incident stone formation, the multivariate relative risks for the similar comparisons were 1.89 (1.51 to 2.36) for women and 1.19 (0.83 to 1.70) in men. Height was inversely associated with the prevalence of stone disease but was not associated with incident stone formation. These results suggest that body size is associated with the risk of stone formation and that the magnitude of risk varies by gender. Additional studies are necessary to determine whether a reduction in body weight decreases the risk of stone formation, particularly in women.

scholarly journals Effect of Drinking Water Hardness on Kidney Stones Formation in Ranya District

2020 ◽  
Vol 4 (1) ◽  
pp. 1-6
Author(s):  
Akram O. Esmail ◽  
Bahast A. Qadir ◽  
Hawnaz Q. Hamad
Keyword(s):  
Drinking Water ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Kidney Diseases ◽  
Stone Formation ◽  
Risk Index ◽  
Water Hardness ◽  
Magnesium Content ◽  
Chi Square ◽  
Kidney Stone Formation

This study was conducted in Rania District, Raparin University, during September 2018–March 2019, to test the relation between water hardness and kidney stone formation. The investigation depended on questionnaire form which was distributed on 100 person in Raparin (Rania, Hajiawa, and Chwarqurna) and patients whom vested the Rania clinical during December 1, 2018–January 22, 2019 which were 238 patients and only 20 of them had kidney stones developing which represent 8.4% of the total kidney diseases. The results indicated to significant effect of gender at level of significant 5% on kidney stones formation, 10% of male, and 18% of female having kidney stones. The results of Chi-square test indicated to highly significant effect of age on kidney stone formation at level of significant (0.001). The kidney stone formation increased from 19.23% to 75% with an increase in age class from (14–34) to (54 or more) year. The negative correlation coefficient value of (r = −0.63*) was recorded between water hardness and stone risk index due to the high magnesium content of drinking water in the studied area.

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