The strength of functional connectivity between the frontoparietal and default mode systems correlates with behavioral performance on a variety of tasks in the Human Connectome Project

Psychosis proneness has been linked to heightened Openness to Experience and to cognitive deficits. Openness and psychotic disorders are associated with the default and frontoparietal networks, and the latter network is also robustly associated with intelligence. We tested the hypothesis that functional connectivity of the default and frontoparietal networks is a neural correlate of the openness-psychoticism dimension. Participants in the Human Connectome Project (N = 1003) completed measures of psychoticism, openness, and intelligence. Resting state functional magnetic resonance imaging was used to identify intrinsic connectivity networks. Structural equation modeling revealed relations among personality, intelligence, and network coherence. Psychoticism, openness, and especially their shared variance, were related positively to default network coherence and negatively to frontoparietal coherence. These associations remained after controlling for intelligence. Intelligence was positively related to frontoparietal coherence. Research suggests psychoticism and openness are linked in part through their association with connectivity in networks involving experiential simulation and cognitive control. We propose a model of psychosis risk that highlights roles of the default and frontoparietal networks. Findings echo research on functional connectivity in psychosis patients, suggesting shared mechanisms across the personality-psychopathology continuum.

Download Full-text

Functional Connectivity Analysis of Brain Default Mode Networks Using Hamiltonian Path

CNS & Neurological Disorders - Drug Targets ◽

10.2174/1871527314666161124120040 ◽

2017 ◽

Vol 16 (1) ◽

pp. 44-50 ◽

Cited By ~ 4

Author(s):

Zhuqing Jiao ◽

Kai Ma ◽

Huan Wang ◽

Ling Zou ◽

Jianbo Xiang

Keyword(s):

Functional Connectivity ◽

Hamiltonian Path ◽

Connectivity Analysis ◽

Default Mode ◽

Functional Connectivity Analysis

Download Full-text

Resting State Functional Connectivity in the Default Mode Network: Relationships Between Cannabis Use, Gender, and Cognition in Adolescents and Young Adults

NeuroImage Clinical ◽

10.1016/j.nicl.2021.102664 ◽

2021 ◽

pp. 102664

Author(s):

Megan M. Ritchay ◽

Ashley A. Huggins ◽

Alexander L. Wallace ◽

Christine L. Larson ◽

Krista M. Lisdahl

Keyword(s):

Young Adults ◽

Functional Connectivity ◽

Default Mode Network ◽

Resting State ◽

Cannabis Use ◽

Adolescents And Young Adults ◽

Resting State Functional Connectivity ◽

Default Mode

Download Full-text

Age-related differences in resting state functional connectivity in pediatric migraine

The Journal of Headache and Pain ◽

10.1186/s10194-021-01274-y ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Tiffany Bell ◽

Akashroop Khaira ◽

Mehak Stokoe ◽

Megan Webb ◽

Melanie Noel ◽

...

Keyword(s):

Functional Connectivity ◽

Resting State ◽

Power Spectra ◽

Interaction Effects ◽

Resting State Functional Connectivity ◽

Default Mode ◽

Pediatric Migraine ◽

Age Related ◽

Status Interaction ◽

Underlying Mechanisms

Abstract Background Migraine affects roughly 10% of youth aged 5–15 years, however the underlying mechanisms of migraine in youth are poorly understood. Multiple structural and functional alterations have been shown in the brains of adult migraine sufferers. This study aims to investigate the effects of migraine on resting-state functional connectivity during the period of transition from childhood to adolescence, a critical period of brain development and the time when rates of pediatric chronic pain spikes. Methods Using independent component analysis, we compared resting state network spatial maps and power spectra between youth with migraine aged 7–15 and age-matched controls. Statistical comparisons were conducted using a MANCOVA analysis. Results We show (1) group by age interaction effects on connectivity in the visual and salience networks, group by sex interaction effects on connectivity in the default mode network and group by pubertal status interaction effects on connectivity in visual and frontal parietal networks, and (2) relationships between connectivity in the visual networks and the migraine cycle, and age by cycle interaction effects on connectivity in the visual, default mode and sensorimotor networks. Conclusions We demonstrate that brain alterations begin early in youth with migraine and are modulated by development. This highlights the need for further study into the neural mechanisms of migraine in youth specifically, to aid in the development of more effective treatments.

Download Full-text

Heritability and interindividual variability of regional structure-function coupling

Nature Communications ◽

10.1038/s41467-021-25184-4 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Zijin Gu ◽

Keith Wakefield Jamison ◽

Mert Rory Sabuncu ◽

Amy Kuceyeski

Keyword(s):

Functional Connectivity ◽

Structure Function ◽

Regional Differences ◽

Regional Scale ◽

Brain Regions ◽

Diffusion Weighted Mri ◽

Regional Structure ◽

Human Connectome Project ◽

Structural Connections ◽

The Relationship

AbstractWhite matter structural connections are likely to support flow of functional activation or functional connectivity. While the relationship between structural and functional connectivity profiles, here called SC-FC coupling, has been studied on a whole-brain, global level, few studies have investigated this relationship at a regional scale. Here we quantify regional SC-FC coupling in healthy young adults using diffusion-weighted MRI and resting-state functional MRI data from the Human Connectome Project and study how SC-FC coupling may be heritable and varies between individuals. We show that regional SC-FC coupling strength varies widely across brain regions, but was strongest in highly structurally connected visual and subcortical areas. We also show interindividual regional differences based on age, sex and composite cognitive scores, and that SC-FC coupling was highly heritable within certain networks. These results suggest regional structure-function coupling is an idiosyncratic feature of brain organisation that may be influenced by genetic factors.

Download Full-text

Association Between Brain Activation and Functional Connectivity

Cerebral Cortex ◽

10.1093/cercor/bhy077 ◽

2018 ◽

Vol 29 (5) ◽

pp. 1984-1996 ◽

Cited By ~ 13

Author(s):

Dardo Tomasi ◽

Nora D Volkow

Keyword(s):

Functional Connectivity ◽

Brain Activity ◽

Low Frequency ◽

Brain Activation ◽

Blood Oxygen Level Dependent ◽

Common Source ◽

Functional Connectivity Density ◽

Density Mapping ◽

Human Connectome Project ◽

Bold Responses

Abstract The origin of the “resting-state” brain activity recorded with functional magnetic resonance imaging (fMRI) is still uncertain. Here we provide evidence for the neurovascular origins of the amplitude of the low-frequency fluctuations (ALFF) and the local functional connectivity density (lFCD) by comparing them with task-induced blood-oxygen level dependent (BOLD) responses, which are considered a proxy for neuronal activation. Using fMRI data for 2 different tasks (Relational and Social) collected by the Human Connectome Project in 426 healthy adults, we show that ALFF and lFCD have linear associations with the BOLD response. This association was significantly attenuated by a novel task signal regression (TSR) procedure, indicating that task performance enhances lFCD and ALFF in activated regions. We also show that lFCD predicts BOLD activation patterns, as was recently shown for other functional connectivity metrics, which corroborates that resting functional connectivity architecture impacts brain activation responses. Thus, our findings indicate a common source for BOLD responses, ALFF and lFCD, which is consistent with the neurovascular origin of local hemodynamic synchrony presumably reflecting coordinated fluctuations in neuronal activity. This study also supports the development of task-evoked functional connectivity density mapping.

Download Full-text