scholarly journals Chemical constituents of the whole plant of PHLOGACANTHUS TURGIDUS (FUA EX HOOK.F.) LINDAU

2021 ◽  
Vol 5 (3) ◽  
pp. first
Author(s):  
Nguyen Tan Phat ◽  
Mai Thanh Chi ◽  
Phan Nhat Minh ◽  
Dang Chi Hien ◽  
Mai Dinh Tri
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
2D Nmr ◽  
Published Data ◽  
Cytotoxic Activities ◽  
Phenylethanoid Glycosides ◽  
Whole Plant ◽  
The Family ◽  
First Time

The genus Phlogacanthus belongs to the family Acanthaceae and consists of more than 49 species, These species are widespread in tropical and subtropical zones such as Bangladesh, Bhutan, China, Indonesia, India, Myanmar and Vietnam. In Vietnam, the genus contains about 06 species. The extracts from some species in this genus have been evaluated for biological activities as analgesic, antiinflammatory, antimicrobial, antioxidant, antihyperglycemic and cytotoxic activities. In this study, the whole plant of Phlogacanthus turgidus was collected, dried, cut into small species, and extracted with ethanol to yield the ethanolic extract. Isolation of chemical constituents was performed using column chromatography on silica gel; their structures were elucidated by HRESI-MS, 1D & 2D-NMR and compared with published data. Six compounds, including two nor-isoprenoids: (+)-dehydrovomifoliol (1), (3S,5R,6R,7E,9S)-megastiman-7-ene-3,5,6,9-tetrol (2), two steroids b - sitosterol (3), daucosterol (4), one lignan (+)-syringaresinol (5), a derivative of phenylethanoid glycosides: martynoside (6) were isolated from the ethyl acetate extract of the whole plant of P. turgidus. Among them, 1, 2 were reported for the first time from the genus Phlogacanthus, while 3, 4, 5, 6, were found for the first time from this species.

scholarly journals Syzygium Samarangense : A Review on its Pharmacognostical, Pharmacological and Phytochemical Proৎile

2020 ◽  
Vol 11 (4) ◽  
pp. 6066-6078
Author(s):  
Greeshma G Nair ◽  
Sathianarayanan S
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Human Colon ◽  
Salmonella Typhi ◽  
Cytotoxic Activities ◽  
Human Colon Cancer ◽  
Whole Plant ◽  
The Family ◽  
Anti Oxidant ◽  
Anti Inflammatory

The objective of this review is to document briefly about the chemical constituents, pharmacognostical evaluation and biological activities of Syzygium samarangense belongs to the family Myrtaceae. It is generally called Java Apple, Wax Apple, Blume, Chambekka etc. Syzygium samarangense traditionally used as an astringent. It is also used to treat fever and halt diarrhea. The whole plant contains flavonoids, terpenoids, tannins, phenolic compounds, gallic acid, ellagic acid, squalene, botulin, lupeol, sitosterol, mixture of cycloartenol stearate, lupenyl stearate, β-sitosterol stearate, vitamins and minerals which bearing anti-oxidant, anti- microbial, hypoglycemic, anti-inflammatory, Immunomodulatory, CNS, Anti- diarrheal, anthelmintic and cytotoxic activities. In this review, different parts of the plant, their phytochemical constituents and their corresponding biological activities have been explored. The literatures reported that the fruit part contains carotene, anthocyanin and vescalagin which is used as antioxidant, anti- microbial and hypoglycemic effect. The leaf part contains myricetin, strobopinine, epigallocatechin, aurentiacin which bearing anti-inflammatory and immunomodulatory effect. The alcoholic extracts of leaves, seeds, root bearing analgesic, anti- inflammatory effect in lipopolysaccharide, antioxidant, cytotoxic activity against human colon cancer cell, the studies revealed that the extracts showed a potent anti- microbial activity against salmonella typhi, Escherichia coli, pseudomonas aeruginosa, bacillus subtilis, candida albicans etc. The aqueous extract of fruit prevents diabetes mellitus in rats.

scholarly journals Chemical constituents of ethanol extract of leaves and molluscicidal activity of crude extracts from vitex trifolia linn.

2013 ◽  
Vol 59 (4) ◽  
pp. 19-32 ◽  
Author(s):  
Jeet S. Jangwan ◽  
Rita P. Aquino ◽  
Teresa Mencherini ◽  
Patrizia Picerno ◽  
Raghubir Singh
Keyword(s):  
Ursolic Acid ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
2D Nmr ◽  
Chloroform Extract ◽  
Biomphalaria Alexandrina ◽  
The Family ◽  
Hexane Extracts ◽  
First Time

Abstract β-sitosterol and two triterpenoids: ursolic acid acetate and platanic acid have been isolated from ethanolic extract of Vitex trifola leaves. β-sitosterol was previously isolated from the leaves, stem and seeds of Vitex trifolia. Ursolic acid acetate has been isolated for the first time in this plant species. Platanic acid has been reported for the first time in Vitex trifolia and even in the family of this plant: Verbenaceae. These compounds were characterized using spectroscopic methods including 1D-1HNMR, 13CNMR, ESIMS and 2D-NMR (HSQC, HMBC, COSY) experiments and confirmed by comparison of their NMR data with those from the literature. A preliminary molluscicidal test for ethanol, chloroform and n-hexane extracts of leaves of Vitex trifolia against Biomphalaria alexandrina adult snails showed that ethanol extract of leaves with LC50 value 26.42 mg/l (27.92 mg/l - 24.99 mg/l) was more effective than n-hexane extract with LC50 value 35.48 mg/l (43.81 mg/l - 28.72mg/l) and chloroform extract with LC50 value 46.77 mg/l (53.59 mg/l - 43.81 mg/l) after 24 h exposure.

scholarly journals Chemical constituents of the lichen Dendriscosticta platyphylloides, Lobariaceae

2019 ◽  
Vol 22 (1) ◽  
pp. 165-172
Author(s):  
Dung Thi My Nguyen ◽  
Lien Thi My Do ◽  
Huynh Thi Ngoc Tuyet ◽  
Minh Ky Quang Ho ◽  
Hai Tuan Nguyen ◽  
...  
Keyword(s):  
Cell Lines ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Human Lung Cancer ◽  
Cytotoxic Activities ◽  
Tropical Regions ◽  
Sulforhodamine B ◽  
The Family ◽  
Liver Hepatocellular Carcinoma ◽  
First Time

Introduction: Dendriscosticta is a new genus belong the Sticta wrightii group of the family Lobariaceae. This genus of foliose lichen is widely distributed in tropical regions worldwide. The lichen Dendriscosticta platyphylloides is very abundant in Bidoup forest, Lam Dong province, Vietnam. Methods: The structure of these compounds was elucidated through the interpretation of their 1D and 2D-NMR and HR-MS data. The cytotoxic activities of these compounds against liver hepatocellular carcinoma (HepG2), human lung cancer (NCI-H460), human epithelial carcinoma (HeLa) and human breast cancer (MCF-7) cell lines was performed at the concentration of 100 mg/mL using the sulforhodamine B (SRB) assay. Results: In this paper, we reported the isolation of six known compounds, including (1) 15a-acetoxyhopan-22-ol (2) hopane-15a,22-diol, (3) zeorin, (4) cerevisterol, (5) salvigenin, and (6) 5-hydroxy-3',4',7-trimethoxyflavone. Conclusion: This is the first time that these compounds are isolated from Dendriscosticta genus. These compounds showed no cytotoxic activity against four cell lines.  

scholarly journals Investigation of Phenolic Constituents of Carduncellus eriocephalus Boiss. var. albiflora Gauba and their Biological Activities

2007 ◽  
Vol 2 (8) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Marwan M. Shabana ◽  
Moshera M. El-Sherei ◽  
Mohamed Y. Moussa ◽  
Amani A. Sleem ◽  
Hosam M. Abdallah
Keyword(s):  
Biological Activities ◽  
Ethanolic Extract ◽  
Chemical Investigation ◽  
Butanol Fraction ◽  
Dicaffeoylquinic Acid ◽  
Phenolic Constituents ◽  
The Family ◽  
First Time

The total ethanolic extract (TEE) of Carduncellus eriocephalus Boiss. var. albiflora Gauba showed antioxidant, antihyperglycaemic, and antihyperlipidaemic activities, which were attributed to the n-butanol fraction (BF). Chemical investigation of the BF led to the isolation of a new flavonoid, kaempferol-3- O-β-D-galactopyranoside-6″-sulfate (16), and a phenyl propenyl glycoside, 1-β-D-glucopyranoside-3-phenyl-2-propenol (rosin) (6), which is reported for the first time in the family Asteraceae. Chrysoeriol (1), 3′- O-methylorobol (2), luteolin (3), quercetin (4), myricetin (5), kaempferol 3- O-α-L-arabinopyranoside (7), kaempferol 3- O-β-D-glucopyranoside (8), quercetin 3- O-β-D-glucopyranoside (12), luteolin 7- O-β-D-rutinoside (13), quercetin 3- O-β-D-rutinoside (14), apigenin 7- O-β-D-rutinoside (15), and 3,5-dicaffeoylquinic acid (17) were isolated for the first time from the genus Carduncellus, in addition to apigenin 7- O-β-D-glucopyranoside (9), chryseriol 7- O-β-D-glucopyranoside (10) and luteolin 7- O-β-D-glucopyranoside (11), which have been previously reported for C. eriocephalus.

Cytotoxic Constituents of Viscum coloratum

2012 ◽  
Vol 67 (3-4) ◽  
pp. 129-134 ◽  
Author(s):  
Yun L. Zhao ◽  
Xin Y. Wang ◽  
Li X. Sun ◽  
Rong H. Fan ◽  
Kai S. Bi ◽  
...  
Keyword(s):  
2D Nmr ◽  
Cytotoxic Activities ◽  
Human Tumour ◽  
The Family ◽  
Tumour Cell Lines ◽  
Phytochemical Studies ◽  
First Time ◽  
Human Tumour Cell Lines ◽  
Tof Ms ◽  
Mcf 7

4Phytochemical studies on Viscum coloratum have resulted in the isolation of nineteen compounds. The structures of the isolated compounds were identified on the basis of 1D, 2D NMR and HR-ESI-Q-TOF-MS. Pachypodol () and ombuine (6) were characterized in the family Loranthaceae for the first time. 1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one (8) and 5-hydroxy-3,7,3’-trimethoxyfl avone-4’-O-β-D-glucoside (13) were two new natural compounds, which exhibited cytotoxic activities against four human tumour cell lines (HeLa, SGC-7901, MCF-7, and U251)

scholarly journals Chemical Constituents of Pyrrosia calvata

2015 ◽  
Vol 10 (7) ◽  
pp. 1934578X1501000
Author(s):  
Yu-Jie Chen ◽  
Guo-Yong Xie ◽  
Guang-Kai Xu ◽  
Yi-Qun Dai ◽  
Lu Shi ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Chemical Constituents ◽  
Acid Methyl Ester ◽  
Caffeoylquinic Acid ◽  
Acid Methyl ◽  
Dicaffeoylquinic Acid ◽  
Whole Plant ◽  
The Family ◽  
First Time ◽  
Flavanone Glycoside

A novel flavanone glycoside, 3′,5′,5,7-tetrahydroxy-6- C- β-D-glucopyranosyl-flavanone (1), along with 16 known compounds, ( R/ S)-eriodictyol-8- C- β-D-glucopyranoside (2), quercetin-3- O- α-D-rhamnosyl (1′”→3′”)- β-D-glucopyranoside (3), hemipholin (4), 4 β-carboxymethyl-(-)-epicatechin methyl ester (5), kaempferol (6), quercetin (7), mangiferin (8), chlorogenic acid (9), 1,5- O-dicaffeoylquinic acid (10), 3,5- O-dicaffeoylquinic acid (11), 3- O-caffeoylquinic acid methyl ester (12), 1- O-caffeoyl glycoside (13), 4- O- β-D-glucopyranosyl-caffeic acid (14), 3′- O-methyleplcatechin-7- O- β-D-glucopyranoside (15), hop-22(29)-en-30-ol (16) and diploptene (17), were isolated from the whole plant of Pyrrosia calvata (Backer) Ching. Among them, compounds 2, 3, 4, 10, 11, 13 and 14 were isolated from the family Polypodiaceae for the first time, and compound 5 has not been recorded previously from the genus Pyrrosia.

scholarly journals Chemical Constituents and Biological Activities of the Aerial Parts of Cyperus rotundus (Cypereaceae)

2021 ◽  
Vol 33 (8) ◽  
pp. 1935-1940
Author(s):  
Abdoulaye Hamidou ◽  
Jean Momeni ◽  
Isaac Silvère Gade ◽  
Alfred Ngenge Tamfu ◽  
Emmanuel Talla ◽  
...  
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Cyperus Rotundus ◽  
Antidiabetic Activity ◽  
Phytochemical Study ◽  
Antioxidant Power ◽  
Aerial Parts ◽  
Ferric Reducing Antioxidant Power ◽  
First Time

The present study reports the chemical constituents, antioxidant, anticonvulsant and α-amylase activities of the aerial part of Cyperus rotundus collected in Cameroon. Phytochemical study leads to the isolation of six known compounds alongwith lupeol (1), stigmasterol (2), tetracosanoic acid (3), a mixture of β-sitosterol (4a) and stigmasterol (4b), ursolic acid (5) and saikogenin F (6). Compounds 3, 5 and 6 were isolated for the first time from this species. The structures of these compounds were determined using spectroscopic analysis including 1D and 2D NMR, mass spectrometry and comparison with the literature data. Biological activities carried out on the extracts showed that the methanol extract exhibited good antiradical scavenging activity against DPPH radical (IC50 = 2.873 μg/mL) and very good ferric reducing antioxidant power (FRAP) (IC50 = 7.535 μg/mL). It appeared that the mixture of hexane and ethyl acetate extract at the dose 100 mg/kg protected 66% of mice against convulsion induced by the pentylenetetrazol and 50% of protection when using picrotoxin at the same dose. All the extracts and compounds from this plant showed no inhibition against α-amylase related to antidiabetic activity.

scholarly journals The Phytochemical Investigation and Biological Activities of Berberis Orthobotrys

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Akber Dad ◽  
Iftikhar Ali ◽  
Nadja Engel ◽  
Muhammad Atif ◽  
Hidayat Hussain ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Fusarium Solani ◽  
Leaf Extract ◽  
Biological Activities ◽  
2D Nmr ◽  
Published Data ◽  
Root Extract ◽  
Spectroscopic Methods ◽  
Phytochemical Investigation ◽  
First Time

<p>The leaf extract of <em>Berberis orthobotrys </em>Bien. ex Aitch.<em> </em>(B.o.)<em> </em>afforded three compounds viz., β-sitosterol (<strong>1</strong>), sesamin (<strong>2</strong>) and 10-eicosanol (<strong>3</strong>) which were identified by spectroscopic methods including 1D and 2D NMR, GC-MS, IR and comparison of their spectral data with the published data. To the best of our knowledge these three compounds are reported here for the first time to be isolated from <em>Berberis orthobotrys </em>Bien. ex Aitch.<em> </em>(B.o.). Moreover the root extract exhibited good antilieshmanial activity and root and fruit extracts demonstrated minor antifungal activity against <em>Fusarium solani</em>.</p>

scholarly journals Primary investigating chemical constituents of bioactive extract from Centrostachys aquatica (R.Br.) Wall. ex Moq.-Tand.

2021 ◽  
Vol 13 (3) ◽  
pp. 71-78
Author(s):  
Quoc Luan Ngo ◽  
Thao Cuong Ta ◽  
Thi Manh Huynh Tran ◽  
Minh Dan Le ◽  
Khac Khong Minh Ngo ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Methanol Extract ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Mekong Delta ◽  
Cancer Cell Line ◽  
Published Data ◽  
Antioxidant Ability ◽  
First Time ◽  
Crude Methanol Extract

This study is aimed to screen the biological activities and chemical composition to find evidences for potential medicinal applications of Centrostachys aquatica in the Mekong Delta. Crude methanol extract and subextracts in n-hexane, ethyl acetate, and acetone from Centrostachys aquatica were tested bioactivities. The methanol extract, n-hexane and ethyl acetate subextracts exhibited antimicrobial activity with corresponding MIC values of 200, 100 and 200 µg/mL, respectively. The ethyl acetate subextract was inhibited cytotoxicity against cancer cell line LU-1 with IC50 of 27.66 µg/mL. None of the  extracts showed antioxidant ability. Three known secondary metabolites including oleanolic acid (1), 20(E)-hydroxy-b-ecdysone (2), and b-spinasterol (3) were isolated for the first time from the bioactive (ethyl acetate) subextract of Centrostachys aquatica. Their structures were elucidated by modern spectra as MS, NMR and comparison with published data.

scholarly journals Chemical constituents of the stem barks of Swintonia floribunda Griff. (Anacardiaceae)

2019 ◽  
Vol 2 (1) ◽  
pp. 71-75
Author(s):  
Dang Hoang Phu ◽  
Nguyen Xuan Hai ◽  
Le Huu Tho ◽  
Do Van Nhat Truong ◽  
Nguyen Trung Nhan ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Biological Activities ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Antimicrobial Activities ◽  
Published Data ◽  
Soluble Extract ◽  
Pancreatic Cancers ◽  
2D Nmr Spectra ◽  
Antioxidant And Antimicrobial Activities

Swintonia floribunda Griff. is an evergreen tree that belongs to Anacardiaceae family, which grows at Tay Nguyen, Lam Dong, and Dong Nai Provinces in Vietnam. Swintonia floribunda showed many interesting biological activities such as antitumor effect against breast and pancreatic cancers, antioxidant, and antimicrobial activities. From the stem barks of Swintonia floribunda Griff. (Anacardiaceae) collected in Dong Nai province, three epoxylignans: pinoresinol (1), syringaresinol (2), epipinoresinol (3), together with three other compounds: n-heptacosyl trans-ferulate (4), methyl orsellinate (5), and friedelin (6) have been isolated from the EtOAc-soluble extract. The chemical structure of these compounds were determined by 1D and 2D NMR spectra and comparison with published data. These compounds were first reported in Swintonia floribunda

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