scholarly journals Chemical Constituents and Biological Activities of the Aerial Parts of Cyperus rotundus (Cypereaceae)

2021 ◽  
Vol 33 (8) ◽  
pp. 1935-1940
Author(s):  
Abdoulaye Hamidou ◽  
Jean Momeni ◽  
Isaac Silvère Gade ◽  
Alfred Ngenge Tamfu ◽  
Emmanuel Talla ◽  
...  
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Cyperus Rotundus ◽  
Antidiabetic Activity ◽  
Phytochemical Study ◽  
Antioxidant Power ◽  
Aerial Parts ◽  
Ferric Reducing Antioxidant Power ◽  
First Time

The present study reports the chemical constituents, antioxidant, anticonvulsant and α-amylase activities of the aerial part of Cyperus rotundus collected in Cameroon. Phytochemical study leads to the isolation of six known compounds alongwith lupeol (1), stigmasterol (2), tetracosanoic acid (3), a mixture of β-sitosterol (4a) and stigmasterol (4b), ursolic acid (5) and saikogenin F (6). Compounds 3, 5 and 6 were isolated for the first time from this species. The structures of these compounds were determined using spectroscopic analysis including 1D and 2D NMR, mass spectrometry and comparison with the literature data. Biological activities carried out on the extracts showed that the methanol extract exhibited good antiradical scavenging activity against DPPH radical (IC50 = 2.873 μg/mL) and very good ferric reducing antioxidant power (FRAP) (IC50 = 7.535 μg/mL). It appeared that the mixture of hexane and ethyl acetate extract at the dose 100 mg/kg protected 66% of mice against convulsion induced by the pentylenetetrazol and 50% of protection when using picrotoxin at the same dose. All the extracts and compounds from this plant showed no inhibition against α-amylase related to antidiabetic activity.

scholarly journals Phenolic Fingerprinting, Antioxidant, and Deterrent Potentials of Persicaria maculosa Extracts

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3054 ◽  
Author(s):  
Luisa Quesada-Romero ◽  
Carlos Fernández-Galleguillos ◽  
Jan Bergmann ◽  
María-Eugenia Amorós ◽  
Felipe Jiménez-Aspee ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Antioxidant Capacity ◽  
Macrosiphum Euphorbiae ◽  
Total Phenolic ◽  
Phenolic Profile ◽  
Antioxidant Power ◽  
Aerial Parts ◽  
Ferric Reducing Antioxidant Power ◽  
First Time ◽  
Derivatives Of

Persicaria maculosa (Polygonaceae) (known as lady’s thumb) is an annual morphologically variable weed that is widely distributed in Chile. The purpose of this study was to investigate the antifeedant potential of methanolic (MeOH), ethanolic (EtOH), and dichloromethane (DCM) extracts from the aerial parts of this plant collected in the Valparaíso and Curicó provinces (Chile) and relate this activity to the antioxidant capacity and the presence of phenolic compounds in the extracts. A phenolic profile based on HPLC-ESI-MS/MS allowed the identification of 26 phenolic compounds, most of them glycosyl derivatives of isorhamnetin, quercetin, and kaempferol. In addition, the total phenolic content (TP), total flavonoids (TF), and antioxidant activity measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion scavenging (O2−), ferric-reducing antioxidant power (FRAP), and cupric-reducing antioxidant capacity (CUPRAC) of the extracts are reported. The antifeedant potentials of the plant extracts were tested against Epilachna paenulata, Pseudaletia adultera, Macrosiphum euphorbiae, and Diaphorina citri insects for the first time. The activity against the aphid M. euphorbiae was significant for the DCM extracts of plants from Valparaíso and Curicó (settling % = 23% ± 4% and 23% ± 5%, respectively). The antifeedant activities against the beetle E. paenulata and the lepidoptera P. adultera were significant for Valparaíso extracts, especially when tested against E. Paenulata (IFP = 1.0 ± 0.0). Finally, the MeOH and EtOH extracts from Valparaíso plants reduced the diet consumption of the psilid D. citri (p < 0.05). The results showed that P. maculosa is a good source of flavonoids with some antioxidant capacities and has potential interest as botanical eco-friendly alternative with deterrent activity.

scholarly journals Chemical Constituents of Cichorium intybus and their Inhibitory Effects against Urease and α-Chymotrypsin Enzymes

2011 ◽  
Vol 6 (8) ◽  
pp. 1934578X1100600
Author(s):  
Sumayya Saied ◽  
Shazia Shah ◽  
Zulfiqar Ali ◽  
Ajmal Khan ◽  
Bishnu P. Marasini ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
2D Nmr ◽  
Cichorium Intybus ◽  
Spectroscopic Techniques ◽  
Inhibitory Effects ◽  
Isolation And Identification ◽  
Aerial Parts ◽  
Phytochemical Investigation ◽  
Hydroxyphenylacetic Acid ◽  
First Time

Phytochemical investigation of the aerial parts of Cichorium intybus L. resulted in the isolation and identification of two new natural metabolites, 2,6-di[but-3( E)-en-2-onyl]naphthalene (1), and 3,3′,4,4′-tetrahydroxychalcone (2), along with nine known compounds. Their structures were determined by spectroscopic techniques including 1D and 2D NMR. The known compounds were identified as scopoletin (3), 4-hydroxyphenylacetic acid (4), 3-hydroxy-4-methoxybenzoic acid (5), 4,4′-dihydroxychalcone (6), 6,7-dihydroxycoumarine (7), 1-triacontanol (8), lupeol (9), β-sitosterol (10), and β-sitosterol-3- O-β-glucopyranoside (11). Compounds 4-6 and 8 are reported for the first time from C. intybus. Compounds 2 and 3 showed weak inhibitory activities against urease and α-chymotrypsin enzymes, respectively.

scholarly journals Chemical Constituents of the Aerial Parts ofDaucus carotasubsp.hispidusGrowing in Tunisia

2019 ◽  
Vol 14 (7) ◽  
pp. 1934578X1986351
Author(s):  
Saoussen Hammami ◽  
Abdelsamed I. Elshamy ◽  
Ridha El Mokni ◽  
Ali Snene ◽  
Kanako Iseki ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Squamous Carcinoma ◽  
2D Nmr ◽  
Spectroscopic Techniques ◽  
Aerial Parts ◽  
Weak Activity ◽  
Cervical Cells ◽  
Antimicrobial And Antioxidant Activity ◽  
First Time ◽  
High Resolution Mass Spectroscopy

Three known polyol menthane monoterpenoids, namely, (4 R)-1- p-menthen-6,8-diol (1), (4 R)-1- p-menthen-4,7-diol (2), and (1 R,2 R,4 R)- p-menthane-1,2,4-triol (3), and 6 known phenolics (4-9), in addition to β-sitosterol 3- O-glucoside (10), were isolated from the aerial parts of Daucus carota subsp. hispidus (Ball) Heywood (Family: Apiaceae) growing in Tunisia. The structures of the isolated compounds were established depending upon the spectroscopic techniques including one and two-dimensional nuclear magnetic resonance (1D, and 2D NMR) and high resolution mass spectroscopy (HRMS). The absolute configuration of the compounds 1 to 3 was determined using experimental circular dichroism (CD) for the first time. Compounds 1 to 3 were reported for the first time from this plant. Compounds 1 to 3 exhibited no antimicrobial and antioxidant activity using superoxide dismutase-like activities. Compounds 2 and 3 exhibited weak activity, while 1 showed negative cytotoxic activity against human mouth squamous carcinoma (HSC-2) and human cervical cells (HeLa) cancer cells.

scholarly journals Phytochemical Investigation and Biological Activities of Lantana rhodesiensis

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 846
Author(s):  
Fatimata Nea ◽  
Michel Boni Bitchi ◽  
Manon Genva ◽  
Allison Ledoux ◽  
Alembert Tiabou Tchinda ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Leaf Extract ◽  
Biological Activities ◽  
Phytochemical Study ◽  
Antioxidant Power ◽  
Root Extracts ◽  
Bleaching Test ◽  
Positive Linear Correlation ◽  
Ferric Reducing Antioxidant Power ◽  
Dpph Scavenging

Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a phytochemical study was undertaken, revealing a higher proportion of polyphenols, including flavonoids in L. rhodesiensis leaf extract and moderate proportion in stem and root extracts. The antioxidant activity of the extracts was also determined using three different assays: the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, the FRAP method (Ferric-reducing antioxidant power) and the β-carotene bleaching test. The anti-malarial activity of each extract was also evaluated using asexual erythrocyte stages of Plasmodium falciparum, chloroquine-sensitive strain 3D7. The results showed that the leaf extract exhibited higher antioxidant and anti-malarial activities in comparison with the stem and root extracts, probably due to the presence of higher quantities of polyphenols including flavonoids in the leaves. A positive linear correlation was established between the phenolic compound content (total polyphenols including flavonoids and tannins; and total flavonoids) and the antioxidant activity of all extracts. Furthermore, four flavones were isolated from leaf dichloromethane and ethyl acetate fractions: a new flavone named rhodescine (5,6,3′,5′-tetrahydroxy-7,4′-dimethoxyflavone) (1), 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2), 5-hydroxy-6,7,3′,4′-tetramethoxyflavone (3), and 5,6,3′-trihydroxy-7,4′-dimethoxyflavone (4). Their structures were elucidated by 1H, 13CNMR, COSY, HSQC, HMBC, and MS-EI spectral methods. Aside from compound 2, all other molecules were described for the first time in this plant species.

scholarly journals Phytochemical study of Jurinea mongolica Maxim

2018 ◽  
pp. 53-58
Author(s):  
Dumaa M ◽  
Margit Gruner ◽  
Luebkim Tilo ◽  
Solongo T ◽  
Chunsriimyatav G ◽  
...  
Keyword(s):  
Petroleum Ether ◽  
Mass Spectrometer ◽  
2D Nmr ◽  
Molecular Structures ◽  
Phytochemical Study ◽  
Aerial Parts ◽  
First Time

There are hispidulin, quercetin-3-О-rutinoside, lupeol, taraxasterol, β-sitosterolwere isolated from the ethylacetate, n-buthanol and petroleum ether fractions of the aerial parts of Jurinea mongolica Maxim. grown in Mongolia. Molecular structures of these compounds were elucidated by using TLC, CC, IR, Mass spectrometer and 1H, 13C and 2D NMR (HSQC, HMBC, 1H-1H COSY, NOESY) methods. All of these compounds were isolated from the Mongolian J. mongolica for the first time. Монгол чоногоно (Jurinea mongolica Maxim.) ургамлын фитохимийн судалгаа Манай орны унаган ургамалд багтдаг Монгол чоногоно (Jurinea mongolica Maxim.) ургамлын газрын дээд хэсгийн этилацетат, н-бутанол, петролейний эфирийн фракцаас гиспидулин, кверцетин-3-О-рутинозид, тараксастерол, лупеол, β-ситостерол бодисыг химийн цэвэр төлөв байдлаар ялгав. Тэдгээр бодисын молекулын бүтэц байгууламжийг НУТ, масс спектрометр, хроматомасс спектроскоп, 1Н ПСР, 13С болон хоѐр хэмжээст ЦСР-ын спектроскопын аргаар таньж тодорхойлов. Судалгааны дүнд 2 фенолт нэгдэл, 2 тритерпен, 1 стеролын төрлийн бодисыг энэ зүйл ургамлаас анх удаа олсон нь шинжлэх ухааны шинэ мэдээлэл болов. Түлхүүр үгс: Монгол чоногоно, Нийлмэл цэцэгтэн, фенолт нэгдэл, тритерпен, стерол

scholarly journals Phytochemical Characterization, In Vitro Anti-Inflammatory, Anti-Diabetic, and Cytotoxic Activities of the Edible Aromatic Plant; Pulicaria jaubertii

Molecules ◽  
2021 ◽  
Vol 26 (1) ◽  
pp. 203
Author(s):  
Hamdoon A. Mohammed ◽  
Mohammed F. Abdelwahab ◽  
El-Sayed M. El-Ghaly ◽  
Ehab A. Ragab
Keyword(s):  
Biological Activities ◽  
Hexane Extract ◽  
Hexane Fraction ◽  
Antidiabetic Activity ◽  
Cytotoxic Activities ◽  
Alcoholic Extract ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
First Time

Pulicaria jaubertii is a medicinal herb that alleviates inflammations and fever. Chromatographic separation, phytochemical characterization, and in vitro biological activities of the plant n-hexane extract were conducted for the first time in this study. Six compounds were isolated for the first time from the n-hexane fraction of Pulicaria jaubertii aerial parts and were identified on the bases of NMR and MS analyses as pseudo-taraxaterol (1), pseudo-taraxasterol acetate (2), 3β-acetoxytaraxaster-20-en-30-aldehyde (3), calenduladiol-3-O-palmitate (4), stigmasterol (5), and α-tocospiro B (6). Compound (6) was a rare tocopherol-related compound and was isolated for the first time from family Asteraceae, while compound (3) was isolated for the first time from genus Pulicaria. The total alcoholic extract and n-hexane fraction were tested for their anti-inflammatory, antidiabetic, and cytotoxic activities. The n-hexane fraction has dose dependent red blood cells (RBCs) membrane stabilization and inhibition of histamine release activities with IC50: 60.8 and 72.9 µg/mL, respectively. As antidiabetic activity, the alcoholic extract exerted the most inhibition on the activity of yeast α-glucosidase, with an IC50: 76.8 µg/mL. The n-hexane fraction showed cytotoxic activity against hepatocarcinoma (HepG-2), breast carcinoma (MCF-7), and prostate carcinoma (PC-3) cell lines with IC50: 51.8, 90.8 and 62.2 µg/mL, respectively. In conclusion, the anti-inflammatory effect of Pulicaria jaubertii might be attributed to the triterpenoid constituents of the n-hexane extract of the plant.

scholarly journals Comparison of phenolic profiles and antioxidant activity of three Ornithogalum L. species

2018 ◽  
Vol 44 (3) ◽  
pp. 299-306
Author(s):  
Gülin Renda ◽  
Arzu Özel ◽  
Emine Akyüz Turumtay ◽  
Burak Barut ◽  
Büşra Korkmaz ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Protocatechuic Acid ◽  
Radical Scavenging ◽  
Coumaric Acid ◽  
Antioxidant Power ◽  
Aerial Parts ◽  
Phenolic Profiles ◽  
Ferric Reducing Antioxidant Power ◽  
First Time

Abstract Background Aboveground parts and bulbs of Ornithogalum species are consumed as food and used in traditional medicine in worldwide. Objective It is aimed to report the antioxidant capacity and phenolic compounds content of Ornithogalum sigmoideum, Ornithogalum orthophyllum and Ornithogalum oligophyllum for the first time. Materials and methods Antioxidant activity of the crude methanol extracts of the aerial parts and the bulbs of the species were determined with 1,1-diphenyl-2-picryl-hydrazyl, superoxide radical scavenging, ferrous ion-chelating effect, phosphomolybdenum-reducing antioxidant power and ferric-reducing antioxidant power assay. The ethylacetate, diethylether and water subextracts from leaf and flower were analyzed to quantify selected phenolic compounds by HPLC-UV. Results Among the six extracts, the methanol extract of the aerial parts of O. orthophyllum contained the highest amount of phenolic compounds (GAE, 11.0 mg/g extract). The aerial parts of O. orthophyllum showed higher DPPH and SOD activities than the other extracts with the SC50 values of 0.39±0.05 mg/mL and 0.44±0.08 mg/mL, respectively. Protocatechuic acid, p-hydroxybenzoic acid, vanillic acid and p-coumaric acid were the most abundant compounds at all the subextracts. Conclusion The antioxidant activity is found to be in accordance with the levels of phenolic content in the extracts.

Chemical constituents from Penianthus camerounensis Dekker (Menispermaceae)

2019 ◽  
Vol 74 (10) ◽  
pp. 703-708 ◽  
Author(s):  
Georges Bellier Tabekoueng ◽  
Carine Mvot Akak ◽  
Moses K. Langat ◽  
Anatole Guy Blaise Azebaze ◽  
Alain François Kamdem Waffo ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Chemical Analysis ◽  
Betulinic Acid ◽  
Chemical Constituents ◽  
2D Nmr ◽  
2D Nmr Spectroscopy ◽  
Phytochemical Study ◽  
Chemical Structures ◽  
First Time

AbstractThe phytochemical study of the roots, leaves and twigs of Penianthus camerounensis Dekker (Menispermaceae) has led to the isolation and the characterization of 20 compounds. A ceramide, camerounamide (1), and a furoclerodanediterpenoid, camerounin (2), have not been described previously, while the compounds xylopic acid (3), syringaresinol (4), iso-propylmethylcyclohexa-1,4-diol (5), 1-(28-hydroxyoctacosanoyl)glycerol (6), scoparone (7), friedelin (8), friedelanol (9) and betulinic acid (10) are being reported for the first time from the genus Penianthus alongside 10 known compounds (11–20). Chemical structures were determined using 1D- and 2D-NMR spectroscopy, MS and chemical analysis. Their chemotaxonomic importance is discussed.

scholarly journals Phytochemical and Biological Activity Studies of the Bhutanese Medicinal Plant Corydalis crispa

2012 ◽  
Vol 7 (5) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Phurpa Wangchuk ◽  
Paul A. Keller ◽  
Stephen G. Pyne ◽  
Thanapat Sastraruji ◽  
Malai Taweechotipatr ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Multidrug Resistant ◽  
Scientific Basis ◽  
Phytochemical Study ◽  
Nmr Data ◽  
Tnf Α ◽  
First Time ◽  
Multidrug Resistant Strain

The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for 2 and 3 provided here for the first time. Crude extracts exhibited significant anti-inflammatory (p<0.01) activity against TNF- α production in LPS activated THP-1 cells. The acetylcholinesterase inhibitory activity of compounds 2, 4 and 7 and the antiplasmodial activity of compound 5 against P. falciparum strains TM4/8.2 and K1CB1 (multidrug resistant strain) are reported here for the first time. Stylopine (4) did not show antimalarial activity against the K1CB1 strain in contrast to a previous report. This study generated a scientific basis for the use of this plant in Bhutanese traditional medicine, either individually or in combination with other medicinal ingredients to treat a broad range of disorders. This study also identified compound 5 as potential new antimalarial lead compound.

scholarly journals Chemical constituents of the whole plant of PHLOGACANTHUS TURGIDUS (FUA EX HOOK.F.) LINDAU

2021 ◽  
Vol 5 (3) ◽  
pp. first
Author(s):  
Nguyen Tan Phat ◽  
Mai Thanh Chi ◽  
Phan Nhat Minh ◽  
Dang Chi Hien ◽  
Mai Dinh Tri
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
2D Nmr ◽  
Published Data ◽  
Cytotoxic Activities ◽  
Phenylethanoid Glycosides ◽  
Whole Plant ◽  
The Family ◽  
First Time

The genus Phlogacanthus belongs to the family Acanthaceae and consists of more than 49 species, These species are widespread in tropical and subtropical zones such as Bangladesh, Bhutan, China, Indonesia, India, Myanmar and Vietnam. In Vietnam, the genus contains about 06 species. The extracts from some species in this genus have been evaluated for biological activities as analgesic, antiinflammatory, antimicrobial, antioxidant, antihyperglycemic and cytotoxic activities. In this study, the whole plant of Phlogacanthus turgidus was collected, dried, cut into small species, and extracted with ethanol to yield the ethanolic extract. Isolation of chemical constituents was performed using column chromatography on silica gel; their structures were elucidated by HRESI-MS, 1D & 2D-NMR and compared with published data. Six compounds, including two nor-isoprenoids: (+)-dehydrovomifoliol (1), (3S,5R,6R,7E,9S)-megastiman-7-ene-3,5,6,9-tetrol (2), two steroids b - sitosterol (3), daucosterol (4), one lignan (+)-syringaresinol (5), a derivative of phenylethanoid glycosides: martynoside (6) were isolated from the ethyl acetate extract of the whole plant of P. turgidus. Among them, 1, 2 were reported for the first time from the genus Phlogacanthus, while 3, 4, 5, 6, were found for the first time from this species.

Sign in / Sign up

Export Citation Format

Share Document