EVALUATION OF FACTORS RESPONSIBLE FOR THE OCCURRENCE OF ORAL SUBMUCOUS FIBROSIS IN PATIENTS REFERRED TO DARBHANGA MEDICAL COLLEGE AND HOSPITAL

Oral submucous fibrosis (OSF) is a chronic progressive and irreversible disease affecting the oral, oropharyngeal, and sometimes the esophageal mucous. OSF is a disease that causes changes similar to those of systemic sclerosis (scleroderma) but limited to oral tissues. The disease is seen in those from the Indian subcontinent and from many parts of South-East Asia. It causes significant morbidity (in terms of loss of mouth function as tissues become rigid and mouth opening becomes difficult) and mortality (when transformation into squamous cell carcinoma occurs). The introduction of chewing tobacco containing areca nut into the market has been associated with a sharp increase in the frequency of OSF. Hence based on above findings the present study was planned for Evaluation of Factors Responsible for the Occurrence of Oral Submucous Fibrosis in Patients Referred to Darbhanga Medical College and Hospital. The present study was carried out in the Department of Dentistry, Darbhanga Medical College and Hospital Laheriasarai, Darbhanga Bihar. In the present study 30 cases of the oral submucous fibrosis were enrolled. Oral submucous fibrosis (OSMF) is a chronic insidious disease affecting any part of the oral cavity and sometimes the pharynx. Although, occasionally preceded by or associated with vesicle formation, it is always associated with a juxta-epithelial inflammatory reaction. It is important that preventive efforts be carried out by the concerned authorities and public health professionals in establishing tobacco cessation clinics and tobacco awareness education in such masses (especially the young generation) along with a long standing and a close knit motivation program that enables our future generations to come to avoid the menace of tobacco and its subsequent health effects. Keywords: Oral submucous fibrosis, OSF, oral cavity, Bihar.

Download Full-text

STUDY BASED ON DIAGNOSIS AND EVALUATION OF PATIENTS AFFECTED BY ORAL SUBMUCOUS FIBROSIS (OSMF) FROM BIHAR REGIONS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i11.975 ◽

2019 ◽

Vol 3 (11) ◽

Author(s):

Kumar Manish ◽

Nikita Raman ◽

Abhishek Gautam ◽

Samir Jain ◽

Prakash Chandra Jha ◽

...

Keyword(s):

Oral Submucous Fibrosis ◽

Mouth Opening ◽

Young Generation ◽

Oral Mucosal Lesion ◽

Public Health Professionals ◽

High Incidence ◽

Potentially Malignant ◽

Submucous Fibrosis ◽

Tobacco Education ◽

To Come

OSMF (Oral Submucous Fibrosis) is a widely recognized precancerous condition which is also looked upon as a potentially malignant disorder of and is characterized by a reduction in mouth opening, having palpable circumoral fibrous bands either on one side or bilaterally along with the sensation of “burning mouth”. The condition is defined as “an insidious, chronic disease affecting any part of the oral cavity and sometimes the pharynx. Although occasionally preceded by and/or associated with vesicle formation, it is always associated with juxta-epithelial inflammatory reaction followed by fibroelastic change of the lamina propria, with epithelial atrophy leading to stiffness of the oral mucosa causing trismus and inability to eat”. The increased consumption of commercially prepared arecanut preparations (Gutkha, Pan masala) specially in the younger generation has led to such high incidence of this diseasein certain areas of India. Based on above reported findings the present study was planned for Study of Cases of Oral Submucous Fibrosis (OSMF) from Bihar Region. All the patients were informed consents. The aim and the objective of the present study were conveyed to them. Approval of the institutional ethical committee was taken prior to conduct of this study. Total 30 cases of the patients suffering from oral submucous fibrosis were enrolled in the present study. In conclusion, the result of present study provides information on the prevalence of oral mucosal lesion in our population. It is important that preventive efforts be carried out by the concerned authorities and public health professionals in establishing tobacco cessation clinics and tobacco education in such masses (especially the young generation) along with a long standing and a close knit motivation program that enables our future generations to come to avoid the menace of tobacco and its subsequent health effects. Keywords: Oral Submucous Fibrosis, OSMF, Oral Cancer, Bihar region, etc.

Download Full-text

Effectiveness of Pentoxifylline Therapy for Management of Oral Submucous Fibrosis

Journal of Nepalgunj Medical College ◽

10.3126/jngmc.v19i1.40228 ◽

2022 ◽

Vol 19 (1) ◽

pp. 51-54

Author(s):

Dwarika Prasad Bajgai ◽

Bela Agrawal ◽

Abadhesh Yadav

Keyword(s):

Oral Submucous Fibrosis ◽

Mouth Opening ◽

Burning Sensation ◽

Oral Disease ◽

Medical College ◽

Adjacent Structures ◽

Group A ◽

Submucous Fibrosis ◽

Group B

Introduction: Oral submucous fibrosis is a chronic oral disease characterized by progressive buildup of constricting collagen bands in the cheeks and adjacent structures of the mouth due to chewing of areca nut. This can severely restrict mouth opening and tongue movement causing pain and burning sensation in the mouth. Aims: This study evaluates the efficacy of pentoxifylline in the management of oral submucous fibrosis. Methods: A hospital-based study, conducted in the dental outpatient department of Nepalgunj Medical College from October 2019 to September 2020. Forty-nine patients who were diagnosed histopathologically with oral submucous fibrosis were included. The patients were divided into two groups. In group A, patients were given, 200 mg thrice daily for first 30 days, then dose hiked to 400 mg thrice daily for two more months. Group B patients received treatment with multi-vitamin capsules (B-complex one capsule before sleep daily) for three months. All patients were followed up for six months and were assessed for maximum inter-incisor opening, pain on opening of mouth and burning sensation. Results: There was no statistical difference in mouth opening at baseline and first follow up. The mouth opening was significantly more in group A compared to group B from second follow up which persisted till third follow up (p <0.05). Pain and burning sensation significantly reduced in group A compared to group B from 2nd follow up which persisted till 3rd follow up (p <0.05). Few patients had nausea, dyspepsia and vomiting during treatment in group A which resolved within a few days without the need for cessation of the drug. Conclusion: Pentoxifylline can bring about significant clinical improvements in the symptoms of oral submucous fibrosis like mouth opening, pain and burning sensation, thereby improving the quality of life of the affected individuals.

Download Full-text

Prevalence of OSMF cases in various age groups correlating with habits and treatment outcomes in Saveetha Dental College: A prevalence study

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl3.3519 ◽

2020 ◽

Vol 11 (SPL3) ◽

pp. 1799-1804

Author(s):

Aklesha Behera ◽

Abilasha R ◽

Pratibha Ramani ◽

Gheena S ◽

Hannah R

Keyword(s):

Indian Subcontinent ◽

Oral Submucous Fibrosis ◽

Age Groups ◽

Mouth Opening ◽

Study Groups ◽

Patient Records ◽

Tobacco Products ◽

Precancerous Condition ◽

Male Preponderance ◽

Submucous Fibrosis

Oral submucous fibrosis is a chronic, progressive, scarring precancerous condition of the oral cavity seen predominantly in the Indian subcontinent and southeast Asia. OSMF is caused by consumption of areca nuts and tobacco products. Patients suffer from trismus and other related problems. Interincisal mouth opening ranges between 24 to 55 mm in this study, hence making the study groups between I to III. The aim of the study is to find a correlation between age, habits and treatment outcome in OSMF patients. Data was procured from patient records of 86000 patients who visited from between June 2019 and March 2020 and analysis was done. Age is between 21 to 64 years. Male preponderance is seen 92.4% pan chewing is common (35.9%) Interincisal opening is between 24 to 55 mm, making the OSMF grade I and II. OSMF affects people aged 21 to 64 years and the interincisal mouth opening is between 24 to 55 mm, making the grades I and II.

Download Full-text

Oral Submucous Fibrosis- Correlation between Clinical Findings and Histopathological Grading

Bengal Journal of Otolaryngology and Head Neck Surgery ◽

10.47210/bjohns.2018.v26i2.166 ◽

2018 ◽

Vol 26 (2) ◽

pp. 91-98

Author(s):

K Prabhu ◽

Hitendra Prakash Singh ◽

Sunil Kumar ◽

Malti Kumari Maurya ◽

Veerendra Verma ◽

...

Keyword(s):

Oral Submucous Fibrosis ◽

Significant Risk ◽

Mouth Opening ◽

Clinical Findings ◽

Areca Nut ◽

Chewing Tobacco ◽

Direct Association ◽

Submucous Fibrosis ◽

Clinical Grading ◽

Histopathological Grading

Introduction Oral Submucous fibrosis (OSMF) occurs in young adults, who are in the habit of chewing tobacco mixed with areca nut and its various commercially available preparations. The disease results in progressive inability to open the mouth due to the submucosal fibrosis initiated by chronic inflammation affecting mainly oral mucosa. Authors undertook the present study to correlate the clinical features of OSMF to histopathological features and to find out aetiopathological factors of this condition. Materials and Methods A total of 123 clinically diagnosed OSMF patients, in the age range of 17 to 70 years were studied. Mouth opening was measured using a scale and was recorded in millimeters. Incisional biopsy was taken from the representative areas in the oral cavity. The patients were graded clinically and histopathologically and results were analyzed and discussed. Result Most of the patients were in the age group of 20-30 years (37.4%) with male predominance. The duration of either tobacco or areca nut chewing ranged from 1 to 35 yrs. Most patients had these habits for 6-19 yrs. Majority (55.3% & 54.5%) of the patients belonged to grade-2 (clinical grading) and intermediate grade (HPE grading) respectively. The HPE grading showed significant and direct association with duration of ill habits. The HPE grading showed significant and direct association with clinical grading (χ2=204.08, p<0.001). Discussion The HPE grading showed significant and direct association with duration of ill habits and also with clinical findings of restriction of mouth opening and inter incisal distance. The HPE findings showed significant and direct association with clinical grading i.e. when the clinical grading increases, the histopathological grading also increases. Conclusion OSMF is a disease with a high incidence. It also carries a significant risk of transformation to oral cancer. As no effective medical and surgical treatment is available for this condition; it is desirable to diagnose OSMF at early stages.

Download Full-text

CLINICAL ASSESSMENT OF OCCURRENCE OF ORAL SUBMUCOUS FIBROSIS IN PATIENTS FROM PATNA DENTAL COLLEGE & HOSPITAL

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i10.765 ◽

2019 ◽

Vol 3 (10) ◽

Author(s):

Dr. Tanoj Kumar ◽

Anurag Rai ◽

Dr. Minti Kumari ◽

Dr. Shweta Rai ◽

Dr. Avanindra Kumar ◽

...

Keyword(s):

Oral Mucosa ◽

Clinical Assessment ◽

Histopathological Examination ◽

Oral Submucous Fibrosis ◽

Mouth Opening ◽

Oral Pathology ◽

Areca Nut ◽

College Hospital ◽

Medical College ◽

Submucous Fibrosis

Oral submucous fibrosis is a chronic progressive scarring disease of oral cavity and oropharynx characterized by epithelial atrophy and juxta epithelial inflammatory reaction with progressive fibrosis of the lamina propria and deeper connective tissue. The resulting stiffness of the oral mucosa then causes a progressive decrease in mouth opening. Hence based on above findings the present study was planned for Clinical Assessment of Occurrence of Oral Submucous Fibrosis in Patients from Patna Medical College & Hospital. The present study was planned in Department of Oral Pathology, Patna Dental College & Hospital, Patna. Total 50 cases of the patient diagnosed with the Oral Sub mucous Fibrosis (OSMF) were evaluated in the present study. History, examination and investigation of patients were done in detail as per predesigned proforma. Histopathological examination of biopsy tissue from oral mucosa was done in patients who had taken pre-therapy and post-therapy (if and when required). X-ray of temporomandibular joint was requested (whenever needed). OSMF is a commonly occurring and widely spread premalignant condition increasingly affecting the youth. The occurrence of OSMF in gutkha chewers is far faster and more severe as compared in other forms of areca nut products chewers. The easy availability and promotions of these areca nut products especially gutkha and pan masala outside the schools colleges and social places has impacted younger population in India which has led to the increased occurrence of OSMF. Keywords: Oral Submucous Fibrosis, OSFM, gutkha, pan masala, etc.

Download Full-text

Application of injection Kenacort, intradermal route in oral submucous fibrosis

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20200037 ◽

2020 ◽

Vol 6 (2) ◽

pp. 316

Author(s):

Manjunath K. ◽

Amardeep Singh ◽

Manjunatha Rao S. V.

Keyword(s):

Soft Tissues ◽

Oral Submucous Fibrosis ◽

Mouth Opening ◽

Cost Effective ◽

Intradermal Injection ◽

Research Centre ◽

P Value ◽

Medical College ◽

History Of ◽

Submucous Fibrosis

Background: Oral submucous fibrosis is a potentially pre-malignant disease, that results in progressive juxta-epithelial fibrosis of oral soft tissues, resulting in increased loss of tissue mobility, marked rigidity and inability to open the mouth. Actual treatment includes iron, multi vitamins, lycopene, pentoxifyline, steroid injections and human placental extracts. Currently available treatment with intradermal injection of Kenacort with hyaluronidase is effective to some extent.Methods: This study was conducted at Basaveshwara Medical College and Hospital, Research Centre, Chitradurga, Karnataka, in the Otorhinolaryngology Department from February 2019 to August 2019 for 6 months duration. A total of 40 patients were included in this study. Mouth opening was recorded from baseline to 6 weeks. Cases were followed up for 6 months thereafter. Patients with positive history of chewing of betel-nuts, pan, gutkha and age from 18-50 years males and females were included in this study. Patients undergoing any surgery, allergic conditions, age more than 50 years were excluded. Mouth opening was assessed by objective type and subjective type.Results: There was significant increase in mouth opening in patients after administration of intra-dermal Kenacort injection and oral lycopene. The results were statistically significant and patients responded better and p value <0.001.Conclusions: Management of moderate oral submucous fibrosis should include counselling of patients along with oral lycopene with intradermal injection of Kenacort with hyaluronidase, is highly efficacious and cost- effective in improving the mouth opening and reducing other symptoms in patients with OSMF, whereas advanced stages should be treated surgically.

Download Full-text

Clinical profile and oral sub mucous fibrosis

Nepalese Journal of ENT Head and Neck Surgery ◽

10.3126/njenthns.v5i1.16851 ◽

2017 ◽

Vol 5 (1) ◽

pp. 5-7

Author(s):

Rishi Bhatta ◽

M. Pyakurel

Keyword(s):

Oral Cavity ◽

Oral Submucous Fibrosis ◽

Cross Sectional Study ◽

Clinical Profile ◽

Betel Quid ◽

Cross Sectional ◽

Medical College ◽

Dependent Relationship ◽

Submucous Fibrosis ◽

Dose Dependent

Objectives: Oral submucous fibrosis (OSMF) is an insidious precancerous disease mostly seen in the Southeast Asia. This paper aims to study on clinical profile of patients with OSMFMaterial and Methods: This cross sectional study was done in department of ENT and HNS, Nepalgunj Medical College and Teaching Hospital. In outpatient department patients with OSMF were ask to fill up a questionnaire that included identification of patient, occupation, their symptoms and habit of taking betel quid or paan, gutkha, etc. Oral cavity was examined and lesion along with its extent and severity was noted. Intra lesional steroid and antioxidant and physiotherapy were main stay of treatment.Results: There were total 136 patients (98 male and 38 female) from 15th Dec 2013 to 15th Jan 2015. Age of patient ranged from 16 years to 53 years and average being 25.6years. Most common preparation taken was gutkha 131(96.3%) followed by betel nut, betel quid etc. Only 24(17.6%) were taking these preparations for less than 1 year. Common presenting complaints were difficulty in opening mouth followed by burning sensation and dryness of mouth. Clinically, the extent of fibrous band was found to be more commonly involving soft palate, pillars and buccal mucosa. Isolated involvement of different region of oropharynx or oral cavity was less common. Correlation of grade of trismus and average duration of taking these different preparations was highly significant. (p=0.008)Conclusions: Oral submucous fibrosis is commonly associated with intake of gutkha having dose dependent relationship with trismus. Further studies are required why only a small fraction of those using betel quid develop the disease.

Download Full-text

Medical management of oral submucous fibrosis

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20173037 ◽

2017 ◽

Vol 3 (3) ◽

pp. 628

Author(s):

Anjana Agrawal ◽

Yashaswi Kaushal ◽

Sudhakar Vaidya ◽

Kriti Shrivastava

Keyword(s):

Oral Cavity ◽

Medical Management ◽

Indian Subcontinent ◽

Oral Submucous Fibrosis ◽

Predisposing Factors ◽

Dietary Habit ◽

Progressive Development ◽

Long Time ◽

Submucous Fibrosis

Background: In 1952 Schwartz coined the term “atrophica idiopathica mucosa oris” to describe an oral fibrosing disease he discovered in 5 Indian women from Kenya. Oral submucous fibrosis of oral cavity is a chronic progressive debilitating disease and premalignant condition of oral cavity. The condition is well recognized for its malignant potential and it is particularly associated with aracanut chewing. It is characterized by burning sensation in mouth particularly while eating spicy food and progressive development of inability to open mouth. Worldwide estimate of oral submucous fibrosis indicate that 2.5 million people are affected with a higher incidence in Indian subcontinent. Methods: This is an observational type of study of 100 patients with oral submucous fibrosis attending ENT OPD. Results: We observed that with effective combination of treatment and avoiding predisposing factors and with long time follow-up we got markedly good results. Conclusions: Although medical management does not completely cure the disease but optimal doses of injection corticosteroid with injection hyaluronidase with avoidance of predisposing factors and improvement of dietary habit with prolong follow up is effective in some extent.

Download Full-text

Maintenance of Increased Mouth Opening in Oral Submucous Fibrosis Patient Treated with Nasolabial Flap Technique

Case Reports in Dentistry ◽

10.1155/2014/842578 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4

Author(s):

Milind Naphade ◽

Bhushan Bhagat ◽

Dwarkadas Adwani ◽

Ranjit Mandwe

Keyword(s):

Chronic Disease ◽

Oral Cavity ◽

Oral Mucosa ◽

Oral Submucous Fibrosis ◽

Mouth Opening ◽

Oral Carcinoma ◽

Nasolabial Flap ◽

Flap Technique ◽

Submucous Fibrosis ◽

Malignant Changes

Oral submucous fibrosis (OSMF) is an insidious chronic disease affecting any part of the oral cavity and sometimes the pharynx with epithelial atrophy leading to stiffness of the oral mucosa, causing trismus and inability to eat. However, a more serious complication of this disease is the risk of the development of oral carcinoma. A case of OSMF reported with initial interincisal mouth opening; 8 mm which was treated surgically with nasolabial flap technique followed by active mouth opening exercises for 6 months with Hister’s jaw exerciser. The patient could maintain mouth opening of 32 mm at the end of 18-months followup. The patient was observed closely for any malignant changes in the oral cavity.

Download Full-text

A prospective study of evaluation of methods to decrease the morbidity in oral submucous fibrosis

International Journal of Advances in Scientific Research ◽

10.7439/ijasr.v1i1.1660 ◽

2015 ◽

Vol 1 (1) ◽

pp. 28 ◽

Cited By ~ 2

Author(s):

Dr. Kamal Devgan ◽

Dr. Priyank Mistry ◽

Dr. Tapan Nagpal

Keyword(s):

Oral Cavity ◽

Prospective Study ◽

Oral Submucous Fibrosis ◽

Mouth Opening ◽

Burning Pain ◽

Chronic Disorder ◽

Submucous Fibrosis ◽

A Prospective Study ◽

Upper Third ◽

Tongue Mobility

Aim: To evaluate the effect of antioxidants, intralesional steroids and laser in decreasing morbidity in patients of oral submucous fibrosisIntroduction: Oral submucous fibrosis (OSMF) is a chronic disorder characterized by progressive fibrosis of the lining mucosa of the upper digestive tract involving the oral cavity, oropharynx, and rarely the upper third of the esophagus, resulting in intolerance to spicy foods, burning sensation in the mouth, limitation of mouth opening and tongue mobility, xerostomia, dysphagia and hoarseness. OSMF has been reported to occur commonly in conjunction with premalignant diseases such as leukoplakia and lichen planus and therefore aprecursor to oral cavity cancer in many cases.Materials and Methods: This prospective study included 60 patients with OSMF attending the Ear Nose & Throat Clinic of Dhiraj Hospital, Piparia. Patients of OSMF were evaluated as per Performa and for proper treatment planning were broadly classified into 4 groups based on classification suggested by Sinha et al.Conclusion: Lycopene, an antioxidant has significant response in early cases of OSMF in decreasing the burning pain in oral cavity in OSMF. Inj. triamcinolone and Inj. hyaluronidase, given submucosally havesignificant response in early cases of OSMF to improve cheek flexibility.CO2 laser have significant results in achieving satisfactory mouth opening in OSMF but notcheek flexibility.

Download Full-text