scholarly journals TO EVALUATE THE EFFECT OF TOPICAL 2% REBAMIPIDE OPHTHALMIC SUSPENSION IN PATIENTS WITH DRY EYE DISEASE.

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Shakti Krishan Rajguru ◽  
Udesh Rajpurohit
Keyword(s):  
Dry Eye ◽  
Ophthalmic Solution ◽  
Public Health Problem ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Control Group ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test ◽  
Ophthalmic Suspension

Background: Dry eye is an important public health problem causing ocular discomfort, fatigue and visual disturbance that may interfere with daily activities Methods: It is a prospective, randomized, analytical hospital based study. Minimum Sample size of 80 patients which is randomly allocated in the study (cases) and control group.  In the study group topical 2% rebapimide ophthalmic suspension and in control group 0.5% caboxymethyl cellulose ophthalmic solution were given after comprehensive ophthalmic evaluation. Results: In mild OSDI score chi square test showed p value as 0.07 which was statistically not significant. In moderate OSDI score chi square test showed p value as 0.07 which was statistically not significant.  In severe OSDI score chi square test showed p value as 0.04 which was statistically significant. Conclusion: Rebamipide 2% ophthalmic suspension is an effective treatment in dry eye disease due to mucin deficiency. There was significant improvement in signs and symptoms of dry eye Keywords: OSDI, Dry eye, Rebamipide 2% ophthalmic suspension

scholarly journals Shift Work and Dry Eye Disease in the Korean Working Population: A Population-Based Cross-Sectional Study

2021 ◽  
Vol 18 (10) ◽  
pp. 5492
Author(s):  
Joonho Ahn ◽  
So-Jung Ryu ◽  
Jihun Song ◽  
Hyoung-Ryoul Kim
Keyword(s):  
Shift Work ◽  
Dry Eye ◽  
Population Based ◽  
Cross Sectional Study ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Chi Square ◽  
Cross Sectional ◽  
Shift Workers ◽  
Chi Square Test

This study aimed to evaluate the association between shift work and dry eye disease (DED) in the general population. The 2011 Korea Health Panel (KHP) was used. Chi-square test and multivariate logistic regression were used to assess the relationship between shift work and DED. Stratification analysis was conducted by sex and age. Overall, the odds ratio (OR) of DED according to shift work did not showed significant results (adjusted OR = 1.230, 95% CI 0.758–1.901). When findings were stratified based on age older or younger than 40 years, the OR of DED increased to 2.85 (95% CI: 1.25–5.90) in shift workers under 40 years of age. Our results show an association between shift work and DED in a group of younger subjects.

scholarly journals Factors Related to the Incidence of Typhoid Fever in the Work Area Health Office of Jayawijaya Regency

2021 ◽  
Vol 5 (1) ◽  
pp. 49-56
Author(s):  
Rahmad Suryawan Ura ◽  
Yuly Peristiowati
Keyword(s):  
Typhoid Fever ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
District Health Office ◽  
District Health ◽  
Chi Square ◽  
Work Area ◽  
Chi Square Test ◽  
Test Result

Typhoid fever is a disease that is prone to occur in Indonesia, because of the characteristics of the climate that is very prone to diseases related to the seasons. The purpose of this study is to analyze factors related to the incidence of typhoid fever in the Working Area of the Jayawijaya District Health Office. The research design used is quantitative analytics method using quantitative data. The type of approach used is case control. The population is 74 patients with typhoid fever. The large sample taken as many as 37 respondents, with a large comparison of samples between the number of respondents in the case group is 37 respondents, and 37 respondents as a control group, so the total number of samples is 74 respondents. Sampling techniques used in this study is a simple random sampling technique. Based on the results of the study, it is known that there is no relationship between age and the incidence of typhoid fever in the Working Area of the Jayawijaya District Health Office. Chi-square test result obtained p-Value Sig (0.445) > α (0.05). While it is known that there is a relationship between the level of knowledge, the level of education, hygiene of individual respondents with the incidence of typhoid fever in the Work Area of the Health Office of Jayawijaya Regency. Chi-square test results obtained p- value (0.000) < α (0.05) and environmental sanitation with the incidence of Typhoid Fever in the Work Area of the Jayawijaya District Health Office. Chi-square test result obtained p-value (0.001) < α (0.05). Based on the results of the study is expected to increase kinship with patients as well as by providing health services visits to the patient's home.

scholarly journals The Development of Dry Eye Disease after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

2020 ◽  
Vol 17 (11) ◽  
pp. 3829
Author(s):  
Chia-Yi Lee ◽  
Kun-Lin Yang ◽  
Chi-Chin Sun ◽  
Jing-Yang Huang ◽  
Hung-Chih Chen ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Sinus Surgery ◽  
Eye Disease ◽  
Cumulative Probability ◽  
Control Group ◽  
Study Group ◽  
Diagnostic Code ◽  
Research Database

We aim to evaluate the risk of dry eye disease (DED) occurrence in patients with surgery-indicated chronic rhinosinusitis (CRS) via the national health insurance research database in Taiwan. After exclusion, patients with a diagnostic code of CRS and had received functional endoscopic sinus surgery (FESS) were regarded as having surgery-indicated CRS and enrolled in the study group, then each patient in the study group was age- and gender-matched to four non-CRS patients that served as the control group. The outcome was considered as the development of DED and Cox proportional hazard regression was used for the statistical analysis, which involved multiple potential risk factors of DED. A total of 6076 patients with surgery-indicated CRS that received FESS and another 24,304 non-CRS individuals were enrolled after exclusion. There were 317 and 770 DED events in the study group and the control group during the 16-year follow-up interval, and the study group demonstrated a significantly higher adjusted hazard ratio (1490, 95% confidence intervals (CI): 1.303-1.702) of DED development compared to the control group in the multivariable analysis. In addition, the cumulative probability analysis illustrated a positive correlation of DED occurrence and the disease period of surgery-indicated CRS (p < 0.0001). In the subgroup analysis, both genders revealed a higher but not significant incidence of developing DED in the study group. In conclusion, the existence of surgery-indicated CRS will increase the risk of developing DED, which correlated to the disease interval.

scholarly journals New Therapeutic Strategy and Innovative Lubricating Ophthalmic Solution in Minimizing Dry Eye Disease Associated with Cataract Surgery: A Randomized, Prospective Study

2020 ◽  
Vol 37 (4) ◽  
pp. 1664-1674 ◽  
Author(s):  
Paolo Fogagnolo ◽  
Eleonora Favuzza ◽  
Daniele Marchina ◽  
Michela Cennamo ◽  
Roberto Vignapiano ◽  
...  
Keyword(s):  
Prospective Study ◽  
Cataract Surgery ◽  
Dry Eye ◽  
Therapeutic Strategy ◽  
Ophthalmic Solution ◽  
Dry Eye Disease ◽  
Eye Disease

scholarly journals Apigenin ameliorates ocular surface lesions in a rat model of dry eye disease

2019 ◽  
Vol 17 ◽  
pp. 205873921881868
Author(s):  
Limei Liu ◽  
Dongdong Wei ◽  
Hongkun Xu ◽  
Changhui Liu
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Histopathological Examination ◽  
Tear Film ◽  
Interleukin 10 ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Necrosis Factor Alpha

To study the effects of apigenin on dry eye disease (DED) in rats. Rats were divided into six groups: (I) normal control group, (II) DED control group, (III) vehicle control group, (IV) DED + apigenin 10 mg/kg, (V) DED + apigenin 20 mg/kg, and (VI) DED + apigenin 50 mg/kg. Schirmer test, tear film break-up time (BUT), and corneal fluorescein staining were used to evaluate the effects of apigenin on the ocular surface. The related inflammatory cytokines were detected by enzyme-linked immunosorbent assay (ELISA). Histopathological examination and inflammatory index were also performed. The results showed that administration of apigenin was shown a significant effect on the recovery of ocular surface function. Compared to the control group, apigenin treatment in DED rats significantly decreased the level of the tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6); however, the interleukin-10 (IL-10) level was increased. Histopathological examination further verified the anti-inflammatory effects of apigenin on DED rats. The results demonstrated that apigenin could protect DED rats via inhibition of inflammation, suggesting that it may have potential as a therapy for DED.

scholarly journals Channa striata (Ikan Gabus) Extract and the Acceleration of Tuberculosis Treatment: A True Experimental Study

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Isa Ma’rufi ◽  
Khaidar Ali ◽  
Ign Arya Sedemen ◽  
P. Purwanto ◽  
Abu Khoiri
Keyword(s):  
Experimental Study ◽  
Intervention Group ◽  
International Health ◽  
Tuberculosis Treatment ◽  
Control Group ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test ◽  
Channa Striata ◽  
True Experiment

Tuberculosis is international health problem, which is classified in Global Emergency disease since 1992. The objective of the study is to determine the effect of Channa striata extract toward the acceleration of tuberculosis treatment. The study used true experiment, in which the intervention of the study was Channa striata supplementation to respondent. In addition, Chi-square was used to analyze the data with SPSS version 22. The result is the proportion of respondent classified in negative category in intervention group within week 0, week 1, week 2, week 3, and week 4 being 10.7%, 35.9%, 56.3%, 70.9%, and 90.3%, respectively. Besides, the proportion of respondent classified in negative category in control group within week 0, week 1, week 2, week 3, and week 4 was 13.4%, 23.7%, 37.1%, 49.5%, and 68%, respectively. Based on Chi-square test, the P value of Channa striata supplementation toward the acceleration of tuberculosis treatment week 1, week 3, and week 4 is 0.045, 0.019, and 0.005 (P< α; α=0.05), respectively. It means that there were differences between Channa striata supplementation and acceleration of tuberculosis treatment among respondent. Therefore, Channa striata treatment was significantly related to the acceleration of tuberculosis recovery.

The Effect Of Oxytosin Massage Through The Back On The Production Of Breast Milk In Post Partum Mother In The Mother Of Permata Bunda Subdistrict Babat

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Dwi Kurnia purnama Sari
Keyword(s):  
Breast Milk ◽  
Milk Production ◽  
Health Workers ◽  
Statistical Tests ◽  
Post Partum ◽  
Significant Degree ◽  
Control Group ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test

Every minute of one baby indonesia died because they did not to obtain breast milk (BM) in the first hour of birth, problems in the provision of breastfeeding can because production breastfeeding not out.One way to overcome the incomplete milk production is by doing a massage of oxytocin through the back. This message can relax the mother’s so that stimulate oxcytocin reflex and milk production also smoothly. The purpose of this research to know the influence of massage oxytocin through the back to production breastfeeding on the post partum. This research using design Quasy experimental that involves 30 respondents taken with systematic random sampling. Respondents divided into 2 groups, namely the control group were 15 respondents and group experimental were 15 respondents.Data collection use observation checklist.Data analyzed using chi-square test with a significant degree α ≤ 0.05. The results of statistical tests chi square obtained p value = 0,028 (α< 0,05)thus H1 accepted that mean there are influence massage oxytocin through the back to production breastfeeding on the post partum. The research at the clinic Permata BundaSubdistrict Babat that is the massage oxytocin through the back to production breastfeeding. Because massage oxytocin through the back can stimulate reflexes oxytocin hormone. Expected for health workers can provide health education about massage oxytocin through the back to the community so later expected all the community be able to apply massage oxytocin through the back to overcome it swift sailboat production breastfeeding.

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