scholarly journals Assessment of Risk Factors and the Effect of Drug Abuse on the Incidence of Ischemic Heart Disease in Patients Less Than 40 Years Old

2021 ◽  
Vol 11 (1) ◽  
pp. 31751.1-31751.6
Author(s):  
Javad Karimi ◽  
◽  
Mohamadreza Maghsoudi ◽  
Lida Shojaei Arani ◽  
Shahrooz Yazdani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Family History ◽  
Alcohol Consumption ◽  
Ischemic Heart Disease ◽  
Anabolic Steroids ◽  
Positive Family History ◽  
Ischemic Heart ◽  
History Of ◽  
Acute Mi

Background: in this study, we examined the risk factors and the effects of substance abuse on the incidence of ischemic heart disease in patients less than 40 years old in Shahid Rajaei Hospital in Karaj from 2019-2020. Methods: This case-control study was done on 70 patients in the cases and 70 cases in the control groups. All demographic data, including age, gender, place of residence, weight, height, body mass index, cardiovascular (CVD) risk factors, including hypertension, high levels of blood fats, diabetes, a history of smoking cigarettes, tobacco, crystal meth, and cocaine, alcohol consumption, as well as a history of taking supplements for bodybuilding, and sex-enhancing drugs were obtained. Afterward, blood levels of glucose and fats were evaluated and urine analysis for the presence of drugs, such as amphetamine, methamphetamine, buprenorphine, benzodiazepines, cannabinoids, cocaine, morphine, methadone, tramadol, and tricyclic antidepressants (TCA) was done. SPSS software v. 22 was used for data analysis. Results: Among the studied underlying factors and drugs, family history, high blood pressure, diabetes, smoking, and low-density lipoprotein (LDL) levels above 130 mg/dL were significantly associated with a higher risk of acute myocardial infarction (MI) (P<0.05). Interestingly, alcohol consumption and the use of tobacco, opium, methadone, heroin, cocaine, cannabis, amphetamines, methamphetamine, tramadol, benzodiazepines, TCA, buprenorphine, and anabolic steroids were not significantly associated with acute MI under 40 years (P>0.05). Conclusion: according to the results of the present study, it seems that a positive family history of MI under the age of 55, hypertension, diabetes, smoking, and LDL levels above 130 mg/dL are more significant risk factors for acute MI in patients under 40 years of age in comparison with the consumption of alcohol and the use of hookah, opium, methadone, heroin, cocaine, cannabis, amphetamine, methamphetamine, tramadol, benzodiazepines, TCA, buprenorphine, and anabolic steroids. It should be noted that further studies in this area are recommended.

scholarly journals Comparison of Family History of Sudden Cardiac Death in Nonischemic and Ischemic Heart Disease

2012 ◽  
Vol 5 (4) ◽  
pp. 757-761 ◽  
Author(s):  
Eeva Hookana ◽  
M. Juhani Junttila ◽  
Kari S. Kaikkonen ◽  
Olavi Ukkola ◽  
Y. Antero Kesäniemi ◽  
...  
Keyword(s):  
Heart Disease ◽  
Family History ◽  
Sudden Cardiac Death ◽  
Ischemic Heart Disease ◽  
Cardiac Death ◽  
Ischemic Heart ◽  
History Of

scholarly journals Association of Diabetes and Hypertension as risk factors with Ischemic Heart Disease among patients visiting a Public Sector Tertiary Care Hospital of Karachi, Pakistan

2021 ◽  
Vol 10 (4) ◽  
pp. 215-219
Author(s):  
Zulfiqar Ali Shaikh ◽  
Javeria Shamim ◽  
Akmal Khurshid Bhatti ◽  
Sahar Soomro ◽  
Zareen Kiran ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Family History ◽  
Public Sector ◽  
Ischemic Heart Disease ◽  
Sedentary Lifestyle ◽  
Tertiary Care ◽  
Ischemic Heart ◽  
P Value ◽  
Care Hospital

Background: Ischemic Heart Disease (IHD) is a leading cause of morbidity and mortality worldwide. IHD results from myocardial ischemia, and occurs whenever perfusion outgrows the demand. Though lethal, but can be prevented by modification of predisposing conditions, most important are diabetes and hypertension. Almost fifty percent of IHD patients are found hypertensive with or without being diabetic. The objective of the study was to determine association of diabetes and hypertension as risk factors for IHD patients Methods: This was a hospital-based cross-sectional study that included 199 IHD patients of 35-70 years age, visiting Civil Hospital Karachi, a tertiary care public sector hospital, from September 2017 to January 2018 by using non-probability convenient sampling technique. The patients were approached in the hospital and briefed about the purpose of the study. A pre-tested, structured close ended questionnaire was used to collect the data. Data entry and analysis were done by using SPSS version 20.0. A p-value of <0.05 was considered as statistically significant. Results: Out of 199 participants, 156 (78%) were males while 43 (22%) were females; 119 60%) were 56-65 years of age. Family history of ischemic heart diseases was unremarkable in 126 (63%) patients. In total, 122 (61%) were diabetic; among them, 24 were of less than 40years and 98 of more than 40years of age. The older age of the diabetics had a direct association with the risk of IHD (p-value <0.05). About 83% had a non-significant family history for diabetes; and 83% of the total study participants were having a sedentary lifestyle. Out of 199, 166 (83%) had never checked their blood pressures earlier. The lifestyle, diet, addiction, and duration of hypertension had a strong association with IHD (p-value <0.05). Conclusion: IHD occurs more frequently in males of 56-65 years age, with insignificant family history for IHD and diabetes. The IHD is associated with hypertension and diabetes along with sedentary lifestyle, unhealthy diet and smoking/tobacco addiction.

Atherosclerosis and Predictors of Cardiovascular Mortality in Hemophilia.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 1216-1216 ◽  
Author(s):  
Carolyn Foley ◽  
Lawrence A. Nichols ◽  
Margaret V. Ragni
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Ischemic Heart Disease ◽  
Cardiovascular Risk Factors ◽  
Cardiovascular Mortality ◽  
Coronary Stenosis ◽  
Ischemic Heart ◽  
Similar Frequency ◽  
History Of

Abstract The degree of coronary stenosis in men with hemophilia is similar to the general population, yet coronary symptoms and cardiovascular mortality are significantly lower, as we and others have previously showed. Although actor VIII deficiency may be protective against ischemic heart disease (IHD), the role of standard cardiovascular risk factors, most of which are associated with elevated factor VIII, in predicting ischemic heart disease or mortality in hemophilia is not known. We, therefore, conducted a case-control study to compare risk factors for IHD between hemophilic men (n=14) and non-hemophilic controls (n=42), matched 3:1 by age, race, and gender. Cardiovascular risk factors included hypertension, hypercholesterolemia, obesity, creatinine elevation, old age, and history of smoking, diabetes, and coronary symptoms (chest pain, angina, infarction). Clinical data were obtained from de-identified medical records on the cases and controls from the University of Pittsburgh Medical Center (UPMC) Medical Archival Records System (MARS), using an honest broker system. Intraluminal coronary stenosis was evaluated by a semi-quantitative scoring system, with 0=minimal (&lt;25%), 1=mild (³ 25%), 2=moderate (³ 50%), and 3=severe (³ 75%). Continuous data were analyzed by student’s t test, and discrete data were analyzed by chi square test with Yate’s continuity correction, or Fisher’s exact test. Cases and controls did not differ in mean age at death, 40 vs. 41 years, p&gt;0.025; frequency of coronary symptoms, 0 of 14 (0%) vs. 4 of 42 (9.5%), p=0.305; degree of intraluminal coronary stenosis &gt;25% at autopsy, 11 of 14 (78.6%) vs. 25 of 42 (59.5%), p=0.118; or in coronary stenosis &gt;75% at autopsy, 2 of 14 (14.3%) vs. 8 of 42 (19.0%), p=0.302. There was also no difference in the frequency of cardiovascular risk factors between cases and controls, including hypertension (systolic &gt;140 or diastolic &gt;90 mm Hg), 4 of 14 (28.6%) vs. 12 of 42 (28.6%), p = 0.266; smoking, 5 of 14 (37.7%) vs. 14 of 37 (p=0.775); or hypercholesterolemia, 5 of 14 (35.7%) vs. 8 of 42 (19.0%), p = 0.419. Although a significantly fewer cases than controls had BMI &gt; 25, 3 of 14 (21.4%) vs. 28 of 42 (66.7%), p=0.003; diabetes, 0 of 14 (0%) vs. 9 of 38 (23.7%), p=0.044; and creatinine &gt;1.2 mg/dl, 1 of 14 (7.1%) vs. 13 of 39 (33.3%), p=0.047, these findings did not persist after controlling for age and HIV infection. The proportion of hemophilic cases who succumbed to cardiopulmonary death, however, was significantly lower than in non-hemophilic controls, 0 of 14 (0%) vs. 14 of 42 (33.3%), p=0.009, which persisted after correction for age. Other than HIV infection, which was more common among those with severe hemophilia (&lt;0.01 U/ml) than mild or moderate hemophilia (F.VIII ³ 0.01 U/ml), 8 of 9 (88.9%) vs. 1 of 5 (20.0%), p=0.022, hemophilia severity did not affect the proportion with &gt;25% intraluminal coronary stenosis, 7 of 9 (77.8%) vs. 4 of 5 (80.0%), p=0.494; or with &gt;75% intraluminal stenosis, 0 of 9 (0%) vs. 2 of 5 (40.0%), p=0.110; coronary symptoms, p=1.00; hypertension, p=0.419; hypercholesterolemia, p=0.315; creatinine &gt;1.2, p=0.357; or history of smoking, p=0.315; diabetes, p=1.00; BMI ³ 25, p=0.247; or coronary symptoms, p=1.00. In conclusion, hemophilic men not only have a similar frequency of coronary symptoms and a similar degree of intraluminal coronary stenosis as age-, gender-, and race-matched non-hemophilic controls, they also appear to have a similar frequency of cardiovascular risk factors. These findings suggest, but do not prove, that factor VIII deficiency, even in the presence of cardiovascular risk factors and atherosclerotic vessels, may be protective against thrombotic coronary occlusion and ischemic heart disease.

Family history of ischemic heart disease and risk of acute myocardial infarction

2003 ◽  
Vol 37 (3) ◽  
pp. 183-187 ◽  
Author(s):  
Michaela Bertuzzi ◽  
Eva Negri ◽  
Alessandra Tavani ◽  
Carlo La Vecchia
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Disease ◽  
Family History ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
History Of

scholarly journals Population Risk of Ischemic Heart Disease Depending on the Volume of Alcohol Consumption by the Population (ЭССЕ-РФ Study in the Kemerovo Region)

Kardiologiia ◽  
2019 ◽  
Vol 59 (1) ◽  
pp. 62-68 ◽  
Author(s):  
S. A. Maksimov ◽  
D. P. Cygankova
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Alcohol Consumption ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Alcoholic Beverages ◽  
Alcohol Abusers ◽  
Additional Risk

Purpose: to assess relationship between the prevalence of cardiovascular risk factors and associated population risk of ischemic heart disease (IHD) alcohol consumption in the Siberian region (Kemerovo Region).Materials and methods.This work was carried out within the framework of a multicenter epidemiological study “Epidemiology of CardioVascular Diseases in the regions of the Russian Federation” (ЭССЕ-РФ in the Kemerovo region) in 2013. In the final form, the sample size was 1628 individuals aged 25–64 years. We analyzed data on frequency, volume, and type of consumed alcoholic beverages, as well as on the presence of a number of risk factors of cardiovascular diseases and IHD. Alcohol consumption was estimated by the original method, volume of alcohol consumed in a year was categorized as absent (non-drinkers), moderate, medium, and strong. The calculation of the population risk of IHD was carried out according to the author’s methodology, taking into account the prevalence of risk factors and their contribution to the development of IHD.Results. Prevalence of several risk factors among non-drinkers was significantly different (p<0.05) compared with drinkers with varying degrees of alcohol consumption. In men, there were differences in low physical activity, hypertriglyceridemia, excess weight, education, in women – in anxiety, low physical activity, hypertriglyceridemia, educational qualifications, smoking. In nondrinking men, the additional risk of IHD associated with risk factors was slightly reduced (–1.1 %). In groups of moderate, moderate, and strong alcohol consumption, risk of IHD was higher than the population risk by 2.2 %, 0.7 % and 6.5 %, respectively. In non-drinking women high burden of risk factors accounted for additional risk of IHD (4.5 %). In women with moderate and medium alcohol consumption the risk of IHD was 2.5 and 1.9 %, respectively, lower compared with population risk. Abuse of alcohol in women caused significant increase in the burden of risk factors and, accordingly, was associated with high additional risk of IHD (18.7 %).Conclusion. Predominantly linear in men and J-shaped in women relationship between prevalence of risk factors and volume of alcohol consumption accounted for analogous tendencies in population IHD risk. Specific for men is close to linear dependence of additional IHD risk on population IHD risk with insignificant variability in non-drinkers, moderate and medial consumers, and with significant growth in alcohol abusers. Women have a J-shaped relationship: in extreme categories (non-drinkiers and alcohol abusers), the risk of IHD is higher than the population risk, while in the middle categories (moderate and medial consumers) it is lower than the population risk.

scholarly journals Rate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study

2021 ◽  
Author(s):  
Magnus N. Ebbesen ◽  
Maria D’Souza ◽  
Charlotte Andersson ◽  
Jawad H. Butt ◽  
Christian Madelaire ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Heart Disease ◽  
Family History ◽  
Ischemic Heart Disease ◽  
Dilated Cardiomyopathy ◽  
Family Member ◽  
Ischemic Heart ◽  
Degree Relative ◽  
History Of

Background It is poorly understood why some patients with atrial fibrillation develop heart failure (HF) and others do not. We examined the rate of developing HF in patients with atrial fibrillation with and without first‐degree family members with HF or dilated cardiomyopathy (DCM). Methods and Results Using Danish nationwide registries, patients born after 1942 diagnosed with atrial fibrillation in the period 2005 to 2015 were identified and followed for up to 5 years. Patients with pre‐existing HF, DCM, and/or ischemic heart disease diagnoses were excluded. Exposure was defined as a first‐degree relative with HF or DCM. The rate of developing the composite end point of HF or death, and the components, was estimated with multivariable Cox proportional hazard regression models. We included 10 605 patients. A total of 17% had a family member with DCM/HF. Having a family member with HF/DCM was associated with an increased 5‐year risk of the composite of HF/death (cumulative incidence, 9.2% [95% CI, 7.8–10.7] versus 5.6% [95% CI, 5.0–6.1]; adjusted hazard ratio [HR] 1.36 [95% CI, 1.13–1.64]). (HF 8.4% [95% CI, 7.0–9.8] versus 4.5% [95% CI, 4.1–5.0]); (adjusted HR, 1.49 [95% CI, 1.22–1.82]). However, familial HF/DCM was not significantly associated with an increased 5‐year risk and rate of death (0.8% [95% CI, 0.4–1.2] versus 1.1% [95% CI, 0.8–1.3]); (adjusted HR, 0.80 [95% CI, 0.46–1.39]). Conclusions In patients with incident atrial fibrillation without prior ischemic heart disease or HF diagnoses, 1 of 6 had a first‐degree relative with HF, and having such a family history of HF/DCM was associated with an 87% increase in 5‐year incidence of HF compared with those without.

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