scholarly journals A Mini Review of the Covid-19, Vaccine Platform and Future Preparedness

Author(s):  
Md Ather Hussain Ansari ◽  
Md Sadique Hussain ◽  
Mohit

Many countries are engaged in making vaccine against COVID-19 as the world records more than 38 million SARS-CoV-2 infections and more than one million deaths. It has prompted nations to close the borders, halted companies, kept people inside their homes, and numerous other measures to prevent their spread. We systematically searched on Google scholar, PubMed, LitCovid, and MedRxiv using the certain search terms for published articles. The infection raging through communities is expected to have evoked some degree of immunity in many asymptomatic and recovered individuals. However, the level of protective immunity and duration of such immunity have not been studied in depth. At the same time, spanning from the conventional whole virus vaccine to recombinant vaccines using Adenovirus vectors and first-of-its kind mRNA vaccines are in human trials. Before the effectiveness and safety of such vaccines are established billions of doses have been produced and stockpiled to save time in production and distribution. Antigenic diversity and the potential role of passive surveillance in COVID-19 regulation are explored in this report.

Author(s):  
Ali Forouzanfar ◽  
Hamideh Sadat Mohammadipour ◽  
Fatemeh Forouzanfar

: Periodontal diseases are highly prevalent and can affect high percentage of the world population. Oxidative stress and inflammation plays an important role in the pathogenesis of periodontal diseases. Nowadays, more attention has been focused on the herbal remedies in the field of drug discovery. Green tea is an important source of polyphenol antioxidants, it has long been used as a beverage worldwide. The most interesting polyphenol components of green tea leaves that are related with health benefits are the catechins. Taken together this review suggested that green tea with its wide spectrum of activities could be a healthy alternative for controlling the damaging reactions seen in periodontal diseases.


2021 ◽  
Vol 29 (Supplement_1) ◽  
pp. i45-i46
Author(s):  
A Peletidi ◽  
R Kayyali

Abstract Introduction Obesity is one of the main cardiovascular disease (CVD) risk factors.(1) In primary care, pharmacists are in a unique position to offer weight management (WM) interventions. Greece is the European country with the highest number of pharmacies (84.06 pharmacies per 100,000 citizens).(2) The UK was chosen as a reference country, because of the structured public health services offered, the local knowledge and because it was considered to be the closest country to Greece geographically, unlike Australia and Canada, where there is also evidence confirming the potential role of pharmacists in WM. Aim To design and evaluate a 10-week WM programme offered by trained pharmacists in Patras. Methods This WM programme was a step ahead of other interventions worldwide as apart from the usual measuring parameters (weight, body mass index, waist circumference, blood pressure (BP)) it also offered an AUDIT-C and Mediterranean diet score tests. Results In total,117 individuals participated. Of those, 97.4% (n=114), achieved the programme’s aim, losing at least 5% of their initial weight. The mean % of total weight loss (10th week) was 8.97% (SD2.65), and the t-test showed statistically significant results (P<0.001; 95% CI [8.48, 9.45]). The programme also helped participants to reduce their waist-to-height ratio, an early indicator of the CVD risk in both male (P=0.004) and female (P<0.001) participants. Additionally, it improved participants’ BP, AUDIT-C score and physical activity levels significantly (P<0.001). Conclusion The research is the first systematic effort in Greece to initiate and explore the potential role of pharmacists in public health. The successful results of this WM programme constitute a first step towards the structured incorporation of pharmacists in public’s health promotion. It proposed a model for effectively delivering public health services in Greece. This study adds to the evidence in relation to pharmacists’ CVD role in public health with outcomes that superseded other pharmacy-led WM programmes. It also provides the first evidence that Greek pharmacists have the potential to play an important role within primary healthcare and that after training they are able to provide public health services for both the public’s benefit and their clinical role enhancement. This primary evidence should support the Panhellenic Pharmaceutical Association, to “fight” for their rights for an active role in primary care. In terms of limitations, it must be noted that the participants’ collected data were recorded by pharmacists, and the analysis therefore depended on the accuracy of the recorded data, in particular on the measurements or calculations obtained. Although the sample size was achieved, it can be argued that it is small for the generalisation of findings across Greece. Therefore, the WM programme should be offered in other Greek cities to identify if similar results can be replicated, so as to consolidate the contribution of pharmacists in promoting public health. Additionally, the study was limited as it did not include a control group. Despite the limitations, our findings provide a model for a pharmacy-led public health programme revolving around WM that can be used as a model for services in the future. References 1. Mendis S, Puska P, Norrving B, World Health Organization., World Heart Federation., World Stroke Organization. Global atlas on cardiovascular disease prevention and control [Internet]. Geneva: World Health Organization in collaboration with the World Heart Federation and the World Stroke Organization; 2011 [cited 2018 Jun 26]. 155 p. Available from: http://www.who.int/cardiovascular_diseases/publications/atlas_cvd/en/ 2. Pharmaceutical Group of the European Union. Pharmacy with you throughout life:PGEU Annual Report [Internet]. 2015. Available from: https://www.pgeu.eu/en/library/530:annual-report-2015.html


As they prepare for graduation, college students often make numerous plans for the future. They consider the job market and prospects for marriage, family, and other relationships. Pursuing a diversity-rich future is also important, and in this chapter, the five interviewees discuss the potential role of culture in their post-college lives. Additional considerations include looking at the world through a global lens, approaching diversity as a value, and engaging the outrage of those who have suffered at the hands of injustice. Though even the best crystal ball cannot predict what will happen tomorrow, today's careful planning with sensitivity towards culture may be sufficient for ensuring a brighter road ahead.


Author(s):  
Мелек Зебитовна Умархажиева

В статье исследована проблема оборота недоброкачественных лекарственных средств в мире и на территории России. Рассмотрена статистика выявления и изъятия недоброкачественных лекарственных средств на территории России. Выявлены основные причины производства и распространения таких средств. Отмечена роль Федеральной службы по надзору в сфере здравоохранения России (Росздравнадзора) в борьбе с указанным фальсификатом, а также правовые последствия за их оборот. This article examines the problem of turnover of substandard medicines in the world and in Russia. Statistics of detection and withdrawal of substandard medicines in Russia are considered. The main reasons for the production and distribution of such funds are identified. The role of the Federal service for supervision of healthcare in Russia (Roszdravnadzor) in the fight against these funds, as well as the legal consequences for their turnover, is noted.


2017 ◽  
Vol 181 (19) ◽  
pp. 510-510 ◽  
Author(s):  
Jo Hockenhull ◽  
Andrea E Turner ◽  
Kristen K Reyher ◽  
David C Barrett ◽  
Laura Jones ◽  
...  

Food-producing animals throughout the world are likely to be exposed to antimicrobial (AM) treatment. The crossover in AM use between human and veterinary medicine raises concerns that antimicrobial resistance (AMR) may spread from food-producing animals to humans, driving the need for further understanding of how AMs are used in livestock practice as well as stakeholder beliefs relating to their use. A rapid evidence assessment (REA) was used to collate research on AM use published in peer-reviewed journals between 2000 and 2016. Forty-eight papers were identified and reviewed. The summary of findings highlights a number of issues regarding current knowledge of the use of AMs in food-producing animals and explores the attitudes of interested parties regarding the reduction of AM use in livestock. Variation between and within countries, production types and individual farms demonstrates the complexity of the challenge involved in monitoring and regulating AM use in animal agriculture. Many factors that could influence the prevalence of AMR in livestock are of concern across all sections of the livestock industry. This REA highlights the potential role of farmers and veterinarians and of other advisors, public pressure and legislation to influence change in the use of AMs in livestock.


Author(s):  
Ahmed S. Ali ◽  
Ekram A. Saied ◽  
Sharifa M. Theeban ◽  
Mazen M. Humayran ◽  
Assmaa Ahmed Shaker ◽  
...  

Background: Many publications discussed the potential role of medicinal plants in the management of COVID-19. However, clinical studies of the efficacy and safety of specified phytochemical(s) are limited. Objectives: To explore the pharmacological profile of specified compounds against COVID-19 Method: Systematic literature search of academic databases to explore specified phytochemicals for the management of COVID-19 using appropriate search terms. Rayyan software was used to organize 786 citations of which. 236 articles were included in this review. Results: Initially 70 compounds were identified to have a potential role in the management of COVID-19. In this review, 18 compounds were selected for further search Conclusion: In vitro anti-SARS-CoV-2activity has been demonstrated for a variety of natural compounds. However, preclinical research for most phytochemicals is scarce, and only a few compounds have been evaluated in clinical trials against COVID-19. A comprehensive pharmacological profile of these phytochemicals is urgently needed.


2021 ◽  
Vol 9 (2) ◽  
pp. 31-41

Coccidiosis is a major protozoal disease that severely affects livestock and other animals, especially poultry. Seven species of Eimeria cause avian coccidiosis in poultry and evolve from the epithelial cells of intestine, readily induce illness and cause death to a varying extent. Prophylactic chemotherapy was a dominant choice for the control of coccidiosis but resistance to the drug was a major factor of therapy failure. Protective immunity was produced in chickens with any of Eimeria species as only species-specific immunity can be produced by recently used vaccines. Attenuation can be achieved by the serial passages in all seven Eimeria species. In chicken, the first attempt against coccidiosis caused the introduction of live oocysts, the basis of which led to the discovery of first live attenuated commercial vaccine, Paracox1. As the emerged recombinant vaccines were replaced as a first choice, there is still a dire need to do more work on new techniques like DNA vaccine formulation along with the role of dendritic cells to produce immunity and cross-protection against avian coccidiosis. This article describes step-by-step developments in the vaccination process from the last 70 years along with a brief discussion on novel techniques to induce immunity against coccidiosis.


Author(s):  
Michael Gr. Voskoglou ◽  
Abdel-Badeeh M. Salem

The article focuses on the potential role of Probability Theory and Artificial Intelligence in the battle against the pandemic of COVID-19, which, starting from China on December 2019, has created a chaos in the world economy and the lives of people, causing hundreds of thousands of deaths until now. After discussing the importance of the reproduction number Ro of the viruses, the Bayesian Probabilities are used for measuring the creditability of the diagnostic tests for the novel coronavirus. Artificial Intelligence designs are also described which are used as tools against COVID-19 and a Case-Based Reasoning expert system is proposed for the COVID-19 diagnosis.


Author(s):  
Beatrice Ragnoli ◽  
Mario Malerba

COVID-19, a novel severe acute respiratory syndrome (SARS) emerging in China’s Hubei province in late 2019, due to a new coronavirus (SARS-CoV-2), is causing a global pandemic involving many areas of the world, which so far counts more than 43 million cases and more than 1,155,000 deaths worldwide [...]


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