scholarly journals Research Progress on the pathogenic mechanism of Streptococcus suis 2

2021 ◽  
Vol 23 (104) ◽  
pp. 30-35
Author(s):  
Mingcheng Liu ◽  
Xiaojing Xia ◽  
Xingyou Liu ◽  
Oksana Kasianenko
Keyword(s):  
Virulence Factors ◽  
Pathogenic Bacteria ◽  
Streptococcus Suis ◽  
Pathogenic Mechanism ◽  
Host Cells ◽  
Research Progress ◽  
Epithelial Surface ◽  
The Third ◽  
Third Stage ◽  
Fatal Sepsis

Streptococcus suis (S.suis) is an important zoonotic pathogen that can cause many diseases in pigs, such as sepsis, arthritis, endocarditis, and meningitis, of which meningitis is the most serious. There are 35 serotypes, and serotype two is the most virulent. At the same time, Streptococcus suis serotype 2(SS2) can also infect humans, causing severe public health problems. Although SS2 has attracted significant attention worldwide, the research on its pathogenesis is still limited. The adhesion of pathogenic bacteria to the surface of host cells or tissues and its subsequent invasion and diffusion are the critical steps of pathogenic bacteria. Moreover, the interaction between pathogen and host is involved in these processes. Therefore, to study the pathogenic mechanism of pathogenic bacteria is to study the interaction between pathogenic bacteria and host. This paper described several common virulence factors, such as CPS, SLY, MRP, EF, SAO, Srt, FBPS, SadP, and Eno. Under the actions of virulence factors, SS2 adheres and colonizes to the mucosal and epithelial surface of host cells. Then SS2 invades into deeper tissues and bloodstream. If SS2 in the blood does not cause fatal sepsis, It can go to the third stage. The third stage is to cross the BBB and access the CNS and ultimately causes meningitis. During pathogenesis, SS2 interacts with multiple host cells, such as neutrophils, macrophages, epithelial cells, and microvascular endothelial cells to evade the innate or adaptive immunity of the host.

Tests of Antarctic soils for insect parasitic nematodes

1990 ◽  
Vol 2 (3) ◽  
pp. 221-222 ◽  
Author(s):  
Christine T. Griffin ◽  
M.J. Downes ◽  
W. Block
Keyword(s):  
Pathogenic Bacteria ◽  
Parasitic Nematodes ◽  
Antarctic Soils ◽  
The Third ◽  
Obligate Parasites ◽  
Wide Range ◽  
Third Stage ◽  
Stage Juvenile ◽  
New Hosts ◽  
Growth And Reproduction

Nematodes of the families Heterorhabditidae and Steinernematidae are obligate parasites of a wide range of insects (Poinar 1979). The third stage juvenile of these nematodes is a non-feeding infective form which carries symbiotic insect-pathogenic bacteria (Xenorhabdus spp.) in its intestine. Under favourable conditions the juveniles can survive for months in the soil. They are attracted to and enter insects. After invading the haemocoel they release the symbiont. The bacteria multiply, kill the host by septicaemia, and provide suitable conditions for nematode growth and reproduction. After one to two weeks, the newly formed infective juveniles leave the cadaver and seek new hosts.

scholarly journals Delivery of Toxins and Effectors by Bacterial Membrane Vesicles

Toxins ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 845
Author(s):  
Adrian Macion ◽  
Agnieszka Wyszyńska ◽  
Renata Godlewska
Keyword(s):  
Virulence Factors ◽  
Pathogenic Bacteria ◽  
Membrane Vesicles ◽  
Cell Types ◽  
Oral Bacteria ◽  
Host Cells ◽  
Target Cells ◽  
Tissue Destruction ◽  
Secretion Systems ◽  
The Central Nervous System

Pathogenic bacteria interact with cells of their host via many factors. The surface components, i.e., adhesins, lipoproteins, LPS and glycoconjugates, are particularly important in the initial stages of colonization. They enable adhesion and multiplication, as well as the formation of biofilms. In contrast, virulence factors such as invasins and toxins act quickly to damage host cells, causing tissue destruction and, consequently, organ dysfunction. These proteins must be exported from the bacterium and delivered to the host cell in order to function effectively. Bacteria have developed a number of one- and two-step secretion systems to transport their proteins to target cells. Recently, several authors have postulated the existence of another transport system (sometimes called “secretion system type zero”), which utilizes extracellular structures, namely membrane vesicles (MVs). This review examines the role of MVs as transporters of virulence factors and the interaction of toxin-containing vesicles and other protein effectors with different human cell types. We focus on the unique ability of vesicles to cross the blood–brain barrier and deliver protein effectors from intestinal or oral bacteria to the central nervous system.

scholarly journals A Program of Yersinia enterocoliticaType III Secretion Reactions Is Activated by Specific Signals

2001 ◽  
Vol 183 (17) ◽  
pp. 4970-4978 ◽  
Author(s):  
Vincent T. Lee ◽  
Sarkis K. Mazmanian ◽  
Olaf Schneewind
Keyword(s):  
Virulence Factors ◽  
Calcium Concentration ◽  
Serum Proteins ◽  
Host Cells ◽  
Extracellular Medium ◽  
Environmental Signals ◽  
Type Iii ◽  
The Third ◽  
Genes Encoding ◽  
Successful Establishment

ABSTRACT Successful establishment of Yersinia infections requires the type III machinery, a protein transporter that injects virulence factors (Yops) into macrophages. It is reported here that theYersinia type III pathway responds to environmental signals by transporting proteins to distinct locations. Yersinia enterocolitica cells sense an increase in extracellular amino acids (glutamate, glutamine, aspartate, and asparagine) that results in the activation of the type III pathway. Another signal, provided by serum proteins such as albumin, triggers the secretion of YopD into the extracellular medium. The third signal, a decrease in calcium concentration, appears to be provided by host cells and causesY. enterocolitica to transport YopE and presumably other virulence factors across the eukaryotic plasma membrane. Mutations in several genes encoding regulatory molecules (lcrG,lcrH, tyeA, yopD,yopN, yscM1, andyscM2) bypass the signal requirement of the type III pathway. Together these results suggest that yersiniae may have evolved distinct secretion reactions in response to environmental signals.

scholarly journals Research progress in China on the virulence factors of Streptococcus suis serotype

2013 ◽  
Vol 37 ◽  
pp. 487-491
Author(s):  
Xiuwei YUE ◽  
Yixuan HOU ◽  
Xiuguo HUA ◽  
Shujie WANG ◽  
Zhibiao YANG ◽  
...  
Keyword(s):  
Virulence Factors ◽  
Streptococcus Suis ◽  
Research Progress ◽  
Suis Serotype

The Coherence of Mary Barton: Romance, Realism, and Utopia

2015 ◽  
Vol 5 (3) ◽  
pp. 185-200
Author(s):  
Robert Z. Birdwell
Keyword(s):  
Thomas Carlyle ◽  
The Novel ◽  
Second Stage ◽  
The Third ◽  
Third Stage ◽  
Three Stages ◽  
Mode Of Production

Critics have argued that Elizabeth Gaskell's first novel, Mary Barton (1848), is split by a conflict between the modes of realism and romance. But the conflict does not render the novel incoherent, because Gaskell surpasses both modes through a utopian narrative that breaks with the conflict of form and gives coherence to the whole novel. Gaskell not only depicts what Thomas Carlyle called the ‘Condition of England’ in her work but also develops, through three stages, the utopia that will redeem this condition. The first stage is romantic nostalgia, a backward glance at Eden from the countryside surrounding Manchester. The second stage occurs in Manchester, as Gaskell mixes romance with a realistic mode, tracing a utopian drive toward death. The third stage is the utopian break with romantic and realistic accounts of the Condition of England and with the inadequate preceding conceptions of utopia. This third stage transforms narrative modes and figures a new mode of production.

Bankruptcy Model Construction and its Limitation in Input Data Quality

2019 ◽  
Vol 10 (2) ◽  
pp. 117-125
Author(s):  
Dana Kubíčková ◽  
◽  
Vladimír Nulíček ◽  
Keyword(s):  
Data Quality ◽  
Normal Distribution ◽  
Input Data ◽  
Model Construction ◽  
The Third ◽  
Third Stage ◽  
Discriminant Analyses ◽  
One Year ◽  
The University ◽  
Multivariate Discriminant

The aim of the research project solved at the University of Finance and administration is to construct a new bankruptcy model. The intention is to use data of the firms that have to cease their activities due to bankruptcy. The most common method for bankruptcy model construction is multivariate discriminant analyses (MDA). It allows to derive the indicators most sensitive to the future companies’ failure as a parts of the bankruptcy model. One of the assumptions for using the MDA method and reassuring the reliable results is the normal distribution and independence of the input data. The results of verification of this assumption as the third stage of the project are presented in this article. We have revealed that this assumption is met only in a few selected indicators. Better results were achieved in the indicators in the set of prosperous companies and one year prior the failure. The selected indicators intended for the bankruptcy model construction thus cannot be considered as suitable for using the MDA method.

How well do voice-hearing assessment measures capture the positive experiences of individuals?

2019 ◽  
Author(s):  
Lucy Armstrong ◽  
Lorna Hogg ◽  
Pamela Charlotte Jacobsen
Keyword(s):  
Systematic Review ◽  
Lived Experience ◽  
Second Stage ◽  
The Third ◽  
Third Stage ◽  
Hearing Assessment ◽  
Positive Experiences ◽  
Assessment Measures ◽  
Stage 1 ◽  
The Voice

The first stage of this project aims to identify assessment measures which include items on voice-hearing by way of a systematic review. The second stage is the development of a brief framework of categories of positive experiences of voice hearing, using a triangulated approach, drawing on views from both professionals and people with lived experience. The third stage will involve using the framework to identify any positve aspects of voice-hearing included in the voice hearing assessments identified in stage 1.

Pèlerinages barrésiens

2013 ◽  
pp. 116-123
Author(s):  
Claire Bompaire-Evesque
Keyword(s):  
Large Scale ◽  
The Self ◽  
Joan Of Arc ◽  
The Third ◽  
National Importance ◽  
The Earth ◽  
Third Stage ◽  
The Dead

This article is a inquiry about how Barrès (1862-1923) handles the religious rite of pilgrimage. Barrès stages in his writings three successive forms of pilgrimage, revealing what is sacred to him at different times. The pilgrimage to a museum or to the birthplace of an artist is typical for the egotism and the humanism of the young Barrès, expressed in the Cult of the Self (1888-1891). After his conversion to nationalism, Barrès tries to unite the sons of France and to instill in them a solemn reverence for “the earth and the dead” ; for that purpose he encourages in French Amities (1903) pilgrimages to historical places of national importance (battlefields; birthplace of Joan of Arc), building what Nora later called the Realms of Memory. The third stage of Barrès’ intellectual evolution is exemplified by The Sacred Hill (1913). In this book the writer celebrates the places where “the Spirit blows”, and proves open to a large scale of spiritual forces, reaching back to paganism and forward to integrative syncretism, which aims at unifying “the entire realm of the sacred”.

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