scholarly journals Fabrication of smart titanium implants by femtosecond laser synthesis.

2021 ◽  
Author(s):  
Sivaprasad Chinnakkannu Vijayakumar
Keyword(s):  
Femtosecond Laser ◽  
Effective Means ◽  
Pure Titanium ◽  
Titanium Substrate ◽  
Health Care Industry ◽  
Titanium Implants ◽  
Femtosecond Laser Irradiation ◽  
Care Industry ◽  
Cell Mobility ◽  
Oxide Phases

A 3-D nanostructure particle network of TiO2, TiO, Ti3O oxide nanoparticles is synthesized by ultra-short pulsed femtosecond laser irradiation from a Grade 2 pure titanium substrate. This study investigated the properties of the resulting nanostructure and underneath phase transformed surface for biomaterial applications. Controlled tuning of surface chemistry and phases of the 3-D network were found to directly influence the cell mobility. The presented findings support a previously unrealized capacity by nano-core shell like particles and its phases for reducing cell proliferation on a biomaterial. Both osteoblast and fibroblast cells improved controllability and anisotropic migration with the developed nanostructure. The corresponding oxide phases which influenced this controllability was analysed in detail with possible potential in health care industry. The results suggest an effective means to improve biomaterial life thereby increasing implant life.

scholarly journals Fabrication of smart titanium implants by femtosecond laser synthesis.

2021 ◽  
Author(s):  
Sivaprasad Chinnakkannu Vijayakumar
Keyword(s):  
Femtosecond Laser ◽  
Effective Means ◽  
Pure Titanium ◽  
Titanium Substrate ◽  
Health Care Industry ◽  
Titanium Implants ◽  
Femtosecond Laser Irradiation ◽  
Care Industry ◽  
Cell Mobility ◽  
Oxide Phases

A 3-D nanostructure particle network of TiO2, TiO, Ti3O oxide nanoparticles is synthesized by ultra-short pulsed femtosecond laser irradiation from a Grade 2 pure titanium substrate. This study investigated the properties of the resulting nanostructure and underneath phase transformed surface for biomaterial applications. Controlled tuning of surface chemistry and phases of the 3-D network were found to directly influence the cell mobility. The presented findings support a previously unrealized capacity by nano-core shell like particles and its phases for reducing cell proliferation on a biomaterial. Both osteoblast and fibroblast cells improved controllability and anisotropic migration with the developed nanostructure. The corresponding oxide phases which influenced this controllability was analysed in detail with possible potential in health care industry. The results suggest an effective means to improve biomaterial life thereby increasing implant life.

scholarly journals Synthesis of bio-functionalized three-dimensional titania nanofibrous 3 using femtosecond laser ablation

2021 ◽  
Author(s):  
Amirhossein Tavangar ◽  
Bo Tan ◽  
Krishnan Venkatakrishnan
Keyword(s):  
Femtosecond Laser ◽  
Three Dimensional ◽  
Titanium Substrate ◽  
Chemical Properties ◽  
Femtosecond Laser Ablation ◽  
Cell Interaction ◽  
Primary Objective ◽  
Femtosecond Laser Irradiation ◽  
Ambient Conditions

The primary objective of current tissue regeneration research is to synthesize nano-based platforms that 24 can induce guided, controlled, and rapid healing. Titanium nanotubes have been extensively considered 25 as a new biomaterial for biosensors, implants, cell growth, tissue engineering, and drug delivery systems. 26 However, cell adhesion to nanotubes is poor due to their chemical inertness, as well as the one-dimen- 27 sional structure, and surface modification is required to enhance nanotube–cell interaction. While there 28 have been a considerable number of studies on growing titanium nanotubes, synthesizing a three-dimen- 29 sional (3-D) nano-architecture which can act as a growth support platform for bone and stem cells has 30 not been reported so far. Therefore, we present a novel technique to synthesize and grow 3-D titania 31 interwoven nanofibrous structures on a titanium substrate using femtosecond laser irradiation under 32 ambient conditions. This surface architecture incorporate the functions of 3-D nano-scaled topography 33 and modified chemical properties to improve osseointegration while at the same time leaving space to 34 deliver other functional agents. The results indicate that laser pulse repetition can control the density 35 and pore size of engineered nanofibrous structures. In vitro experiments reveal that the titania nanofi- 36 brous architecture possesses excellent bioactivity and can induce rapid, uniform, and controllable 37 bone-like apatite precipitation once immersed in simulated body fluid (SBF). This approach to synthesiz- 38 ing 3-D titania nanofibrous structures suggests considerable promise for the promotion of Ti interfacial 39 properties to develop new functional biomaterials for various biomedical applications.

scholarly journals Synthesis of bio-functionalized three-dimensional titania nanofibrous 3 using femtosecond laser ablation

2021 ◽  
Author(s):  
Amirhossein Tavangar ◽  
Bo Tan ◽  
Krishnan Venkatakrishnan
Keyword(s):  
Femtosecond Laser ◽  
Three Dimensional ◽  
Titanium Substrate ◽  
Chemical Properties ◽  
Femtosecond Laser Ablation ◽  
Cell Interaction ◽  
Primary Objective ◽  
Femtosecond Laser Irradiation ◽  
Ambient Conditions

The primary objective of current tissue regeneration research is to synthesize nano-based platforms that 24 can induce guided, controlled, and rapid healing. Titanium nanotubes have been extensively considered 25 as a new biomaterial for biosensors, implants, cell growth, tissue engineering, and drug delivery systems. 26 However, cell adhesion to nanotubes is poor due to their chemical inertness, as well as the one-dimen- 27 sional structure, and surface modification is required to enhance nanotube–cell interaction. While there 28 have been a considerable number of studies on growing titanium nanotubes, synthesizing a three-dimen- 29 sional (3-D) nano-architecture which can act as a growth support platform for bone and stem cells has 30 not been reported so far. Therefore, we present a novel technique to synthesize and grow 3-D titania 31 interwoven nanofibrous structures on a titanium substrate using femtosecond laser irradiation under 32 ambient conditions. This surface architecture incorporate the functions of 3-D nano-scaled topography 33 and modified chemical properties to improve osseointegration while at the same time leaving space to 34 deliver other functional agents. The results indicate that laser pulse repetition can control the density 35 and pore size of engineered nanofibrous structures. In vitro experiments reveal that the titania nanofi- 36 brous architecture possesses excellent bioactivity and can induce rapid, uniform, and controllable 37 bone-like apatite precipitation once immersed in simulated body fluid (SBF). This approach to synthesiz- 38 ing 3-D titania nanofibrous structures suggests considerable promise for the promotion of Ti interfacial 39 properties to develop new functional biomaterials for various biomedical applications.

scholarly journals Surface Modification of Titanium with Heparin-Chitosan Multilayers via Layer-by-Layer Self-Assembly Technique

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Yao Shu ◽  
Guomin Ou ◽  
Li Wang ◽  
Jingcai Zou ◽  
Quanli Li
Keyword(s):  
Surface Modification ◽  
Self Assembly ◽  
Pure Titanium ◽  
Titanium Substrate ◽  
Titanium Implants ◽  
Layer By Layer ◽  
Assembly Technique ◽  
Titanium Surfaces ◽  
Modification Of Titanium ◽  
Positively Charged

Extracellular matrix (ECM), like biomimetic surface modification of titanium implants, is a promising method for improving its biocompatibility. In this paper chitosan (Chi) and heparin (Hep) multilayer was coated on pure titanium using a layer-by-layer (LbL) self-assembly technique. The Hep-Chi multilayer growth was carried out by first depositing a single layer of positively charged poly-L-lysine (PLL) on the NaOH-treated titanium substrate (negatively charged surface), followed by alternate deposition of negatively charged Hep and positively charged Chi, and terminated by an outermost layer of Chi. The multilayer was characterized by DR-FTIR, SEM, and AFM, and osteoblasts were cocultured with the modified titanium and untreated titanium surfaces, respectively, to evaluate their cytocompatibilityin vitro. The results confirmed that Hep-Chi multilayer was fabricated gradually on the titanium surface. The Hep-Chi multilayer-coated titanium improved the adhesion, proliferation and differentiation of osteoblasts. Thus, the approach described here may provide a basis for the preparation of modified titanium surfaces for use in dental or orthopedic implants.

ON THE FORMATION OF TITANIUM/TITANIUM OXIDE NANOFIBROUS STRUCTURES AND NANOSPHERES USING FEMTOSECOND LASER IN AIR

NANO ◽  
2011 ◽  
Vol 06 (02) ◽  
pp. 123-130 ◽  
Author(s):  
M. ALUBAIDY ◽  
K. VENKATAKRISHNAN ◽  
B. TAN
Keyword(s):  
Femtosecond Laser ◽  
Titanium Substrate ◽  
Raman Analysis ◽  
X Ray ◽  
Oxide Phases ◽  
Energy Pulse ◽  
Time Observation ◽  
Lower Temperature ◽  
Transient Thermal ◽  
First Time

In this paper, we report a unique growth of nanofibrous structures and nanospheres of titanium using femtosecond laser in air and without the need for any type of catalyst. The femtosecond laser was used to generate nanoparts on a titanium substrate. The irradiated substrate is assumed to be subjected to plane stress type of temperature variation and a new method combining finite difference and Runge–Kutta 4 transient thermal model has been developed to calculate the temperature distribution on the top surface of the substrate during laser ablation. A Matlab code has been developed and validated with the known results from the literature. Scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), X-ray diffractograms (XRD) and micro-Raman analysis were conducted to characterize the microstructure and revealed metallic and oxide phases in the nanostructure analyses. Results showed that nanofibers and nanospheres were grown in the order of few hundreds nanometers or more. The effect of the laser power on the energy/pulse and hence the temperature was studied. It was found that high temperature results in the formation of nanofibers while lower temperature results in formation of nanospheres. This first time observation could have potential application in biomedical, optoelectronics and photocatalysis.

Generation of nano-bumps on transparent quartz glass surface under femtosecond laser irradiation

2008 ◽  
Author(s):  
Wei Guo ◽  
Zeng Bo Wang ◽  
Lin Li ◽  
Zhu Liu ◽  
Boris Luk’yanchuk ◽  
...  
Keyword(s):  
Femtosecond Laser ◽  
Laser Irradiation ◽  
Quartz Glass ◽  
Glass Surface ◽  
Femtosecond Laser Irradiation

In vitro Behaviour of Alumina-Hydroxiapatite Composites Coatings

2018 ◽  
Vol 69 (6) ◽  
pp. 1416-1418
Author(s):  
Alexandru Szabo ◽  
Ilare Bordeasu ◽  
Ion Dragos Utu ◽  
Ion Mitelea
Keyword(s):  
Pure Titanium ◽  
Titanium Substrate ◽  
High Strength ◽  
Biological Properties ◽  
Commercially Pure Titanium ◽  
Hvof Spraying ◽  
Before And After ◽  
Sbf Solution ◽  
Oxygen Fuel

Hydroxyapatite (HA) is a very common material used for biomedical applications. Usually, in order to improve its poor mechanical properties is combined or coated with other high-strength materials.The present paper reports the manufacturing and the biocompatibility behaviour of two different biocomposite coatings consisting of alumina (Al2O3) and hydroxyapatite (HA) using the high velocity oxygen fuel (HVOF) spraying method which were deposited onto the surface of a commercially pure titanium substrate. The biological properties of the Al2O3-HA materials were evaluated by in vitro studies. The morphology of the coatings before and after their immersing in the simulated body fluid (SBF) solution was characterized by scanning electron microscopy (SEM). The results showed an important germination of the biologic hydroxyapatite crystallite on the surface of both coatings.

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