C-Oxyalkylation of Arylamines, Enamines, and Nitrogen-Containing Heterocycles with Polyfluorinated Carbonyl Compounds as a Synthetic Route to Biologically Active Compounds
Keyword(s):
Using hexafluoroacetone and trifluoropyruvic acid esters as representative examples, the results of investigations on the reactions of polyfluorinated carbonyl compounds with arylamines, cyclic azomethine–enamines, and nitrogen-containing heterocycles are reviewed. For the first time, the peculiarities of the C-oxyalkylation of nitrogen-containing π-systems with polyfluorinated carbonyl compounds are considered systematically. The results on biological assays of the resulting fluorine-containing products of the C-oxyalkylation are presented. The promising routes for further development of this field from the viewpoint of the creation of new biologically active compounds are outlined.
2017 ◽
Vol 89
(8)
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pp. 1105-1117
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Keyword(s):
2020 ◽
Vol 27
(6)
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pp. 838-853
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