scholarly journals Characterization and Liquefaction Hazard Assessment of Two Hungarian Liquefied Sites from the 1956 Dunaharaszti Earthquake

2020 ◽  
Author(s):  
Zoltán Bán ◽  
Erzsébet Győri ◽  
László Tóth ◽  
Zoltán Gráczer ◽  
András Mahler
Keyword(s):  
Hazard Assessment ◽  
Back Analysis ◽  
Seismic Loading ◽  
Ground Acceleration ◽  
The Past ◽  
Annual Probability ◽  
Moderate Seismicity ◽  
Liquefaction Hazard ◽  
Back Calculation

The seismicity of Hungary can be considered moderately active, nevertheless contemporary reports from the past approx. 350 years documented surface manifestations of liquefaction occurrences. The last such earthquake was the 1956 Dunaharaszti ground motion, for which the location of two liquefied sites could be identified approx. 60 years after the event. This provided an excellent opportunity to analyze possibly the only accessible liquefied sites in Hungary. Analysis of the two sites included field and laboratory tests allowing the back-calculation of maximum horizontal ground acceleration of the earthquake. This parameter was previously unknown because the closest seismometer saturated during the event. The performed back-analysis using the principles of paleoliquefaction studies was the first of such analyses in the country. In areas with low to moderate seismicity, geotechnical engineers often neglect and overlook liquefaction hazard, however, when it is addressed, the hazard is often overestimated due to improper characterization of the seismic loading and site characterization. To explore this observation more deeply, probabilistic seismic and liquefaction hazard assessment were carried out at the two liquefied sites and it was found that this conclusion is also valid for Hungary, but the degree of conservatism of the pseudo-probabilistic procedures decreases with increasing earthquake return period (lower annual probability of occurrence).

scholarly journals Overestimation of liquefaction hazard in areas of low to moderate seismicity due to improper characterization of probabilistic seismic loading

2019 ◽  
Vol 116 ◽  
pp. 681-691 ◽  
Author(s):  
Kevin W. Franke ◽  
Bret N. Lingwall ◽  
T. Leslie Youd ◽  
Jenny Blonquist ◽  
Jingwen He Liang
Keyword(s):  
Seismic Loading ◽  
Moderate Seismicity ◽  
Liquefaction Hazard

The Use of Advanced Analytical Techniques for Characterization of the Chemical, Physical, and Crystallographic Nature of a Surface

1973 ◽  
Vol 31 ◽  
pp. 132-133 ◽  
Author(s):  
R. E. Herfert
Keyword(s):  
Surface Characterization ◽  
Analytical Techniques ◽  
X Ray Diffraction ◽  
Depth Of Penetration ◽  
X Ray ◽  
The Past ◽  
Transmission Electron ◽  
Scanning Electron

Studies of the nature of a surface, either metallic or nonmetallic, in the past, have been limited to the instrumentation available for these measurements. In the past, optical microscopy, replica transmission electron microscopy, electron or X-ray diffraction and optical or X-ray spectroscopy have provided the means of surface characterization. Actually, some of these techniques are not purely surface; the depth of penetration may be a few thousands of an inch. Within the last five years, instrumentation has been made available which now makes it practical for use to study the outer few 100A of layers and characterize it completely from a chemical, physical, and crystallographic standpoint. The scanning electron microscope (SEM) provides a means of viewing the surface of a material in situ to magnifications as high as 250,000X.

‘The Wretch of To-day, may be happy To-morrow’

2017 ◽  
Author(s):  
Sarah Lloyd
Keyword(s):  
Emotional Experience ◽  
The Past

This chapter explores what we can know about the conceptualization and representation of by poorer Britons. It draws on ‘pauper letters’ to parish authorities, written tactically, and on autobiographies and letters composed by the relatively poor, noting echoes of the characterization of happiness by elite social commentators. It draws attention to a growing interest (linked to the development of the concept of nostalgia) in the emotional charge that could be derived from reflection on emotional experience as people contrasted past happiness with present misery, or vice versa. While reading such accounts may lead us to think that we are penetrating the interior lives of marginal people in the past, Lloyd suggests that our response is probably coloured by the fact that we are heirs to these ways of conceptualizing and representing experience. We need to work harder to glean insight from earlier ways of representing happiness and suffering.

The Problem of Divine Hiddenness

2018 ◽  
Author(s):  
Michael C. Rea
Keyword(s):  
Problem Of Evil ◽  
Philosophical Discussion ◽  
Detailed Characterization ◽  
The Past ◽  
Divine Hiddenness ◽  
The Problem Of Evil ◽  
The Relationship

This chapter provides a detailed characterization of the various meanings of the term “divine hiddenness,” carefully and rigorously articulates the version of the problem of divine hiddenness that has dominated contemporary philosophical discussion for the past twenty-five years, and then explains the relationship between that problem and the problem of evil.

scholarly journals Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future

2020 ◽  
Vol 21 (18) ◽  
pp. 6623 ◽  
Author(s):  
Marc Bienz ◽  
Salima Ramdani ◽  
Hans Knecht
Keyword(s):  
Immune System ◽  
Targeted Therapy ◽  
Signaling Pathways ◽  
Hodgkin Lymphoma ◽  
Genetic Instability ◽  
Host Immune System ◽  
Cellular Interactions ◽  
Classical Hodgkin Lymphoma ◽  
The Past

Our understanding of the tumorigenesis of classical Hodgkin lymphoma (cHL) and the formation of Reed–Sternberg cells (RS-cells) has evolved drastically in the last decades. More recently, a better characterization of the signaling pathways and the cellular interactions at play have paved the way for new targeted therapy in the hopes of improving outcomes. However, important gaps in knowledge remain that may hold the key for significant changes of paradigm in this lymphoma. Here, we discuss the past, present, and future of cHL, and review in detail the more recent discoveries pertaining to genetic instability, anti-apoptotic signaling pathways, the tumoral microenvironment, and host-immune system evasion in cHL.

Site effects of the Denis-Perron dam (SM-3): A case study in Eastern North America

2021 ◽  
pp. 875529302110194
Author(s):  
Daniel Verret ◽  
Denis LeBœuf ◽  
Éric Péloquin
Keyword(s):  
North America ◽  
Ground Motion ◽  
Site Effects ◽  
Transfer Functions ◽  
Ground Motions ◽  
Published Data ◽  
Eastern North America ◽  
Ground Acceleration ◽  
Large Dams ◽  
Moderate Seismicity

Eastern North America (ENA) is part of a region with low-to-moderate seismicity; nonetheless, some significant seismic events have occurred in the last few decades. Recent events have reemphasized the need to review ENA seismicity and ground motion models, along with continually reevaluating and updating procedures related to the seismic safety assessment of hydroelectric infrastructures, particularly large dams in Québec. Furthermore, recent researchers have shown that site-specific characteristics, topography, and valley shapes may significantly aggravate the severity of ground motions. To the best of our knowledge, very few instrumental data from actual earthquakes have been published for examining the site effects of hydroelectric dam structures located in eastern Canada. This article presents an analysis of three small earthquakes that occurred in 1999 and 2002 at the Denis-Perron (SM-3) dam. This dam, the highest in Québec, is a rockfill embankment structure with a height of 171 m and a length of 378 m; it is located in a narrow valley. The ground motion datasets of these earthquakes include the bedrock and dam crest three-component accelerometer recordings. Ground motions are analyzed both in the time and frequency domains. The spectral ratios and transfer functions obtained from these small earthquakes provide new insights into the directionality of resonant frequencies, vibration modes, and site effects for the Denis-Perron dam. The crest amplifications observed for this dam are also compared with previously published data for large dams. New statistical relationships are proposed to establish dam crest amplification on the basis of the peak ground acceleration (PGA) at the foundation.

scholarly journals Synthesis and Characterization of Store-Operated Calcium Entry Inhibitors Active in the Submicromolar Range

2020 ◽  
Vol 21 (24) ◽  
pp. 9777
Author(s):  
Camille Le Guilcher ◽  
Tomas Luyten ◽  
Jan B. Parys ◽  
Mathieu Pucheault ◽  
Olivier Dellis
Keyword(s):  
Cell Activation ◽  
Interleukin 2 ◽  
Calcium Entry ◽  
Ip3 Receptors ◽  
Excitable Cells ◽  
Cellular Targets ◽  
Entry Inhibitors ◽  
The Past ◽  
Store Operated Calcium Entry

The store-operated calcium entry, better known as SOCE, forms the main Ca2+ influx pathway in non-excitable cells, especially in leukocytes, where it is required for cell activation and the immune response. During the past decades, several inhibitors were developed, but they lack specificity or efficacy. From the non-specific SOCE inhibitor 2-aminoethyl diphenylborinate (2-APB), we synthetized 16 new analogues by replacing/modifying the phenyl groups. Among them, our compound P11 showed the best inhibitory capacity with a Ki ≈ 75 nM. Furthermore, below 1 µM, P11 was devoid of any inhibitory activity on the two other main cellular targets of 2-APB, the IP3 receptors, and the SERCA pumps. Interestingly, Jurkat T cells secrete interleukin-2 under phytohemagglutinin stimulation but undergo cell death and stop IL-2 synthesis when stimulated in the presence of increasing P11 concentrations. Thus, P11 could represent the first member of a new and potent family of immunosuppressors.

2D Self-assembly and Electronic Characterization of Oxygen-Boron-Oxygen-Doped Chiral Graphene Nanoribbons

2021 ◽  
Author(s):  
Lei Jin ◽  
Nerea Bilbao ◽  
Yang Lv ◽  
Xiao-Ye Wang ◽  
Soltani Paniz ◽  
...  
Keyword(s):  
Edge Effects ◽  
Self Assembly ◽  
Quantum Confinement ◽  
Graphene Nanoribbons ◽  
One Dimensional ◽  
The Past ◽  
Different Types

Graphene nanoribbons (GNRs), quasi-one-dimensional strips of graphene, exhibit a nonzero bandgap due to quantum confinement and edge effects. In the past decade, different types of GNRs with atomically precise structures...

scholarly journals B.05 Hemi-laryngopharyngeal spasm (HELPS) syndrome: The discovery, cure, and characterization of a new neurological condition

2017 ◽  
Vol 44 (S2) ◽  
pp. S11-S11
Author(s):  
C Honey ◽  
M Morrison
Keyword(s):  
Surgical Care ◽  
Review Of The Literature ◽  
The Past ◽  
First Case ◽  
Patient Reported ◽  
Operative Outcome ◽  
Small Cohort ◽  
The Common ◽  
Similar Motor

Background: We published the world’s first case of hemi-laryngpharyngeal spasm (HELPS) syndrome cured by microvascular decompression (MVD) of the Xth cranial nerve in 2016. We now present a small cohort of patients (n=3) successfully treated with surgery in order to better delineate the common characteristics of this syndrome, diagnostic tests of choice, nuances of their surgical care and outcomes of their treatment. Methods: The history and physical examination of three patients with HELPS syndrome are presented. Pre-operative laryngoscopy, neuroimaging, response to botox and intra-operative videos are detailed. Post-operative outcome and complications are presented. Results: Each patient reported similar motor (choking) and sensory (coughing) features in their history. Episodic choking relentlessly progressed over the years until it occurred while sleeping and with frightening severity prompting tracheostomy in one patient and intubation in another. A “tickling” sensation deep in the throat triggered episodic coughing that worsened over the years until it occurred while sleeping and with frightening severity (syncope and incontinence). Conclusions: A review of the literature suggests that patients with similar symptoms, often called episodic laryngospasm in the past, have been treated with psychotherapy or antacids. With the recognition that a clearly defined subset of these patients have HELPS syndrome, we can offer them the potential of a neurosurgical cure.

Sign in / Sign up

Export Citation Format

Share Document