scholarly journals Cosmetics vs Cosmeceuticals Why to Choose Cosmeceutials?

2019 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Online Reviews ◽  
Regulatory Agencies ◽  
Medicinal Products ◽  
Informed Decisions ◽  
Global Trend ◽  
Cosmetic Industry ◽  
Peer Reviewers ◽  
Physiologic Effect ◽  
Medicinal Properties ◽  
The Difference

The global trend in the cosmetic industry towards developing ‘medicinally’ active cosmetics, and in the pharmaceutical industry towards ‘cosmetically’ oriented medicinal products. All cosmeceuticals claim to contain functional ingredients with either therapeutic, disease-fighting or healing properties. It provides external aesthetic benefits; the additional medicinal properties of cosmeceuticals are based on molecular structure, biological function relationships, and modes of action related to healing, anti-aging, free radical rampage reduction, dead epidermal cell exfoliation, and so on. In cosmeceuticals the importantance to know the interaction between skin and cosmeceuticals which could even be influenced by environmental fact. Online reviews and beauty blogs have created a community of peer reviewers that we encourage trust in Beauty Brand’s. The science of it all remains extremely crucial in making informed decisions for your skin. More than just Cosmetics, “Cosmeceuticals” is a term that every beauty junkie should learn more about this 2018. This study paper speaks about the science behind cosmeceuticals and how to make informed decisions when choosing beauty products. Today’s Cosmeceuticals are serving as a bridge between personal care products and pharmaceuticals; there is no regulatory category for Cosmeceuticals; hence this review tries to understand regulatory scenario as well the difference between drug and cosmetics is enlightened. The paper is an earnest endeavor to evaluate a Cosmeceutical product that claims a beneficial physiologic effect. This review paper is to give recent knowledge about the latest trend of cosmetic industry New challenges will also be presented to government regulatory agencies as more chemicals with true biological activity are invented and tested.

Conditions for Use of Food Additives Based on a Budget for an Acceptable Daily Intake1

1979 ◽  
Vol 42 (5) ◽  
pp. 429-434 ◽  
Author(s):  
SØREN C. HANSEN
Keyword(s):  
Body Weight ◽  
Food Additives ◽  
Daily Intake ◽  
Common Market ◽  
Regulatory Agencies ◽  
Acceptable Daily Intake ◽  
Quantitative Expression ◽  
Total Intake ◽  
The Difference ◽  
Food And Drink

Use of food additives is regulated qualitatively in the European Common Market through the EEC directives on food additives, while the concept of Acceptable Daily Intake (ADI) provides a quantitative expression of safe amounts for the guidance of regulatory agencies. It is suggested that a permissible quantity or quantities, the ceiling, should be agreed upon for each permitted additive on the basis of its ADI and in accordance with the procedure described here. The estimation of intake of food and drink starts from the child, who on the basis of body weight has the highest consumption. When dealing with total intake (expressed as energy, weight or volume per kg body weight per day), occupational and climatical variations between adults are largely contained in the difference between child and adult. It is possible to calculate the highest concentration in foodstuffs which is consistent with the ADI, under the assumption that the additive occurs evenly distributed in the whole diet of a child. This concentration is called the primary ceiling. To obtain the technological effect, however, higher concentrations may be needed, and to accomodate this the ceiling may have to be raised. This can be done if the use of the additive can be excluded from or reserved for part of the diet.

Exploring customer online reviews for new product development: The case of identifying reinforcers in the cosmetic industry

2019 ◽  
Vol 41 (2) ◽  
pp. 250-273 ◽  
Author(s):  
Moutaz Haddara ◽  
Jenny Hsieh ◽  
Asle Fagerstrøm ◽  
Niklas Eriksson ◽  
Valdimar Sigurðsson
Keyword(s):  
Product Development ◽  
New Product Development ◽  
New Product ◽  
Online Reviews ◽  
Cosmetic Industry

Sanitization of Equipment and Material Used in the Production of Plasma Derivatives by Standard Procedures Results in Removal and Inactivation of Prions.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3641-3641
Author(s):  
Albrecht Groener ◽  
Waltraud Seyfert-Brandt ◽  
Wolfram Schäfer
Keyword(s):  
Prion Protein ◽  
Sandwich Elisa ◽  
Reduction Factor ◽  
Proteinase K ◽  
Spongiform Encephalopathy ◽  
Infectious Agents ◽  
Medicinal Products ◽  
Cleaning Procedures ◽  
The Difference ◽  
Alkaline Cleaning

Abstract Prions are novel infectious agents causing neurodegenerative disorders such as scrapie, bovine spongiform encephalopathy (BSE), and (variant) Creutzfeldt-Jakob disease ((v)CJD). The infectious agents consist mainly, if not exclusively, of a malformed protein termed PrPSc, which accumulates in the brain of infected individuals. This PrPSc is resistant to proteinase K treatment. As there are concerns that minute amounts of prions from a donor in the incubation period for CJD / vCJD may contaminate the equipment and material used for the production of plasma-derived medicinal products and, therefore, may taint subsequently produced batches of these products, we evaluated the cleaning capacity of selected cleaning procedures used within the production of plasma proteins: NaOH and commercial alkaline cleaning solutions at different concentrations to clean and sanitize equipment and materials (e.g., resin). Sanitization of equipment was evaluated employing microsomal preparations from brains of Sc237-infected hamsters dried onto stainless steel coupons for 1 day, subsequently placed in 0.1 N NaOH, various concentrations of commercial cleaning solutions CIP-100 / CIP-150, and water as a control, respectively, followed by rinsing in water, and recovered from the coupons by wiping off with swabs. The cleaning efficacy was calculated as the difference of the recovered prion load (in log10) of a coupon with dried-on PrPSc without any further treatment and after treatment with 0.1 N NaOH or commercial cleaning solutions. PrPSc was quantified utilizing a Conformation Dependent Immunoassay (CDI) [Safar et al., Nat Med1998; 4: 1157–1165] in a sandwich configuration. In addition, prion inactivation by NaOH and commercial alkaline cleaning solutions could be demonstrated when prions were incubated in these solutions and treated with proteinase K. Furthermore, the removal of prions from chromatographic resins was studied by incubation of resin with microsomes from Sc237 hamster brain, extensive washing of the resin and subsequently incubating the resin in either water for injection or in 0.1 N NaOH followed by a treatment of both samples with or without proteinase K (PK). In order to extract all residual prion protein from the resin, all four samples were incubated at elevated temperature in guanidinium-HCl and residual prions were quantified utilizing a sandwich ELISA format according to the CDI. From the PK treated sanitized resin no residual prion protein could be detected resulting in a reduction factor of ≥3 log10 compared to non-sanitized (WFI incubated) resin. The experimental data clearly demonstrate that prions, if they were in plasma, would be removed from the surface of equipment and resins used in the production of plasma-derived products and furthermore inactivated by standard cleaning procedures according to cGMP. Therefore, a potential risk for batches of plasma-derived medicinal products produced in succession due to cross-contamination by carry-over of prions can be excluded.

scholarly journals Verb Based Sentiment Research

2019 ◽  
Vol 8 (2S11) ◽  
pp. 2468-2471
Keyword(s):  
Sentiment Analysis ◽  
Research Work ◽  
Online Reviews ◽  
Parts Of Speech ◽  
Pos Tagging ◽  
New Strategy ◽  
Semantic Orientation ◽  
The Difference ◽  
Pos Tagger ◽  
Speech Tagging

Sentiment Analysis is one of the leading research work. This paper proposes a model for the description of verbs that provide a structure for developing sentiment analysis. The verbs are very significant language elements and they receive the attention of linguistic researchers. The text is processed for parts-of-speech tagging (POS tagging). With the help of POS tagger, the verbs from each sentence are extracted to show the difference in sentiment analysis values. The work includes performing parts-of-speech tagging to obtain verb words and implement TextBlob and VADER to find the semantic orientation to mine the opinion from the movie review. We achieved interesting results, which were assessed effectively for accuracy by considering with and without verb form words. The findings show that concerning verb words accuracy increases along with emotion words. This introduces a new strategy to classify online reviews using components of algorithms for parts-of-speech..

scholarly journals Contrasting patterns of litterfall seasonality and seasonal changes in litter decomposability in a tropical rainforest region

2014 ◽  
Vol 11 (6) ◽  
pp. 7901-7929
Author(s):  
S. A. Parsons ◽  
V. Valdez-Ramirez ◽  
R. A. Congdon ◽  
S. E. Williams
Keyword(s):  
Seasonal Changes ◽  
Biogeochemical Cycles ◽  
Dry Season ◽  
Tropical Region ◽  
Soil N ◽  
Wet Season ◽  
Evergreen Forests ◽  
P Limitation ◽  
Global Trend ◽  
The Difference

Abstract. The seasonality of litter inputs in forests has important implications for understanding ecosystem processes and biogeochemical cycles. We quantified the drivers of seasonality in litterfall and leaf decomposability, using plots throughout the Australian wet tropical region. Litter fell mostly in the summer (wet, warm) months in the region, but other peaks occurred throughout the year. Litterfall seasonality was modelled well with the level of deciduousness of the site (plots with more deciduous species had lower seasonality than evergreen plots), temperature (higher seasonality in the uplands), disturbance (lower seasonality with more early secondary species) and soil fertility (higher seasonality with higher N : P/P limitation) (SL total litterfall model 1 = deciduousness + soil N : P + early secondary sp: r2 = 0.63, n = 30 plots; model 2 = temperature + early secondary sp. + soil N : P: r2 = 0.54, n = 30; SL leaf = temperature + early secondary sp. + rainfall seasonality: r2 = 0.39, n = 30). Leaf litter decomposability was lower in the dry season than in the wet season, driven by higher phenolic concentrations in the dry, with the difference exacerbated particularly by lower dry season moisture. Our results are contrary to the global trend for tropical rainforests; in that seasonality of litterfall inputs were generally higher in wetter, cooler, evergreen forests, compared to generally drier, warmer, semi-deciduous sites that had more uniform monthly inputs. We consider this due to more diverse litter shedding patterns in semi-deciduous and raingreen rainforest sites, and an important consideration for ecosystem modellers. Seasonal changes in litter quality are likely to have impacts on decomposition and biogeochemical cycles in these forests due to the litter that falls in the dry being more recalcitrant to decay.

scholarly journals Altered Hepatic Foci in Rat Liver as Weight of Evidence of Carcinogenicity: The Canadian Perspective

1989 ◽  
Vol 17 (4_part_1) ◽  
pp. 709-715 ◽  
Author(s):  
Desmond C. Mahon
Keyword(s):  
Rat Liver ◽  
Risk Estimation ◽  
Weight Of Evidence ◽  
Regulatory Agencies ◽  
Carcinogenic Potential ◽  
Canadian Perspective ◽  
Altered Hepatic Foci ◽  
The Difference

The use of AHF in the rat as a predictive lesion for carcinogenesis has been frequently suggested. Regulatory agencies require that the data used to determine carcinogenic potential and for estimating risk cannot be open to different interpretations. The degree of uncertainty in establishing relationships between the different foci phenotypes, their fate, and the difference in results with different protocols precludes the use of these data is establishing carcinogenic hazard or in quantitative risk estimation.

Pengaruh Ukuran Partikel, Perbandingan Jumlah Pelarut dan Waktu Maserasi terhadap Perolehan Rendemen Aquilaria Malaccensis Lam.

2021 ◽  
Vol 2 (2) ◽  
pp. 54
Author(s):  
Miftahurrahmah Miftahurrahmah ◽  
Hasnah Ulia ◽  
Harmiwati N. H
Keyword(s):  
Essential Oil ◽  
Raw Materials ◽  
Operating Time ◽  
Raw Material ◽  
Aquilaria Malaccensis ◽  
Cosmetic Industry ◽  
The World ◽  
The Difference ◽  
Size Of Particles ◽  
Material Preparation

Aquilaria Malaccensis Lam. is one of the most popular plants contains essential oil, both of them used by pharmaceutical and also cosmetic industry. The plants used in this study came from Jambi, Indonesia which is known, It’s one of the best quality agarwood in the world. This study aims to determine the best conditions for the yield so that it can be produced on an industrial scale. The study reviewed the effect of yield based on size of particles, ratio of solvent, and the operating time, maceration. The research was carried out in three steps. The first, raw material preparation, fermentation and maceration, and then evaporation. Preparation of raw materials is prepared in three variables, 2-5 cm, ±2cm, and size <40 mesh. Methanol is the solvent that will be used in multiple ratio of solvent to agarwood, its 1:7, 1:9, and 1:11(gr/ml). In addition, the maceration time was varied for each sample, 1 day, 2 days, and 3 days. Based on the research variables, obtained essential oil of agarwood dark brown in colour, with a special fragrance of agarwood. Based on the difference in particle size, it is known that size <40 mesh, yield is 3.16%, while for the larger size, 2-5 cm, the yield is 3.12%. In the variable ratio of the amount of solvent used, it is known that 1:9 (gr/ml) is the best point for yield. At maceration step known that 2-3 days, it doesn’t gives a significant change, 2.12 g for 3 days, and 1.92 g for 2 days.

scholarly journals The therapeutic potential of truffle fungi: a patent survey

2014 ◽  
Vol 1 (1) ◽  
pp. 305-318 ◽  
Author(s):  
Małgorzata Gajos ◽  
Florian Ryszka ◽  
Joerg Geistlinger
Keyword(s):  
Therapeutic Potential ◽  
Symptom Relief ◽  
Well Being ◽  
Therapeutic Benefits ◽  
Cosmetic Industry ◽  
Medicinal Properties ◽  
Sedative Action ◽  
Further Development ◽  
Health And Well Being ◽  
Menopause Symptom

The purpose of this article is to research and retrieve patent information regarding the therapeutic use of truffles. Truffles have a unique value as a foodstuff and impact positively on human health and well-being. They are applied in such industries as the pharmaceutical industry and the cosmetic industry. Patent documentation available in the Espacenet network and the Patentscope service were analyzed by key word and patent specifications were examined to describe state of the art and to identify scientific research trends in therapeutic applications of truffles. Medicinal properties of truffles such as the anticancer or cardiovascular effect, a reduction in blood lipids, immunological resistance and increased energy were identified. Other therapeutic benefits include sedative action, prevention of hormonal imbalances in women, pre-menopause symptom relief, senile urethritis and prostate disorders, sleep disorders and increased absorption of calcium from milk. Truffles can also be used to alleviate symptoms of milk intolerance such as diarrhoea or bloating, to ease rheumatic pains and to treat and prevent further development or recurrence of senile cataract.

scholarly journals Good Manufacturing Practice for Medicinal Products in Bulgaria: an Analysis of Regulatory Inspection Findings

Folia Medica ◽  
2020 ◽  
Vol 62 (1) ◽  
pp. 165-171
Author(s):  
Assena H. Stoimenova ◽  
Bogdan J. Kirilov ◽  
Stanislav R. Gueorguiev ◽  
Elina S. Petkova-Gueorguieva ◽  
Sava G. Ognianov
Keyword(s):  
Good Manufacturing Practice ◽  
Regulatory Agencies ◽  
European Economic Area ◽  
Medicinal Products ◽  
Eu Member States ◽  
Economic Area ◽  
Drug Agency ◽  
Human Use ◽  
National Competent Authorities

Background: The manufacture of medicinal products for human use in the European Economic Area is governed by European Directives and Regulations stipulating the relevant principles and guidelines of Good Manufacturing Practice, describing the minimum standard to be fulfilled in the production processes. &nbsp; Aim: To present analysis of the deficiencies reported following Good Manufacturing Practice inspections in Bulgaria in two consecutive years (2016, 2017) and to compare them with results from similar inspections reported by other EU member states. &nbsp; Materials and methods: A retrospective study was carried out by reviewing the complete Good Manufacturing Practice inspection reports of all manufacturers conducted by the Bulgarian Drug Agency in 2016 and 2017, according to relevant requirements and applicable local legislation. The items reviewed were scope of inspection, type of companies, classification of deficiencies &ndash; &lsquo;critical&rsquo;, &lsquo;major&rsquo; and &lsquo;other significant deficiencies&rsquo;, their nature and reference to EU Good Manufacturing Practice. &nbsp; Results: The analyzed data included 55 inspections, revealing 460 various deficiencies, of which 2 were critical and 102 &ndash; major. Twenty inspections were performed in 2016 vs. 35 inspections in 2017. The pattern of deficiencies was similar to the findings of other EU regulatory agencies, showing that equivalent requirements were applied. Our analysis showed that Bulgarian Drug Agency inspectors rarely raised deficiencies related to Computer Systems, Qualification/Validation, Personnel and Qualification of Suppliers unlike other EU regulators agents. &nbsp; Conclusions: Our analysis of Good Manufacturing Practice inspection findings in 2016 and 2017 showed that the Bulgarian Drug Agency demonstrated its ability to detect non-compliances and take necessary regulatory actions. Quality related issues constitute the main reasons for non-compliances with the requirements. Publishing the results from the inspections performed by the national competent authorities enhances the regulatory transparency that can be useful for industry to improve its Good Manufacturing Practice compliance.

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