scholarly journals Asco annual meeting 2021 Some news to use in our oncological practice

Every year, ASCO Annual Meeting provides new options for the treatment of our patients What are the news this year about breast cancer? I would initially highlight the presentation made in the plenary, results that modify our decisions in daily practice.

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2978
Author(s):  
Chia-Jung Li ◽  
Yen-Dun Tony Tzeng ◽  
Yi-Han Chiu ◽  
Hung-Yu Lin ◽  
Ming-Feng Hou ◽  
...  

Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies.


Weed Science ◽  
1998 ◽  
Vol 46 (6) ◽  
pp. 647-651 ◽  
Author(s):  
Gary Comstock

Author' note: This article is based on remarks made in February 1998 at the annual meeting of the Weed Science Society of America in Chicago. Those remarks were in turn based on an article, to be published in Spanish, titled “Es Antinatural la Manipulación Genética de los Animales?” The Spanish version will appear in the Proceedings of the Segundo Congreso Caribeno de Bioetica, University of Puerto Rico, Mayaguez, March 1998. It addresses the question of the engineering of animals; the focus here is the engineering of plants. Whether one considers flora or fauna, the unnaturalness objection raises the same cluster of concerns. Consequently, an assessment of those concerns need not vary significantly in turning from animals to plants.


1893 ◽  
Vol 39 (167) ◽  
pp. 581-583
Author(s):  
D. Hack Tuke

Dr. Eugene Riggs, of St. Paul, Minn., U.S.A., the Chairman of the Committee on the History of the Treatment of the Insane, appointed by the National Conference of Corrections and Charities, read the report at its twentieth annual meeting, held June 12-18, 1893, at Chicago. The article is evidently drawn up by himself, and endorsed by the Committee. It constitutes an interesting and valuable review of the progress made in the care of the insane, the first era being that of neglect, the second that of detention more or less severe in character, and the third that in which we live, including the last twenty years. Dr. Riggs commences with the dawn of intelligence in the care of the insane in England in 1792, when the Retreat at York was founded. The period between this date and 1815 is recognized as one coincident in France with the beneficent work of Pinel, reinforced a little later by that of Esquirol. “Since that time both there and here (America) the battle for the increasingly intelligent application of that principle has been going on.”


2021 ◽  
Vol 1 (3) ◽  
pp. 38-42
Author(s):  
Liliia Kononenko ◽  

The attempt to expand the traditional academic ideas about diagnostics in social work has been made, in particular the selection of social diagnostic methods, the purposes of their application, professional situations and focus groups in which these methods can be applied.The research determines the opportunities of application social diagnostics in pedagogical practice, to identify the optimal methods of social diagnostics and the conditions in which it is advisable to apply this type of diagnostic by professional participants of the educational process.Other methods have been proposed in addition to the classic list of social diagnostic methods, such as interlocution, interviews and surveys of all types; they are unpopular in modern social and socio-pedagogical work, but due to their accessibility, validity, ease of processing and in formativeness can be used even by recent graduates. These include a genogram, a family sociogram, as well as an eco-map, the map of social environment and the map of social contacts.The viability of applying social diagnostic methods in a teacher’s daily practice for preventing, revealing and solving social problems has been determined.During the investigation, the author concludes that social diagnostic is the most significant technique among many universal ones that a social worker/social pedagogue can use in his/her work. The optimal location for diagnostic work is an educational institution. It provides quick access to the client base with the widest range, allows you to work with clients in the system of social relations, enables diagnostic work with less motivational pressure, covers relationships with parents/families and facilitates their involvement in preventive work


Author(s):  
Mengyao Xu ◽  
Shan Huang ◽  
Xiaoli Dong ◽  
Yanan Chen ◽  
Miao Li ◽  
...  

Abstract Metastases are the main cause of cancer-related mortality in breast cancer. Although significant progress has been made in the field of tumor metastasis, the exact molecular mechanisms involved in tumor metastasis are still unclear. Here, we report that ATOH8-V1, a novel isoform of ATOH8, is highly expressed in breast cancer and is a negative prognostic indicator of survival for patients. Forced expression of ATOH8-V1 dramatically enhances, while silencing of ATOH8-V1 decreases the metastasis of breast cancer cell lines. Moreover, ATOH8-V1 directly binds to the RhoC promoter and stimulates the expression of RhoC, which in turn enhances the metastasis of breast cancer. Altogether, our data demonstrate that ATOH8-V1 is a novel pro-metastatic factor that enhances cancer metastasis, suggesting that ATOH8-V1 is a potential therapeutic target for treatment of metastatic cancers.


2000 ◽  
Vol 86 (4) ◽  
pp. 304-306 ◽  
Author(s):  
Cinzia Motta ◽  
Gianluca Cartia ◽  
Alfredo Muni ◽  
Mauro Giudici ◽  
Giorgio Falcetto ◽  
...  

The aim of the study was to evaluate in our institute the technique of sentinel node (SN) identification and biopsy in the surgical treatment of early breast cancer. Between June 1998 and November 1999 54 patients (age range, 31–75 years) where studied. Inclusion criteria were age less than 75 years, indication for conservative surgery, absence of palpable axillary nodes, Karnofksy index >70. Lymphoscintigraphy was performed 16–18 hours prior to surgery, following injection of 0.1–0.2 mL of 99mTc-Nanocoll: the administered activity was 3–4 MBq in group A (44 pts) and 7–8 MBq in group B (10 pts). The colloids were administered by transdermal supralesional injection in 49 patients with palpable nodules and by intraparenchymal ultrasound-guided injection in five patients with non-palpable nodules. Planar projections were performed starting from the 5th until the 80th min (or 180th in the event of late migration). In 10 patients further projections were acquired 14–18 h following tracer administration. All nodes identified by gamma probe (MR 100 Pol. Hi. Tech) were histologically evaluated by immunohistochemistry and standard histology. Scintigraphic visualization of the SN was obtained in 49 patients: in 38 of these patients there was only one SN while in 11 patients there were two or three SNs. The delayed scan made in 10 patients did not show any further nodes. In all patients given US-guided perilesional injections migration was late (after at least 60 min). Our study confirms the validity of the scintigraphic procedure, its safety for patients and health care workers, and the feasibility of interdisciplinary collaboration.


2019 ◽  
Vol 12 (4) ◽  
pp. 312-314 ◽  
Author(s):  
Christoph Suppan ◽  
Marija Balic

Summary Early stage HER2-positive cancer outcomes have been substantially improved over the last two decades, but there is still some potential for improvement. Several studies on the preoperative/postoperative treatment of HER2-positive breast cancer were presented at the American Society of Clinical Oncology (ASCO) 2019 annual meeting.


2020 ◽  
Vol 13 (3) ◽  
pp. 349-352
Author(s):  
Arik Galid

Summary The San Antonio Breast Cancer Summit is one of the most important meetings worldwide for physicians who treat breast cancer. As traveling there is always somewhat of an adventure due to the distance and the time of the year (winter) and access is not easy for all physicians, the goal of this article is to provide an overview of the presentations dealing with hormone-receptor-positive breast cancer, capecitabine, prevention, and hormone replacement therapy. Data and results should positively influence daily practice.


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