scholarly journals Study of blood glucose and SGPT lowering effects of Daphne Mucronata Royle in induced diabetic rabbits

2017 ◽  
pp. 132-143
Author(s):  
AZIZ ULLAH
Keyword(s):  
Blood Glucose ◽  
Glucose Level ◽  
Methanol Extract ◽  
Enzyme Level ◽  
Diabetic Control ◽  
Reduce Blood Glucose ◽  
Reduce Blood Glucose Level ◽  
Reduction Effect ◽  
Daphne Mucronata ◽  
Diabetic Rabbits

This study was carried out to study Anti-diabetic effect of the plant Daphne mucronataextract in alloxan induced diabetic rabbits. To the first fifteen healthy rabbits taken and divided them into five groups as each group contains three numbers of rabbits. Group one kept in normal condition means no induction or treatment observed. Group second was given the diabetic control dose in quantity (12mg/kg). Group three also treated with the dose rate (125mg/kg) the D. Mucronata(methanol) extract. Similarly group no four was treat with the subject extract in the concentration of (225mg/kg). And the last fifth group of rabbits had the dosage of extract (325mg/kg). This mechanism of entrance was orally ingestion and the treatment duration was eight hours, after each of the next two hours from the start the blood samples were collected, serum separated and the glucose level determined by the method known by Kit method. After all the observations we reached to an impressive conclusion that the D. Mucronata(methanol) extract has significant potential to reduce blood glucose level and also recognized to be effective to reduce the blood SGPT enzyme level, so it can be suggested that this plant has such antidiabetic and SGPT reduction effect.

scholarly journals Hypoglycemic and Hypocholestrolemic study of Monothica boxifolia Falc. in induced diabetic Rabbits

2017 ◽  
pp. 144-151
Author(s):  
TAO SHIHENG
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Cholesterol Level ◽  
Glucose Level ◽  
Normal Control ◽  
Blood Test ◽  
Diabetic Control ◽  
The Body ◽  
Diabetic Rabbits

In the present examination, antidiabetic capability of Monothica separates (methanol) has been assessed in alloxan-prompted diabetic hares. Fifteen solid, bunnies were separated into four unique gatherings including, Normal control, Diabetic control , treated with Monothicamethanol remove, with 3 hares in each gathering. The concentrates were given orally for 24 hours, 100 mg, 200 mg, 300 mg extricate per bunny every day. At regular intervals blood test was gathered, serum isolated and absolute glucose level, cholesterol level was controlled by unit strategy. The body weight was recorded on like clockwork interim. The Monothecamethanol extricates lowered blood glucose and cholesterol level demonstrated greatest decrease adequately. The treatment with theseconcentrates additionally diminished the blood glucose and cholesterol. Along these lines, it is presumed that the Monothecapossessnoteworthy antidiabetic movement.

scholarly journals Effect of Baluran Gum Arabic on Blood Glucose Level in Diabetic Rat (Rattus Novergicus )

2021 ◽  
Vol 9 (2) ◽  
pp. 81
Author(s):  
Hidayat Teguh Wiyono ◽  
Eva Tyas Utami ◽  
Dinna Wahyu Putri Wardhani
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Gum Arabic ◽  
Diabetic Rat ◽  
Control Group ◽  
Normal Range ◽  
Reduce Blood Glucose ◽  
Reduce Blood Glucose Level

Diabetes mellitus is a metabolic disease which indicated with increasing blood glucose level. Carbohidrate, protein, mineral and secondary metabolite (alkaloid, tannin and saponin) can be benefical to treat diabetes mellitus. Rats were randomly divided into three groups. First, control group. Second, STZ group, untreated diabetic. Third, STZ+GA 15% group, diabetic treated with GA 15%. Result showed that blood glucose level before STZ induction on control and STZ group within normal range 78,57±11,90 mg/dL and 74,85±6,86 mg/dL. Blood glucose level significantly increase after STZ induction on STZ and STZ+GA 15% group become 375±6,53 mg/dL and 346,42±50,23 mg/dL. Diabetic rat treated with GA 15% revealed decrease in blood glucose level compared to untreated diabetic rat. Blood glucose level on STZ+GA 15% group continuously decrease become 96,42±13,45 mg/dL and 82,14±9,19 mg/dL. In conclusion, GA 15% could reduce blood glucose level on diabetic rat.

scholarly journals High antioxidant level in cajanus sajan reduces blood glucose level and improves blood lipid profile of rats as diabetes mellitus models

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Yuli Laraeni ◽  
I Gusti Ayu Nyoman Danuyanti ◽  
Ersandhi Resnhaleksmana ◽  
Iswari Pauzi ◽  
I Komang Agusjaya Mataram ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Glucose Level ◽  
Blood Lipid ◽  
Polyol Pathway ◽  
Protein Glycation ◽  
Blood Lipid Profile ◽  
Reduce Blood Glucose ◽  
Reduce Blood Glucose Level

Hyperglycemia in DM was able to increase glucose auto-oxidation, protein glycation, and polyol pathway activation. As a result, it can accelerate the formation of reactive oxygen compounds acting as the main factor causing DM complication. Prior to our evaluation of pigeon bean Tempe with formulations of 25%, 50% and 75%, we tested the number and activity of its antioxidant. Then we substituted it on standard feed for 14 days to find the effects on glucose level and lipid profile. The effects was then compared to that before the intervention. The result showed that the total and activity of antioxidant in pigeon bean Tempe (Cajanus sajan) was 15% and 41.30% respectively. On the other side, pigeon bean Tempe with a formulation of 75% was more able to reduce blood glucose level, total cholesterol, triglycerides, and LDL-cholesterol by 44.08%, 34.38%,35.80%, and 43.22% respectively (p<0.05) if compared to pigeon bean Tempe with formulations of 25% and 50%. Meanwhile pigeon bean Tempe with formulation of 75% provided better effects for an increase of HDL level 56.20% (p<0.05). All test results on Tempe formulation used were compared to that before intervention.

scholarly journals Effects of Fruits Extracts of Three Medicinal Plants on the Blood Glucose Level of Glucose-induced Hyperglycemic and Normal Rabbit Models

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
Ikram Ilahi ◽  
Asghar Khan ◽  
Ubaid Ullah ◽  
Imran Khan ◽  
Jawad Ali ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Medicinal Plants ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Methanol Extract ◽  
Second Phase ◽  
Glucose Lowering ◽  
Fruit Extracts ◽  
Lowering Activity

The fruits of Pistacia integerrima (PI), Withania coagulans (WC) and Withania somnifera (WS) have been reported for their medicinal values. The aim of the present study was to compare the glucose lowering activities of the fruit extracts of these three medicinal plants in glucose induced non-diabetic hyperglycemic and normal rabbit models. During the first phase of experiments, the effects of oral administration of 70% methanol extract of each plant fruit (600 mg/kg body weight) and glibenclamide (5 mg/kg body weight) were studied on the glucose level of glucose induced hyperglycemic rabbits, while in the second phase of experiments, the effects of each fruit extract (600 mg/kg body weight) and glibenclamide (5 mg/kg body weight) were assessed on the glucose level of normal rabbits. Among the three fruit extracts, maximum reduction in the blood glucose level was caused by the PI extract (P ˂0.05). The glucose lowering activity of the PI extract was greater than that of the standard, glibenclamide (5mg/kg), during the first phase of experiments. However during the second phase of experiments the hypoglycemic effect of the PI extract was comparable to that of the standard, glibenclamide (5mg/kg). In conclusion the present study reveals that the 70% methanol extract of Pistacia integerrima fruit can decrease glucose level significantly in glucose induced non-diabetic hyperglycemic and normal rabbit models.

scholarly journals ANTI-HYPERGLYCEMIC EFFECT OF DIFFERENT FRACTIONS OF ANNONA RETICULATA LEAF

2016 ◽  
pp. 256
Author(s):  
Soumya Prakash Rout ◽  
Durga Madhab Kar ◽  
Laxmidhar Maharana
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Ethyl Acetate ◽  
Glucose Level ◽  
Ethyl Acetate Fraction ◽  
Diabetic Control ◽  
Control Group ◽  
Alcoholic Extract ◽  
Diabetic Control Group ◽  
Annona Reticulata

<p>ABSTRACT<br />Context: Several species of the genus Annona were reported to have hypoglycemic properties and this makes Annona reticulata Linn. (Annonaceae)<br />an interesting plant for investigating its anti-hyperglycemic potential.<br />Objective: Different fractions prepared from hydro-alcoholic extract of A. reticulata leave were investigated for their blood glucose lowering effect on<br />Streptozotocin (STZ) induced hyperglycemic rats.<br />Methods: Ethyl acetate, methanol, and residual fractions (at dose level of 100 mg/kg by oral route) prepared from the hydro-alcoholic extract of<br />A. reticulata leave were administered for 14 consecutive days to STZ induced hyperglycemic rats for evaluation of their anti-hyperglycemic potential.<br />Anti-hyperglycemic potential was assessed by observation of a decrease in fasting blood glucose level.<br />Results: The studies revealed that ethyl acetate fraction decreased the blood glucose level of hyperglycemic rats from 447.67 to 234.17 mg/dL and is<br />significant (p&lt;0.001) when compared with diabetic control group. The residual fraction and methanolic fraction decreased blood glucose level from<br />417.83 to 402.50 mg/dL and 432.33 to 371.67 mg/dL respectively but not significant when compared with the diabetic control group. Standard drug<br />metformin (dose 300 mg/kg) reduced the blood glucose level from 447.33 to 219.50 mg/dL.<br />Discussion: Ethyl acetate fraction at tested dose level was capable not only to control the elevated blood glucose level but also able to attenuate<br />certain secondary parameters associated with STZ induced hyperglycemia.<br />Conclusion: This study suggested that the ethyl acetate fraction prepared from hydro-alcoholic extract of A. reticulata leave exhibit potential antihyperglycemic<br />property<br />in the tested<br />experimental<br />models and should be investigated<br />further.<br />Keywords: Streptozotocin, Diabetes, Dyslipidemia.</p>

Utilization of Fructose, Galactose and Glucose by Diabetic Rabbits

1957 ◽  
Vol 188 (3) ◽  
pp. 543-546 ◽  
Author(s):  
Sachchidananda Banerjee ◽  
Eswaramangalath Ramankutty Divakaran
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Intravenous Injection ◽  
Considerable Increase ◽  
True Blood ◽  
Alternate Source ◽  
Diabetic Rabbits

Fructose, galactose and glucose were fed to normal and alloxan-diabetic rabbits. Some of the animals received an intravenous injection of dihydroergotamine prior to the feeding of fructose. The levels of these sugars and true glucose were estimated in samples of blood collected for varying periods after the administration of these sugars. These sugars were also determined in the urine of the animals. Fructose and galactose were removed from the blood very rapidly in both the normal and diabetic rabbits and insignificant amounts of these sugars appeared in the urine. There was a considerable increase in the true blood glucose level and increased amount of glucose appeared in the urine of diabetic rabbits after fructose or galactose was fed. Dihydroergotamine partly suppressed this hyperglycemia after the administration of fructose. Alloxan-diabetic rabbits in spite of their normal ability to initiate the metabolism of fructose and galactose, either transform a considerable amount of these sugars into glucose or spare the utilization of blood glucose. Superiority of these sugars as alternate source of energy is questioned.

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