Functional rice giant embryo and Aranghyangchal reduce blood glucose level and enhance antioxidative defense status in high fat-fed mice

2014 ◽  
Vol 17 (3) ◽  
pp. 141-146
Author(s):  
Mi Young Kang ◽  
Soo Im Chung ◽  
Mingze Xu ◽  
Sang Chul Lee
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Antioxidative Defense ◽  
High Fat ◽  
Reduce Blood Glucose ◽  
Reduce Blood Glucose Level ◽  
Giant Embryo

scholarly journals Effect of Baluran Gum Arabic on Blood Glucose Level in Diabetic Rat (Rattus Novergicus )

2021 ◽  
Vol 9 (2) ◽  
pp. 81
Author(s):  
Hidayat Teguh Wiyono ◽  
Eva Tyas Utami ◽  
Dinna Wahyu Putri Wardhani
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Gum Arabic ◽  
Diabetic Rat ◽  
Control Group ◽  
Normal Range ◽  
Reduce Blood Glucose ◽  
Reduce Blood Glucose Level

Diabetes mellitus is a metabolic disease which indicated with increasing blood glucose level. Carbohidrate, protein, mineral and secondary metabolite (alkaloid, tannin and saponin) can be benefical to treat diabetes mellitus. Rats were randomly divided into three groups. First, control group. Second, STZ group, untreated diabetic. Third, STZ+GA 15% group, diabetic treated with GA 15%. Result showed that blood glucose level before STZ induction on control and STZ group within normal range 78,57±11,90 mg/dL and 74,85±6,86 mg/dL. Blood glucose level significantly increase after STZ induction on STZ and STZ+GA 15% group become 375±6,53 mg/dL and 346,42±50,23 mg/dL. Diabetic rat treated with GA 15% revealed decrease in blood glucose level compared to untreated diabetic rat. Blood glucose level on STZ+GA 15% group continuously decrease become 96,42±13,45 mg/dL and 82,14±9,19 mg/dL. In conclusion, GA 15% could reduce blood glucose level on diabetic rat.

scholarly journals Study on Hypoglycaemic Effect of Spirulina platensis on Long-Evans Rats

1970 ◽  
Vol 45 (2) ◽  
pp. 163-168 ◽  
Author(s):  
MOF Mridha ◽  
MAA Jahan ◽  
N Akhtar ◽  
JL Munshi ◽  
Z Nessa
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Spirulina Platensis ◽  
Hypoglycaemic Effect ◽  
High Fat ◽  
High Concentration ◽  
Reference Drug ◽  
Reduce Blood Glucose ◽  
Long Evans

Spirulina containing high concentration of functional nutrients is emerging as an important therapeutic food. So the present study was designed to evaluate the hypoglycaemic properties of Spirulina platensis on long-evans rats. Two sets of experiment were conducted, the 1st set was compared with the effect of Spirulina platensis, glibenclamide, glucose and water after feeding 60 minutes. Glibenclamide was used as a standard reference drug. The findings clearly indicated that the oral administration of Spirulina platensis (150mg/kg b.w) significantly tended to reduce blood glucose level of rat than that of glibenclamide. In the 2nd experiment long-term hypoglycaemic effect of Spirulina platensis 0.5% and 2.5% fed with high fat high sugar containing diet and 150mg/kg b.w with normal laboratory diet was also observed. The 2nd findings also indicated that the blood glucose level was significantly decreased in both the diet when supplemented with Spirulina platensis. Key words: Diabetic mellitus; High fat diet; Hypoglycaemic; Spirulina platensis; Body weight DOI: 10.3329/bjsir.v45i2.5715Bangladesh J. Sci. Ind. Res. 45(2), 163-168, 2010

scholarly journals High antioxidant level in cajanus sajan reduces blood glucose level and improves blood lipid profile of rats as diabetes mellitus models

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Yuli Laraeni ◽  
I Gusti Ayu Nyoman Danuyanti ◽  
Ersandhi Resnhaleksmana ◽  
Iswari Pauzi ◽  
I Komang Agusjaya Mataram ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Glucose Level ◽  
Blood Lipid ◽  
Polyol Pathway ◽  
Protein Glycation ◽  
Blood Lipid Profile ◽  
Reduce Blood Glucose ◽  
Reduce Blood Glucose Level

Hyperglycemia in DM was able to increase glucose auto-oxidation, protein glycation, and polyol pathway activation. As a result, it can accelerate the formation of reactive oxygen compounds acting as the main factor causing DM complication. Prior to our evaluation of pigeon bean Tempe with formulations of 25%, 50% and 75%, we tested the number and activity of its antioxidant. Then we substituted it on standard feed for 14 days to find the effects on glucose level and lipid profile. The effects was then compared to that before the intervention. The result showed that the total and activity of antioxidant in pigeon bean Tempe (Cajanus sajan) was 15% and 41.30% respectively. On the other side, pigeon bean Tempe with a formulation of 75% was more able to reduce blood glucose level, total cholesterol, triglycerides, and LDL-cholesterol by 44.08%, 34.38%,35.80%, and 43.22% respectively (p<0.05) if compared to pigeon bean Tempe with formulations of 25% and 50%. Meanwhile pigeon bean Tempe with formulation of 75% provided better effects for an increase of HDL level 56.20% (p<0.05). All test results on Tempe formulation used were compared to that before intervention.

scholarly journals Study of blood glucose and SGPT lowering effects of Daphne Mucronata Royle in induced diabetic rabbits

2017 ◽  
pp. 132-143
Author(s):  
AZIZ ULLAH
Keyword(s):  
Blood Glucose ◽  
Glucose Level ◽  
Methanol Extract ◽  
Enzyme Level ◽  
Diabetic Control ◽  
Reduce Blood Glucose ◽  
Reduce Blood Glucose Level ◽  
Reduction Effect ◽  
Daphne Mucronata ◽  
Diabetic Rabbits

This study was carried out to study Anti-diabetic effect of the plant Daphne mucronataextract in alloxan induced diabetic rabbits. To the first fifteen healthy rabbits taken and divided them into five groups as each group contains three numbers of rabbits. Group one kept in normal condition means no induction or treatment observed. Group second was given the diabetic control dose in quantity (12mg/kg). Group three also treated with the dose rate (125mg/kg) the D. Mucronata(methanol) extract. Similarly group no four was treat with the subject extract in the concentration of (225mg/kg). And the last fifth group of rabbits had the dosage of extract (325mg/kg). This mechanism of entrance was orally ingestion and the treatment duration was eight hours, after each of the next two hours from the start the blood samples were collected, serum separated and the glucose level determined by the method known by Kit method. After all the observations we reached to an impressive conclusion that the D. Mucronata(methanol) extract has significant potential to reduce blood glucose level and also recognized to be effective to reduce the blood SGPT enzyme level, so it can be suggested that this plant has such antidiabetic and SGPT reduction effect.

scholarly journals Pengaruh Fraksi Air Buah Lemon (Citrus limon) terhadap Kadar Glukosa Darah Mencit Tua yang Diberi Pakan Tinggi Lemak

2019 ◽  
Vol 1 (1) ◽  
pp. 54-58
Author(s):  
Rina Permatasari ◽  
Yuke Andriane ◽  
Herry Garna ◽  
Oky Haribudiman ◽  
R.A. Retno Ekowati
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Citrus Limon ◽  
High Fat ◽  
Median Difference ◽  
Water Fraction ◽  
Significant Difference ◽  
Old Mice

Diabetes melitus merupakan salah satu penyakit yang menjadi masalah terbesar pada abad 21. Obesitas (terutama obesitas viseral) dan resistensi insulin sering disertai dengan sekelompok kelainan yang disebut sindrom metabolik yang mencakup intoleransi glukosa, trigliserida tinggi, kolesterol HDL rendah, dan hipertensi. Lemon mengandung flavonoid yang dipercaya mempunyai aktivitas menurunkan kadar glukosa darah. Tujuan penelitian ini mengetahui perubahan kadar glukosa darah pada mencit tua yang diberi pakan tinggi lemak setelah pemberian fraksi air buah lemon (Citrus limon). Penelitian dilakukan di Laboratorium Hewan Gedung Farmasi ITB dan Laboratorium Hewan Fakultas Kedokteran Universitas Islam Bandung pada bulan April−Juni 2018. Metode penelitian ini adalah eksperimental laboratorium murni in vivo dengan desain penelitian rancangan acak lengkap terhadap 28 mencit tua jantan galur DDY yang terbagi dalam lima kelompok, yakni kontrol normal, kontrol negatif, konsentrasi 20,6 mg/20 gBB, 41,2 mg/20 gBB, dan 82,4 mg/20 gBB. Pengukuran glukosa darah puasa dilakukan setelah masa adaptasi, saat perlakuan (hari ke-15), dan setelah perlakuan menggunakan glukosameter. Analisis data menggunakan Uji Kruskall-Wallis dan Uji Friedman. Hasil penelitian menunjukkan perbedaan median GDP1 antarkelompok yang signifikan (p=0,05), perbedaan median GDP2 yang tidak signifikan (p=0,08), dan perbedaan median GDP3 yang tidak signifikan (p=0,66). Terdapat perbedaan median GDP1−3 yang signifikan antara kelompok konsentrasi fraksi air buah lemon (p=0,04). Simpulan, fraksi air buah lemon memiliki efek menurunkan glukosa darah.EFFECT OF WATER FRACTION OF LEMON (CITRUS LIMON) ON BLOOD GLUCOSE LEVEL OF OLD MICE GIVEN HIGH-FAT DIETDiabetes mellitus is one of the biggest problems of the 21st century. Obesity (especially visceral obesity) and insulin resistance often present with a group of disorders commonly called metabolic syndrome including glucose intolerance, high triglycerides, low HDL cholesterol, and hypertension. Flavonoid compounds in lemon is believed to have blood glucose lowering activity. The purpose of this study was to determine changes in blood glucose level in old mice given a high-fat diet after administration of water fraction of lemon (Citrus limon). This study was held at Animal Laboratory of Pharmacy ITB and Animal Laboratory of Faculty of Medicine Bandung Islamic University in April to June 2018. The method of this study was pure in vivo laboratory experiment with a completely randomized design to 28 old male DDY strain mices divided into five groups; normal control, negative control, concentration 20.6 mg/20 gBW, 41.2 mg/20 gBW, and 82.4 mg/20 gBW. Fasting blood glucose measurements were performed after adaptation, ongoing treatment (day 15), and after treatment using glucosemeter. Data analysis used Kruskall-Wallis test and Friedman test. The results showed that there was a significant GDP1 median difference of each groups (p=0.05), a nonsignificant GDP2 median difference (p=0.08), and GDP3 median difference were not significantly different (p=0.66). There was a statistically significant difference between median GDP1−3 between each water fraction of lemon concentration groups (p=0.04). Conclusion, the water fraction of lemon has the effect of lowering blood glucose.

scholarly journals Sargassum fusiforme Polysaccharides Prevent High-Fat Diet-Induced Early Fasting Hypoglycemia and Regulate the Gut Microbiota Composition

Marine Drugs ◽  
2020 ◽  
Vol 18 (9) ◽  
pp. 444
Author(s):  
Bin Wei ◽  
Qi-Wu Zhong ◽  
Song-Ze Ke ◽  
Tao-Shun Zhou ◽  
Qiao-Li Xu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Gut Microbiota ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Relative Abundance ◽  
High Fat Diet ◽  
Fasting Blood Glucose ◽  
Fasting Blood Glucose Level ◽  
High Fat ◽  
Fasting Hypoglycemia

A low fasting blood glucose level is a common symptom in diabetes patients and can be induced by high-fat diet (HFD) feeding at an early stage, which may play important roles in the development of diabetes, but has received little attention. In this study, five polysaccharides were prepared from Sargassumfusiforme and their effects on HFD-induced fasting hypoglycemia and gut microbiota dysbiosis were investigated. The results indicated that C57BL/6J male mice fed an HFD for 4 weeks developed severe hypoglycemia and four Sargassumfusiforme polysaccharides (SFPs), consisting of Sf-2, Sf-3, Sf-3-1, and Sf-A, significantly prevented early fasting hypoglycemia without inducing hyperglycemia. Sf-1 and Sf-A could also significantly prevent HFD-induced weight gain. Sf-2, Sf-3, Sf-3-1, and Sf-A mainly attenuated the HFD-induced decrease in Bacteroidetes, and all five SFPs had a considerable influence on the relative abundance of Oscillospira, Mucispirillum, and Clostridiales. Correlation analysis revealed that the fasting blood glucose level was associated with the relative abundance of Mucispinllum and Oscillospira. Receiver operating characteristic analysis indicated that Mucispinllum and Oscillospira exhibited good discriminatory power (AUC = 0.745–0.833) in the prediction of fasting hypoglycemia. Our findings highlight the novel application of SFPs (especially Sf-A) in glucose homeostasis and the potential roles of Mucispinllum and Oscillospira in the biological activity of SFPs.

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