scholarly journals Design and Synthesis of Two Azete Derivatives Using some Chemical Strategies

2021 ◽  
Vol 12 (4) ◽  
pp. 5567-5578
Keyword(s):  
Chemical Structure ◽  
Spectroscopic Methods ◽  
Design And Synthesis ◽  
Good Yielding ◽  
Chemical Strategies

There are several methods for preparing nitrogen-containing four-membered heterocycles using some reagents that require special conditions such as higher temperatures or differences in the pH. This research aimed to prepare two azete derivatives from 1-Bromo-3,5-dinitrobenzene using some chemical strategies. The chemical structure was characterized by NMR spectroscopic methods. The results indicate that protocols used to synthesize two azete analogs do not require special conditions to give a good yielding. In conclusion, is reported a facile method for the synthesis of two azete derivatives.

Synthesis of a New Dioxaspiro[bicyclo[3.3.1]nonane-oxabicyclo[6.2.0]deca- 1(10),8-dien-4-one Derivative Using Some Chemical Strategies

2020 ◽  
Vol 17 (5) ◽  
pp. 393-402
Author(s):  
Figueroa-Valverde Lauro ◽  
Rosas-Nexticapa Marcela ◽  
Lopez-Ramos Maria ◽  
Diaz Cedillo Francisco ◽  
Mateu-Armand Virginia ◽  
...  
Keyword(s):  
Elemental Analysis ◽  
Chemical Structure ◽  
Spectroscopic Techniques ◽  
Easy Method ◽  
Chemical Strategies

There are several protocols for the preparation of bicyclic derivatives; however, some methods use dangerous and require special conditions. The aim of this study was to synthesize a new Dioxaspiro[ bicyclo[3.3.1]nonane-oxabicyclo[6.2.0]-deca-1(10), 8-dien-4-one (compound 8). Compound 8 was prepared using some reactions such as; i) etherification, ii) reduction, iii) amidation, iv) imination and v) 2+2 addition. The chemical structure of 8 and its intermediaries were completely characterized by spectroscopic techniques and elemental analysis. The synthesis showed a yield of 85% for compound 8. In this study, an easy method for the preparation of compound 8 is reported.

Design and synthesis of novel benzimidazoles containing 1,2,3-triazolesas in vitro, anticancer and anti-oxidant agents

2021 ◽  
Vol 25 (11) ◽  
pp. 104-109
Author(s):  
Gullapelli Kumaraswamy ◽  
Ravichandar Maroju ◽  
Srinivas Bandari ◽  
Gouthami Dasari ◽  
Gullapelli Sadanandam
Keyword(s):  
Spectroscopic Methods ◽  
Moderate Activity ◽  
Design And Synthesis ◽  
Anti Cancer ◽  
Excellent Activity ◽  
Test Organisms ◽  
Anti Oxidant ◽  
High Yields ◽  
Cancer Activity

A novel series of 2-(1-((1-substitutedphenyl-1H-1,2,3- triazol-4-yl)methoxy)ethyl)-1-((1-substituted phenyl- 1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazole (3a-j)derivatives was synthesized in moderate to high yields. The structures of all the synthesized compounds were characterized by 1HNMR, 13CNMR and Mass spectroscopic methods. The title compounds were screened for their anti-oxidant activity and anti-cancer activity. The cancer activity results reveal that the compounds 3j, 3b and 3f are showing promising activity and remaining compounds exhibited moderate activity against all the tested cancer cell lines. The anti-oxidant activity also shows that the compounds 3c and 3d have shown excellent activity and remaining compounds were also found to exhibit moderate activity against the test organisms employed.

Design and synthesis of a new furan-steroid-propanone derivative using some chemical strategies

Steroids ◽  
2020 ◽  
Vol 160 ◽  
pp. 108654
Author(s):  
Figueroa-Valverde Lauro ◽  
Rosas-Nexticapa Marcela ◽  
Lopez-Ramos Maria ◽  
Diaz Cedillo Francisco ◽  
Garcimarero-Espino E. Alejandra ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Chemical Strategies

Oxidative Aging of Natural Rubber Vulcanizates. Part III. Crosslink Scission in Monosulfidic Networks

1969 ◽  
Vol 42 (3) ◽  
pp. 924-935 ◽  
Author(s):  
T. Colclough ◽  
J. I. Cunneen ◽  
G. M. C. Hrggins
Keyword(s):  
Natural Rubber ◽  
Physical Properties ◽  
Chemical Structure ◽  
Spectroscopic Methods ◽  
Chemical Probes ◽  
Conjugated Diene ◽  
Strain Measurements ◽  
Oxidative Aging ◽  
Tert Butyl Hydroperoxide ◽  
Natural Rubber Vulcanizates

Abstract A natural rubber vulcanizate containing almost entirely monosulfidic crosslinks was oxidized in oxygen and with tert-butyl hydroperoxide. The changes in physical properties due to oxidation were followed by stress—strain measurements, and the changes in chemical structure were investigated with chemical probes, and by spectroscopic methods. The results show that when the oxidized vulcanizates are heated at 75° C, the monosulfidic crosslinks are broken, that crosslinks containing two sulfur atoms are formed, and that conjugated diene and triene structures are introduced into the main polyisoprene chains.

Chemical structure of tar-sand bitumens by 13C and 1H n.m.r. spectroscopic methods

Fuel ◽  
1982 ◽  
Vol 61 (5) ◽  
pp. 402-410 ◽  
Author(s):  
Toshimitsu Suzuki ◽  
Maki Itoh ◽  
Yoshinobu Takegami ◽  
Yoshihisa Watanabe
Keyword(s):  
Chemical Structure ◽  
Spectroscopic Methods

scholarly journals Four Flavan-3-ol Compounds From The Stembark of Chisocheton balansae C.DC. (MELIACEAE)

Molekul ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 9
Author(s):  
Unang Supratman ◽  
Mohamad Fajar ◽  
Supriatno Salam ◽  
Rani Maharani ◽  
Desi Harneti ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
13C Nmr ◽  
Chemical Structure ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Stem Bark ◽  
Spectroscopic Methods ◽  
Endemic Plants ◽  
North Sulawesi ◽  
First Time

Chisocheton balansae C.DC., is one of the Meliaceae family plants which is the endemic plants from Soputan Mountain, North Sulawesi, Indonesia. This study was aimed to determine the chemical structure of flavan-3-ol compounds from ethyl acetate extract of C. balansae C.DC stembark. Dried powder of C. balansae C.DC stem bark was extracted consecutively with n-hexane, ethyl acetate, and methanol solvents. Four flavan-3-ol compounds, named catechin (1), epicatechin (2), epigallocatechin-3-O-gallate (3), and epicatechin-3-O-gallate (4) were successfully isolated from ethyl acetate extract. The chemical structure of these isolates was determined by spectroscopic methods (1H-NMR, 13C-NMR, DEPT, and 2D-NMR) and comparison with previous reported spectral data. These compounds are first time reported from this plant.

scholarly journals Design and Synthesis of Three Tetracyclic-Dione Derivatives and their Biological Activity on Perfusion Pressure Using an Isolated Rat Heart Model

2021 ◽  
Vol 12 (1) ◽  
pp. 253-263
Keyword(s):  
Biological Activity ◽  
Rat Heart ◽  
Perfusion Pressure ◽  
Isolated Rat Heart ◽  
Coronary Resistance ◽  
Heart Model ◽  
Design And Synthesis ◽  
Second Stage ◽  
Chemical Strategies ◽  
Isolated Rat

Several tetracyclic derivatives have been prepared with different biological activity; however, there are few reports on the effects exerted by the tetracyclic derivatives on the cardiovascular system. The objective of this investigation was to prepare three tetracyclic-dione derivatives (compounds 3 to 5) to evaluate their biological activity on perfusion pressure and coronary resistance. The first stage was achieved by the synthesis of three tetracyclic‐dione analogs using some chemical strategies. The second stage involves evaluating biological activity from tetracyclic‐derivatives on perfusion pressure and coronary resistance using an isolated rat heart model. The results showed that only compound 5 increases perfusion pressure and coronary resistance compared with the control conditions. In conclusion, the biological activity of compound 5 exerted against perfusion pressure and coronary resistance depends on the functional groups involved in their chemical structure.

scholarly journals Anionic Copolymerization of Styrene Sulfide with Elemental Sulfur (S8)

Materials ◽  
2020 ◽  
Vol 13 (11) ◽  
pp. 2597
Author(s):  
Jakub Wręczycki ◽  
Dariusz M. Bieliński ◽  
Marcin Kozanecki ◽  
Paulina Maczugowska ◽  
Grzegorz Mlostoń
Keyword(s):  
Thermal Stability ◽  
Raman Spectroscopy ◽  
Ring Opening ◽  
Chemical Structure ◽  
Elemental Sulfur ◽  
Ring Opening Polymerization ◽  
Spectroscopic Methods ◽  
Initial Ratio ◽  
Anionic Copolymerization ◽  
Thermal Stability Of

The superior ability of thiiranes (episulfides) to undergo ring-opening polymerization (ROP) in the presence of anionic initiators allows the preparation of chemically stable polysulfide homopolymers. Incorporation of elemental sulfur (S8) by copolymerization below the floor temperature of S8 permits the placement of a large quantity of sulfur atoms in the polysulfide mainchain. The utility of styrene sulfide (2-phenylthiirane; StS) for copolymerization with elemental sulfur is reported here. A few polysulfides differing depending on the initial ratio of S8 to StS and copolymerization time were synthesized. Various spectroscopic methods (1H NMR, 13C NMR, Raman spectroscopy and FTIR spectroscopy) were applied to characterize the chemical structure of the copolymers. Additionally, the phase structure and thermal stability of the synthesized polysulfides were investigated using DSC and TGA, respectively. The successful anionic copolymerization of styrene sulfide and elemental sulfur has been demonstrated.

Thujin, a novel lactone isolated from the discolored heartwood of Thuja plicata Donn.

1988 ◽  
Vol 66 (1) ◽  
pp. 51-53 ◽  
Author(s):  
Lehong Jin ◽  
Jack W. Wilson ◽  
Eric P. Swan
Keyword(s):  
Chemical Structure ◽  
Thuja Plicata ◽  
Spectroscopic Methods ◽  
Red Cedar ◽  
Western Red Cedar ◽  
Thuja Plicata Donn

The chemical structure of a novel lactone isolated from the discolored heartwood of living western red cedar (WRC) (Thuja plicata Donn.) trees has been determined as 3,3,4,7,7,8-hexamethyl-2,6-dioxa-1,5-anthracene-dione, and given the trivial name thujin (1). The isolation, purification, and determination of the structure were carried out by a combination of chemical, chromatographic, and spectroscopic methods.

scholarly journals Isolation and Identification of the Antimicrobial Agent Beauvericin from the EndophyticFusarium oxysporum5-19 with NMR and ESI-MS/MS

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Huawei Zhang ◽  
Chuanfen Ruan ◽  
Xuelian Bai ◽  
Miao Zhang ◽  
Shuangshuang Zhu ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Fermentation Broth ◽  
Inhibitory Effect ◽  
Positive Control ◽  
Spectroscopic Methods ◽  
Isolation And Identification ◽  
Esi Ms ◽  
Bioactive Natural Products ◽  
Pathogenic Microbes ◽  
C Nmr

Endophytic microbe has been proved to be one of rich sources of bioactive natural products with potential application for new drug and pesticide discovery. One cyclodepsipeptide, beauvericin, was firstly isolated from the fermentation broth ofFusarium oxysporum5-19 endophytic onEdgeworthia chrysanthaLinn. Its chemical structure was unambiguously identified by a combination of spectroscopic methods, such as HRESI-MS and1H and13C NMR. ESI-MS/MS was successfully used to elucidate the splitting decomposition route of the positive molecule ion of beauvericin. Antimicrobial results showed that this cyclodepsipeptide had inhibitory effect on three human pathogenic microbes,Candida albicans,Escherichia coli, andStaphylococcus aureus. In particular, beauvericin exhibited the strongest antimicrobial activity againstS. aureuswith MIC values of 3.91 μM, which had similar effect with that of the positive control amoxicillin.

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