scholarly journals Effect of Levothyroxine Replacement on Lipid Profile and Renal Function of Primary and Subclinical Hypothyroid Patients

2017 ◽  
Vol 7 (3) ◽  
pp. 187-193
Author(s):  
Ahmed Salam Mir ◽  
Zafar Ahmed Latif ◽  
SM Ashrafuzzaman ◽  
Faria Afsana
Keyword(s):  
Renal Function ◽  
Lipid Profile ◽  
Overt Hypothyroidism ◽  
Cross Sectional ◽  
Multiple Systems ◽  
Levothyroxine Replacement ◽  
Observational Cohort ◽  
Outpatient Departments ◽  
Thyroxine Replacement ◽  
Hypothyroid Patients

Background: Hypothyroidism is an important endocrine disorder associated with deleterious effects on multiple systems including cardiovascular, musculoskeletal, renal and nervous system. It is established that thyroxine replacement shows improvement in many clinical and biochemical parameters of overt hypothyroidism, but there is scarce data about these disorders in this sub-continent. The present study intends to find out the effect of thyroxine replacement on lipid profile and renal function in hypothyroid patients.Methods: This was an observational cohort study, done in endocrine inpatient and outpatient departments of BIRDEM General Hospital from August 2013 to July 2014. Patients with newly detected hypothyroidism, both primary and subclinical, were selected by convenient sampling. A semi-structured questionnaire was used to collect the clinical and laboratory informations from the patients. Baseline clinical and laboratory informations including lipid profile and serum creatinine were collected and e-GFR was calculated. Then tablet levothyroxine was started at a dose of 25 micrograms/day and adjusted by 12.5-25 micrograms/day dose increments 4-6 weekly till FT4 and TSH were normalized. After 6 months, clinical and biochemical data were collected and e-GFR calculated.Results: Seventy four hypothyroid patients were followed up for 6 months. All the patients became euthyroid during this time with thyroxine replacement (mean daily dose of thyroxine 96.61 ±25.62 micrograms). There was significant improvement in hypothyroid symptoms and significant reduction in weight and systolic and diastolic blood pressure in the patients after thyroxine replacement. There was reduction in total cholesterol (187.66 ±19.90 mg/dl to 164.37±17.49 mg/dl, P<0.001), LDL (P<0.001) and triglycerides (P<0.001) but HDL did not increase significantly (31.93 ±2.99 mg/dl to 31.98 ±2.75 mg/dl, P=0.46). Renal function improved significantly in terms of eGFR (74.78±13.70 ml/min/1.73m2 to 89.23±18.24 ml/min/1.73m2, P<0.001).Conclusion: The present study concludes that there is increased prevalence of dyslipidaemia and renal dysfunction in hypothyroid patients in this cross-sectional population. Adequate replacement of thyroxine can, at least in part, reverse these problems. It also shows significant improvement of the patients with subclinical hypothyroidism, which is regarded by many authors as mild thyroid failure.Birdem Med J 2017; 7(3): 187-193

Effect of Levothyroxine Therapy on Hypothyroidism-induced Dyslipidemia

2017 ◽  
Vol 2 (3) ◽  
pp. 107-110
Author(s):  
Shalini Chandra ◽  
Amritanshu Shekhar ◽  
Hariom K Singh ◽  
Iram Shaifali ◽  
Darshan Mehra
Keyword(s):  
Lipid Profile ◽  
Replacement Therapy ◽  
Low Density Lipoprotein ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Overt Hypothyroidism ◽  
Open Label ◽  
Medical College ◽  
Levothyroxine Replacement ◽  
Hypothyroid Patients

ABSTRACT Objective The aims of the present study were to determine the prevalence of hypothyroidism, both subclinical hypothyroidism (SH) and overt hypothyroidism (OH), its correlation with dyslipidemia, and whether replacement therapy with levothyroxine has an effect on plasma lipid profile, i.e., total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) of hypothyroid patients. Materials and methods A prospective, open-label, observational, clinical study was conducted by the Department of Pharmacology in collaboration with the Department of Medicine, Rohilkhand Medical College & Hospital, for a period of 10 months. A total of 50 patients, age 18 to 65 years, of both genders, who were newly diagnosed cases of hypothyroidism with dyslipidemia (Adult Treatment Panel III National Cholesterol Education Program guidelines) were recruited for the study. Levothyroxine replacement therapy was administered and the patients were reassessed at 6 and 36 weeks for an effect on lipid profile and body mass index. Results In cases of OH, baseline TC, TG, LDL, and HDL were 231.01 ± 27.84, 148.18 ± 10.72, 149.07 ± 12.38, and 35.42 ± 6.73 mg/dL, which was reduced to 177.33 ± 23.17, 123.15 ± 29.50, 118.44 ± 29.85, and 47.86 ± 8.53 mg/dL after 36 weeks of levothyroxine therapy (p < 0.05). Conclusion In cases of OH associated with dyslipidemia, levothyroxine therapy achieved a favorable lipid profile in significant number of cases. How to cite this article Shekhar A, Singh HK, Chandra S, Shaifali I, Mehra D. Effect of Levothyroxine Therapy on Hypothyroidism-induced Dyslipidemia. Int J Adv Integ Med Sci 2017;2(3):107-110.

scholarly journals Evaluation of renal function in subclinical hypothyroidism

2018 ◽  
Vol 10 (01) ◽  
pp. 050-055 ◽  
Author(s):  
Vijayetha P. Patil ◽  
Alagilwada S. Shilpasree ◽  
Vidya S. Patil ◽  
Kangokar R. Pravinchandra ◽  
Deepti G. Ingleshwar ◽  
...  
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Subclinical Hypothyroidism ◽  
Linear Regression Analysis ◽  
Laboratory Diagnosis ◽  
Thyroid Stimulating Hormone ◽  
Function Parameter ◽  
Overt Hypothyroidism ◽  
Free Triiodothyronine ◽  
Cross Sectional

Abstract INTRODUCTION: Patients with subclinical hypothyroidism (SCH) have a few or no symptoms or signs of thyroid dysfunction and thus by its very nature, SCH is a laboratory diagnosis. Serum creatinine is elevated and glomerular filtration rate (GFR) values are reversibly reduced in overt hypothyroid patients. We hypothesize that SCH also may be associated with low GFR. AIMS AND OBJECTIVES: The objective of this study was (1) to know the effect of SCH on kidney function, (2) to find the correlation between the renal function parameter creatinine, estimated GFR (eGFR), and thyroid-stimulating hormone (TSH), and (3) to know if creatinine values can be predicted by TSH values in SCH cases. MATERIALS AND METHODS: This is a hospital-based cross-sectional study for 1 year. A total of 608 subjects of either sex were included in the study and were divided into 3 groups: (1) SCH, (2) overt hypothyroidism (OHT), and (3) euthyroidism (ET). TSH, free triiodothyronine, free thyroxine, and serum creatinine were estimated and eGFR was calculated using modification of diet in renal disease study equation and the chronic kidney disease epidemiology collaboration equations. RESULTS: Serum creatinine levels were higher and eGFR was lower significantly in the subclinical hypothyroid group when compared to the control ET group (P < 0.001). The overtly hypothyroid group had significantly higher levels of serum creatinine and lower eGFR when compared to both the groups (P < 0.001). Significant correlation between TSH, creatinine, and eGFR was found in OHT group only. Linear regression analysis showed the regression in creatinine upon TSH is attributable to 44.5% among OHT group, 48.2% in SCH group. CONCLUSION: It can be concluded that the SCH group behaves biochemically similar to OHT group and changes in serum creatinine reflect tissue hypothyroidism in SCH cases.

scholarly journals Fatigability: An Early Marker of Diminished Renal Function?

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 208-208
Author(s):  
Ann Moore ◽  
Michelle Shardell ◽  
Pei-Lun Kuo ◽  
Ajoy Karikkineth ◽  
Luigi Ferrucci ◽  
...  
Keyword(s):  
Renal Function ◽  
Perceived Exertion ◽  
Fatigue Threshold ◽  
P Value ◽  
Cross Sectional ◽  
Men And Women ◽  
Multiple Systems ◽  
Poor Renal Function ◽  
Baltimore Longitudinal Study ◽  
Using Data

Abstract Renal function declines markedly with age due to normal aging and/or disease processes and impacts multiple systems. Diminished renal function may manifest as low exercise tolerance and fatigue threshold. Using data on 951 well-functioning (usual gait speed &gt;.67m/s and no difficulty walking ¼ mile) men and women (51%) aged 60-89 years in the Baltimore Longitudinal Study of Aging, we evaluated the cross-sectional association between perceived fatigability (Rating Perceived Exertion after 5-minute treadmill walk at 1.5mph) categorized as 6-7, 8-9, 10-11 and 12+ and GFR using Cockcroft-Gault. For each fatigability increment, likelihood of suboptimal (GFR=75-89, 21%), diminished (GFR=60-74, 26%) and poor renal function (GFR=15-59, 30%) relative to GFR≥90 was respectively OR(95%CI)p-value 1.51(1.16-1.96).002, 1.38(1.04-1.83).027 and 1.68(1.22-2.31).002 adjusted for demographics, weight, height, smoking, exercise and anemia. Findings were similar for men and women. Perceived fatigability may facilitate identification of apparently well-functioning older adults on the precipice of suboptimal to poor renal function.

Correlation of creatinine with TSH levels in overt hypothyroidism — A requirement for monitoring of renal function in hypothyroid patients?

2012 ◽  
Vol 45 (3) ◽  
pp. 212-214 ◽  
Author(s):  
Vandana Saini ◽  
Amita Yadav ◽  
Megha Kataria Arora ◽  
Sarika Arora ◽  
Ritu Singh ◽  
...  
Keyword(s):  
Renal Function ◽  
Overt Hypothyroidism ◽  
Hypothyroid Patients ◽  
Tsh Levels

scholarly journals Low thyroid function is not associated with an accelerated deterioration in renal function

2018 ◽  
Vol 34 (4) ◽  
pp. 650-659 ◽  
Author(s):  
Christiaan L Meuwese ◽  
Merel van Diepen ◽  
Anne R Cappola ◽  
Mark J Sarnak ◽  
Michael G Shlipak ◽  
...  
Keyword(s):  
Renal Function ◽  
Thyroid Hormone ◽  
Thyroid Function ◽  
Age Groups ◽  
Thyroid Stimulating Hormone ◽  
Overt Hypothyroidism ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Adult Age

Abstract Background Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Methods Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included. Thyroid hormone status was defined using clinical cut-off values. Estimated glomerular filtration rates (eGFR) were calculated by means of the four-variable Modification of Diet in Renal Disease (MDRD) formula. For this IPD meta-analysis, eGFR at baseline and eGFR change during follow-up were computed by fitting linear regression models and linear mixed models in each cohort separately. Effect estimates were pooled using random effects models. Results A total of 72 856 individuals from 16 different cohorts were included. At baseline, individuals with overt hypothyroidism (n = 704) and subclinical hypothyroidism (n = 3356) had a average (95% confidence interval) −4.07 (−6.37 to −1.78) and −2.40 (−3.78 to −1.02) mL/min/1.73 m2 lower eGFR as compared with euthyroid subjects (n = 66 542). In (subclinical) hyperthyroid subjects (n = 2254), average eGFR was 3.01 (1.50–4.52) mL/min/1.73 m2 higher. During 329 713 patient years of follow-up, eGFR did not decline more rapidly in individuals with low thyroid function compared with individuals with normal thyroid function. Conclusions Low thyroid function is not associated with a deterioration of renal function. The cross-sectional association may be explained by renal dysfunction causing thyroid hormone alterations.

scholarly journals Pattern of dyslipidemia in hypothyroid patients: A cross sectional study

2016 ◽  
Vol 6 (2) ◽  
pp. 156
Author(s):  
K. G. Kibria ◽  
M. R. Alam ◽  
H. K. Paul ◽  
M. Fariduddin ◽  
M. A. Hasanat
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Thyroid Function ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Thyroid Function Tests ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hypothyroid Patients

<p><strong>Background:</strong> An association between thyroid dysfunction and dyslipidemia prevails. Levels of total cholesterol, low density lipoprotein cholesterol, triglycerides tend to increase as thyroid function declines.</p><p><strong>Objective:</strong> To find out the pattern of dyslipidemia in hypothyroid patients. <strong></strong></p><p><strong>Methods:</strong> Sixty cases were selected as a sample of convenience in this cross sectional study from in-patienl depa1tment of Medicine and Endocrinology, BSMMU. Meticulous history taking and thorough clinical examinations were done. Report of lipid profile and thyroid function tests were recorded from patients file. All the information's were recorded in a pre-designed sttuctured questionnaire. Collected data were classi­fied, edited, coded and entered into the computer for statistical analysis by using SPSS. <strong></strong></p><p><strong>Results:</strong> Among the 60 cases, 43 (72%) were female; 17(28%) were male. Age range was 24-59 years with a mean age of 38.80 (± I 0.35) years. Majority 38(65%) were housewife, followed by service holder 11(18.33%), 08(13.3%) were business men and 02(3.3%) had other occupations. Majority 42(70%) patients were taking thyroxin. Mean Total cholesterol (TC), LDL cholesterol, Triglycer­ide (TG) and HDL were 222.20(±42.25); 138.63(±31.51); 243.36(±83.13) and 37.30(±5.12) respectably. <strong></strong></p><p><strong>Conclusion:</strong> All hypothyroid subjects had dyslipidemia. The present study indicated that hypothyroidism was associated with an abnormal lipid profile, especially with respect to the levels of total cholesterol and triglyceride.</p>

scholarly journals TO STUDY THE PATTERN OF DYSLIPIDEMIA IN HYPOTHYROID PATIENTS

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Mohammed Tarik ◽  
Subhash Chandra
Keyword(s):  
Lipid Profile ◽  
Cross Sectional Study ◽  
Thyroid Function Tests ◽  
History Taking ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lipid Abnormalities ◽  
Hypothyroid Patients ◽  
Thyroid Dysfunctions ◽  
Structured Questionnaire

Background: Thyroid hormones play an important role in regulating lipid metabolism and thyroid dysfunctions can result in lipid abnormalities which increase the risk of endothelial dysfunction, hypertension and cardiovascular disease. Methods: A cross-sectional study was conducted on 100 patients selected as a sample of convenience in this cross sectional study from out-patient department of Medicine. Meticulous history taking and thorough clinical examinations were done. Report of lipid profile and thyroid function tests were recorded from patients file. All the information's were recorded in a pre-desigaed structured questionnaire. Collected data were classified, edited, coded and entered into the computer for statistical analysis by using Epi-info software. Results: The serum TC, TG and LDL levels in hypothyroid individuals were significantly higher than euthyroid subjects. Conclusion: We conclude that hypothyroid subjects had dyslipidemia. The present study indicated that hypothyroidism was associated with an abnormal lipid profile, especially with respect to the levels of TC, LDL and TG. Keywords: Total cholesterol, Triglycerides and LDL

scholarly journals Hypothyroidism and Platelet Parameter Evaluation

2020 ◽  
pp. 25-34
Author(s):  
Fatma S. Shehata ◽  
Yasser M. Abd Elraouf ◽  
Hisham A. El Serogy ◽  
Wael F. Mohamed
Keyword(s):  
Clinical Pathology ◽  
Cross Sectional Study ◽  
Control Group ◽  
Overt Hypothyroidism ◽  
Cross Sectional ◽  
Distribution Width ◽  
Healthy Control ◽  
Platelet Parameter ◽  
Diagnostic Work ◽  
Hypothyroid Patients

Aims: To evaluate the effect of subclinical and overt hypothyroidism on mean platelet volume (MPV) and platelet distribution width (PDW). Study Design: Cross sectional study. Place and Duration of Study: Outpatient Clinic of Diabetes, Metabolism and Endocrinology Unit in internal medicine department and clinical pathology, Tanta University, Egypt in a period between June 2018 to June 2019. Methodology: We tested 250 subjects; 50 healthy control and 200 hypothyroid patients (all were female; age ≥18 years old age) without any medical history, then patients were subdivided into newly diagnosed group and another group on l-thyroxin treatment. Platelet parameters (MPV, PDW) were assessed in all of them. Results: MPV & PDW is increasing in hypothyroid patients than control group (8.93 ± 0.62), more in overt group (10.88 ± 0.57) than subclinical group (10.02 ± 0.55). No significant reduction in MPV and PDW in patients on l-thyroxin treatment which suggest that l-thyroxin treatment couldn’t produce difference till patients reaching their target level being euthyroid. Conclusion: We recommend the usefulness of MPV and PDW as inexpensive markers of platelet activation in diagnostic work-up of athero-thrombotic complications risk in patients with subclinical and overt hypothyroidism.

scholarly journals Serum Lipid Profile in Hypothyroid Patients in Nepal

2015 ◽  
Vol 2 (4) ◽  
pp. 33-36
Author(s):  
Sudip Aryal ◽  
A Joshi
Keyword(s):  
Thyroid Hormone ◽  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Whole Body ◽  
Control Group ◽  
Overt Hypothyroidism ◽  
Significant Difference ◽  
Record Card ◽  
And Control ◽  
Hypothyroid Patients

INTRODUCTION: Hypothyroidism is non-curable common endocrine disorder in which the thyroid gland is unable to produce enough thyroid hormone. Present with a number of symptoms, Having a low level of thyroid hormone affects our whole body. Untreated hypothyroidism can be the cause of raised cholesterol levels. Many study have shown association between hypothyroidism and lipid profile. In this study, we evaluate the mean lipid profile status in subclinical hypothyroidism and hypothyroid patients.  MATERIAL AND METHODS: A hospital based retrospective study done from the record card maintained in Alka Hospital, Jawalakhel. Total number of participants were 215. Out of which 73 had overt hypothyroidism, 92 had subclinical hypothyroidism and 50 were taken as control. SPSS version 20 was used for data analysis.  RESULTS: The level of LDL, TG and TC was significantly higher in case of overt hypothyroidism as compared to control group, but no significant difference was found in subclinical hypothyroidism and control group. TG level was significantly lower in subclinical hypothyroidism cases.  CONCLUSION: Elevated HDL, LDL & TC is seen in overt hypothyroid patients. It is important to screen for lipid profile in hypothyroid patients.DOI: http://dx.doi.org/10.3126/jucms.v2i4.12065Journal of Universal College of Medical Sciences (2014) Vol.02 No.04 Issue 08Page: 33-36

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