scholarly journals High Specific C-Reactive Protein in Prediction of the Early Outcome of Primary Intra Cerebral Hemorrhage

2021 ◽  
pp. 54-61
Author(s):  
Khaled Eltoukhy ◽  
Mohamed Gomaa ◽  
Yasmin Ibrahim ◽  
Mohamed Saad
Keyword(s):  
Cerebral Hemorrhage ◽  
Hemorrhagic Stroke ◽  
Multivariable Analysis ◽  
University Hospital ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Test Kit ◽  
Hs Crp ◽  
Ct Brain

Background: Primary intra cerebral hemorrhage (ICH) has high rate of disability and death. Many factors was supposed to be predictors of the outcome. The significance of measuring C-reactive protein (CRP) levels to predict the outcome is uncertain, and data have been controversial. The objective of our clinical study was to determine the relationship of hs-CRP levels with bad outcome. The authors tested if (independent of confounding factors) hs-CRP levels was elevated on admission (< 24 hours after ictus). Fifty patients with acute spontaneous hemorrhagic stroke, within 24 hours of onset confirmed by CT brain were admitted at neurology department, Mansoura University Hospital from June 2017 to September 2018. Age and sex cross-matched 50 healthy persons were studied as control group. Patient and control groups were subjected to full history, general and neurological examination, GCS on admission, National Institute of Health Stroke Scale (NIHSS) on admission, ICH score and Canadian scale on admission and after 30 days, Venous Blood samples were taken within 24 hours of onset and tested for routine laboratory investigations (liver function, serum creatinine, CBC and blood glucose) and High Sensitive C-Reactive Protein level using Enzyme Immunoassay Test Kit. Computed tomography (CT) brain was repeated 72 hours later. Multivariable regression analyses were used to evaluate associations of hs-CRP concentration and ICH outcome. Kaplan–Meier analysis was used for survival. Results: This study revealed that Hs-CRP is significantly higher in patient group (9.3 mg/l) when compared to control group (0.68 mg/dl) with p value < 0,001. There was statistically significant correlation between NIHSS and hs-CRP levels but there was no statistically significant correlation between hs-CRP levels and stroke outcome. Conclusion: Taking these covariates into multivariable analysis revealed that there is correlation between hs-CRP and hemorrhagic stroke but it cannot be used as a predictor of its outcome.

scholarly journals ROLE OF CARDIAC MARKERS IN CHRONIC RENAL FAILURE PATIENTS.

2020 ◽  
pp. 81-82
Author(s):  
Ramesh Chandra Thanna ◽  
B K Agarwal ◽  
Rakesh Romday ◽  
Neha Sharma
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Positive Association ◽  
Morbidity And Mortality ◽  
Control Group ◽  
High Morbidity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Introduction: Cardiovascular diseases (CVD) are known as important reasons of the increased morbidity and mortality observed in patients with chronic renal failure (CRF). The association of serum Interlukin-6 , homocysteine as well as other cardiovascular risk factors in relation to existence and cause of CVD were investigated. Method: In this study 200 CRF patients were recruited and further stratified into group with Male and Female as case groups. Those without renal failure were assigned as control group (n=200). Results: The patients with CRF showed a significant increase in plasma levels of Cpk-MB homocysteine and C-reactive protein (CRP) compared to control. The positive association were observed between homocysteine, Urea and Hs-CRP, IL_6 . It shows a significant Association of parameters in CRF . Conclusion: The results demonstrated elevation in plasma values IL-6 , homocysteine and HS-CRP in patients with CRF . However, these modifications may be lead to atherosclerosis and consequence CVD event. These parameters may be important with respect to the high morbidity and mortality of CVD found in patients with CRF.

scholarly journals Serum High Sensitive C-Reactive Protein in Obese Persons with Normal Glucose Tolerance & Impaired Fasting Glucose

2018 ◽  
Vol 4 (1) ◽  
pp. 21-24
Author(s):  
Soniya Fahmi ◽  
Sunjida Shahriah ◽  
Omma Hafsa Any ◽  
Mahbuba Akter ◽  
Samia Afrin
Keyword(s):  
Fasting Glucose ◽  
Normal Glucose Tolerance ◽  
Control Group ◽  
Case Group ◽  
Obese Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Normal Glucose ◽  
Obese Subjects ◽  
Hs Crp

Background: Obesity, characterized by increased fat mass and is currently regarded as a proinflammatory state and frequently associated with increased risk of cardiovascular diseases including Myocardial Infarction and also future risk for development of metabolic disorders such as T2DM. Highsensitivity C-reactive protein is a well-known inflammatory marker. Objective: In this study we aimed to determine the levels of serum high-sensitive C-reactive protein in obese parsons with normal glucose tolerance (NGT) and obese with impaired fasting glucose (IFG) individuals. Methodology: This was a case-control study which was conducted in the Department of Biochemistry, ZH Sikder Women’s Medical College, Dhaka during the period of July 2014 to June 2015. The age, sex and body mass index (BMI ≥ 30 kg / m²) matched 25 obese subjects with NGT were selected as control group and 25 obese patients with IFG were selected as case group. We measured levels of serum high sensitive Creactive protein in all groups. Subjects of both obese groups had significantly higher hs-CRP levels than the normal range. Results: A total number of 50 subjects were recruited for this study of which 25 obese subjects with NGT were selected as control group and 25 obese patients with IFG were selected as case group. The level of hs-CRP in obese with NGT and with IFG were found 2.91±1.56 mg/L & 3.42±1.72 mg/L, respectively. There are no significant difference between hs-CRP levels of obese subjects than the subjects with IFG (p>0.1). Conclusion: This study finding has concluded that obesity raises serum hsCRP level. IFG obese individuals are not at much higher cardiovascular and metabolic risk level than normal obese parsons. Bangladesh Journal of Infectious Diseases 2017;4(1):21-24

On-admission Serum High-Sensitivity C-Reactive Protein Level Independently Predicts In-Hospital Mortality and Adverse Cardiovascular Events in ST-elevation Acute Myocardial Infarction

2021 ◽  
pp. 263246362110553
Author(s):  
Anggoro Budi Hartopo ◽  
Indah Sukmasari ◽  
Maria Patricia Inggriani ◽  
Thomas Rikl ◽  
Stefi Geovani Valentin Hayon ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Events ◽  
Multivariable Analysis ◽  
High Sensitivity ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
St Elevation ◽  
Hs Crp ◽  
Elevation Acute Myocardial Infarction

Background: Inflammatory biomarkers are associated with adverse cardiovascular events during ST-elevation acute myocardial infarction (STEMI). We aimed to investigate the role of inflammatory biomarkers, high-sensitivity C-reactive protein (hs-CRP), and soluble ST-2 (sST2), for prediction of adverse cardiovascular events in STEMI. Methods: This was a prospective cohort study that consecutively enrolled patients with STEMI. Subjects were observed during hospitalization until discharge or fatal events happened. Adverse cardiovascular event was a compilation of cardiac mortality, acute heart failure, cardiogenic shock, reinfarction, and malignant ventricular arrhythmia. Blood samples were withdrawn on admission and inflammatory biomarkers (hs-CRP and sST2) were measured. The receiver operator characteristics curve and multivariable analysis were performed to determine which inflammatory biomarkers predict in-hospital adverse cardiovascular events and mortality. Result: Of 166 subjects, the in-hospital adverse cardiovascular events occurred in 41 subjects (24.6%) and mortality occurred in 16 subjects (9.6%). Subjects with in-hospital adverse cardiovascular events and mortality had a significantly higher hs-CRP level, but comparable sST2 level than subjects without events. The hs-CRP level was the most precise biomarkers to predict in-hospital adverse cardiovascular events (hs-CRP cut-off ≥2.75 mg/L) and mortality (hs-CRP cut-off ≥7 mg/L). Multivariable analysis indicated hs-CRP ≥2.75 mg/L as an independent predictor for in-hospital adverse cardiovascular events (adjusted odds ratio [OR]: 2.79, 95% confidence interval [CI]: 1.05-7.39, P = .039) and hs-CRP ≥7 mg/L for mortality (adjusted OR: 5.45, 95% CI: 1.13-26.18, P = .034) in STEMI. Conclusion: On admission, hs-CRP level independently predicted in-hospital adverse cardiovascular events, at cut-off level ≥2.75 mg/L, and mortality, at cut-off level ≥7 mg/L, in STEMI patients.

scholarly journals Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ertuğrul Kurtoğlu ◽  
Hasan Korkmaz ◽  
Erdal Aktürk ◽  
Mücahid Yılmaz ◽  
Yakup Altaş ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systemic Inflammation ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Artery Disease ◽  
The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

scholarly journals Analysis on the Clinical Characteristics of 36 Cases of Novel Coronavirus Pneumonia in Kunming

2020 ◽  
Author(s):  
Haiyan Fu ◽  
Hongjuan Li ◽  
Xiaoqing Tang ◽  
Xiang Li ◽  
Jie Shen ◽  
...  
Keyword(s):  
T Cells ◽  
Normal Control ◽  
Cd8 T Cells ◽  
Clinical Characteristics ◽  
Normal Control Group ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Novel Coronavirus

AbstractObjectiveTo analyze the clinical characteristics of patients with novel coronavirus pneumonia in Kunming City, and to study the correlation between nutritional status and immune function.MethodsClinical data of 36 patients with novel coronavirus pneumonia in isolation area of Kunming Third People’s Hospital from January 31 to February 15, 2020 were collected, and the basic situation, clinical characteristics, laboratory examination and CT imaging characteristics were analyzed. Serum albumin (ALB), prealbumin (PAB), hypersensitive c-reactive protein (hs-crp), CD3T cells, CD4T cells, CD8T cells and normal control group were analyzed. A simple linear regression analysis of the relationship between proalbumin and T cell subpopulation counts in the blood of patients.Results(1) The patients with new coronavirus pneumonia in Kunming were mainly of common type. (2) 50% of the patients’ first symptoms were fever and cough; (3) The total number of white blood cells in peripheral blood was normal or decreased in 23 cases (79%), and the lymphocyte count decreased in 5 cases (13.89%), without anemia. Hypersensitive c-reactive protein increased in 19 (52.78%) cases, and procalcitonin increased in 1 case. Albumin decreased in 5 cases (13.89%), proalbumin decreased in 15 cases (41.67%), alanine transaminase increased slightly in 4 cases (11.11%), alanine transaminase increased slightly in 4 cases (11.11%), total bilirubin increased slightly in 11 cases (30.56%), and renal function and blood coagulation were normal. Absolute value of CD3+T cells is with a decrease in 21 cases (58.3%), CD4+T in 28 cases (77.8%), CD8+T in 17 cases (47.2%), and CD4+/ CD8+ inverse in 6 cases (16.7%). (4) The prealbumin, CD3 T cells, CD4 T cells and CD8 T cells in the new coronavirus pneumonia group were significantly lower than those in the normal control group, and the hypersensitive c-reactive protein was higher than that in the normal control group. (5) The levels of PAB in the serum of the patients were linearly correlated with hs-crp, CD3 T cells, CD4 T cells and CD8 T cells, and the correlation coefficients were −0.474, 0.558, 0.467 and 0.613, respectively, showing statistical differences.ConclusionThe clinical characteristics of the novel coronavirus pneumonia in Kunming are different from those in Wuhan. The changes of serum proalbumin and T cell subsets are relatively obvious. Changes in serum proalbumin may contribute to the early warning of novel coronavirus pneumonia. The nutritional status of patients with common and mild pneumonia should be considered.

Correlation Between High Sensitivity C-Reactive Protein Level and Executive Function Disorders in Elderly Patients

2020 ◽  
Vol 17 (7) ◽  
pp. 3113-3116
Author(s):  
Dyah Anetta Afri Rukmi ◽  
Joseph Eko Wahono Rahardjo
Keyword(s):  
Executive Function ◽  
Elderly Patients ◽  
Complete Blood Count ◽  
High Sensitivity ◽  
High Serum ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

C-Reactive Protein is a marker of inflammation and vascular disease. The high serum of high-sensitivity C-Reactive Protein (hs-CRP) concentration was associated with interruption the integrity of the frontal-subcortical circuit. To determine the correlation between high serum concentration of hs-CRP and executive function disorder in elderly patients. Thirty six elderly patients was examined by using a case control study. The subjects were enrolled from the out-patient at Neurology Department Dr. Soetomo General Hospital, Surabaya, Indonesia. The time period was 4 months (April to July 2015). Executive function was measured with the Trail Making Test B (TMT B) and divided into two groups, case and control. Complete blood count and serum hs-CRP concentration were measured from nonfasting blood samples. Chi-square test was used for data analysis. Eighteen subjects were enrolled in the case group (3 men, 15 women) and the other 18 subjects were enrolled in the control group (4 men, 14 women). Executive function disorder was found in 17 (94,4%) subjects of case group and 11 (61,1%) subjects of control group. High levels of hs-CRP was not associated with executive function, with p = 0,149 and adjusted OR 5,629 (CI 95% 0, 538-58, 860). These data suggested that high levels of hs-CRP was not associated with executive function in elderly patients.

scholarly journals Evaluating the role of high-sensitivity C-reactive protein in asthmatic Iraqi patients and its correlation with parameters of patients’ clinical characteristics and pulmonary function tests

2016 ◽  
Vol 7 (3) ◽  
pp. 47-53
Author(s):  
Muhammed Saleh Najdat ◽  
Ahmed M Lutfi
Keyword(s):  
Pulmonary Function ◽  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Pulmonary Function Tests ◽  
High Sensitivity ◽  
Control Group ◽  
Inhaled Corticosteroid ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Aims and Objectives: To evaluate the relevance of high-sensitivity assays for C-reactive protein (hs-CRP), as a sensitive marker of inflammation in asthmatic Iraqi patients. Additionally, correlations of serum levels of hs-CRP with patients’ clinical characteristics and pulmonary function tests (PFTs) will be studied in a cross-sectional design.Materials and Methods: A random sample of 58 individuals were divided into a healthy (control) group (n = 12) and two groups of adult patients with chronic stable asthma; (n = 22) patients had been receiving inhaled corticosteroids (inhaled corticosteroid-positive, or ICS+VE, group) for the past 2–3 months, and (n = 24) steroid-naive patients (inhaled corticosteroid-negative, or ICS-VE, group). The selected individuals were subjected to hs-CRP measurement and PFTs.Results: The forced expiratory volume in one second (FEV1)/forced vital capacity (FVC), was measured in all subjects. In the ICS+VE and the ICS-VE groups, there was a significant correlation between the level of hs-CRP and FEV1/FVC with r: ?0.891 and a p-value of < 0.0005 for both groups. In the ICS-VE group, 78.5% had significant clinical symptoms, whereas only 22.7% of the ICS+VE group had significant clinical symptoms. This difference (for the prevalence of clinical symptoms) was significant with a chi-square value of 19.59, degree of freedom (df) = 1, and p < 0.0005.Conclusion: In the ICS-VE group, the level of hs-CRP was significantly higher than in both the ICS+VE group and the control group. The values of the PFTs were significantly lower in the ICS-VE group. The prevalence of clinical features was significantly higher in the ICS-VE group.Asian Journal of Medical Sciences Vol. 7(3) 2016 47-53

scholarly journals Pengaruh Pemberian Sari Ubi Ungu (Ipomea batatas L.) Terhadap KadarHigh Sensitivity C-Reactive Protein(hs-CRP) Pada Tikus Sprague Dawley Dengan Pakan Tinggi Lemak

2018 ◽  
Vol 7 (4) ◽  
pp. 155
Author(s):  
Irene Nucifera Puspitadewi ◽  
Ani Margawati ◽  
Hartanti Sandi Wijayanti
Keyword(s):  
High Sensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Sprague Dawley ◽  
C Reactive Protein ◽  
Control Group Design ◽  
Reactive Protein ◽  
Ipomea Batatas ◽  
Post Test ◽  
Hs Crp

Latar Belakang: Komposisi makanan tinggi lemak dapat menjadi faktor terjadinya obesitasyang menyebabkan oksidasi lemak. Oksidasi lemak dapat menyebabkan inflamasi yang dikarakterisasikan dengan tingginya kadar High Sensitivity C-Reactive Protein (hs-CRP). Ubi ungu kaya akan antioksidan terutama antosianin yang mungkin dapat menurunkan kadar hs-CRP. Penelitian ini bertujuan untuk mengetahui pengaruh sari ubi ungu terhadap kadar hs-CRP tikus sprague dawley dengan pakan tinggi lemak.Metode: Jenis penelitian ini adalah true experimental dengan  pre-post test control group design. 24 tikus sprague dawley jantan dibagi menjadi 4 kelompok yaitu kontrol negatif, kontrol positif, perlakuan 1 dan perlakuan 2. Perlakuan 1 dan 2 diberikan sari ubi ungu dengan dosis 2 gram/200grBB dan 3 gram/200grBB berturut-turut selama 6 hari. Sebelum dan sesudah perlakuan, kadar hs-CRP dianalisis dengan menggunakan metode ELISA (Enzyme Linked Immunosorbent Assay).Hasil: Selisih kadar  hs-CRP pada keolompok kontrol negatif, kontrol positif, perlakuan 1 dan perlakuan 2 adalah 0.4±0.20, -0.07±4.70, -4.3±0.79 dan -8.1±0.45. Terdapat perbedaan signifikan kadar  hs-CRP antar kelompok sesudah intervensi (p=<0.001). Pada kelompok perlakuan 2 terdapat penurunan yang paling tinggi (persen delta 33,33% dengan nilai p=<0.001).Simpulan: Sari ubi ungu dapat menurunkan kadar  High Sensitivity C-Reactive Protein (hs-CRP) secara signifikan.

scholarly journals To study the association of high sensitivity C-reactive protein with metabolic syndrome

2018 ◽  
Vol 6 (2) ◽  
pp. 572 ◽  
Author(s):  
Vinod Saini ◽  
Abhishek Gupta ◽  
Mayank Arora ◽  
S. K. Virmani
Keyword(s):  
Metabolic Syndrome ◽  
High Sensitivity ◽  
Case Control ◽  
High Density ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Care Hospital ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Background: Metabolic Syndrome is a constellation of dyslipidemia (elevated triglycerides, low high-density lipoproteins (HDL)), elevation of arterial blood pressure (BP), dysregulated glucose homeostasis, and increased abdominal obesity.Methods: We studied the association of high sensitivity C-reactive protein with metabolic syndrome by case-control method in our tertiary care hospital in West U.P.Results: The mean age of cases and controls was 52.6 ± 7.7 and 51.4±7.0 years, respectively. There were 25 (50%) male and 25 (50%) female in case groups, and 27 (54%) males and 23 (46%) females in control group. Our analysis revelaed that there was a significant association between hs-CRP and the central obesity when compared in case-control group (3.57 vs 0.96 mg/L) (p value <0.001). There was no significant association between hs-CRP and high triglycerides, hypertension, diabetes, and reduced high density lipoprotein cholesterol.Conclusions: Raised hsCRP level can be considered as a surrogate marker of chronic inflammation in patients with metabolic syndrome.

scholarly journals The Relationship between C-Reactive Protein and COPD Patients

2021 ◽  
pp. 227-235
Author(s):  
G. A. Bhuvaneshwar ◽  
. Dayanandan
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Control Group ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Obstructive Pulmonary Disease ◽  
Reactive Protein ◽  
Gold Stage ◽  
Copd Patients ◽  
Hs Crp

Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable, and treatable chronic inflammatory respiratory disease that affects 210 million people globally. Due to inflammation the resultant IL6 increases the level of C-REACTIVE PROTEIN (CRP) from hepatocytes. This study was conducted to evaluate the association of C-Reactive Protein in COPD patients. The study also includes the key role of C-reactive protein (CRP) in assessing the acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD), which has proven to be more valuable. This was a prospective study conducted over a period of three months between February 2021 and April 2021 at the department of General Medicine in Saveetha Medical College Hospital, Chennai. In a study of 50 patients, 25 were patients with COPD and 25 were a control group of healthy people. High Sensitivity C-Reactive Protein (hs-CRP), blood gases, spirometry, Body Mass Index (BMI), 6 Minute Walk Distance (6MWD) and GOLD stage of severity were measured. The serum hs-CRP was then evaluated for any correlation with the predictors of outcomes of COPD subjects. hs-CRP levels were higher in patients with COPD than in healthy individuals (4.82 / 0.8 mgl). A correlation was found between hs-CRP and the following variables: FEV1 (r = -0.813; p < 0.01), 6MWD (r = -0.876; p < 0.01), GOLD stage (r = 0.797; p < 0.01) and evaluated. This study revealed that there is certain increase in hs-CRP in COPD patients due to inflammation. It acts not only as an inflammatory diagnostic marker, but also plays a role as predictor for the outcome of the disease and reducing the mortality rate.

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