scholarly journals Haemoglobin, Serum Iron Level and Cardiovascular Status in Advanced Stages of Chronic Kidney Disease Patients admitted in A Tertiary Care Centre

2021 ◽  
Vol 33 (1) ◽  
pp. 34-39
Author(s):  
Md Yousuf Ali ◽  
Md Ehsanul Alam ◽  
Aminur Rahman ◽  
Nadira Majid
Keyword(s):  
Haemoglobin Level ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Ferritin Level ◽  
Iron Level ◽  
Serum Iron Level ◽  
Number Of Patients ◽  
Significant Difference ◽  
History Of ◽  
Advanced Stages

Background: Anaemia due to advanced stages of chronic kidney disease increases morbidity of patients. Early detection and correction of anaemia may be helpful in preventing the progress of the disease & its cardiovascular outcomes. The objective of this study was to evaluate hemoglobin, serum iron level and cardiovascular status in advanced of CKD patients. Methods: This was a cross sectional observational study on 150 cases of diagnosed advanced stages (3B,4 &5) of CKD patients in indoor of department of medicine of Mitford Hospital, Dhaka from July 2019 to January 2020. Convenience sampling was done. Data were analyzed with SPSS 26. Results: Total number of patients were 150. Male were 93 (62%) and female were 57 (38%). The mean (±SD) age was 55.22 (±10.30) years (range 33 - 75 years). Among the study subjects 38% had history of blood transfusion, 60% had history of iron supplementation and 12% subjects received erythropoietin. Mean (±SD) haemoglobin level was 7.61 (±2.54) g/dl. Seventy percent of the study subjects had haemoglobin level < 9 g/dl and rest had ³9 g/dl. Significant difference was found in between these two groups (p = 0.036). In the present study, mean (±SD) serum iron level was 15.59 (±07.39) μmol/l. In 46% of the study subjects, iron level was 7.3μ mol/l and 52% had iron level between 7.3 to 23.6 μmole/ lit. Mean (± SD) ferritin level of the study subjects was 155.22 (±92.32) ng/ ml. In 58% of the study subjects ferritin level was < 100ng/ ml and 42% had >100 ng/ml. Significant difference was found in between these two groups (p = 0.041) (Table-IV). Ferritin level had significant positive relationship with blood transfusion, iron and erythropoietin supplementation on logistic regression analysis. Haemoglobin and serum ferritin level was positively correlated with eGFR of the study subjects. Statistical analysis showed significant relationship between eGFR with haemoglobin and serum ferritin. Forty six percent of the study subjects had Transferrin saturation (TSAT) level below 20%. Fifty four percent subjects had a TSAT level above 20%. Significant difference was found in between these two groups (p = 0.001). In correlation analysis, haemoglobin, serum ferritin and TSAT level in the study subjects had negative relationship with duration of CKD in years. Relationship of haemoglobin and TSAT level with duration of CKD was statistically significant. In correlation analysis, serum TIBC level had negative relationship with haemoglobin level which was statistically significant. Serum iron, ferritin and TSAT level in the study subjects were positively correlated with haemoglobin level. Relationship of haemoglobin with serum iron level and TSAT level was statistically significant. Twenty percent of the study subjects had peripheral vascular disease, 111 (74%) of the study subjects had hypertension, 66 (44%) had ischaemic heart disease, 27 (18%) had a history of acute myocardial infarction, 24 (16%) had chronic heart failure, 93 (62%) had dyslipidemia and 27 (18%) patients had history of stroke. Conclusion: In this study it was observed that TSAT appears to be a more useful indicator for measuring the frequency of iron deficiency than serum iron, TIBC and serum ferritin. The cardiovascular comorbidities plagued significant number of patients with advanced CKD. Bangladesh J Medicine July 2022; 33(1) : 34-39

The Potential Clinical Significance of the Serum Iron and Ferritin Status in Lung Cancer Patients

2020 ◽  
Vol 5 (4) ◽  
pp. 189-195
Author(s):  
Fei Fei Guo ◽  
◽  
Shi Jia Cheng ◽  
Yi Ning Liu ◽  
Jiu Wei Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Stage Iv ◽  
Iron Level ◽  
Serum Iron Level ◽  
Lung Cancer Patients

Background An increasing number of studies have shown that iron, one of the indispensable trace elements in the human body, is closely related to the occurrence and development of cancer. However, few studies have clearly demonstrated the role of the iron levels in lung cancer patients, or the potential effects of inflammation on iron levels. Methods The clinical data for lung cancer patients and non-lung cancer participants were retrospectively analyzed. The serum iron and ferritin levels were measured and compared using a rank-sum test. The correlation between the serum iron/ferritin and C-reactive protein (CRP) was analyzed by rank correlation. The cut-off values for continuous variables were obtained by the receiver operating characteristic curve (ROC) method. An analysis of potential prognostic factors in lung cancer patients was conducted by univariate and multivariate survival analyses. Results The serum iron levels in patients with extensive small-cell lung cancer (SCLC) were lower than those with limited-stage SCLC, and the levels of serum ferritin and CRP in those with extensive SCLC were higher than those with limited-stage SCLC. Similarly, the serum iron levels in patients with stage IV non-small cell lung cancer (NSCLC) were lower than those of patients with stage Ⅰ-Ⅲ disease, and the levels of serum ferritin and CRP in those with stage IV NSCLC were higher than those in stages Ⅰ-Ⅲ. The serum iron level was negatively correlated with the level of CRP, while the serum ferritin level was positively correlated with CRP. The stage of lung cancer, but not the serum iron/ ferritin level, was an independent prognostic factor in lung cancer patients. Conclusions The serum iron and ferritin levels are associated with the staging of lung cancer. The later stages of lung cancer are associated with a lower serum iron level, a higher serum ferritin level, and a higher CRP level. Inflammation may play an important role in regulating the serum iron and ferritin levels in lung cancer patients.

scholarly journals Evaluation of Iron Status in Diabetic CKD Stage 5 Pre- Dialysis Patients

2013 ◽  
Vol 3 (1) ◽  
pp. 5-10
Author(s):  
Wasim Md. Mohosinul Haque ◽  
Arif Mahmud ◽  
Muhammad Abdur Rahmin ◽  
Jesmin Jahan ◽  
Sarker Mohammad Sajjad ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Haemoglobin Level ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Iron Status ◽  
Ferritin Level ◽  
Negative Relationship ◽  
Diabetic Patients ◽  
Number Of Patients ◽  
Ckd Stage

Objective: To evaluate the iron status among patients with diabetes mellitus and CKD stage 5, who have not started dialysis yet. Methodology: This cross-sectional study was carried on a total of 50 adult diabetic patients with stage 5 CKD, in the Department of Nephrology, BIRDEM General Hospital, Dhaka over 6 months. Results: Total number of patients was 50. Sixty two percent were male and 38% were female. Mean age was 55.22 (range 33-75) years. Mean± SD hemoglobin and ferritin levels were 7.61±2.54 mg/dl and 155.22±92.32 ng/ml respectively. Seventy percent of the study subjects had haemoglobin level d” 9 mg/dl. In 48% of the study subjects, ferritin level was less than 100ng/ml. Fourty six percent of the study subjects had TSAT level below 20%. Haemoglobin, serum ferritin and TSAT level in the study subjects had negative relationship with duration of CKD. Haemoglobin and serum ferritin levels were positively correlated with eGFR of the study population. TIBC level had negative relationship with haemoglobin level which was statistically significant. Serum iron, ferritin and TSAT level in the study subjects were positively correlated with haemoglobin level. Relationship of haemoglobin with serum iron and TSAT level was statistically significant. Statistical analysis showed relationship between eGFR with haemoglobin and serum ferritin level was significant (P<0.05). Conclusion: Most of the diabetic CKD stage 5 patients had reduced hemoglobin level and iron deficiency is one of the contributory factors and TSAT is the better indicator for iron deficiency than serum iron, TIBC and ferritin level. Birdem Med J 2013; 3(1): 5-10 DOI: http://dx.doi.org/10.3329/birdem.v3i1.17120

scholarly journals Serum Iron Level as a Potential Predictor of Coronavirus Disease 2019 Severity and Mortality: A Retrospective Study

2020 ◽  
Vol 7 (7) ◽  
Author(s):  
Kang Zhao ◽  
Jucun Huang ◽  
Dan Dai ◽  
Yuwei Feng ◽  
Liming Liu ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Iron ◽  
Iron Status ◽  
Iron Concentration ◽  
Iron Level ◽  
Serum Iron Level ◽  
Amyloid A ◽  
Significant Difference ◽  
Before And After ◽  
Low Serum

Abstract Background Various types of pulmonary diseases are associated with iron deficiency. However, information on iron status in coronavirus disease 2019 (COVID-19) is scarce. Methods This study included 50 hospitalized patients with confirmed COVID-19. The role of serum iron in predicting severity and mortality of COVID-19 was evaluated. Results The most common symptoms of COVID-19 patients in this study were cough (82%), fever (64%), and chest distress (42%). Of the 50 patients, 45 (90%) patients had abnormally low serum iron levels (&lt;7.8 μmol/L). The severity of COVID-19 was negatively correlated with serum iron levels before and after treatment and was positively correlated with C-reactive protein, serum amyloid A, D-dimer, lactate dehydrogenase, urea nitrogen, and myoglobin levels. Decreased serum iron level could predict the transition of COVID-19 from mild to severe and critical illness. Seven (53.8%) patients with a lower serum iron level after treatment in the critical group had died. There was a significant difference in posttreatment serum iron levels between COVID-19 survivors and nonsurvivors. Conclusions Serum iron deficiency was detected in the patients with COVID-19. The severity and mortality of the disease was closely correlated with serum iron levels. Low serum iron concentration was an independent risk factor for death in COVID-19 patients.

scholarly journals Role of vitamin D, serum zinc, and serum iron deficiency in community-acquired pneumonia in children

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Asmaa Alhusseiny Ahmed Alsharkawy ◽  
Ahmed R. Rezk
Keyword(s):  
Vitamin D ◽  
Serum Iron ◽  
Serum Zinc ◽  
Community Acquired Pneumonia ◽  
Control Group ◽  
Iron Level ◽  
Healthy Children ◽  
Serum Iron Level ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract Background Community-acquired pneumonia is a major cause of death among children. Inadequate nutrition disrupts the immune system and increases the susceptibility to infections. We aimed to evaluate the association between vitamin D, serum zinc, and iron, and pneumonia. A case-control study was conducted at the outpatient clinic and emergency room of Children’s Hospital. Thirty-one patients with community-acquired pneumonia and 36 healthy children (control group) underwent serum sampling for vitamin D, zinc, and iron. Results Most patients had mild form (n = 17, 54.8%). All patients survived and were discharged. The serum iron level showed a non-significant difference between pneumonia and control groups (p ˃ 0.05). TIBC, vitamin D, and serum zinc were significantly lower in the patient group than the control group (P value = 0.04, < 0.001, and 0.03, respectively). Vitamin D deficiency was highly associated with the severity of pneumonia (P value = 0.008). Conclusion Adequate serum zinc and vitamin D levels may be protective against infection with community-acquired pneumonia in children aged from 2 months to 5 years old, but not iron.

scholarly journals A low serum iron level is a potential predictor of poor renal function in patients following laparoscopic sleeve gastrectomy: a retrospective study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tien-Chou Soong ◽  
I.-Jung Feng ◽  
Jen-Yin Chen ◽  
I.-Wen Chen ◽  
Hong-Yi Tong ◽  
...  
Keyword(s):  
Renal Function ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Serum Iron ◽  
Large Scale ◽  
Iron Level ◽  
Regression Analyses ◽  
Serum Iron Level ◽  
Poor Renal Function ◽  
Significant Difference

AbstractThis study aimed to assess the association of serum iron level (Iron) with the estimated glomerular filtration rate (eGFR) after bariatric surgery (BS). We reviewed 210 patients with mean age of 39.1 ± 10.6 years (body mass index, 41.4 ± 5.5 kg/m2) undergoing BS. The primary outcome was the relationship between Iron and eGFR at 12-month after surgery. Multiple linear regression analyses were performed using postoperative eGFR as dependent variables and using Iron and other variables (i.e., age) as independent variables. At 12-month follow-up, 94 patients were analyzed. BMI significantly decreased, whereas serum iron level significantly increased. Although the percentage of patients with eGFR of < 90 mL/min/1.73 m2 increased during the study period, no significant difference was found in postoperative 12-month eGFR. No correlations were noted between Iron and eGFR at baseline and postoperative 1 and 6 months, whereas a significant relationship was observed between Iron and postoperative 12-month eGFR. Multiple linear regression analyses revealed that Iron and presence of diabetes were the independent predictors of postoperative 12-month eGFR. This pilot study showed a positive association of postoperative serum iron level with renal function in this patient population. Further large-scale trials are needed to confirm the findings.

scholarly journals ZAT BESI DI PENDONOR TERATUR DAN YANG TIDAK TERATUR (Iron in Regular and NonRegular Donors)

2018 ◽  
Vol 21 (3) ◽  
pp. 257
Author(s):  
Irna Diyana Kartika ◽  
Lince Wijoyo ◽  
Syahraswati Syahraswati ◽  
Rachmawati Muhiddin ◽  
Darwati Muhadi ◽  
...  
Keyword(s):  
Serum Iron ◽  
Blood Donors ◽  
Blood Donation ◽  
Ferritin Level ◽  
Iron Level ◽  
Donor Blood ◽  
Serum Iron Level ◽  
Cross Sectional ◽  
South Sulawesi ◽  
Average Serum

Blood donation is a process of taking blood from someone, either voluntarily or as a replacement donor blood banked for later usein blood transfusions. Regular donors are donors who regularly donate blood between 3−4 times a year. Nonregular donors are thosewho do not routinely donate blood in a year. Each donor donating one bag of blood, suffered a loss of approximately 200 mg of iron.The purpose of this study was to know the differences in the levels of iron profiles in regular and nonregular donors. The study wasconducted cross sectional on 65 samples of blood from the UPTD Transfusi Darah South Sulawesi Provincial Health Office, consisting of34 regular donors and 31 nonregular donors. Serum iron and TIBC levels were examined using ABX Pentra 400 with colorimetric andimmunoturbidimetry method. Ferritin level was examined using Elecsys with ECLIA principle. The data were then analyzed by unpairedT test. In this study, the regular donors showed an average serum iron level of 87.09 μg/dL, TIBC level 255.41 μg/dL and ferritin level121.27 μg/dL. The nonregular donors, showed an average serum iron level of 83.26 μg/dL, TIBC level was 261.80 μg/dL and ferritinlevel was 158.62 μg/dL. The results showed no significant differences between the levels of iron profiles in regular and nonregulardonors. Based on this study, it can be concluded that regular and nonregular blood donation did not affect the levels of iron profiles. Itis recommended to conduct a further cohort research to know the levels of iron profiles in blood donors by comparing before and afterdonating blood.

scholarly journals Determination of Level of Serum Iron among Routine Iron Supplemented Pregnant Women Attending Private Clinic in Sulaimani City, Kurdistan-Iraq

2021 ◽  
Vol 11 (1) ◽  
pp. 76-79
Author(s):  
Sardar M. Weli ◽  
Osama H. Shareef ◽  
Syamand A. Qadir
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Serum Iron ◽  
Age Groups ◽  
First Trimester ◽  
Private Clinic ◽  
Iron Level ◽  
Serum Iron Level ◽  
Significant Difference ◽  
Questionnaire Form

Iron deficiency, with or without anemia, is common in pregnant women and more than half of the anemia’s in the world are due to the deficiency of iron in the serum. The aims of this study were to determine the percentage and level of serum iron among iron supplemented pregnant women in different trimesters and in different age groups among supplemented pregnant women in Sulaimani city. This study was carried out in the private clinic in the Sulaimani city-Kurdistan Region of Iraq. The pregnant women were participated and enrolled between the first of December 2018 and first of December 2019. Two hundred and seventy-five healthy and iron supplemented pregnant women were selected randomly and the questionnaire form, which contains information about age of mothers and their gestational age, was filled and serum iron level was measured by COBAS C111 analyzer. The results of this study found that the percentage of iron deficiency among participants was high 33%, 45%, and 52.6 % in the first trimester in different age groups <25, 25–35, and above 35 years old, respectively. However, in the third trimesters decreased to 12.5%, 7.1%, and 3.7% in <25, 25–35, and above 35 years old, respectively. Regarding serum iron levels, the present study found that there were significant differences between ages 25 and 35 with age <25 years. However, there was no significant difference between first, second, and third trimesters. This study concludes that the percentage of iron deficiency among supplemented pregnant women was high compared to other cities or other countries. Pregnant women who their ages <25 are at risk of serum iron deficiency. On the other hand, pregnancy trimesters had no effects on the serum iron level among supplemented pregnant women.

scholarly journals Association of Serum Iron and Ferritin Levels in Patients of Cholelithiasis: A Cross-Sectional Study

2020 ◽  
Vol 3 (1) ◽  
pp. 42-27
Author(s):  
Madhukar Rajaram Wagh ◽  
Sunil Joshi
Keyword(s):  
Serum Ferritin ◽  
Serum Cholesterol ◽  
Serum Iron ◽  
Gallstone Disease ◽  
Control Group ◽  
Case Group ◽  
Iron Level ◽  
Serum Iron Level ◽  
The Mean ◽  
And Control

Background: Cholelithiasis is a common abdominal disorder resulting in increasing hospital admissions. About 10-12% of adults develop gallstones. Aim of this study was to find out any association of serum iron and ferritin levels in patients of cholelithiasis. Subjects and Methods: Present study was conducted at the department of surgery, tertiary care institute of for the period 1 year. For the study purpose 70 gall stone cases and 70 normal healthy matched controls were taken as study participants. After explaining about the study to the subjects, an informed consent will be obtained, followed by a detailed history with clinical examination with more emphasis on the parameters given below in outcome variable (ultrasonography finding, serum iron level, serum ferritin level, serum cholesterol). Results: The mean age in the case group (gallstones present) is 43.12 years, as compared to the control group the mean age is 41.05 years, The study shows in the case group 64% of patient was female and 36% was male and in the control group 76% of patient was female and 24% was male. In this study 46 (65.7%) patients with gallstones have the value of serum iron less than normal (normal value: >40 µg/dl). Our study shows, there are 35 female patients with gallstone disease who have serum iron levels below the normal value Most of the patients with gallstone disease whose serum iron levels are subnormal are females. Our study shows that the mean serum iron between cases and control was statistically significant p 0.05. There is no effect of anemia on serum cholesterol. In this study the mean serum cholesterol between cases and control was statistical insignificant (p>0.7)) In the case group, 20 of male and 36 of female patients have normal serum ferritin levels. The number of females having normal serum ferritin levels (in both case and control groups) is more. Conclusion: Gallstones are more prevalent in female population than males. Serum ferritin association is insignificant as it increases other condition with inflammation also. Low serum iron level associated with high risk of cholelithiasis as this may lead to super saturation of bile.

scholarly journals Evaluation of Osveral efficacy in reducing ferritin levels in patients with thalassemia major

2017 ◽  
Vol 6 (11) ◽  
pp. 2556
Author(s):  
Afshin Fathi ◽  
Majid Vafaie ◽  
Firouz Amani ◽  
Nadia Mohebbi
Keyword(s):  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Iron Level ◽  
Serum Iron Level ◽  
Significant Difference ◽  
Quasi Experimental ◽  
One Year ◽  
And Control

Background: Beta thalassemia is one of the inherited blood diseases in which the production of specific chains in hemoglobin decreases. Esfarlal is a shaltor which is used in these patients as a single dose per day. Since it is prescribed orally, it is easier to tolerate the drug and control the serum iron level of the patient. The aim of this study was to evaluate the efficacy of Osveral in reducing ferritin levels in patients with thalassemia major.Methods: This quasi-experimental study was performed on 48 patients with thalassemia major who referred to Bu-Ali hospital for receiving blood. At the beginning of the study, the required data were collected along with patients' tests including hemoglobin, ferritin, TSH, T4, CBC diff, BUN AST, ALT, BS and creatinine CBC diff. The Osveral drug was prescribed and the patients were evaluated monthly for up to 6 months on the basis of complications. In the first three months after the start of the drug, the serum ferritin level was measured, the dose was adjusted and 6 months after late, the previous tests were again requested, and the auditory and visual examinations were performed, and the information entered the checklist. Data were analyzed using SPSS statistical software.Results: Among all patients, 27 (56.2%) were male and the rest were women with a mean age of 22.22 ± 8.77 years. The results showed that during one year of study, hemoglobin level increased and ferritin level decreased significantly, and other parameters didn’t show significant difference. Nausea and vomiting were the most common complications among patients, which was higher after Osveral than before receiving Osveral.Conclusions: Results showed that Osveral is effective in reducing the level of ferritin in patients with thalassemia major, but control of hematuria is recommended when using this drug.

scholarly journals Correlation of serum iron and ferritin levels in patients of cholelithiasis and comparison with healthy individuals

2019 ◽  
Vol 6 (6) ◽  
pp. 1981
Author(s):  
Yogendra Dadhich ◽  
Girish Bhardwaj ◽  
Gaurab Goel ◽  
Rajendra Mandia
Keyword(s):  
Serum Ferritin ◽  
Serum Cholesterol ◽  
Serum Iron ◽  
Systemic Disease ◽  
Gall Stone ◽  
Female Gender ◽  
Iron Level ◽  
Serum Iron Level ◽  
The Mean ◽  
And Control

Background: Gall stones have afflicted man kinds since antiquity. Gall stone disease is prevalent, major source of morbidity and costly health problem. Presence of stones in the gallbladder is referred to as cholelithiasis, from the Greek chol-(bile)+lith (stone)+iasis-(process). If gallstones migrate into the ducts of the biliary tract, the condition is referred to as choledocholithiasis.  Methods: It is case control study. Inclusion criteria were, patients aged above 18 years suffering from cholelithiasis confirmed by USG. The exclusion criteria were, patients having hematological disorder, having any systemic disease leading to iron deficiency, on drugs causing gallstones and pregnant females.Results: Study shows females were affected more in case (64%) and control (76%) group with mean age was of case (42.84 years) and control (40.64 years) group. 24% of patients was anaemic in cases. The mean serum cholesterol between cases and control was statistical insignificant (p=0.252). The mean serum ferritin between cases and control was statistical insignificant (p=0.800).Conclusions: The study of 100 cases, based on serum iron, serum cholesterol, serum ferritin and hemoglobin, concludes that the disease is more prevalent in female gender. Serum ferritin association is insignificant as it increases other condition with inflammation also. Low serum iron level associated with high risk of cholelithiasis as this may lead to super saturation of bile.

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