Arsenic Intoxication Presenting as Peripheral Neuropathy

Chronic Arsenic Toxicity may have varied clinical presentations ranging from non-cancerous manifestations to malignancy of skin and different internal organs. Chronic arsenic exposure results in dermatologic manifestations prior to overt clinical neuropathy. Arsenic neuropathy causes painful paresthesias and, with higher level or continued exposure, length-dependent weakness. We are reporting two cases of chronic arsenic poisoning who presented initially as peripheral sensory motor neuropathy and skin manifestations. Arsenic poisoning was suspected because many of the other family members also developed similar symptoms simultaneously. The hair samples of these patients contained markedly elevated levels of arsenic. Also the water samples from their household and the neighboring households were found to have alarming levels of inorganic arsenic. Provision of arsenic free drinking water halt further deterioration of symptoms and there was significant improvement of their dermatological & neurological conditions. DOI: http://dx.doi.org/10.3329/bjn.v28i2.17184 Bangladesh Journal of Neuroscience 2012; Vol. 28 (2): 128-131

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Environmental Arsenic Contamination and its Effect on Dental Caries Experience in School Children

Journal of Advanced Oral Research ◽

10.1177/2229411217729083 ◽

2017 ◽

Vol 8 (1-2) ◽

pp. 21-25

Author(s):

Manju R. ◽

Amitha M. Hegde ◽

Anisha Keshan

Keyword(s):

Arsenic Exposure ◽

Caries Experience ◽

Control Group ◽

Study Group ◽

Hair Samples ◽

Icdas Ii ◽

Chronic Arsenic Exposure ◽

The Mean ◽

And Control ◽

Possible Cause

Aims and Objectives: To assess the effect of exposure to arsenic by drinking water and caries prevalence in children. Material and Methods: A total of 200 children between 10 to 14 years of age, 100 each from study village (Hutti, Raichur district, Karnataka) and control village (Sanduru, Bellary district, North Karnataka) were included in the study. Water samples from both the villages were analyzed for arsenic levels. Arsenic levels were determined in the hair and nail samples from the subjects to assess chronic arsenic exposure. Caries experience was measured by the DMFT/deft index and the severity of caries was measured by modified ICDAS-II index. Results: The mean concentration of arsenic in the study group was found to be 2.44 ppm in the hair samples and 2.72 ppm in the nail samples as compared to 0.12 ppm in both hair and nail samples in the control group. These values were statistically significant ( p < 0.001). The mean DMFT score in the control group was 0.99 and in the study group was 2.45, which was statistically significant ( p < 0.05) using SPSS version 21. Conclusion: Chronic arsenic exposure could be a possible cause for the increased caries experience in children in the study group.

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A retrospective review of the dermatologic manifestations of chronic arsenic poisoning in the Philippines

International Journal of Dermatology ◽

10.1111/ijd.13615 ◽

2017 ◽

Vol 56 (7) ◽

pp. 721-725 ◽

Cited By ~ 7

Author(s):

Sheena Maureen T. Sy ◽

Charissa M. Salud-Gnilo ◽

Claudine Yap-Silva ◽

Erin Jane L. Tababa

Keyword(s):

Retrospective Review ◽

The Philippines ◽

Arsenic Poisoning ◽

Chronic Arsenic Poisoning ◽

Dermatologic Manifestations

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Chronic arsenic exposure increases TGFalpha concentration in bladder urothelial cells of Mexican populations environmentally exposed to inorganic arsenic

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2006.12.015 ◽

2007 ◽

Vol 222 (3) ◽

pp. 264-270 ◽

Cited By ~ 31

Author(s):

Olga L. Valenzuela ◽

Dori R. Germolec ◽

Víctor H. Borja-Aburto ◽

José Contreras-Ruiz ◽

Gonzalo G. García-Vargas ◽

...

Keyword(s):

Arsenic Exposure ◽

Inorganic Arsenic ◽

Urothelial Cells ◽

Chronic Arsenic Exposure ◽

Mexican Populations

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Dynamic alteration in miRNA and mRNA expression profiles at different stages of chronic arsenic exposure-induced carcinogenesis in a human cell culture model of skin cancer

Archives of Toxicology ◽

10.1007/s00204-021-03084-2 ◽

2021 ◽

Author(s):

Mayukh Banerjee ◽

Ana Ferragut Cardoso ◽

Laila Al-Eryani ◽

Jianmin Pan ◽

Theodore S. Kalbfleisch ◽

...

Keyword(s):

Skin Cancer ◽

Mrna Expression ◽

Hacat Cell ◽

Arsenic Exposure ◽

Differentially Expressed ◽

Rna Seq ◽

Mesenchymal Transition ◽

Chronic Arsenic Exposure ◽

Pathway Analyses ◽

Time Point

AbstractChronic arsenic exposure causes skin cancer, although the underlying molecular mechanisms are not well defined. Altered microRNA and mRNA expression likely play a pivotal role in carcinogenesis. Changes in genome-wide differential expression of miRNA and mRNA at 3 strategic time points upon chronic sodium arsenite (As3+) exposure were investigated in a well-validated HaCaT cell line model of arsenic-induced cutaneous squamous cell carcinoma (cSCC). Quadruplicate independent HaCaT cell cultures were exposed to 0 or 100 nM As3+ for up to 28-weeks (wk). Cell growth was monitored throughout the course of exposure and epithelial-mesenchymal transition (EMT) was examined employing immunoblot. Differentially expressed miRNA and mRNA profiles were generated at 7, 19, and 28-wk by RNA-seq, followed by identification of differentially expressed mRNA targets of differentially expressed miRNAs through expression pairing at each time point. Pathway analyses were performed for total differentially expressed mRNAs and for the miRNA targeted mRNAs at each time point. RNA-seq predictions were validated by immunoblot of selected target proteins. While the As3+-exposed cells grew slower initially, growth was equal to that of unexposed cells by 19-wk (transformation initiation), and exposed cells subsequently grew faster than passage-matched unexposed cells. As3+-exposed cells had undergone EMT at 28-wk. Pathway analyses demonstrate dysregulation of carcinogenesis-related pathways and networks in a complex coordinated manner at each time point. Immunoblot data largely corroborate RNA-seq predictions in the endoplasmic reticulum stress (ER stress) pathway. This study provides a detailed molecular picture of changes occurring during the arsenic-induced transformation of human keratinocytes.

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Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway

Toxicology Letters ◽

10.1016/j.toxlet.2020.06.006 ◽

2020 ◽

Vol 332 ◽

pp. 155-163 ◽

Cited By ~ 1

Author(s):

Linqing Wu ◽

Zengbin Wang ◽

Xiaotong Li ◽

Xiaoli He ◽

Yanfei Han ◽

...

Keyword(s):

Malignant Transformation ◽

Arsenic Exposure ◽

Chronic Arsenic Exposure

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Biotic and Abiotic Factors Influencing Arsenic Biogeochemistry and Toxicity in Fluvial Ecosystems: A Review

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17072331 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2331

Author(s):

Laura Barral-Fraga ◽

María Teresa Barral ◽

Keeley L. MacNeill ◽

Diego Martiñá-Prieto ◽

Soizic Morin ◽

...

Keyword(s):

Abiotic Factors ◽

Arsenic Exposure ◽

Inorganic Arsenic ◽

Future Research ◽

Strong Impact ◽

Trophic Relations ◽

Fluvial Systems ◽

Pampean Streams ◽

Micro Organisms ◽

Different Origins

This review is focused on the biogeochemistry of arsenic in freshwaters and, especially, on the key role that benthic microalgae and prokaryotic communities from biofilms play together in through speciation, distribution, and cycling. These microorganisms incorporate the dominant iAs (inorganic arsenic) form and may transform it to other arsenic forms through metabolic or detoxifying processes. These transformations have a big impact on the environmental behavior of arsenic because different chemical forms exhibit differences in mobility and toxicity. Moreover, exposure to toxicants may alter the physiology and structure of biofilms, leading to changes in ecosystem function and trophic relations. In this review we also explain how microorganisms (i.e., biofilms) can influence the effects of arsenic exposure on other key constituents of aquatic ecosystems such as fish. At the end, we present two real cases of fluvial systems with different origins of arsenic exposure (natural vs. anthropogenic) that have improved our comprehension of arsenic biogeochemistry and toxicity in freshwaters, the Pampean streams (Argentina) and the Anllóns River (Galicia, Spain). We finish with a briefly discussion of what we consider as future research needs on this topic. This work especially contributes to the general understanding of biofilms influencing arsenic biogeochemistry and highlights the strong impact of nutrient availability on arsenic toxicity for freshwater (micro) organisms.

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Inorganic arsenic exposure affects pain behavior and inflammatory response in rat

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2008.01.029 ◽

2008 ◽

Vol 229 (3) ◽

pp. 374-385 ◽

Cited By ~ 11

Author(s):

P AGUIRREBANUELOS ◽

C ESCUDEROLOURDES ◽

L SANCHEZPENA ◽

L DELRAZO ◽

J PEREZURIZAR

Keyword(s):

Inflammatory Response ◽

Arsenic Exposure ◽

Inorganic Arsenic ◽

Pain Behavior

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A risk–benefit analysis approach to seafood intake to determine optimal consumption

British Journal Of Nutrition ◽

10.1017/s0007114511005010 ◽

2011 ◽

Vol 107 (12) ◽

pp. 1812-1822 ◽

Cited By ~ 23

Author(s):

Véronique Sirot ◽

Jean-Charles Leblanc ◽

Irène Margaritis

Keyword(s):

Arsenic Exposure ◽

Inorganic Arsenic ◽

Hierarchical Cluster ◽

Good Health ◽

Benefit Analysis ◽

Food Contaminants ◽

Public Health Perspective ◽

Contaminant Exposure ◽

Consumption Level ◽

Risk Benefit Analysis

Seafood provides n-3 long-chain PUFA (n-3 LC-PUFA), vitamins and minerals, which are essential to maintain good health. Moreover, seafood is a source of contaminants such as methylmercury, arsenic and persistent organic pollutants that may affect health. The aim of the present study was to determine in what quantities seafood consumption would provide nutritional benefits, while minimising the risks linked to food contaminants. Seafood was grouped into clusters using a hierarchical cluster analysis. Those nutrients and contaminants were selected for which it is known that seafood is a major source. The risk–benefit analysis consisted in using an optimisation model with constraints to calculate optimum seafood cluster consumption levels. The goal was to optimise nutrient intakes as well as to limit contaminant exposure with the condition being to attain recommended nutritional intakes without exceeding tolerable upper intakes for contaminants and nutrients, while taking into account background intakes. An optimum consumption level was calculated for adults that minimises inorganic arsenic exposure and increases vitamin D intake in the general population. This consumption level guarantees that the consumer reaches the recommended intake for n-3 LC-PUFA, Se and I, while remaining below the tolerable upper intakes for methylmercury, Cd, dioxins, polychlorobiphenyls, Zn, Ca and Cu. This consumption level, which is approximately 200 g/week of certain fatty fish species and approximately 50 g/week of lean fish, molluscs and crustaceans, has to be considered in order to determine food consumption recommendations in a public health perspective.

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