scholarly journals Role of Urinary Calcium and Creatinine Ratio in Assessing Bone Resorption in Lepromatous Leprosy

2021 ◽  
Vol 48 (3) ◽  
pp. 28-33
Author(s):  
Saima Akhter ◽  
Md Qamrul Hassan Jaigirdar ◽  
Md Mostaque Mahmud ◽  
Shawana Haque ◽  
Rahat Bin Habib
Keyword(s):  
Bone Resorption ◽  
Lepromatous Leprosy ◽  
Urinary Calcium ◽  
Control Group ◽  
X Rays ◽  
Creatinine Ratio ◽  
Leprosy Patients ◽  
Healthy Control ◽  
Hands And Feet

Bony changes in lepromatous leprosy are one of the causes of deformity and disability. Fasting calcium and creatinine ratio in urine is used as a bone resorption marker in a number of diseases such as hyperthyroidism, osteoporosis, multiple myeloma, paget’s disease and sarcodosis. In lepromatous leprosy assessment of bone resorption might be done with that marker. To assess the role of fasting urinary calcium and creatinine ratio as a marker of bone resorption in patients with lepromatous leprosy. A case control study was conducted on 28 patients diagnosed as lepromatous leprosy and 28 age-matched healthy control. The participants who fulfilled all inclusion and exclusion criteria were studied by measuring fasting urinary calcium and creatinine level as well as observing X-rays of both hands and feet of affected individuals. The mean age of cases 38.1±14.2 years and 38.9±12.9 years was in control group. Male - female ratio was 3.6: 1. It was observed that 10.7% leprosy patients showed urinary Ca/Cr ratio >0.20 (0.13±0.12) and 10.7% healthy control showed urinary Ca/Cr ratio ratio>0.20 (mean ±SD 0.11±0.7). the difference was not statistically significant (p>0.05). X-ray finding was positive in 14.3% leprosy patients and none of the control group. That difference was not significant statistically (p>0.05). there was no relation between raised urinary Ca/Cr ratio and positive findings of bone resorption on x-rays among the leprosy cases. Bangladesh Med J. 2019 Sep; 48 (3): 28-33

scholarly journals Role of Calcium Therapy on Urinary Calcium/Creatinine Ratio in Healthy Pregnant Women and Pre-eclamptic Women

1970 ◽  
pp. 7-9
Author(s):  
Sabiha Yasmin Moni ◽  
Mamun Rashid ◽  
Hosne Ara Begum ◽  
Sahin Ara ◽  
Nazimuddin Ahmed
Keyword(s):  
Pregnant Women ◽  
Urinary Calcium ◽  
The Other ◽  
Control Group ◽  
Creatinine Ratio ◽  
Normal Range ◽  
Urinary Creatinine ◽  
Before And After ◽  
Observational Group

The study has been carried out to observe the effect of calcium therapy on urinary calcium/creatinine ratio in healthy gravid women and pre-eclamptic women. Calcium/creatinine ratio has been considered for early detection of pre-eclamptic toxaemia (PET). So for the diagnosis of PET we try to investigate relation of urinary calcium, urinary creatinine, urinary calcium/creatinine ratio before and after calcium therapy. For this purpose total number of 60 healthy gravid and clinically suspected PET women of 20- 28 weeks of pregnancy having age ranged from, 17-39 years were selected. Of these 30 healthy pregnant women were taken as control group and another clinically diagnosed 30 PET women were taken as observational group. Urinary calcium/creatinine ratio was within normal range in healthy pregnant women and after calcium therapy this ratio was not significantly changed. On the other hand urinary calcium/creatinine ratio in PET women was significantly decreased and this ratio was significantly increased after calcium therapy. These observations suggest that low calcium/creatinine ratio help in early prediction of PET and calcium supplement during pregnancy may reduce the incidence of PET. DOI: 10.3329/bjpp.v25i1.5738Bangladesh J Physiol Pharmacol 2009; 25(1&2) : 7-9

scholarly journals Studying the Role of C-Reactive Protein in Patients with Sleeve Gastrectomy in Baghdad

2021 ◽  
Vol 3 (1) ◽  
pp. 55-60
Author(s):  
Mohammed Abbas Fadil ◽  
Raya Ezat Maroof ◽  
Moayed Abbas Fadil
Keyword(s):  
Sleeve Gastrectomy ◽  
Healthy Person ◽  
Control Group ◽  
C Reactive Protein ◽  
Serum Samples ◽  
Reactive Protein ◽  
Medical City ◽  
Healthy Control ◽  
And Control

Obesity and severe obesity are increasing serious health problems with an epidemic percentage in most countries. In Sleeve gastrectomy, a part of the stomach structure is removed, limiting its capacity by about two to three. A total of thirty blood samples were collected from patients with obesity and the result was compared with healthy person throughout the time from November 2019 to September 2020. Before sleeve gastrectomy and after more than 6 months of sleeve surgery, the sample was collected from the Medical City/Baghdad Teaching Hospital, the withdrawal was again taken at home to have pre and post sleeve gastrectomy, Patient age ranged between [20-46] years for obese patients and healthy control. Then the serum samples were obtained from patients and control group to screen for C-reactive protein by agglutination method. The result of the present study found that the positivity of CRP in pre-operation is higher than that of post-operative with high significance [P<0.005].

Platelet Functions are Decreased in Obesity and Restored after Weight Loss: Evidence for a Role of the SERCA3-Dependent ADP Secretion Pathway

2019 ◽  
Vol 119 (03) ◽  
pp. 384-396 ◽  
Author(s):  
Ziane Elaïb ◽  
Jose Lopez ◽  
Muriel Coupaye ◽  
Kevin Zuber ◽  
Yann Becker ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass Surgery ◽  
Calcium Signalling ◽  
Adenosine Diphosphate ◽  
Control Group ◽  
Obese Patients ◽  
Secretion Pathway ◽  
Healthy Control ◽  
Platelet Functions

AbstractIn obesity, platelets are described as hyperactive, mainly based on increased platelet size and presence of pro-thrombotic plasmatic molecules. We explored platelet functions, including calcium signalling in obesity, and the effect of weight loss. We included 40 obese patients (women with body mass index [BMI] of ≥ 35 kg/m2) who were to undergo gastric bypass surgery and 40 healthy lean subjects (women with BMI of < 25 kg/m2) as a control group. Approximately 1 year after surgery, the obese patients lost weight (75% had a BMI < 35 kg/m2). They were explored a second time with the same healthy control for the same platelet experiments. Compared with controls, obese patients' platelets displayed reduced sensitivity to thrombin (aggregation EC50 increased by 1.9 ± 0.3-fold, p = 0.005) and a lower Ca2+ response (70 ± 7% decrease, p < 10−4). In 17 pairs of patients, we performed additional experiments: in obese patients' platelets, thrombin-induced αIIbβ3 activation was significantly lower (p = 0.003) and sarco-endoplasmic reticulum Ca2+ATPase (SERCA3) expression was decreased (48 ± 6% decrease, p < 10−4). These differences were abolished after weight loss. Interestingly, pharmacological inhibition of SERCA3 activity in control group's platelets mimicked similar alterations than in obese patients' platelets and was associated with defective adenosine diphosphate (ADP) secretion. Addition of ADP to agonist restored platelet functions in obese patients and in SERCA3-inhibited control platelets (five experiments) confirming the direct involvement of the SERCA3-dependent ADP secretion pathway. This is the first study demonstrating that platelets from obese patients are hypo-reactive, due to a deficiency of SERCA3-dependent ADP secretion. Weight loss restores SERCA3 activity and subsequent calcium signalling, αIIbβ3 activation, platelet aggregation and ADP secretion.

scholarly journals Class-I human leukocyte alleles in leprosy patients from Southern Brazil

2011 ◽  
Vol 44 (5) ◽  
pp. 616-620 ◽  
Author(s):  
Danilo Santana Alessio Franceschi ◽  
Luiza Tamie Tsuneto ◽  
Priscila Saamara Mazini ◽  
William Sergio do Sacramento ◽  
Pâmela Guimarães Reis ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Hla Class I ◽  
Innate Immune ◽  
Class I ◽  
Control Group ◽  
Southern Brazil ◽  
Hla Genotyping ◽  
Leprosy Patients ◽  
Direct Counting

INTRODUCTION: The present study was designed to investigate a possible role of HLA (histocompatibility leucocyte antigen) class-I alleles (HLA-A, -B, and -C) in leprosy patients from Southern Brazil. METHODS: Two hundred and twenty-five patients with leprosy and 450 individuals for the control group were involved in this research. HLA genotyping was performed through PCR-SSO protocols (One Lambda, USA); the frequency of these alleles was calculated in each group by direct counting, and the frequencies were then compared. RESULTS: There was an association between HLA-A*11 (6.9% vs 4.1%, p=0.0345, OR=1.72, 95% CI=1.05-2.81), HLA-B*38 (2.7% vs. 1.1%, p=0.0402, OR=2.44, 95% CI=1.05-5.69), HLA-C*12 (9.4% vs. 5.4%, p=0.01, OR=1.82, 95% CI=1.17-2.82), and HLA-C*16 (3.1% vs. 6.5%, p=0.0124, OR=0.47, 95% CI=0.26-0.85) and leprosy per se. In addition, HLA-B*35, HLA-C*04, and HLA-C*07 frequencies were different between lepromatous (LL) and tuberculoid (TT) patients. However, after adjusting for the number of alleles compared, Pc values became nonsignificant. CONCLUSIONS: Although our results do not support the previous findings that HLA class-I alleles play a role in leprosy pathogenesis, we suggest new studies because of the importance of the association between the HLA and KIR in the innate immune response to leprosy.

The Role of Acetabulum Geometry and Femoral Head-Neck Ratio in the Development of Osteoarthritis in Young Men

2007 ◽  
Vol 17 (3) ◽  
pp. 131-136 ◽  
Author(s):  
B. Halle ◽  
D.M. Halle ◽  
T. Torfing ◽  
S. Overgaard
Keyword(s):  
Femoral Head ◽  
Young Men ◽  
Control Group ◽  
Case Group ◽  
Trauma Patients ◽  
X Rays ◽  
Osteoarthritis Of The Hip ◽  
Total Coverage ◽  
Head Neck

We studied the role of acetabulum geometry and head neck ratio in the development of osteoarthritis of the hip in young men. Contrary to previous studies we evaluated the significance of the anterior, posterior and total coverage of the femoral head, the influence of the femoral neck and the consequence of acetabular retroversion on standardized x-rays. Men aged 26–55 years who earlier had a total hip arthroplasty were included in the case group. This group was compared to a control-group of men treated as trauma patients. The study indicates that acetabular dysplasia and retroversion and a relative decreased head neck ratio are associated with osteoarthritis of the hip in young men.

Iron Chelation, Blood Transfusion and Splenectomy Decreases Angiogenesis in Patients with Thalassemia Major

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 5428-5428
Author(s):  
Duran Canatan ◽  
Seref Olgar ◽  
Aslihan Kara ◽  
Hicran Hicyilmaz ◽  
Nihal Balta
Keyword(s):  
Blood Transfusion ◽  
Iron Chelation ◽  
Thalassemia Major ◽  
Extramedullary Hematopoiesis ◽  
Control Group ◽  
Transfusion Rate ◽  
Transfusion Therapy ◽  
Cardiac Decompensation ◽  
Healthy Control

Abstract Introduction: Thalassemia major (TM) is an important cause of severe anemia that necessitates regular blood transfusion to prevent the profound weakness and cardiac decompensation caused by the anemia. However, iron overloading is an inevitable consequence of prolonged transfusion therapy. In addition, extramedullary hematopoiesis and hemosiderosis cause spleen, liver and marrow enlargement. In recent years the role of angiogenesis has been investigated in physiologic and pathologic conditions. However, it is known that angiogenetic factors, especially vascular endothelial growth factor (VEGF), cause differentiation of the hemangioblast. The role of angiogenesis has been investigated in different kinds of anemia, such as malignancy related anemia and sickle cell anemia. However, the role of angiogenesis has not been investigated in thalassemia major (TM) patients. In this study the angiogenesis was researched in thalassemic patients by serum VEGF measurement. Material and method: Forty-four consecutive patients with TM were included in this prospective study. TM patients’ findings were compared with those of a healthy control group (n=12). Blood samples were analyzed using commercially available ELISA kits for VEGF Results: VEGF levels were not affected by hemoglobin levels, ferritin levels, or chelation type (p&gt;0.05). However, VEGF was positively affected by chelation starting age and negatively affected by yearly blood transfusion rate (p&lt;0.05). In addition, VEGF of patients who underwent splenectomy was higher than those who didn’t undergo splenectomy (p&lt;0.05). In conclusion, VEGF causes differentiation of hemangioblasts, however, early starting transfusion age and regular blood transfusion decrease angiogenesis in thalassemic patients. The besides regular blood transfusion and effective chelation therapy, splenectomy decreases angiogenesis in this group of patients.

scholarly journals Role of Glutathione S-transferase Mu 1 and Glutathione S-transferases Theta 1 Polymorphism in the Risk of Developing Type 2 Diabetes Mellitus at Universitas Sumatera Utara Hospital, Medan

2021 ◽  
Vol 9 (A) ◽  
pp. 1240-1244
Author(s):  
Zaimah Z. Tala ◽  
Mutiara Indah Sari
Keyword(s):  
Diabetes Mellitus ◽  
Healthy Control Group ◽  
Control Group ◽  
P Value ◽  
Genotype Distribution ◽  
Gstt1 Null Genotype ◽  
Pcr Products ◽  
Healthy Control ◽  
Glutathione S Transferases

BACKGROUND: Diabetes mellitus is associated with an increased production of reactive oxygen species (ROS) and a reduction in antioxidant defense. Glutathione S-transferases (GSTs) is group of multifunction antioxidant enzyme can be used as important biomarkers for DM..  GSTM1, T1 genes variant polymorphism result in decreased or loss of enzyme activity. AIM: The study aimed to evaluate the role of GSTM1 and GSTT1 gene polymorphism in the risk of developing T2DM. METHODS: GSTM1 and GSTT1 polymorphisms were genotyped in 87 T2DM patients and 87 healthy control group to analyze their association with T2DM susceptibility by using multiplex Polymerase Chain Reaction (PCR). PCR products were electrophoresed using agarose 2%. Odds ratio (OR) with 95% confidence interval (CI) and P value were calculated using SPSS software (version 21.0). RESULTS: The genotype distribution of GSTM1 and GSTT1 were not different between T2DM patients and healthy control group (p = 0.542, OR= 0.780, CI 95%=0.350-1.737 and p=0.879, OR=1.047, CI 95%=0.577-1.903). The genotype distribution of combination of GSTM1 and GSTT1 were also not not different between T2DM patients and healthy control group (p = 0.640, OR= 0.640, CI 95%=0.224-1.83 and p=0.551, OR=0.721, CI 95%=0.245-2.120. CONCLUSION: In summary, this study showed that GSTT1 null, GSTM1 null, the combination of GSTM1 null and GSTT1 null genotype or combination of GSTM1 null and GSTT1 positive (or contrary) did not have any risk of developing T2DM at Universitas Sumatera Utara Hospital, Medan.  

Importance of the FcγRIIa-Arg/His-131 Polymorphism in Heparin-induced Thrombocytopenia Diagnosis

1998 ◽  
Vol 79 (03) ◽  
pp. 523-528 ◽  
Author(s):  
Raphaël Saffroy ◽  
Dominique Lasne ◽  
Gilles Chatellier ◽  
Martine Aiach ◽  
Francine Rendu ◽  
...  
Keyword(s):  
Serotonin Release ◽  
Positive Answer ◽  
Control Group ◽  
Normal Donor ◽  
Heparin Induced Thrombocytopenia ◽  
Weak Association ◽  
Healthy Control ◽  
Release Assay ◽  
The Mean

SummaryHeparin-induced thrombocytopenia (HIT) involves heparin-dependent antibodies which induce platelet activation. In the present study, we searched for a relationship between the polymorphism of the Fc receptor (FcγRIIa) and the development of HIT. In this purpose, all the donors were genotyped for their FcγRIIA and HIT patients were selected on the basis of at least one positive answer by 14C-serotonin release assay (SRA). The frequency distribution of the FcγRIIa polymorphism in the HIT patient group was similar to that observed in the healthy control group. Moreover, a statistical analysis taking into account our results and those of 3 previously published studies, suggested at most only a weak association between HIT and the FcγRIIa-131 polymorphism.Laboratory tests used to diagnose HIT rely on the activation of normal donor platelets but fail to detect every HIT positive patient. We determined the role of FcγRIIa-131 polymorphism on the reactivity of control platelets to HIT plasmas. When control platelet FcγRIIa-131 was of Arg/Arg form, only 47% of the HIT plasmas were positive by SRA, compared to 81% and 74% for His/His or His/Arg forms, respectively. We also compared the level of anti PF4/heparin antibodies in the HIT plasmas with the response obtained by SRA. The mean anti PF4/heparin antibodies level in HIT plasma was significantly lower in negative SRA than in positive tests when using control platelets from FcγRIIa-Arg/Arg131 and heterozygous donors. Thus, the variability of control platelets to respond to HIT plasmas in the SRA test is related to both the FcγRIIa-131 polymorphism, and to the amount of anti PF4/heparin antibodies.

Taste Sensitivity to Phenylthiourea Among Leprosy and Filarial Patients in Coastal Andhra Pradesh

1972 ◽  
Vol 21 (4) ◽  
pp. 332-336
Author(s):  
B.R. Busi
Keyword(s):  
Healthy Subjects ◽  
Andhra Pradesh ◽  
Healthy Control Group ◽  
Taste Sensitivity ◽  
Control Group ◽  
Normal Individuals ◽  
Significant Difference ◽  
Leprosy Patients ◽  
Healthy Control

SummaryTaste blindness for PTC has been studied in (a) 416 leprosy patients and 424 healthy subjects, and (b) 261 filarial patients and 136 normal individuals of both sexes. A significant difference was found between leprosy patients and the healthy control group in the proportion of nontasters (χ2 = 4.096, for 1 DF, P〈0.05). No significant difference could be observed between the filariasis and the control group (χ2 = 0.605, for 1 DF, P〉0.30).

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