scholarly journals Synthesis, Characterization and Antimicrobial Studies of Schiff Base Ligand-Derived from Amoxicillin and Benzaldehyde

2016 ◽  
Vol 19 (2) ◽  
pp. 211-214
Author(s):  
Asif Iqbal ◽  
Farhana Hoque
Keyword(s):  
Schiff Base ◽  
Pharmaceutical Journal ◽  
Spectroscopic Techniques ◽  
Disc Diffusion ◽  
Melting Point Determination ◽  
Antibacterial And Antifungal Activities ◽  
Antimicrobial Studies ◽  
Point Determination ◽  
Antibacterial And Antifungal

Advanced research into synthetic chemistry has pointed out several organic compounds with antimicrobial potential. Schiff bases are one of such compounds. This research aims at the synthesis of a Schiff base out of a fairly common antibiotic amoxicillin and benzaldehyde. The synthesized compound was characterized by different spectroscopic techniques. It was also subjected to melting point determination, TLC and solubility tests. The Schiff base was screened for antibacterial and antifungal activities in-vitro by disc diffusion method.Bangladesh Pharmaceutical Journal 19(2): 211-214, 2016

scholarly journals Synthesis, Characterization and Study of Antimicrobial Activities of Mannich Bases Incorporating 1,2,4-Triazole Nucleus

2021 ◽  
Vol 2 (01) ◽  
pp. 19-27
Author(s):  
Rhambus Rawat ◽  
Prem Shankar Deo ◽  
Bhushan Shakya
Keyword(s):  
Schiff Base ◽  
Heterocyclic Compounds ◽  
Environmental Science ◽  
Biological Activities ◽  
Antimicrobial Activities ◽  
Mannich Bases ◽  
New Drugs ◽  
Spectroscopic Techniques ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Heterocyclic compounds containing triazole moiety have great importance in the field of medicine, pharmaceuticals, biochemistry, biology, therapeutics, environmental science, and industry. Triazoles and their derivatives have been extensively used in the development of new drugs. Biological activities of Schiff bases are highly investigated, but Mannich bases are on the verge of their development, and they are being synthesized in large number nowadays. In this work, Mannich bases are synthesized by incorporation 1,2,4-triazole moiety through Schiff base using different amines. Mannich bases are found to exhibit highly effective antibacterial and antifungal activities. The formation of synthesized compounds - 1,2,4-triazole-5-thione, Schiff base (4) and Mannich bases (5a and 5b) - are confirmed and characterized by spectroscopic techniques like UV, FTIR 1H-NMR and 13C-NMR. The activity of the synthesized compounds was tested against bacterial and fungal strain.

Antimicrobial Activity of Essential Oil from Pinus yunnanensis Franch.var tenuifolia Growing in China

2012 ◽  
Vol 430-432 ◽  
pp. 438-442 ◽  
Author(s):  
Yu Hong Tian ◽  
Zi Li ◽  
Shi Hua Wu ◽  
Qiong Huang
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Gas Chromatography Mass Spectrometry ◽  
Disc Diffusion ◽  
Bacterial Strains ◽  
Antibacterial And Antifungal Activities ◽  
Pinus Yunnanensis ◽  
Agar Dilution ◽  
Antibacterial And Antifungal

The in vitro antimicrobial activity of the essential oil from needles of Pinus yunnanensis Franch.var tenuifolia was investigated. The essential oil was obtained by hydro-distillation and analyzed by gas chromatography-mass spectrometry (GC-MS) method. The major compound of the essential oil was α-pinene (22.542%), followed by β-caryophyllene (16.636%), 1,2,4a,5,8,8a-hexahydro-4,7-dimethyl-1-(1-methylethyl)-naphthalene (5.085%), β-cubebene (4.779%), elixene (4.442%), α-cadinol (3.528%),α-caryophyllene (3.459%) and limonene (3.428%). The antimicrobial activity of oil was evaluated by using disc diffusion and agar dilution methods, respectively. The results indicated that the essential oil held moderate antimicrobial activity against tested microorganisms. The essential oil did not differ remarkably in its antibacterial and antifungal activities. The minimum inhibitory concentrations (MICs) were 40 ml/l for bacterial strains, and 80 ml/l for fungal strains.

scholarly journals Novel Zinc(II) Complexes of Heterocyclic Ligands as Antimicrobial Agents: Synthesis, Characterisation, and Antimicrobial Studies

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Ramesh S. Yamgar ◽  
Y. Nivid ◽  
Satish Nalawade ◽  
Mustapha Mandewale ◽  
R. G. Atram ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Antimicrobial Agents ◽  
Spectroscopic Techniques ◽  
Schiff Base Ligands ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
Antimicrobial Studies

The synthesis and antimicrobial activity of novel Zn(II) metal complexes derived from three novel heterocyclic Schiff base ligands 8-[(Z)-{[3-(N-methylamino)propyl]imino}methyl]-7-hydroxy-4-methyl-2H-chromen-2-one, 2-[(E)-{[4-(1H-1,2,4-triazol-1-ylmethyl)phenyl]imino}methyl]phenol, and (4S)-4-{4-[(E)-(2-hydroxybenzylidene)amino]benzyl}-1,3-oxazolidin-2-one have been described. These Schiff base ligands and metal complexes are characterised by spectroscopic techniques. According to these data, we propose an octahedral geometry to all the metal complexes. Antimicrobial activity of the Schiff base ligand and its metal complexes was studied against Gram negative bacteria:E. coliandPseudomonas fluorescens, Gram positive bacteria:Staphylococcus aureus,and also against fungi, that is,C. albicansandA. niger. Some of the metal complexes show significant antifungal activity (MIC < 0.2 μg/mL). The “in vitro” data has identified [Zn(NMAPIMHMC)2]·2H2O, [Zn(TMPIMP)2]·2H2O, and [Zn(HBABO)2]·2H2O as potential therapeutic antifungal agents againstC. albicansandA. niger.

scholarly journals Phytochemical and biological investigation of Indian medicinal plant of givotia rottlerifromis griff

2021 ◽  
Vol 3 (2) ◽  
pp. 54-63
Author(s):  
Mohanraj V ◽  
Sakthivel R.V ◽  
Karthick M
Keyword(s):  
2D Nmr ◽  
Docking Studies ◽  
Hiv Protease ◽  
Melting Point Determination ◽  
Biological Investigation ◽  
Antimicrobial Studies ◽  
Soxhlet Apparatus ◽  
Point Determination ◽  
Pure Methanol ◽  
Antibacterial And Antifungal

A study on givotia rottlerifomis griff shows that studies on a tremendous of pharmacological and physiological activities and other applications. Moreover, givotia rottlerifomis griff has diverse physiological effects. This tempted us to use the bark of givotia rottlerifomis griff for extraction of new compound from the extract. Attempt is made to develop an efficient method for isolation of compounds from the barks of givotia rottlerifomis griff. Our scheme of work is to separate a portion by treatment with pure methanol (CH3OH) using soxhlet apparatus at boiling temperature and the sample is crystallized to separate to the pure compound. The compound was identified further by chromatographic studies, melting point determination, and spectral analysis (IR, 1D and 2D NMR) etc. Furthermore, antimicrobial studies are tested various antibacterial and antifungal species and also molecular docking studies are checked with HIV protease with Schrodinger 9.5 software.

scholarly journals Synthesis of disulphide-Schiff base derivatives and investigations of in vitro antimicrobial activities against some human pathogens

2017 ◽  
Vol 1 (3) ◽  
pp. 230-234 ◽  
Author(s):  
Sefa Durmuş ◽  
Aslıhan Dalmaz ◽  
Görkem Dülger ◽  
Duygu Bircan Kadıoğlu
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Control Group ◽  
Human Pathogens ◽  
Antibacterial And Antifungal Activities ◽  
Schiff Base Derivatives ◽  
Antibacterial And Antifungal

Abstract Thio-Schiff bases are becoming increasingly widespread in various branches such as the preparation of certain medicines, cosmetic products, and polymer production. In particular, the presence of antibacterial, antifungal, antiviral, antitumor and antimalarial properties of Schiff bases containing sulfur in the structure has made these compounds attractive in different disciplines. In this study, different derivatives of dimeric disulfide-Schiff bases have been synthesized. The antibacterial and antifungal activities of the synthesized these compounds were investigated in vitro against some human pathogens (Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Candida albicans, C. tropicalis, C. guilliermondii and C. glabrata). Test microorganisms were isolated from the patients appyling to Medical Faculty Hospital of Duzce University were used. Diffusion method was used to determine the antimicrobial activities of the compounds.standard antibacterial (Cefotaxime, Amoxicillin/clavulanicacid) and antifungal (Posaconazole) antibiotics were used as the control group and the results were compared. The result indicated that antimicrobial activity of Disulphide-Schiff Base Derivatives exhibited less activity against bacteria as compared to AMC30 (Amoxicillin/clavulanicacid), but highly effective against bacteria as compared to CTX30 (Cefotaxime). In addition, the compounds exhibited less activity against yeast.

scholarly journals Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Basavapatna N. Prasanna Kumar ◽  
Kikkeri N. Mohana ◽  
Lingappa Mallesha ◽  
Kikkeri P. Harish
Keyword(s):  
Mass Spectra ◽  
Significant Activity ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Antimicrobial Studies ◽  
Antimicrobial Evaluation ◽  
Oxadiazole Derivatives ◽  
Ft Ir ◽  
Antibacterial And Antifungal

A series of new 1,3,4-oxadiazole derivatives, 4(a–h), containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, 1H NMR, mass spectra, and also by elemental analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that compounds 4c, 4f, and 4g showed significant activity against tested strains.

scholarly journals Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Tanveer MahamadAlli Shaikh ◽  
Habtamu Debebe
Keyword(s):  
Antimicrobial Activities ◽  
New Drugs ◽  
Diffusion Method ◽  
Indole Derivatives ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Standard Drug ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Indole motifs are one of the most significant scaffolds in the discovery of new drugs. We have described a synthesis of new N-substituted indole derivatives (1-3), and their in vitro antimicrobial activities were investigated. The synthesis of titled compounds has been demonstrated by utilizing commercially available starting materials. The antibacterial and antifungal activities were performed using new strains of bacteria Staphylococcus aureus, Escherichia coli, and Candida albicans using the disc diffusion method. Notably, the compound 4-(1-(2-(1H-indol-1-yl) ethoxy) pentyl)-N,N-dimethyl aniline (1) was found to be most potent than the other analogues (2 and 3), which has shown higher inhibition than the standard drug chloramphenicol.

scholarly journals Chemical Composition and Antimicrobial Activity of the Essential Oil of Saccocalyx satureioides Coss. et Dur

2006 ◽  
Vol 1 (8) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Hocine Laouer ◽  
Salah Akkal ◽  
Claire Debarnot ◽  
Bruno Canard ◽  
Uwe J. Meierhenrich ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Hepatitis C ◽  
Chemical Composition ◽  
Essential Oil ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

The chemical composition of the essential oil of Saccocalyx satureioides Coss. et Dur. (Lamiaceae) was analyzed by chiral and achiral GC/MS and 42 components were identified. The main constituents were (+)-α-terpineol (35.9%), thymol (15.6%) and borneol (12.4%). The in vitro antibacterial and antifungal activities of the essential oil were assessed by the disc diffusion method, and were significant on the six microorganisms tested. A moderate inhibitory activity against hepatitis C virus polymerase was also evidenced.

scholarly journals Antimicrobial Activity and In Silico Molecular Docking Studies of Pentacyclic Spiro[oxindole-2,3′-pyrrolidines] Tethered with Succinimide Scaffolds

2021 ◽  
Vol 12 (1) ◽  
pp. 360
Author(s):  
Sonia Askri ◽  
Amal Dbeibia ◽  
Chadlia Mchiri ◽  
Sarra Boudriga ◽  
Michael Knorr ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Structural Complexity ◽  
Cascade Reactions ◽  
Docking Studies ◽  
Trna Synthetase ◽  
Pharmacokinetic Studies ◽  
Spectroscopic Techniques ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Three-component cascade reactions of (E)-3-arylidene-1-methyl-pyrrolidine-2,5-diones, L-valine and various isatin derivatives are described. A series of 17 spiropyrrolidine derivatives with wide structural complexity and diversity have been thus obtained in moderate to excellent yields under mild reaction conditions. The structure and stereochemistry of these N-heterocyclic cycloadducts has been established by spectroscopic techniques and unambiguously confirmed by a single-crystal X-ray diffraction analysis performed on one derivative. UV-visible spectra have been recorded for all new compounds. Furthermore, the synthesized N-heterocyclic compounds have been screened for their in vitro antibacterial and antifungal activities. Several derivatives exhibited moderate to good activities, comparable to those of the known standard drugs Amphotericin B and Tetracycline. Structural activity relationships (SARs) and molecular docking of the most promising derivatives into the binding sites of glucosamine 6-phosphate synthase (GlcN6P) and methionyl-trna-synthetase (1PFV) were also established. Furthermore, pharmacokinetic studies indicate that the heterocycles exhibit acceptable predictive ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties and good drug ability.

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