scholarly journals Persistence of respiratory symptoms among COVID-19 survivors

2021 ◽  
pp. 19-21
Author(s):  
Mohammed Mirazur Rahman ◽  
AKM Mosharraf Hossain ◽  
Mohammed Atiqur Rahman ◽  
Shamim Ahmed ◽  
Rajashish Chakrabortty ◽  
...  
Keyword(s):  
Observational Study ◽  
Respiratory Symptoms ◽  
Respiratory Medicine ◽  
Cross Sectional ◽  
Persistent Symptoms ◽  
Medical University

This cross-sectional observational study was conducted among COVID-19 patients at Department of Respiratory Medicine, Bangabandhu Sheikh Mujib Medical University from July 2020 to December 2020. During follow-up around three months (90.62±2.21days) after the onset of the first COVID-19 symptoms, 500 patients were taken as the study sample. Our study aimed to assess the persistent symptoms in patients who were discharged from the hospital after recovery from COVID-19. This study has shown that persistent respiratory symptoms were common after COVID-19 and the majority of patients were symptom-free three months after COVID-19 onset. BSMMU J 2021; 14 (COVID -19 Supplement): 19-21

scholarly journals Evaluation of Myelosupression during Imatinib Mesylate Therapy in Patients with Chronic Myeloid Leukaemia

2020 ◽  
Vol 15 (2) ◽  
pp. 189-192
Author(s):  
Lutfunnahar Khan ◽  
Masuma Ahmed Salsabil ◽  
Jannatul Ferdous ◽  
Md Rezwonul Haque
Keyword(s):  
Imatinib Mesylate ◽  
Kinase Inhibitor ◽  
Myeloproliferative Neoplasm ◽  
Chronic Phase ◽  
Study Data ◽  
Military Hospital ◽  
Cross Sectional ◽  
Drug Of Choice ◽  
Medical University

Introduction:Chronic Myloid Leukaemia (CML) is a myeloproliferative neoplasm that originates in an abnormal pluripotent stem cell. Imatinib, a tyrosine kinase inhibitor, is the drug of choice for CML in the present time. During therapy, a few patients develop myelosuppression and present with cytopenias. Objectives: To evaluate myelosupression during therapy with Imatinib mesylate in patients with Chronic myloid leukaemia in chronic phase. Materials and Methods: This cross sectional observational study was carried out at department of Haematology, Combined Military Hospital, Dhaka and Haematology OPD, Bangabandhu Sheikh Mujib Medical University (BSMMU) from October 2011 to September 2012. A total of 30 patients fulfilling the inclusion criteria were included in this study. Data were collected in a structured proforma, analyzed with SPSS and expressed in mean, frequency and percentage. Results: Patients mean age was 38.96±9.37 years ranging from 23 to 56 years. Among 30 study subjects, male and female patients were 22(73%) and 08(27%) respectively. Most of the patients presented with generalized weakness (83.3%), weight loss (53.3%), fever (26.7%), pain abdomen (36.6%) and fullness of abdomen (33.3%). Twenty (66.67%) cases develop anaemia, 02(10%) cases leucopenia, 07(23.33%) cases thrombocytopenia and 11(36.6%) patients develop different combination of bicytopenia and 2% patients developed pancytopenia after being treated with Imatinib. Conclusion:   Various degrees of myelosupression with cytopenias may occur in few patients of CML on Imatinib therapy. Regular hematologic follow-up is required so that the drug may be stopped or dose modified as per the individual’s needs. JAFMC Bangladesh. Vol 15, No 2 (December) 2019: 189-192

scholarly journals Status of microsatellite instability in different histomorphological patterns of colorectal carcinoma among a group of Bangladeshi people

2021 ◽  
Vol 8 (12) ◽  
pp. 1799
Author(s):  
Momammed Mustafizur Rahman ◽  
Shabnam Imam ◽  
Sayedatun Nessa ◽  
A. K. M. Maruf Raza ◽  
Farida Arjuman ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Observational Study ◽  
Microsatellite Instability ◽  
University Hospital ◽  
Biological Behavior ◽  
Cancer Tissue ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference ◽  
Medical University

Background: This cross- sectional observational study was carried out with an aim to look for microsatellite instability (MSI) status in colorectal carcinoma and their association with different histomorphological patterns and biological behavior of colorectal carcinoma.Methods: This cross-sectional observational study was done in the Department of Pathology, Bangabandhu Sheikh Mujib Medical University Hospital (BSMMU), Dhaka, Bangladesh during September 2014 to October 2015. A total of 39 surgically resected sample of colorectal carcinoma were included. Consent from each patient was taken. The samples were histopathologically evaluated according to the standard protocol. The statistical analyses were done using Statistical packages for social sciences (SPSS 15) for Windows.Results: A total of 39 cases of colorectal carcinoma were included in this study. Majority of the patients (55.5%) was in 6th decade in MSI and 29.1% were MSI absent group. The mean age was found 47.67±10.97 years in present group and 47.84±14.26 years in absent group. The difference was not statistically significant (p>0.05). TNM stage with MSI was observed. The mean CEA level was 100.74±103.66 and 60.43±91.72. The mean Hb was 9.72±1.99 % and 9.92±2.17, the range was 7.2-12.2 and 4.6-13.4 among the groups. The mean difference was not statistically significant (p>0.05). Ulcerated was 3 (33.3%) and 19 (64.5%). Stage 3 tumor was 4 (44.4%) and 16 (51.6%). Grade 2 tumor was 5 (55.6%) and 17 (58.0%).Conclusions: For the first time in Bangladesh, this study was undertaken to evaluate the microsatellite instability (MSI) status in colorectal cancer tissue and their association with different histomorphological patterns of colorectal carcinoma.   

scholarly journals Impact of dexamethasone on persistent symptoms of COVID-19: an observational study

2021 ◽  
Author(s):  
Alice Milne ◽  
Nick Maskell ◽  
Charlie Sharp ◽  
Fergus W Hamilton ◽  
David T Arnold
Keyword(s):  
Observational Study ◽  
Significant Proportion ◽  
Symptom Burden ◽  
Life Assessment ◽  
Persistent Symptoms ◽  
Dexamethasone Group ◽  
Related Quality ◽  
Health Related ◽  
The Uk

Introduction Dexamethasone has been shown to reduce mortality for patients hospitalised with acute COVID-19 pneumonia. However, a significant proportion of patients suffer persistent symptoms following COVID-19 and little is known about the longer-term impact of this intervention on symptom burden. Methods Patients initially hospitalised with COVID-19 were prospectively recruited to an observational study (April-August 2020) with follow-up at 8 months (Dec 2020-April 2021) post-admission. A review of ongoing symptoms using a standardised systems-based proforma was performed alongside health-related quality of life assessment. In the UK, patients with COVID-19 (requiring oxygen) only received dexamethasone following the pre-print of the RECOVERY trial (June 2020), or as part of randomisation to that trial, allowing for a comparison between patients treated and not treated with dexamethasone. Results Between April to August 2020, 198 patients were recruited to this observational study. 87 required oxygen and were followed up at 8-months, so were eligible for this analysis. Of these 39 received an inpatient course of dexamethasone (cases) and 48 did not (controls). The groups were well matched at baseline in terms of age, comorbidity and frailty score. Over two-thirds of patients reported at least 1 ongoing symptom at 8-month follow-up. Patients in the dexamethasone group reported fewer symptoms (n=73, 1.9 per patient) than the non-dexamethasone group (n=152, 3.2 per patient) (p = 0.01). Conclusions In conclusion, in this case-control observational study, patients who received oral dexamethasone for hospitalised COVID-19 were less likely to experience persistent symptoms at 8-month follow-up. These are reassuring results for physicians administering dexamethasone to this patient group.

Short Paper: Risk Factors for Long-Term Persistent Symptoms in COVID-19 in an Outpatient Cohort (Preprint)

2020 ◽  
Author(s):  
James O'Keefe ◽  
Ghazala A Datoo O’Keefe ◽  
Anthony Mufarreh
Keyword(s):  
Risk Factors ◽  
Categorical Variables ◽  
Short Paper ◽  
Symptom Duration ◽  
Continuous Variables ◽  
Cross Sectional ◽  
Persistent Symptoms ◽  
Long Term Follow Up

BACKGROUND Symptom descriptions in outpatients with COVID-19 are limited to cross-sectional surveys and longitudinal follow-up of long term symptoms has not been reported. Symptom duration is important for patient and provider knowledge in managing outpatient COVID-19. OBJECTIVE Describe the presence of symptoms at long term follow-up of patients managed in an outpatient telemedicine program for acute COVID-19. METHODS Chart review of clinical notes for acute COVID-19 and long term follow-up calls. Descriptive analysis were conducted using Wilcoxon rank-sum for continuous variables and chi-square or Fisher’s Exact as appropriate for categorical variables. RESULTS Minor symptoms were reported by 55 patients (34.8%) and 7 (4.4%) reported major ongoing symptoms at follow-up call. Factors associated with prolonged symptoms include older age, provider reported higher symptom severity at intake visit, and BMI >30. Symptoms which persisted include shortness of breath on exertion, wheeze, nausea, and joint pain. CONCLUSIONS Persistence of symptoms after acute COVID-19 in outpatients is common. Risk factors may help predict which patients are more likely to have prolonged symptoms.

scholarly journals DEMMI Scores, Length of Stay, and 30-Day Readmission of Acute Geriatric Patients in Denmark: A Cross-Sectional Observational Study with Longitudinal Follow-Up

Geriatrics ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 8 ◽  
Author(s):  
Dorte Melgaard ◽  
Maria Rodrigo-Domingo ◽  
Marianne M. Mørch ◽  
Stephanie M. Byrgesen
Keyword(s):  
Length Of Stay ◽  
Observational Study ◽  
Geriatric Patients ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Mobility Index ◽  
Sit To Stand ◽  
The Mean ◽  
Mobility Aid

The aims of this study are to describe the mobility of acute geriatric patients, the length of stay, and to characterise patients who were readmitted within 30 days based on the De Morton Mobility Index (DEMMI). A cross-sectional observational study with longitudinal follow-up was conducted in the period from 1 March 2016 to 31 August 2016. Inclusion criteria were acute geriatric patients hospitalised for a minimum of 24 h. Of the 418 patients hospitalised during the study period, 246 (59%) participated in this study (44% male, median age 83 years [70; 94]). For patients in an acute geriatric department, the median DEMMI score was 41 and the mean score was 39.95. Patients with a DEMMI score ≤40 show a significantly lower Barthel 100 index, lower 30 s. sit-to-stand scores and were significantly more likely to be bedridden or, amongst those not bedridden, to use a mobility aid. Lower DEMMI scores were associated with longer admissions. DEMMI seems to have the ability to predict discharge within one week. There was no significant association between a lower DEMMI score and higher risk for 30-day readmission. Further research is needed to determine whether the DEMMI is suitable for identifying the patient’s need for further rehabilitation following the discharge.

scholarly journals Ultrasound screening for fetal abnormalities

2016 ◽  
Vol 10 (2) ◽  
Author(s):  
Shazia Khalid Khan ◽  
Shahida Sheikh ◽  
Amatullah Zarreen
Keyword(s):  
Risk Factors ◽  
Observational Study ◽  
Congenital Malformations ◽  
Mode Of Delivery ◽  
Ultrasound Screening ◽  
Cross Sectional ◽  
Incidence Risk ◽  
Pattern Diagnosis ◽  
Recent Trends

The aim of the study was to review the recent trends in the incidence, risk factors, pattern, diagnosis and management of various congenital anomalies in our population. This cross-sectional, observational study included sixty pregnant women aged 20-35 years. Mode of delivery was decided after considering all these aspects. Total eight (13.3%) fetuses had congenital malformations. The follow-up of these ladies revealed that 26 (43.3%) were lost on follow-up, so the incidence of congenital malformations at birth was found to be 5.8%.

scholarly journals Prevalence of unmet needs for spasticity management in care home residents in the East Midlands, United Kingdom: a cross-sectional observational study

2019 ◽  
Vol 33 (11) ◽  
pp. 1819-1830 ◽  
Author(s):  
Laura Edwards ◽  
Benjamin Ellis ◽  
Clare Donnellan ◽  
Hanan Osman ◽  
Naseer Haboubi ◽  
...  
Keyword(s):  
United Kingdom ◽  
Observational Study ◽  
Unmet Needs ◽  
Care Home ◽  
Unmet Need ◽  
Passive Movement ◽  
Cross Sectional ◽  
The United Kingdom ◽  
East Midlands

Objective: To establish the prevalence of unmet need for spasticity management in care home residents in two counties of the United Kingdom. Design: Cross-sectional observational study with a six-month follow-up arm for participants with identified unmet needs. Setting: 22 care homes in Derbyshire and Nottinghamshire. Subjects: 60 care home residents with upper motor neuron syndrome–related spasticity. Interventions: No intervention. When unmet needs around spasticity management were identified, the participant’s general practitioner was advised of these in writing. Main measures: Resistance to Passive Movement Scale to assess spasticity; recording of (a) the presence of factors which may aggravate spasticity, (b) potential complications of spasticity, (c) spasticity-related needs and (d) current interventions to manage spasticity. Two assessors judged the presence or absence of needs for spasticity management and whether these needs were met by current care. Results: Out of 60 participants, 14 had no spasticity-related needs; 46 had spasticity-related needs; 11 had needs which were being met by current care and 35 participants had spasticity-related needs at baseline which were not being met by their current care. These were most frequently related to the risk of contracture development or problems with skin hygiene or integrity in the upper limb. In total, 6 participants had one or more pressure sores and 35 participants had one or more established joint contractures. A total of 31 participants were available for follow-up. Informing general practitioners of unmet needs resulted in no change to spasticity management in 23/31 cases. Conclusion: Care home residents in this study had high levels of unmet need for spasticity management.

scholarly journals Opt-out bloodborne virus screening: a cross-sectional observational study in an acute medical unit

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e022777
Author(s):  
Niamh Allen ◽  
Collette Faherty ◽  
Andre Davies ◽  
Anne Lyons ◽  
Margarent Scarry ◽  
...  
Keyword(s):  
Observational Study ◽  
Routine Practice ◽  
Tertiary Referral Hospital ◽  
Cross Sectional ◽  
Medical Unit ◽  
Acute Medical Unit ◽  
Panel Testing ◽  
Opt Out ◽  
Lost To Follow Up

ObjectiveRecent treatment developments for HIV, hepatitis C virus (HCV) and hepatitis B virus (HBV) have greatly improved prognoses. Current screening practices are mainly risk based and are suboptimal. Improved efforts are critically needed to identify persons with these viruses. The aims of this study were to assess the feasibility of an opt-out bloodborne virus (BBV) screening programme in an acute medical unit (AMU) and to describe the prevalence of HIV, HBV and HCV in this population.Design and settingThis was a cross-sectional observational study in the AMU of a tertiary referral hospital in Galway, a city in the west of Ireland.Participants1936 patients entered the study; 54% were male, mean age was 53.1 years (SD 19.6). During the study period, all patients attending the AMU aged ≧16 years who were having bloods drawn and who had the ability to verbally consent for an additional blood sample met the inclusion criteria for the study.ResultsOver 44 weeks, 1936/4793 (40.4%) patients consented to BBV panel testing. Diagnosed prevalence rates for HIV, HBV and HCV were 0.5/1000, 2/1000 and 1.5/1000, respectively. There was one HIV-positive result; the patient was already engaged in care. Four patients tested positive for HBV surface antigen; one new diagnosis, one previously lost to follow-up and two already engaged in care. Three patients had active HCV infection; two had been lost to follow-up and are now linked back into services.ConclusionBBV testing uptake of 40.4% is higher than previous studies in AMU settings that used opt-in strategies, but lower than expected, possibly due to not incorporating testing into routine practice. The diagnosed prevalence of HBV is notable as little data currently exist about its prevalence in Ireland. These data are valuable in order to inform further prevention strategies for these infections in low-prevalence settings.

scholarly journals Clinical and Radiological Outcomes of Recovered COVID-19 Patients- An Observational Study during the Early Phase of Pandemic

2021 ◽  
Author(s):  
Disha Atul Padalkar ◽  
Medha Bargaje ◽  
Purwa Prakash Doke ◽  
Sarosh Gilani ◽  
Varad Nadkarni ◽  
...  
Keyword(s):  
Observational Study ◽  
Pulmonary Rehabilitation ◽  
Severe Disease ◽  
Multivariate Logistic Regression Analysis ◽  
Medical Attention ◽  
Post Discharge ◽  
Cross Sectional ◽  
Health Crisis ◽  
Persistent Symptoms ◽  
The Impact

Introduction: The pandemic caused by the Coronavirus Disease 2019 (COVID-19) has caused huge economic and health crisis. It is reported to have pulmonary sequelae which can overburden the healthcare systems. Survivors needing medical attention in the form of pulmonary rehabilitation should be prioritised. Aim: To study the impact of COVID-19 infection in terms of the pulmonary and extrapulmonary sequelae. Materials and Methods: This cross-sectional observational study was carried out at a tertiary hospital in India. Recovered COVID-19 patients who were admitted from April to July 2020 were enrolled. Participants with radiological evidence of pneumonia during hospitalisation were assessed two months post-discharge. They were evaluated for persistent symptomatology, chest radiography, Six-Minute Walk Test (6MWT). The relationship between the outcome parameters with the baseline epidemiology, laboratory and radiology were evaluated by using student t-test, Mann- Whitney U test and multivariate logistic regression analysis. Results: Thirty participants were recruited. Their mean age was 47.93 years. Males were more than females. Persistent symptoms were reported by 17 (56.66%) and 4 (13.33%) developed pulmonary fibrosis on Chest X-Ray (CXR). Prolonged hospitalisation (mean >20 days) strongly correlated to the fibrosis (p=0.022). A fall in the finger oxygen saturation after the 6MWT was significant (p≤0.001). Higher serum levels of lactate dehydrogenase and D-dimer were associated with a more severe disease (p=0.02 and p≤0.001, respectively). Conclusion: Convalescent phase of COVID-19 is characterised by persistent symptomatology in half of the recovered patients. Simple and inexpensive CXRs and the 6MWT can be used as the primary investigation to identify post COVID-19 patients requiring pulmonary rehabilitation in resource limited settings.

Sign in / Sign up

Export Citation Format

Share Document