scholarly journals Antimicrobial Activity of Metal Cystine Complexes

1970 ◽  
Vol 5 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Jahan Ara Khanam ◽  
Most. Ferdousi Begum ◽  
Jesmine Ara ◽  
Mele Jesmin ◽  
M Abu Taher ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Cytotoxic Activity ◽  
Full Text ◽  
Antimicrobial Activities ◽  
Biologically Active ◽  
The Other ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Cytotoxic Studies

Metal cystine complexes of nickel(II), mercury(II) and cadmium(II) have been synthesized and their antimicrobial activities have been evaluated. It is found that mercury(II) cystine and cadmium(II) cystine complexes have pronounced antibacterial and antifungal activities. On the other hand nickel(II) cystine shows moderate activities. The LC50 values of nickel(II) cystine, mercury(II) cystine and cadmium(II) cystine are found to be 5.2, 8.0 and 7.2 ?g ml-1, respectively. These values were obtained from cytotoxic studies indicating that they are biologically active compounds. Key words: Antimicrobial activity, Cytotoxic activity; Metal amino acid complexes. Dhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

Evaluation of In vitro Antimicrobial and In vivo Cytotoxic Properties of Peroxo Coordination Complexes of Mg(II), Mn(II), Fe(II) & Ni(II)

1970 ◽  
Vol 3 (1) ◽  
Author(s):  
Kudrat E Zahan ◽  
MD. Shamin Hossain ◽  
Shuranjan Sarkar ◽  
Md. Mukhlesur Rahman ◽  
Md. Akhter Farooque ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Cytotoxic Activity ◽  
Full Text ◽  
Brine Shrimp ◽  
Coordination Complexes ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Six newly synthesized nickel peroxo coordination complexes, [Mg2(2-ap)2(O2)(OH), A], [Mn(2-ap) (ED)(O2), B], [Fe(2-ab)(ED)(O2), C], [Fe(2-ap)(ED)(O2), D], [Ni2(2-ab)2(O2)(OH), E] and [Ni2(2-ap)2(O2)(OH), F] showed significant antibacterial and antifungal activities. The minimum inhibitory concentrations (MIC) of these compounds were found in the range of 8-128 µg/ml. Among these compounds, F showed maximum cytotoxicity (LC50 = 3.62 µg/ml) in brine shrimp lethality bioassay. Key words: Peroxo coordination complexes; Antimicrobial activity; antifungal activity; cytotoxic activity. Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Synthesis and Evaluation of Antimicrobial and Cytotoxic Activity of Oxathiine-Fused Quinone-Thioglucoside Conjugates of Substituted 1,4-Naphthoquinones

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3577
Author(s):  
Yuri E. Sabutski ◽  
Ekaterina S. Menchinskaya ◽  
Ludmila S. Shevchenko ◽  
Ekaterina A. Chingizova ◽  
Artur R. Chingizov ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Cytotoxic Activity ◽  
Antimicrobial Activities ◽  
Biologically Active ◽  
Hydroxyl Group ◽  
Diffusion Method ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
High Cytotoxic Activity ◽  
Derivatives Of

A series of new tetracyclic oxathiine-fused quinone-thioglycoside conjugates based on biologically active 1,4-naphthoquinones and 1-mercapto derivatives of per-O-acetyl d-glucose, d-galactose, d-xylose, and l-arabinose have been synthesized, characterized, and evaluated for their cytotoxic and antimicrobial activities. Six tetracyclic conjugates bearing a hydroxyl group in naphthoquinone core showed high cytotoxic activity with EC50 values in the range of 0.3 to 0.9 μM for various types of cancer and normal cells and no hemolytic activity up to 25 μM. The antimicrobial activity of conjugates was screened against Gram-positive bacteria (Staphylococcus aureus, Bacillus cereus), Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), and fungus Candida albicans by the agar diffusion method. The most effective juglone conjugates with d-xylose or l-arabinose moiety and hydroxyl group at C-7 position of naphthoquinone core at concentration 10 µg/well showed antimicrobial activity comparable with antibiotics vancomicin and gentamicin against Gram-positive bacteria strains. In liquid media, juglone-arabinosidic tetracycles showed highest activity with MIC 6.25 µM. Thus, a positive effect of heterocyclization with mercaptosugars on cytotoxic and antimicrobial activity for group of 1,4-naphthoquinones was shown.

scholarly journals Antibacterial Potential of Citral Derivatives

2011 ◽  
Vol 6 (9) ◽  
pp. 1934578X1100600
Author(s):  
Soni A. Singh ◽  
Yogesh A. Potdar ◽  
Rasika S. Pawar ◽  
Sujata V. Bhat
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Activities ◽  
Serial Dilution ◽  
Disc Diffusion ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Antibacterial Potential

Nine conjugated acid derivatives from monoterpene citral have been synthesized using ester, amide condensations, Wittig, Knoevenagel, Baylis-Hillman reactions and their antimicrobial activities were evaluated through disc diffusion and serial dilution methods. Several derivatives displayed interesting antimicrobial activity. Particularly, the Baylis-Hillman adducts 8-10 were found to have more potent antibacterial and antifungal activities than standard drugs namely chloramphenicol and nystatin respectively.

scholarly journals Synthesis and Antimicrobial Activity of 7-Hydroxy-3',4'-Methylenedioxy- and 7-Benzyloxy-3',4'-Methylenedioxy Flavanones

2017 ◽  
Vol 9 (3) ◽  
pp. 297-306 ◽  
Author(s):  
R. Ali ◽  
A. Rahim ◽  
A. Islam
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
The Other ◽  
Antifungal Activities ◽  
Fungal Strains ◽  
Antibacterial And Antifungal Activities ◽  
Other Hand ◽  
Antibacterial And Antifungal

7-Hydroxy-3',4'-methylenedioxy- and 7-benzyloxy-3',4'-methylenedioxy flavanones have been synthesized starting from 2,4-dihydroxyacetophenone. Subsequently biocidal activities of the flavanones have been investigated along with their corresponding chalcones against some bacterial and fungal strains. 2'-Hydroxy-4'-benzyloxy-3,4-methylenedioxy chalcone (5) and its corresponding flavanone (7) showed good antibacterial and antifungal activities against some selected bacterial and fungal strains. On the other hand, 2',4'-dihydroxy-3,4-methylenedioxy chalcone (4) showed no antibacterial and antifungal activities while its corresponding flavanone (6) showed a little antibacterial activity only at higher concentration but did not show antifungal activity. The synthesized chalcones and flavanones have been characterized using UV-Vis, IR and 1H NMRspectral data together with elemental analysis.

scholarly journals Synthesis and Antimicrobial Activity of Pyrimidine Salts with Chloranilic and Picric Acids

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
C. Mallikarjunaswamy ◽  
D. G. Bhadregowda ◽  
L. Mallesha
Keyword(s):  
Antimicrobial Activity ◽  
The Other ◽  
Spectral Studies ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Uv Visible ◽  
Antibacterial And Antifungal

Pyrimidine salts such as 2-methyl-5-nitro-phenyl-(4-pyridin-3-yl-pyrimidin-2-yl)-amine (1) and 4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-yl-amino)-phenyl-amine (2) with chloranilic and picric acids were synthesized, and theirin vitroantibacterial and antifungal activities were evaluated. The synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, and1H NMR spectral studies. Compound2aexhibited good inhibition towards antimicrobial activity compared to the other compounds.

scholarly journals Synthesis and Antimicrobial Activity of Novel Benzoxazoles

2012 ◽  
Vol 67 (9-10) ◽  
pp. 466-472 ◽  
Author(s):  
Mustafa Arisoy ◽  
Ozlem Temiz-Arpaci ◽  
Fatma Kaynak-Onurdag ◽  
Selda Ozgen
Keyword(s):  
Antimicrobial Activity ◽  
Inhibitory Concentration ◽  
Antimicrobial Activities ◽  
Microbial Pathogens ◽  
Drug Resistant ◽  
Dilution Technique ◽  
Spectral Techniques ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
New Compounds

A series of 2-(p-substituted-benzyl)-5-[[4-(p-chloro/fluoro-phenyl)piperazin-1-yl]ace tamido] -benzoxazoles were synthesized in need of new compounds for the fight against microbial pathogens. Their structures were elucidated by spectral techniques. These new derivatives, along with previously synthesized 2-(p-substituted-benzyl)-5-substituted-benzoxazoles, were evaluated for their antibacterial and antifungal activities against standard strains and drugresistant isolates in comparison with ampicillin, gentamicin sulfate, ofloxacin, vancomycin, fluconazole, and amphotericin B trihydrate. The minimum inhibitory concentration (MIC) of each compound was determined by a two-fold serial dilution technique. The compounds were found to possess a broad spectrum of antimicrobial activities with MIC values of 32 - 256 μg/ml. Although standard drugs were more active against the pathogenes employed in this study, the activities of the new benzoxazoles and reference drugs against drug-resistant isolates of the microorganisms were largely similar

scholarly journals Synthesis, Antibacterial, and Antifungal Activities of Hybrid Molecules Based on Alzheimer Disease Drugs and Bearing an Amino Acid Fragment

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 23 ◽  
Author(s):  
Radoslav Chayrov ◽  
Aleksandra Tencheva ◽  
Hristina Sbirkova-Dimitrova ◽  
Boris Shivachev ◽  
Anna Kujumdzieva ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Alzheimer Disease ◽  
Fungal Infections ◽  
Biological Properties ◽  
X Ray ◽  
Antibacterial And Antifungal Activities ◽  
Acid Fragment ◽  
Hybrid Molecules ◽  
Antibacterial And Antifungal

The objective of the current study was to develop novel compounds–memantine derivatives with antimicrobial activity designed for application in treatment of bacterial and fungal infections in patients suffering from Alzheimer’s disease. To realize this objective, a series of six memantine hybrid molecules were synthesized, characterized by 1H NMR, 13C NMR, MS, X-ray, and tested for their biological properties as anti-Alzheimer agents and their antimicrobial potential.

scholarly journals Facile heterocyclic synthesis and antimicrobial activity of polysubstituted and condensed pyrazolopyranopyrimidine and pyrazolopyranotriazine derivatives

2015 ◽  
Vol 65 (4) ◽  
pp. 399-412 ◽  
Author(s):  
Hend N. Hafez ◽  
Abdulrahman G. Alshammari ◽  
Abdel-Rhman B. A. El-Gazzar
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Agents ◽  
Ammonium Thiocyanate ◽  
Oxidative Cyclization ◽  
The Other ◽  
Secondary Amines ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Abstract Reaction of 6-amino-3-methyl-4-(substituted phenyl)-1,4- dihydropyrano[2,3-c]pyrazole-5-carbonitrile (1) with triethylorthoformate followed by treatment with hydrazine hydrate, formic acid, acetic acid, phenylisocyanate, ammonium thiocyanate and formamide afforded the corresponding pyranopyrimidine derivatives 2-6. Cyclocondensation of 1 with cyclohexanone afforded pyrazolopyranoquinoline 7. One-pot process of diazotation and de-diazochlorination of 1 afforded pyrazolopyranotriazine derivative 8, which upon treatment with secondary amines afforded 9 and 10a- c. Condensation of 2 with aromatic aldehyde gave the corresponding Schiff bases 11a,b, the oxidative cyclization of the hydrazone with appropriate oxidant afforded 11-(4- fluorophenyl))- 2-(4-substituted phenyl)-10-methyl-8,11-dihydropyrazolo-[ 4’,3’:5,6]pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines (12a,b). Structures of the synthesized compounds were confirmed by spectral data and elemental analysis. All synthesized compounds were evaluated for antibacterial and antifungal activities compared to norfloxacin and fluconazole as standard drugs. Compounds 9, 10c, 12a and 15 were found to be the most potent antibacterial agents, with activity equal to that of norfloxacin. On the other hand, compound 5 exhibited higher antifungal activity compared to fluconazole.

scholarly journals Synthesis, Physicochemical Properties and Antimicrobial Activities of Nickel(II) Complexes of 4,4,4-Trifluoro-1-(2-Naphthyl)-1,3-Butanedione and Their Adducts

2018 ◽  
Vol 10 (4) ◽  
pp. 1
Author(s):  
Helen Oluwatola Omoregie
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Physicochemical Properties ◽  
Elemental Analysis ◽  
Antimicrobial Activities ◽  
Octahedral Geometry ◽  
Spectral Measurements ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Nickel(II) complex of 4,4,4-trifluoro-1-(2-Naphthyl)-1,3-butanedione(tfnb) and its 2,2′-bipyridine (bipy), ethylenediamine (en) and 1,10-phenanthroline (phen) adducts were synthesized and characterized by elemental analysis, infrared, electronic spectral, magnetic susceptibility measurements and antimicrobial activities. Three other nickel(II) compounds were synthesized along with these compounds. The bands in the 1651-1513 cm-1 have been assigned as ν(C=O) + ν(C=C). The infrared and electronic spectral measurements are indicative of a probable six-coordinate octahedral geometry for all the nickel(II) complexes and adducts. The antimicrobial activity shows that [Ni(tfnb)2]2H2O complex and its adducts have no antibacterial and antifungal activities.

Synthesis & Anticancer Evaluation of New Substituted 2-(3,4- Dimethoxyphenyl)benzazoles

2019 ◽  
Vol 15 (3) ◽  
pp. 287-297 ◽  
Author(s):  
Cigdem Karaaslan ◽  
Yalcin Duydu ◽  
Aylin Ustundag ◽  
Can O. Yalcin ◽  
Banu Kaskatepe ◽  
...  
Keyword(s):  
Hela Cells ◽  
Parp Inhibitor ◽  
A549 Cells ◽  
Human Tumor ◽  
Antimicrobial Activities ◽  
Sodium Metabisulfite ◽  
Human Tumor Cell Lines ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Mitotic Inhibitor

Background: The benzazole nucleus is found in many promising small molecules such as anticancer and antibacterial agents. Bendamustine (Alkylating agent), Nocodazole (Mitotic inhibitor), Veliparib (PARP inhibitor), and Glasdegib (SMO inhibitor) are being clinically used as anticancer therapeutic which bear benzimidazole moiety. Based on the principle of bioisosterism, in the present work, 23 compounds belonging to 2-(3,4-dimethoxyphenyl)benzazoles and imidazopyridine series were synthesized and evaluated for their anticancer and antimicrobial activities. Objective: A series of new 2-(3,4-dimethoxyphenyl)-1H-benz(or pyrido)azoles were synthesized and evaluated for their anticancer and antimicrobial activities. Method: N-(5-chloro-2-hdroxyphenyl)-3,4-dimethoxybenzamide 1, was obtained by the amidation of 2-hydroxy-5-chloroaniline with 3,4-dimethoxybenzoic acid by using 1,1&'-carbonyldiimidazole. Cyclization of 1 to benzoxazole derivative 2, was achieved by p-toluenesulfonic acid. Other 1H-benz(or pyrido)azoles were prepared by the reaction between 2-aminothiophenol, ophenylenediamine, o-pyridinediamine with sodium metabisulfite adduct of 3,4-dimethoxybenzaldehyde. The NMR assignments of the dimethoxy groups were established by the NOESY spectra. Results: Compound 12, bearing two chlorine atoms at the 5(4) and 7(6) positions of the benzene moiety of benzimidazole was found the most potent analogue against A549 cells with the GI50 value of 1.5 μg/mL. Moreover, 24 showed remarkable cell growth inhibition against MCF-7 and HeLa cells with the GI50 values of 7 and 5.5 μg/mL, respectively. The synthesized compounds have no important antibacterial and antifungal activities. Conclusion: It could be concluded that the introduction of di-chloro atoms at the phenyl ring of 2-(3,4-dimethoxyphenyl)-1H-benzimidazoles increases significant cytotoxicity to selected human tumor cell lines in comparison to other all benzazoles synthesized. Unsubstituted 2-(3,4- dimethoxyphenyl)-imidazopyridines also gave good inhibitory profile against A549 and HeLa cells.

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