scholarly journals Comparative Study between the Effect of Induction Chemotherapy with 66 Gy Three Dimensional Conformal and 46 Gy Conventional Radiotherapy in Stage Iii Non- Small Cell Lung Cancer

2017 ◽  
Vol 12 (1) ◽  
pp. 18-24
Author(s):  
Asma Siddiqua ◽  
Md Nizamul Haque ◽  
Sheikh Golam Mostofa ◽  
Md Moarraf Hossain ◽  
Qamruzzaman Chowdhury
Keyword(s):  
Induction Chemotherapy ◽  
Statistical Significance ◽  
Intervention Group ◽  
Three Dimensional ◽  
Skin Toxicity ◽  
Complete Response ◽  
Stage Iii ◽  
Control Group ◽  
Radiological Response ◽  
Stage Iii Nsclc

A quasi experimental study was carried out among 60 stage III NSCLC patients attending at Radiation Oncology Department of National Institute of Cancer Research & Hospital, Mohakhali, Dhaka from August 2012 to July 2013. Patients were divided into group A and group B purposively to receive Induction Chemotherapy followed by conventional or 3D CRT respectively. The study was designed to observe the radiological response and acute toxicity of stage III NSCLC with induction CT and 3DCRT. Treatment related morbidity was more observed in the intervention group with 43.3% Grade ?2 Pneumonitis, 43.4% Grade ?2 Oesophagitis, 40% Grade 2 skin toxicity and 6.7% Grade?3 anemia. Regarding metastasis, 33.3% patients in the intervention arm and 30% patients in the control arm had presented with metastasis at different sites within this six months period. No statistically significance was found between these two groups (p = .781). Death during follow up was observed in 6.7% patients in the intervention group and 3.3 % patients in the control arm which was of no statistically significance difference. (p = 1.00). Complete response was found in 23.3 % patients in intervention group while in control group it was only 6.7%. Partial response was 46.7% and 43.3% respectively. No response was seen in 36.6% patients; 13.3% in the intervention group and 23.3% in the control group. More patients in control group (26.7%) were reported with progressive disease. No statistical significance was found regarding the radiological response between these two arms (p=.114). Both complete and overall responses were better in intervention group than control group.Faridpur Med. Coll. J. Jan 2017;12(1): 18-24

Safety study of induction chemotherapy and synchronous radiotherapy (RT) and cetuximab in stage III non-small cell lung cancer (NSCLC): SCRATCH (Cohort I)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 18032-18032 ◽  
Author(s):  
S. R. Hughes ◽  
J. L. Liong ◽  
A. Miah ◽  
S. Ahmad ◽  
M. Leslie ◽  
...  
Keyword(s):  
Induction Chemotherapy ◽  
Initial Dose ◽  
Performance Status ◽  
Locally Advanced ◽  
Skin Toxicity ◽  
Stage Iii ◽  
Study Cohort ◽  
Neck Carcinoma ◽  
Stage Iii Nsclc ◽  
Grade 3

18032 Background: The addition of cetuximab can increase the efficacy of chemotherapy for advanced NSCLC. Concomitant cetuximab and RT is superior to RT alone for locally advanced squamous cell head & neck carcinoma. The SCRATCH study (cohort I) is a phase I study to assess the safety of synchronous cetuximab and radical RT in patients with Stage III NSCLC. Methods: Cohort I will contain 12 patients with inoperable stage III NSCLC. Inclusion criteria are performance status 0–1, adequate organ function, and disease encompassable within a radical RT volume. Exclusion criteria are previous malignancy, thoracic RT or treatment with EGFR targeted therapy. Patients receive platinum-based induction chemotherapy, followed by weekly intravenous cetuximab (initial dose 400mg/m2; maintenance dose 250mg/m2) and concomitant RT (64Gy/32fractions/45days). The primary end-point is toxicity. NCI Common Toxicity Criteria (CTC) V3.0 assessments are performed weekly during radiotherapy, and at regular follow-up visits. Results: Data from the first 9 patients is available. 2 patients stopped receiving cetuximab early due to toxicity. 1 experienced grade 3 fatigue following the initial dose, and the other declined further treatment after developing grade 2 skin toxicity. 2 patients have died, 1 from disease progression and 1 from thromboembolic disease. Both deaths occurred between months 2 and 4 post RT and were not attributed to the cetuximab therapy. Of the 7 living patients, 2 have survived 1 year (measured from the first day of induction chemotherapy). The maximum NCI CTC V3.0 scores are summarised in the table below. Conclusions: The results suggest that the early and late toxicities of synchronous cetuximab and radical RT are acceptable. Data on all 12 patients will be available by June 2007. SCRATCH Study cohorts II-IV follow on and will recruit sequentially. They will assess the safety of adding concomitant cisplatin (±vinorelbine) to cetuximab and radical RT. [Table: see text] No significant financial relationships to disclose.

scholarly journals Jacobson and Truax Method: evaluation of the clinical effectiveness of a home care program after prostatectomy

2018 ◽  
Vol 26 (0) ◽  
Author(s):  
Luciana Regina Ferreira Pereira da Mata ◽  
Mariana Ferreira Vaz Gontijo Bernardes ◽  
Cissa Azevedo ◽  
Tânia Couto Machado Chianca ◽  
Maria da Graça Pereira ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Home Care ◽  
Clinical Significance ◽  
Statistical Significance ◽  
Intervention Group ◽  
Nursing Intervention ◽  
Telephone Counseling ◽  
Control Group ◽  
Teaching Program ◽  
Knowledge Variable

ABSTRACT Objective: to exemplify the applicability of the Jacobson and Truax Method in a nursing intervention study that analyzed the effectiveness of a home care teaching program after radical prostatectomy. Method: this is a descriptive study concerning the applicability of the Jacobson and Truax Method in the data analysis of a clinical trial. The intervention consisted of a teaching program for hospital discharge after radical prostatectomy through oral guidance, writing, and telephonic reinforcement. Thirty-four men participated in the intervention group and 34 men participated in the control group. A reliable index of change and clinical significance was calculated for the knowledge variable in both groups. Scatterplots were presented to demonstrate the effectiveness of the method. Results: for 30 individuals in the intervention group, the intervention presented clinically relevant change than in knowledge. In the control group, none of the 34 individuals presented clinical significance of the results related to this variable, that is, the statistical significance identified by the inferential tests did not have clinically relevant changes in the knowledge variable. Conclusion: the educational intervention carried out through the combination of oral, written and telephone counseling was shown to be clinically effective in improving knowledge about home care.

A Randomized Study to Assess the Impact of Pharmacist Counseling of Employer-Based Health Plan Beneficiaries With Diabetes

2011 ◽  
Vol 25 (2) ◽  
pp. 169-179 ◽  
Author(s):  
Dale F. Kraemer ◽  
Wayne A. Kradjan ◽  
Theresa M. Bianco ◽  
Judi A. Low
Keyword(s):  
Diabetes Management ◽  
Statistical Significance ◽  
Glycosylated Hemoglobin ◽  
Randomized Study ◽  
Intervention Group ◽  
Control Group ◽  
Counseling Intervention ◽  
Care Plans ◽  
Pharmacist Counseling ◽  
The Impact

Objective: To assess the impact of pharmacist counseling on empowering people with diabetes to better self-care. Introduction: Community-based pharmacists can play a key role in educating and empowering people in such programs. Methods: A randomized trial compared the effects of pharmacist counseling (intervention group) with printed materials (control group) in diabetic beneficiaries of several employer-based health care plans. All participants also received waiver of out-of-pocket expenses for diabetic-related medications and supplies. Clinical, humanistic, and claim outcomes were evaluated at baseline and at 1 year follow-up. Results: Sixty-seven beneficiaries participated in this study. The 0.50% decrease from baseline in glycosylated hemoglobin (A1c) was statistically significant ( P = .0008) in the intervention group and the difference between the groups approached statistical significance ( P = .076). Beneficiaries in both groups had greater claim costs for diabetic-related medications and supplies during the study year. Both groups also improved in ability to manage their diabetes with the counseling group showing a significantly better understanding of diabetes ( P = .0024). Conclusion: There was a trend toward improvement in A1c in patients counseled by pharmacist with an increased utilization of diabetes-related medications and supplies. Counseling also improved diabetes knowledge and empowered patients to better diabetes management.

scholarly journals Impact of ascorbic acid in reducing the incidence of vancomycin associated nephrotoxicity in critically ill patients: A preliminary randomized controlled trial

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 929
Author(s):  
Nouran Hesham El-Sherazy ◽  
Naglaa Samir Bazan ◽  
Sara Mahmoud Shaheen ◽  
Nagwa A. Sabri
Keyword(s):  
Ascorbic Acid ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Statistical Significance ◽  
Intervention Group ◽  
Secondary Outcome ◽  
Control Group ◽  
Control Groups ◽  
The Absolute ◽  
And Control

Background Antioxidants show nephroprotective effect against vancomycin associated nephrotoxicity (VAN) in animals. This study aimed to assess the ascorbic acid nephro-protective role against VAN clinically. Methods Forty-one critically ill patients were randomly assigned to one of two groups: intervention group (vancomycin IV plus ascorbic acid, n=21) or control group (vancomycin IV only, n=20). Primary outcomes were the incidence of VAN and the absolute change in creatinine parameters, while mortality rate was the secondary outcome. Nephrotoxicity was defined as an increase in serum creatinine (S.cr) by at least 0.5 mg/dL or 50% of baseline for at least two successive measurements. This study is registered at Clinicaltrials.gov (NCT03921099), April 2019. Results Mean absolute S.cr increase was significant when compared between both groups, P-value = 0.036, where S.cr increased by 0.05(0.12) and 0.34(0.55) mg/dL in the intervention and control groups, respectively. Mean absolute Cr.cl decline was significant when compared between both groups, P-value = 0.04, where Cr.cl was decreased by 5.9(17.8) and 22.3(30.4) ml/min in the intervention and control groups, respectively. Incidence of VAN was 1/21(4.7%) versus 5/20(25%) in the intervention and control groups, respectively (RR: 0.19; CI: 0.024–1.49; P-value = 0.093). Mortality was higher in the control group; however, it was not statistically significant, P-value = 0.141. Conclusion Co-administration of ascorbic acid with vancomycin preserved renal function and reduced the absolute risk of VAN by 20.3%, however, the reduction in VAN incidence didn’t reach statistical significance level. Further large multicenter prospective trials are recommended.

Impact of Multimodal Cognitive Training on Cognitive Traits of Children: A Multicentric Interventional Study

2021 ◽  
Author(s):  
Manjunatha R ◽  
Praveen Pankajakshan ◽  
Alphonsa Joseph ◽  
Gyan Kashyap ◽  
Usha Manjunath ◽  
...  
Keyword(s):  
Cognitive Training ◽  
Statistical Significance ◽  
Intervention Group ◽  
Control Group ◽  
Sleep State ◽  
Eyes Closed ◽  
Before And After ◽  
Slow Sleep ◽  
Mini Mental Status Examination ◽  
External Behavior

Abstract In this article, we evaluate the hypothesis that a multimodal cognitive training (MCT) program, the Brighter Minds, can enhance certain inherent traits of a child and thus bring changes in the external behavior. For the study, 186 children (randomized to 93 each in intervention and control group) aged 10-15 years were enrolled from three different locations. Psychometric tests, parental/caregiver interviews and EEG (electroencephalography) tests were conducted before and after the program. Intervention group showed strong statistical significance for improvements in Mini Mental Status Examination (MMSE) (P<0.01) but no significance for Raven’s Standard Progrssive Matrices (SPM) or Susan Harter’s test. The parental/caregiver reported satistically significant improvements in focus (P<0.05), empathy (P<0.05), intuition (P<0.05), comprehension (P<0.05) and understanding of abstract concepts (P<0.05) for the intervention group. For the control, Power Spectral Density (PSD) of the baseline eyes-closed (EC) EEG recording, the spectrum below 20Hz exhibited the characteristic “1/f” spectral scaling of the power-law. This signature matches prior reported evidence in literature of those in wakeful state with EC. The intervention group EC PSD, however, exhibited a signature similar to those in a slow sleep state; reflective of the possible transfer effect of the training on other skills like relaxation. We used unsupervised learning methods with dice distance, on the psychometric and interview data, to show the effect of location and the exposure of a few control children to the program.

P-5 A phase II trial of paclitaxel carboplatin and gemcitabine as induction chemotherapy for stage III NSCLC

Lung Cancer ◽  
2003 ◽  
Vol 41 ◽  
pp. S92
Author(s):  
Carmelo Giannitto Giorgio ◽  
Salvino Saita ◽  
Franco Marletta ◽  
Stefano Cordio ◽  
Dario Giuffrida ◽  
...  
Keyword(s):  
Induction Chemotherapy ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Stage Iii ◽  
Stage Iii Nsclc

Gefitinib (ZD-1839) with concurrent docetaxel and conformal three-dimensional thoracic radiation followed by consolidative docetaxel/gefitinib for patients with stage III NSCLC: A phase I study

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 18165-18165
Author(s):  
A. Blackstock ◽  
J. Petty ◽  
T. Oaks ◽  
M. Porosnicu ◽  
H. Clark ◽  
...  
Keyword(s):  
Phase I ◽  
Dose Level ◽  
Three Dimensional ◽  
Maximum Tolerated Dose ◽  
Stage Iii ◽  
3 Dimensional ◽  
Thoracic Radiation ◽  
Stage Iii Nsclc ◽  
Experienced Grade ◽  
Grade Iii

18165 Background: The safety of 3-dimensional (3D) conformal thoracic radiation delivered with concurrent gefitinib/docetaxel chemotherapy in patients with inoperable stage III NSCLC has not been evaluated. Methods: Patients with inoperable stage III NSCLC received weekly intravenous (i.v.) docetaxel starting at a dose of 15 mg/m2 escalating to 30 mg/m2 in 5 mg/m2 increments and daily gefitinib (250 mg given orally). Patients recieved concurrent thoracic radiation to a dose of 70 Gy utilizing 3-D techniques. The chemoradiation therapy was followed by 2 cycles of consolidative docetaxel (75 mg/m2) given q 21 days and gefitinib 250 mg p.o. for 1 year or until disease progression. Results: Beginning December 2003, 15 patients have been entered to date to this IRB approved phase I trial to determine the maximum tolerated dose of weekly docetaxel when given concurrent with gefitinib and thoracic radiation. The dose-limiting toxicities (DLT) observed were primarily non-hematologic and occured at dose level 3 (25 mg/m2). One patient experienced grade III esophagitis that resulted in a grade III dehydration, a second patient experienced grade III diarrhea while a third patient suffered a grade V interstitial pneumonitis, believed to be related to the gefinitib. While 14 of 15 patients completed the chemoradiation portion of the study and 2 patients completed all planned therapy, 4 patients progressed during therapy, 3 patients discontinued treatment due to toxicity, and 2 patients refused to continue treatment. The median and 1-year survival thus far is 21 months and 56%, respectively. Conclusions: 70 Gy conformal thoracic radiation and concurrent gefitinib/docetaxel thus far appears feasible but with modest toxicity. The study is currently enrolling patients at the weekly 20 mg/m2 docetaxel dose level concurrent with 250 mg of daily gefitinib. This study was supported in-part by Sanofi-Aventis and Astra Zeneca. No significant financial relationships to disclose.

Temporal bone Pneumatization in Otosclerosis

2008 ◽  
Vol 139 (6) ◽  
pp. 850-853 ◽  
Author(s):  
Daniel T. Ganc ◽  
Robert W. Jyung
Keyword(s):  
Temporal Bone ◽  
Statistical Significance ◽  
Three Dimensional ◽  
Neck Surgery ◽  
Adult Patients ◽  
Control Group ◽  
Test Analysis ◽  
Temporal Bone Pneumatization ◽  
History Of ◽  
Temporal Bones

Objectives To determine whether there is a difference in the pneumatization of temporal bones with otosclerosis versus normal temporal bones. Methods A retrospective study of 46 ears from 24 adult patients with otosclerosis and 64 ears from 47 adult patients in a control group. The study group included temporal bone CT scans available from patients with otosclerosis. The control group consisted of patients who had temporal bone CTs for reasons likely unrelated to a history of middle ear disease. Data were obtained with a virtual reality system that allows three-dimensional manipulation and analysis. Results The temporal bone pneumatization for the otosclerosis group was 4.82 ± 2.27 cm3 vs 6.06 ± 2.71 cm3 for the control group. Two-sample t test analysis revealed no statistical significance ( P = 0.059) between pneumatization in the control vs otosclerosis groups. Conclusion There is no difference in temporal bone pneumatization between patients with otosclerosis and a control population. Therefore, temporal bone pneumatization by itself is not an adequate explanation for the apparent protective effect of otosclerosis against otitis media. © 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.

scholarly journals The Effect of Baduanjin on Promoting the Physical Fitness and Health of Adults

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ran Li ◽  
Li Jin ◽  
Ping Hong ◽  
Zi-Hong He ◽  
Chuan-Ye Huang ◽  
...  
Keyword(s):  
Physical Fitness ◽  
Statistical Significance ◽  
Intervention Group ◽  
Blood Lipid ◽  
The Body ◽  
Control Group ◽  
Triceps Brachii ◽  
Fitness And Health ◽  
Subcutaneous Adipose ◽  
Lower Corner

The purpose of study was to assess the efficacy of a 16-week Baduanjin qigong training intervention in promoting physical fitness and health for adults. An experimental design was adopted, and subjects were assigned randomly into an experimental group (n=55) and a control group (n=55). In the intervention group comprised of adults, there were no significant variations in blood glucose, blood lipid, blood pressure, heart rate variability, and vital capacity indices. The body weight and body mass index (BMI) dropped in the intervention group. Compared with the control group, the skinfold thicknesses decreased at lower corner of scapula, triceps brachii, and abdomen, with a statistical significance (P<0.001;P=0.005;P=0.003). By comparing the physical fitness indices, it was found that the increase of the results of sit-and-reach test in the intervention group had statistical significance (P=0.001). In conclusion, it was found by our trial that Baduanjin exercise could significantly improve the physical flexibility and subcutaneous adipose accumulation in the healthy adults.

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