scholarly journals Comparative efficacy of Telakucha (Coccinia indica) leaves and Amaryl(R) Tablet (Glimepiride) in induced diabetes mellitus in rat

1970 ◽  
Vol 6 (2) ◽  
pp. 335-339
Author(s):  
A Amanullah ◽  
M Mostofa ◽  
BS Ahmed ◽  
AR Das
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
The Body ◽  
Comparative Efficacy ◽  
Group A ◽  
Coccinia Indica ◽  
Group B ◽  
Schedule Dose

Thirty healthy rats of both sexes weighing between 150 to 200 gm were selected from among the offspring and randomly divided into six equal groups and rats of Group A and Group B were kept as non hypoglycemic control and hypoglycemic control, respectively. After acclimatization hyperglycemia was induced in five groups of rats (B,C,D,E and F) by administering streptozotocin (STZ) intraperitoneally at a dose of 55 mg/kg body weight. After fifteen days of STZ injection, four groups of rats (C,D,E and F) were administered with Telakucha (Coccinia indica) and Amaryl(R) (Glimepiride) as per schedule dose and all the control and treated rats were closely observed during 14 days of treatment.The oral administration over 14 days of Telakucha (Coccinia indica) leaves extract significantly lowered blood glucose level but was not so potent as patent drug Amaryl(R) (Glimepiride). The herbal preparation also increased body weight but not to the extent caused by the patent drug Amaryl(R) . The Telakucha leaves at 750mg/kg body weight significantly reduced (30.73%) the blood glucose level from 31.24±0.36 mmol/L to 21.64±0.17 mmol/L and significantly increased (5.45%) the body weight from 181.96±21.10g to 191.87±12.42 g. Keywords: Glimepiride; streptozotocin; Telakucha; Diabetes DOI: 10.3329/jbau.v6i2.4831 J. Bangladesh Agril. Univ. 6(2): 335-339, 2008

scholarly journals Comparative study of hypoglycemic effects of oral vildagliptin and voglibose on fasting blood sugar level in albino rats

2021 ◽  
Vol 9 (2) ◽  
pp. 542
Author(s):  
Mukesh Kumar ◽  
Mukesh Kumar ◽  
Akash Chandra ◽  
Uma Shankar Prasad Keshri ◽  
Rajiv Kumar
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Fasting Blood Glucose ◽  
Fasting Blood Sugar ◽  
Group A ◽  
Group B

Background: Diabetes mellitus is a metabolic disorder in which there is increased blood sugar level, glycosuria, dyslipidemia and sometimes ketonemia occurs. Increased blood sugar level leads to characteristic symptoms such as polydipsia, polyurea, blurring of vision, polyphagia and weight loss.Methods: Healthy male Wister rats weighing between 150-250 gm were taken. Total 2 groups A and B were prepared and each group contains 6 animals. Group A was administered voglibose as 0.6 mg/70 kg body weight. Group B was administered vildagliptin as 100 mg/70 kg body weight. Diabetes was induced in group A and B by administration of 120 mg/kg body weight of nicotinamide and 60 mg/kg body weight of streptozocin intraperitoneally. Streptozocin was administered after 15-20 minutes of administration of nicotinamide. After 72 hours of streptozotocin injection, fasting blood glucose level was determined and induction of diabetes was confirmed. The fasting blood samples were collected from all the groups on further days 7, 14, 21 and 28 day to determine the glucose level by glucometer. Results: The decline in fasting blood sugar level by voglibose was 36.4% on day 7, 40.2% on day 14, 43.94% on day 21 and 46.4% on day 28. The reduction in Fasting blood sugar level by vildagliptin was 49% on day 7, 52.25% on day 14 and 54% on day 21 and 28. Thus in group B rats, decline was maximal on day 7 and little fall was recorded on subsequent days. It suggests good efficacy as vildagliptin normalized the blood glucose level effectively.  Conclusions: Vildagliptin was found significantly more effective in lowering fasting blood glucose level than voglibose.

Hepatoproective Nature of Aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model

2021 ◽  
pp. 3716-3720
Author(s):  
Pooja Pooja ◽  
Mazumder Avijit ◽  
Soumya Das
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Standard Drug ◽  
Liver Marker Enzymes

Diabetes is a chronic disease which characterized by hyperglycemia (elevated or abnormally high blood sugar levels) and other metabolic disturbances, including metabolism of lipids and haemostasis. Caesalpinia pulcherrima has previously showed strong anti-diabetic and hepatoprotective potential. The present research work was to investigate the anti-diabetic activity and hepatoprotective activity Caesalpinia pulcherrima in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 45days oral treatment with methanol extract of plant (200 and 300mg/kg) of CPAE on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration methanolic extract of Caesalpinia pulcherrima of showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of Caesalpinia pulcherrima has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug metformin and hence might be of use in the management of diabetes.

scholarly journals Effects of Crude Extract of Neem Bark on the Pancreas of Streptozotocin Induced Diabetic Wistar Rats

2019 ◽  
pp. 1-9
Author(s):  
A. J. Ajibade ◽  
E. O. James ◽  
B. D. Kehinde
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Crude Extract ◽  
Wistar Rats ◽  
Enzymatic Activities ◽  
Diabetic Group ◽  
Bark Extract ◽  
Group A ◽  
Group B

This study investigated the histological and serum enzymatic activities of Azadirachta indica, an Indian medicinal plant, on the pancreas in streptozotocin induced diabetic adult wstar rats. Forty six adult wistar rats weighing 100 g to 220 g were randomly separated into four groups; Group A was regarded as the control , while group B was the diabetic group, C and diabetic – extract treated group. The control group received distilled water throughout the experiment; the remaining three groups were induced with streptozotocin intra-peritoneally to induced diabetes in the wistar rats. After some days, the animals were confirmed diabetic with the help of a measuring glucometer. Thereafter, group B diabetic rats remained untreated while Group C and D were treated with a low dose (250 mg/kg) of the crude neem bark extract and a high dose (500 mg/kg) of the extract respectively for 42 days. The aqueous neem bark extract was suspended in the drinking water of the treated animals for the period of 42 days. The body weights of the animals were weighed weekly and likewise the measurement of the blood glucose level was taken. The animals were sacrificed at the end of 42 days by cervical dislocation and the pancreas was removed and weighed immediately using sensitive weighing balance. The blood samples were collected from the sacrificed animals into EDTA bottle for serum enzymatic analysis. The organ pancreas was fixed in a 10% formol saline, processed and stained with Heamatoxylin and Eosin for general histological study. The microscopic examination of diabetic group showed some degenerative and necrotic cells which made the pancreatic tissue distorted compared with the control that appeared normal. The diabetic group C and D rats treated with the extract showed ameliorative potentials of the extract with improvement in histo-architecture of the pancreatic tissue following recovery from damage. Analysis of the blood serum level showed that the aqueous neem bark extract has ameliorative effect on the enzymatic activities in serum of the treated rats. The alanine amino transferase, aspartate amino transferase and alkaline phosphatase levels were significantly reduced (P<0.05) in the crude extract- treated animals compared with the untreated group B and control group A with significantly increased ( P<0.05 ) enzymatic activities in wistar rats in these groups. The antioxidant status was compromised in diabetic group B with significantly increased (P<0.05) LPO, reduced SOD and GSH compared with significantly reduced (P<0.05) LPO, increased (P<0.05) SOD and GSH in group A- control and Group C and D diabetic-extract treated Wistar rats. Similarly, the blood glucose level increased significantly (P<0.05) in group B diabetic group compared with significantly reduced (P<0.05) blood glucose level in group A control as well as C and D extract-treated rats. The study concluded that crude extract of neem has ameliorative potentials on streptozotocin-induced diabetic wistar rats characterized by oxidative damage which reveals improvement in tissue morphology.

scholarly journals Anti-diabetic Activity of Ethanolic Extract of Elaeocarpus serratus L. in Streptozotocin-Induced Diabetic Rats

2016 ◽  
Vol 8 (01) ◽  
Author(s):  
DH Geetha ◽  
Indhiramuthu Jayashree ◽  
M. Rajeswari
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Liver Marker Enzymes

To investigate the anti-diabetic activity of Elaeocarpus serratus fruit in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 30days oral treatment with ethanol extracts of fruit (200 and 400 mg/kg) of E. serratus on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration ethanolic extract of fruit of E. serratus showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of E. serratus has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug glibenclamide and hence might be of use in the management of diabetes.

scholarly journals EFFECTIVENESS OF BALANCE AND TAI CHI EXERCISE IN EARLY TYPE II DIABETIC AMONG FEMALE POPULATION

2018 ◽  
Vol 11 (5) ◽  
pp. 305
Author(s):  
Rajalaxmi V ◽  
Vijaya Priya V ◽  
Ramachandran S ◽  
Latha S
Keyword(s):  
Blood Glucose ◽  
Waist Circumference ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Tai Chi ◽  
Post Test ◽  
Group A ◽  
The Mean ◽  
Tai Chi Exercise ◽  
Group B

Objective: India is considered to be a diabetic capital as many Indians are diabetic. The common treatment for diabetes is medication. The purpose of this study is to bring out the other remedial measures for diabetic treatment and to create awareness among the people about the alternative measures. This study is about the effect of balancing exercise and tai chi exercises for early diabetic. It is, therefore, possible that an individual can experience a noticeable decreased in blood glucose following a balancing exercise and modified tai chi program. This study is to find out the effect of balancing exercise and tai chi program and to compare the effectiveness.Methods: Once the study is approved by the institutional review board, 50 samples from 65 volunteers with Type 2 diabetes between the age group of 25–35 years were selected from the ACS Medical College and Hospitals based on the inclusion criteria. After getting the consent, the samples were equally divided into two groups; Group A: Balancing exercise and Group B: Tai chi exercise. Both groups received intervention for 8 weeks 6 days/ week 2 sessions/day. Pre- and post-test was done using the outcome measures of blood glucose levels (glucometer), body mass index, and waist circumference (inch tape).Result: On comparing the mean values of waist circumference and blood glucose level between Group A and B, both the groups showed significant reduction in the post-test values. However, Group B tai chi for diabetes shows the mean (34.4) which is effective than the Group A (38.5) for waist circumference (in inches) and also Group B (156.70) is effective than the Group A (184.10) for blood glucose level (mg/dL) at p≤0.05.Conclusion: The study concluded that the balancing exercise and tai chi exercise are effective in the reduction of blood glucose level and waist circumference. However, tai chi is more effective than the balancing exercise.

scholarly journals Comparative efficacy of two medicinal plants and Amaryl® tablet (Glimepiride) in induced diabetes mellitus in rat

1970 ◽  
Vol 6 (2) ◽  
pp. 297-300
Author(s):  
PC Das ◽  
M Mostofa ◽  
AK Sarkar ◽  
M Ali
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Concentration ◽  
The Body ◽  
Antidiabetic Activity ◽  
Herbal Extracts ◽  
Comparative Efficacy ◽  
Trigonella Foenum Graecum ◽  
Coccinia Indica

Comparative efficacy of two indigenous herbal extracts, (Trigonella foenum-graecum seed & Coccinia indica leaves) with the commonly used drug Glimepiride were studied. Healthy young rats (n=30) of both sexes weighting between 150 to 200 gm were selected and divided into six equal groups, as A (Control), B (diabetic), experimental diabetic groups were-C, D, E and F, treated with combined extract of Methi seed and Telakucha leaves- @ 250mg, 500mg, 750mg and Glimepiride 800μg/kg body weight, respectively. The substances were given orally once daily for14 days. The blood glucose concentration were decreased significantly (P<0.01) in groups C, D, E, and F. The body weight increased significantly (P<0.05) by 2.3%, 3.9%, 4.8% and 10.4%, respectively. The herbal extracts significantly reduced in blood glucose level with the increased in body weight. It is indicated that antidiabetic activity of Trigonella foenum-graecum and Coccinia indica are evident that are traditionally used as the herbal preparations by the Ayurvedic practitioners for the control of diabetes mellitus. Keywords: Trigonella foenum graecum; Coccinia indica; Amaryl® Tablet (Glimepiride); Streptozotocin and antidiabetic effect; Diabetes mellitus; Rat DOI: 10.3329/jbau.v6i2.4825 J. Bangladesh Agril. Univ. 6(2): 297-300, 2008

scholarly journals Effect of bitter melon and garlic on blood glucose level and blood cholesterol level in rats in diabetic condition

2018 ◽  
Vol 5 (3) ◽  
pp. 359-363 ◽  
Author(s):  
Rupaly Akhter ◽  
Imrul Hasan Rasel ◽  
Mohammad Saiful Islam
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Dose Rate ◽  
Cholesterol Level ◽  
Glucose Level ◽  
The Body ◽  
Blood Cholesterol ◽  
Bitter Melon ◽  
Blood Cholesterol Level

The aim of this research was designed to investigate the single and combine effect of bitter melon and garlic on blood glucose level and blood cholesterol level in rats in diabetic condition. In this study 60 rats (12 normal rats and 48 alloxan induced diabetic rats) was used for trials. The rats were divided into 5 groups for each trial, each containing 12 individuals as follows: First group was normal control (A), Second group was diabetic control (B), third group was alloxan with bitter melon treated (C). Group D was alloxan and Garlic treated and Group E was alloxan, bitter melon, garlic treated. Then alloxan injection was injected at the dose rate of 100mg/kg body weight intraperitoneally to each rate to induce diabetes in groups B, C, D and E. On 10th day blood glucose level, blood cholesterol level and the body weights were measured for the first time to ensure diabetic induction as well as hypercholesterolemia. Then all the rats of that group were kept for more 21 days for the treatment of hyperglycemia and hypercholesterolemia. During that period on Day 0, 7, 14 and 21st the body weight, blood cholesterol level and blood glucose level were measured. Aqueous extract of bitter melon and garlic were fed at a dose rate of 300mg/kg and 500 mg/kg body weight for 21 days in group C and D respectively and combine in group E. The blood sugar level and blood cholesterol level were reduced in bitter melon, garlic & combine treatment groups compare with untreated group. From these findings it is concluded that the combination of bitter melon and garlic can be used as anti-hyperglycemic and anti- hypercholesterolemic agent. Res. Agric., Livest. Fish.5(3): 359-363, December 2018

scholarly journals Escalating BMI Associated With the Complex Pharmacology of Propranolol: A Case Report

2020 ◽  
pp. 19-24
Author(s):  
Deena M. S. Barrouq ◽  
Tareq Irshaidat
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Treatment Protocol ◽  
The Body ◽  
Case Presentation ◽  
The Public ◽  
Increased Risk ◽  
Health Complications

Background: Improving the awareness of the public about the body weight and the body mass index (BMI) criteria is very important as increased body weight may be associated with an increased risk for many dangerous diseases and health complications. Propranolol is generally prescribed for tachycardia while its most common side effects are bradycardia and masking hypoglycemia. Case Presentation: A tachycardia was diagnosed in a young overweight woman and treated successfully with propranolol but this treatment, unpredictably, was associated with a rapid increase in the weight that classified her as obese. Discussion: The physical (body weight and heart rate) and the biochemical (blood glucose level) monitoring and analysis including the lifestyle provided a deeper insight into the principal details and helped to design a personalized treatment protocol.   Conclusion: A therapeutic dose of propranolol could be linked to uncommon mounting weight change which was associated with a decrease in the blood glucose level and an appetite enhancement.

scholarly journals Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Olubanke O. Ogunlana ◽  
Babatunde O. Adetuyi ◽  
Miracle Rotimi ◽  
lohor Esalomi ◽  
Alaba Adeyemi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Seed Extract ◽  
The Body ◽  
High Concentration ◽  
Group 5

Abstract Background Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characterized by persistent hyperglycemic properties. This global disorder harms organs of the body such as the liver, kidney and spleen. Medicinal plants such as Hunteria umbellate have been shown to possess hypoglycemic, antioxidative and anti-diabetic properties owing to the high concentration of active phytochemical constituents like flavonoids and alkaloids. The present study seeks to evaluate the hypoglycemic activities of ethanolic seed extract of Hunteria umbellate on streptozotocin-induced diabetes rats. Methods Thirty (30) female experimental rats were randomly divided into five groups with six rats per group and were administered streptozotocin (STZ) and Hunteria umbellate as follows. Group 1 served as control and was given only distilled water, group 2 rats were administered 60 mg/kg STZ; Group 3 was administered 60 mg/kg STZ and 100 mg/kg metformin; group 4 rats were administered 60 mg/kg STZ and 800 mg/kg Hunteria umbellate, group 5 rats 60 mg/kg STZ and 400 mg/kg Hunteria umbellate. The fasting blood glucose level of each rat was measured before sacrifice. Rats were then sacrificed 24 h after the last dose of treatment. Results The results showed that Hunteria umbellate significantly reversed STZ-induced increase in fasting blood glucose and increase in body and organs weight of rats. Hunteria umbellate significantly reversed STZ-induced decrease in antioxidant enzyme in liver, kidney and spleen of rats. Hunteria umbellate significantly reversed STZ-induced increase in oxidative stress markers in liver, kidney and spleen of rats. Conclusion Collectively, our results provide convincing information that inhibition of oxidative stress and regulation of blood glucose level are major mechanisms through which Hunteria umbellate protects against streptozotocin-induced diabketes rats.

Antidiabetic potential of polyphenolic-rich fraction of Tamarindus indica seed coat in alloxan-induced diabetic rats

2018 ◽  
Vol 29 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Santosh Singh Bhadoriya ◽  
Aditya Ganeshpurkar ◽  
Ravi Pratap Singh Bhadoriya ◽  
Sanjeev Kumar Sahu ◽  
Jay Ram Patel
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Seed Coat ◽  
Optimum Dose ◽  
Phytochemical Analysis ◽  
Tamarindus Indica ◽  
Tropical Fruit ◽  
Isolated Rat

AbstractBackground:Tamarindusis a monotypic genus and belongs to the subfamily Caesalpinioideae of the family Leguminosae (Fabaceae),Tamarindus indicaL., commonly known as Tamarind tree is one of the most important multipurpose tropical fruit tree species in the India, Sudan, Nigeria, Bangladesh and entire subcontinent.Methods:Hydroethanolic seed coat extract ofTamarindus indica(HETI) was assessed for presence of phytoconstituents and selection of optimum dose through acute and sub acute toxicity study. The single and multidose (14 days) study were conducted to evaluate antidiabetic potential of HETI in alloxan induced rats via determine of blood glucose level, body weight, hematological profile, extra-pancreatic glucose utilization of isolated rat hemi-diaphragm as well as histopathology of rat pancreas.Results:Phytochemical analysis of HETI showed the presence of polyphenol like flavonoids. Single and multidose of HETI significantly (p<0.05; p<0.001) reduced blood glucose level in normoglycaemic, glucose loaded and alloxan induced hyperglycaemic animals. HETI exerts the protective effect on pancreatic β-cells as per results obtained from histopathology of animals. Moreover, HETI increased glucose uptake in isolated rat hemi-diaphragm and prevents decrease in body weight along with recovery of altered hematological parameters.Conclusions:The study revealed that HETI have potent hypoglycaemic action by virtue of its phytoconstituents and it can be used as a herbal medicine for diabetes.

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