scholarly journals Serum Zinc, Copper and Calcium Levels In Female Rheumatoid Arthritic Patients

2012 ◽  
Vol 7 (1) ◽  
pp. 18-22
Author(s):  
Arifa Alam Jelly ◽  
Shelina Begum ◽  
Sultana Ferdousi
Keyword(s):  
Rheumatoid Arthritis ◽  
Colorimetric Method ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Serum Copper ◽  
Copper Level ◽  
Cross Sectional ◽  
Healthy Female ◽  
Copper Zinc ◽  
Medical University

Background: Rheumatoid Arthritis is a chronic multi-system autoimmune inflammatory disease,  characterized by inflammatory synovitis involving symmetrical peripheral joints. Serum copper, zinc  and calcium levels are altered in Rheumatoid Arthritis.Objective: To observe serum zinc, copper and  calcium levels in patients with Rheumatoid Arthritis (RA).Methods: This cross sectional study was  conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University  (BSMMU), Shahbag, Dhaka from January to December 2010. For this, 60 female patients with  Rheumatoid arthritis aged 30-50 years were included in the study group. The patients were selected  from outpatient Department of Rheumatology wing of medicine in Bangabandhu Sheik Mujib Medical  University (BSMMU). For comparison age and BMI matched 30 apparently healthy female were also  studied. Serum calcium level was measured by Colorimetric method. Serum zinc and copper was  measured by Spectrophotometric method. For statistical analysis, independent sample t test was  performed by using SPSS for windows version-12.Results: In this study, serum zinc and calcium  levels were significantly lower (p<0.001) and serum copper level was significantly higher (p<0.001) in  the RA patients than those of control.Conclusion: This study may conclude that hypozincemia and  hypocalcemia and hypercupremia occur in RA. Therefore early detection of these micronutrient  abnormalities may be helpful for the physicians to prevent various complications in RA patients. DOI: http://dx.doi.org/10.3329/jbsp.v7i1.11155 J Bangladesh Soc Physiol. 2012, June; 7(1): 18-22

Estimation of Trace Elements in Gingival Crevicular Fluid and Serum-Comparative Study in Healthy and Periodontitis

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Bhagavathami Meenaksh ◽  
Chitraa R. Chandran ◽  
Aravindhan Thathchari Ranganathan ◽  
Kavindapadi Venkateswaran Rama ◽  
Valarmathy Srinivasan
Keyword(s):  
Trace Elements ◽  
Inductively Coupled Plasma ◽  
Gingival Crevicular Fluid ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Serum Copper ◽  
Cross Sectional ◽  
Inductively Coupled ◽  
Significant Difference ◽  
Copper Zinc

Background: This study aims to determine and compare the levels of trace elements copper, zinc, selenium and chromium in GCF and serum of patients with periodontitis and healthy individuals. Methods: This cross sectional study includes 24 study subjects recruited from the patients reporting to the Department of Periodontics , Tagore Dental College Chennai. All the selected patients were subjected to a clinical examination done by a single examiner. The estimation of trace elements Copper, Zinc, Selenium and Chromium in GCF and serum is performed using Perkin Elmer optima 5300 Inductively Coupled Plasma Emission Spectrometer (ICPOES). Results: GCF and serum copper levels showed no significant difference in both periodontitis and healthy groups . Selenium levels tend to be the same in both groups. Serum zinc levels are more in periodontitis patients than healthy subjects (p less than 0.01). GCF chromium levels are found to be more in patients with periodontitis than healthy. Conclusions : More research is therefore needed to monitor the role of these trace elements C with an increased sample size to ascertain whether they are associated with a reduced risk of periodontitis.

scholarly journals Serum zinc, copper and ferritin levels in transfusion dependent thalassemia patients with iron chelator therapy

2019 ◽  
Vol 14 (1) ◽  
pp. 38-42
Author(s):  
Fatema Tuz Munira ◽  
Shelina Begum
Keyword(s):  
Ferritin Level ◽  
Colorimetric Method ◽  
Serum Zinc ◽  
Study Groups ◽  
Iron Chelator ◽  
Zinc Level ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Zinc Level ◽  
Cross Sectional

Background: Transfusion dependent thalassemia (TDT) patients require regular blood transfusion and iron chelator therapy to maintain their life. Iron chelator may alter serum zinc and copper level in TDT patients. Objective: To observe serum zinc and copper and ferritin levels in transfusion dependent thalassemic patients treated with iron chelator. Method: The present cross sectional study was carried out in the department of Physiology, BSMMU, Dhaka between September 2017 to February 2019. Thirty cases of TDT, aged 5-40 year were included in the study group. Age and sex matched 30 healthy subjects were also studied as control. All the TDT patients were selected from the outpatient Department of Hematology and Transfusion Medicine, BSMMU, Dhaka. Serum zinc was measured by Spectrophotometric method and serum copper and ferritin levels were measured by colorimetric method. For statistical analysis independent sample t test was used. Result: The mean serum zinc level was significantly (p<0.05) lower and serum ferritin level was significantly (p<0.001) higher in TDT compared to control. Again, mean serum copper level and Zn/Cu ratio were not significantly (p>0.05) different in study groups compared to that of control. In addition, 3.3 % TDT patients had hypozincemia and 13.3% TDT patients had hypercupremia. Conclusion: This study may conclude that low serum zinc level and high copper level may be associated with TDT patients treated by combined deferoxamine (DFO) & deferiprone (DFP) iron chelator. J Bangladesh Soc Physiol. 2019, June; 14(1): 38-42

Prognostic factors associating with depression score in male patients; Inflammation, oxidative stress and serum copper and zinc: A cross-sectional study

2020 ◽  
Author(s):  
Majid Ghayour-Mobarhan ◽  
Susan Darroudi ◽  
Batool Tayefi ◽  
Narjes Khalili ◽  
Haniyeh Darroudi ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Cross Sectional Study ◽  
Serum Copper ◽  
Depression Score ◽  
Cross Sectional ◽  
Copper Status ◽  
Two Factors ◽  
Male Patients ◽  
Hs Crp ◽  
Normal Males

Abstract BackgroundThe prevalence of depression increased about 18% during a 10-year period between 2005 and 2015. The aim of the present study was to investigate the association between serum zinc and copper, PAB, SOD and hsCRP in men with depression.MethodsIn this study, 3768 men, were recruited as part of MASHAD study. Demographic, anthropometric and metabolic data measured and recorded for all subjects. The Beck Depression Inventory (BDI) was used for assessing depression in all participants. Serum zinc and copper concentration, hs-CRP, PAB (Pro-oxidant- Antioxidant Balance), and SOD (Superoxide dismutase) were measured in all subjects.Results:The mean level of copper in males with depression is significantly lower than normal males (p < 0.05); despite the lower level of zinc in depressed subjects, this was not significant (p > 0.05). The median of hs-CRP and mean of PAB were significantly higher in depressed subjects (p < 0.001). Logistic regression analysis was performed to determine the odds ratio (OR) for an association of serum zinc, copper, hs-CRP, SOD and PAB with depression in males. The subjects with a serum copper < 80 µg/dl (Q1) had a 1.337 (1.13–1.582) higher chance of depression and the chance of depression increased 1.021(1.013–1.029) with elevating 1 mg/l of serum hs-CRP. 1.021(1.013–1.029). These data remained the same after adjustment for each other’s. Furthermore, our results strongly suggested that hs-CRP and copper were the independent risk factors for depression in male patients.Conclusion:Inflammation and copper status, not zinc concentration, are two factors that may play a role in depression in male patients.

Relationship Between Serum Zinc, Iron and Copper Level and Apoptosis in Human Gastric Mucosa: A Cross-Sectional Study

2011 ◽  
Vol 10 (10) ◽  
pp. 919-924 ◽  
Author(s):  
Beitullah Alipour ◽  
Aida Ghaffari ◽  
Alireza Ostadrahim ◽  
Abdolrasoul Safaiyan ◽  
Jabiz Modaresi ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Copper Level ◽  
Human Gastric Mucosa ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Copper and Copper/Zinc Ratio in a Series of Cystic Fibrosis Patients

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3344
Author(s):  
Marlene Fabiola Escobedo-Monge ◽  
Enrique Barrado ◽  
Carmen Alonso Vicente ◽  
María Antonieta Escobedo-Monge ◽  
María Carmen Torres-Hinojal ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Zinc Deficiency ◽  
Linear Regression Analysis ◽  
Bone Conduction ◽  
Serum Zinc ◽  
Abdominal Ultrasound ◽  
Serum Copper ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Copper Zinc

Cystic fibrosis (CF) patients require a stable and sufficient supply of micronutrients. Since copper is an essential micronutrient for human development, a cross-sectional study was carried out to investigate the serum copper levels, serum copper/zinc (Cu/Zn) ratios, and their relationship with nutritional indicators in a group of CF patients. Anthropometric, biochemical, and dietary measurements, an abdominal ultrasound, and respiratory and pancreatic tests were conducted. Seventeen CF patients were studied (10 females, 59%), 76.5% of whom were ∆F580. Their mean serum copper (113 ± 23 μg/dL) was normal, and there was only one teenager with hypocupremia (6%) and two children with hypercupremia (18%). A significant association between serum copper and zinc levels was discovered. The Cu/Zn ratio was higher than 1.00 for 94% of patients, which is an indicator of an inflammation status. There was no significant correlation between the serum copper concentrations and respiratory and pancreatic function, respiratory colonization, and the results of the abdominal ultrasound. Linear regression analysis showed that serum copper had a positive association with both the Z-score body mass index (BMI) and mean bone conduction speed (BCS). Therefore, since 94% of CF patients had a Cu/Zn ratio > 1.00, this factor must alert us to consider the risk of zinc deficiency and high inflammatory response. The measurement of serum zinc alone does not show one’s zinc status. However, the Cu/Zn ratio may be an indicator of zinc deficiency and the inflammatory status of CF patients.

scholarly journals Serum Levels of Zinc and Copper in Cases of Juvenile Idiopathic Arthritis

2019 ◽  
pp. 1-8
Author(s):  
Hala Salah El Din Talaat ◽  
Mohamed Farouk Mohamed ◽  
Asmaa Ismael Ahmed ◽  
Eman Shafik Shafie
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Serum Level ◽  
Disease Activity ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Copper ◽  
Copper Level ◽  
Cross Sectional ◽  
Female Ratio ◽  
Significant Difference

Background: Juvenile idiopathic arthritis (JIA) represents a heterogeneous group of autoimmune diseases that arises before the age of 16 years and lasts more than 6 months. During acute inflammation of the disease, serum copper concentration increases and zinc decreases, that could point to the possible pharmacological properties of these trace elements. Aim: To measure the serum level of zinc and copper in patients with juvenile idiopathic arthritis (JIA) with different subtypes and correlate the levels of zinc and copper with the disease activity. Methods: This cross-sectional study was done on 40 patients already diagnosed clinically with JIA; patients were followed-up at the Rheumatology Outpatient Clinic, Children's Hospital, Cairo University. Results: Out of forty patients, 16 were males (40%) and 24 were females (60%) with a male to female ratio (M: F) of 1:1.5. Out of the forty patients 17 were in activity and 23 were without activity. Thirty age and sex matched controls were included for comparison. Serum copper level was significantly higher in patients with JIA than those of the controls (P= 0.017) while there were no significant difference in serum level of zinc between JIA patients and that of the controls. Conclusion: Alteration of serum copper and zinc probably is a defense response against JIA; increased copper may be due to inflammation associated, these elements could serve as biomarkers for the disease activity.

scholarly journals Implication of serum zinc level with duration and clinical type of vitiligo

2016 ◽  
Vol 6 (2) ◽  
pp. 99
Author(s):  
Sohail Mirza ◽  
Mohammad Eakub Ali ◽  
Lubna Khondker ◽  
Md. Shirajul Islam Khan ◽  
Nadia Islam ◽  
...  
Keyword(s):  
Large Scale ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference ◽  
Medical University ◽  
The Relationship

<p><strong>Background:</strong> Vitiligo is a common dermatological disorder characterized by acquired, idiopathic, progressive, hypomelanosis of the skin and hair, with total absence of melanocytes microscopically. <strong></strong></p><p><strong>Objective:</strong> The study was conducted to find out the relationship between serum zinc level and clinical spectrum of vitiligo. <strong></strong></p><p><strong>Methods:</strong> A cross sectional study conducted in the departmenl of Dermatology and Venereology and department of Biochemistry, Bang­abandbu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh and the period of study was from May 2010 to October 2011. <strong></strong></p><p><strong>Results:</strong> The mean difference of sernm zinc level in male and female of both groups were significant (p&lt;0.05) but the mean serum zinc level was not significantly different (p&gt;0.05) among various clinical types ofvitiligo. ln case oflocalized vitiligo mean serum zinc level was 755.3 ± 288.6, in case of acrofacial viriligo mean serum zinc level was 821.4 ± 259.6 and in case of generalized vitiligo mean sernm zinc level was 771.6 ± 222.2. The difference of mean sernm zinc level observed between family history positive and negative group were not statistically significant (p&gt;0.05). The difference of mean senun zinc level was also not statistically significant (p&gt;0.05) among &lt;1 year, 1-10 years and 11-20 years duration groups of vitiligo patients. A negative correlation (r = -0.227) was observed between duration of symptom with senun zinc level in this study.<strong> </strong></p><p><strong>Conclusion:</strong> This study showed low level of serum zinc in vitiligo patients. Large-scale studies are needed to confirm these findings and multicenter study should be carried out to reveal the accurate pattern of zinc status in vitiligo.</p>

scholarly journals Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3578
Author(s):  
Marlene Fabiola Escobedo-Monge ◽  
Enrique Barrado ◽  
Joaquín Parodi-Román ◽  
María Antonieta Escobedo-Monge ◽  
María Carmen Torres-Hinojal ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Atomic Absorption Spectrophotometry ◽  
Cross Sectional Study ◽  
Serum Copper ◽  
Normal Serum ◽  
Zn Deficiency ◽  
Cross Sectional ◽  
Inflammatory State ◽  
Copper Zinc ◽  
The Mean

Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaningfully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population.

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