Relationship Between Serum Zinc, Iron and Copper Level and Apoptosis in Human Gastric Mucosa: A Cross-Sectional Study

2011 ◽  
Vol 10 (10) ◽  
pp. 919-924 ◽  
Author(s):  
Beitullah Alipour ◽  
Aida Ghaffari ◽  
Alireza Ostadrahim ◽  
Abdolrasoul Safaiyan ◽  
Jabiz Modaresi ◽  
...  
Author(s):  
Mamoru Sakurai ◽  
Junko Sasaki ◽  
Hirotsugu Suwanai ◽  
Jumpei Shikuma ◽  
Rokuro Ito ◽  
...  

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Satoshi Matsui ◽  
Tomonaga Ameku ◽  
Daisuke Takada ◽  
Shinji Ono

Abstract Background Hypozincemia contributes to phosphate-induced vascular calcification in model animals of renal failure, but the association between hypozincemia and aortic stenosis (AS) prevalence in patients with end-stage kidney disease remains unreported in clinical settings. Methods To investigate the association between hypozincemia and AS prevalence in patients undergoing hemodialysis, we designed a single-center cross-sectional study. Our outcome “AS” was defined as prevalence of moderate or severe AS or surgical history for AS. Depending on serum zinc levels, we divided patients undergoing hemodialysis into deciles. The association between hypozincemia and AS prevalence was analyzed via logistic regression adjusted for age, sex, dialysis vintage, diabetes history, serum albumin, and history of taking calcium-containing phosphate binder. Results Ninety-three patients undergoing hemodialysis were eligible. The mean serum zinc level was 61.3 ± 13.9 μg/dL. Twelve patients who belonged to 1st decile had serum zinc levels ≤ 48 μg/dL. Of these twelve patients, six patients (50 %) had AS. On the other hand, of eighty one patients who belonged to 2nd–10th deciles (serum zinc levels > 48 μg/dL), thirteen patients (16 %) had AS. Hypozincemia (serum zinc levels ≤ 48 μg/dL) was associated with AS prevalence (P = 0.038; odds ratio 4.43; 95% confidence interval 1.09–18.0). Conclusions AS was more prevalent in patients undergoing hemodialysis with severe hypozincemia in our cross-sectional study, although interventional studies are required to elucidate the benefit of zinc supplementation for AS progression.


2019 ◽  
Vol 192 (2) ◽  
pp. 123-128 ◽  
Author(s):  
Hadi rostamkhani ◽  
Ali Awsat Mellati ◽  
Banafsheh Sadat Tabaei ◽  
Mohammadhossein Alavi ◽  
Seyedeh Neda Mousavi

2018 ◽  
Vol 5 (4) ◽  
pp. 1518 ◽  
Author(s):  
Ubaidur Rehman H. ◽  
Shamshad Ahmed Khan ◽  
Prakash R. Saldanha

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Different studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no significant difference in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a significant difference between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.


2021 ◽  
Vol 6 (6) ◽  

Purpose: Since zinc is required for immunity and inflammation regulations, this paper aimed to investigate serum zinc levels in critically ill patients receiving Enteral (EN) and Oral Nutrition (ON) and correlate these values with demographic, clinical and laboratory parameters. Material and Methods: This is a cross-sectional study. Researchers collected data from electronic medical records in Intensive Care Units (ICUs) of a Brazilian tertiary hospital. Flame Atomic Absorption Spectrophotometry measured serum zinc (normal range: 70-120 mcg/dl). Evaluated variables: age, sex, diagnoses, ICU type, iron, hemoglobin, leukocytes, C-reactive protein, severity score, and mortality. Results: Researches assessed 203 medical records. Mean zinc score was low (EN: 59.13 ±16.26 mcg/dl; ON: 64.75 ±16.80 mcg/dl; p= 0.010). Mean age was high (EN: 77.48 ± 16.26 years; ON: 75.01 ± 13.03 years; p= 0.012). Iron was positively correlated with zinc in EN (p= 0.012). Age was correlated negatively with zinc in ON (p=0.001). Hemoglobin was correlated positively with zinc in EN (p= 0.007) and ON (p= 0.018). Conclusions: Most of the ICU patients had low zinc. EN had lower zinc levels than ON. L


Author(s):  
John Musaba ◽  
Moses Mukosha ◽  
Lubinda Mukololo ◽  
Bellington Vwalika

Background: Micronutrient deficiency is one of the leading public health problems, particularly in lower-middle-income countries. The link between serum zinc (Zn) levels and urinary tract infections (UTIs) among pregnant women is still poorly understood. We investigated the association between maternal serum Zn levels and UTIs among pregnant women at women and newborn hospital in Lusaka, Zambia.Methods: We conducted an analytical cross-sectional study among 228 pregnant women aged 18 to 45 years between 1 September and 30 November 2019. Serum Zn levels were measured using atomic absorption spectrophotometry (AAS), whereas UTIs were determined based on the local hospital guidelines. We used the logistic regression model to determine the association between Zn levels and UTIs. The analysis was done at a significance level of 5% and 95% confidence interval.Results: Of the total participants, 118/228 (51.75%) tested positive for UTIs from urine culture. The mean serum Zn levels in the group diagnosed with UTIs were 53.95 ug/dl (SD=35.10), while in those who had no UTIs, it was 50.05 ug/dl (SD=35.10). In a multivariable logistic regression analysis, we found no evidence of an association between serum Zn levels and UTIs (p=0.435).Conclusions: From the study findings, there was no association between serum Zn levels and UTIs. This result suggests that Zn may not have any role in urinary tract infection. Nevertheless, more extensive studies are needed to confirm our findings.


2018 ◽  
Vol 25 (01) ◽  
pp. 58-62
Author(s):  
Afroz S Kazi ◽  
Aftab Abbasi ◽  
Sana Naz

Objectives: To investigate the histological changes in gastric mucosa of livercirrhosis patients. Study design: Cross sectional study. Place and Duration: Department ofAnatomy and Medicine, Gastroenterology unit, Isra University Hospital (June to December2012). Subjects and Methods: 85 diagnosed cases of liver cirrhosis were selected accordingto inclusion and exclusion criteria. Specimen of 2 mm thickness was taken by punch biopsyfrom gastric body and antrum by endoscope. Tissues were fixed in 10% formaldehyde, 3-5 μsections were stained with H & E for microscopy. Data was analyzed on SPSS version 21.0.Results: Age (mean ±SD) was noted as 47±11.5 years. Of 85, 56 (65.8%) were male and29 (34.1%) female. Frequency of mild, moderate, severe and no gastropathy were notedin 52.94%, 34.12%, 4.71%, and 8.24% respectively. 9.4% of cases show capillary dilationand edematous lamina propria. Conclusion: Microscopy shows gastropathy in majority ofspecimens. Thick gastric mucosa, increased gland size and mucosa capillary dilation wasnoted.


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