Biochemical Changes in Neonates with and without Seizure: A Comparative Study

2021 ◽  
Vol 8 (1) ◽  
pp. 25-29
Author(s):  
ASM Shahidullah ◽  
Rafika Afrose ◽  
Kalpona Deb ◽  
Bina Sen ◽  
Arup Ratan Paul ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Femoral Vein ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Sodium Potassium ◽  
Pediatric Age Group ◽  
Group I ◽  
Calcium Magnesium ◽  
Group Ii

Background: Seizure is a common neurological disorder in the pediatric age group. Objective: Neonates with seizure have decreased in serum calcium, magnesium, sodium, potassium, and glucose if compared to neonates without seizure. Methodology: This comparative cross-sectional study was carried out in the Department of Biochemistry at Mymensingh Medical Collage, Mymensingh, Bangladesh in cooperation with the Department of Pediatric of Mymensingh Medical Collage & Hospital, Mymensingh, Bangladesh from July 2005 to June 2006. Neonates were included in the study. Subjects were divided into two groups designated as group I as control group and group II cases. From each subject at least 2 ml of blood were collected from femoral vein and was collected serum for biochemical analysis. Result: A total of 60 neonates were included in the study. Subjects were divided into two groups-group-I control- (n=20) and group II cases-(n=40). The concentration of serum calcium, magnesium, sodium, potassium, and glucose yielded 7.33 ±0.79, 5.79 ±1.10; 2.18 ± 0.23,1.61 ± 0.25; 134.82 ±3.03, 133.68±8.57; 4.80 ±0.56,5.89 ±2.02; 66.33 ± 8.23, 62.25± 7.96 in group I and group II respectively. Conclusion: Significant decreases of serum calcium, magnesium and significant increase of serum potassium in neonates with seizure are found in this study. The change in serum sodium and glucose are not significant. Journal of Current and Advance Medical Research, January 2021;8(1):25-29

scholarly journals Laparoscopic Management of Adhesions Developed after Peritoneal Nonclosure in Primary Cesarean Section Delivery

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Emaduldin Seyam ◽  
Emad Moussa Ibrahim ◽  
Ayman Moheb Youseff ◽  
Eissa M. Khalifa ◽  
Enas Hefzy
Keyword(s):  
Adhesion Formation ◽  
Cross Sectional Study ◽  
Parietal Peritoneum ◽  
Reproductive Capacity ◽  
Secondary Infertility ◽  
Cross Sectional ◽  
Cesarean Section Delivery ◽  
Visceral Peritoneum ◽  
Group I ◽  
Group Ii

Objective. The aim of the current study was to laparoscopically investigate the effects of peritoneal nonclosure on the sites, types, and degrees of adhesions developed after primary caesarean section (CS) in women complaining of secondary infertility after first CS delivery. Study Design. This was a cross-sectional study, where 250 women suffering from secondary infertility after their first CS had been recruited. They had been classified into group I (n = 89), where both the visceral and parietal peritoneum had been left opened; group II (n = 75), where only the parietal peritoneum had been closed; and group III (n = 86), where both peritoneal layers had been closed. Laparoscopy had been used to classify those adhesions according to the location, severity, and their adverse impact on the reproductive capacity. Results. Both adnexal and nonadnexal adhesions had been found significantly higher in group I, while adnexal types of adhesions were significantly higher after nonclosure of the visceral peritoneum in group II. Laparoscopic tubal surgery performed included tubo-ovariolysis, fimbrioplasty, and neosalpingostomy. Pregnancy rate was found correlating with the adnexal adhesion location and score. Conclusion. Nonclosure of the peritoneum in CS is associated with more adhesion formation, which might adversely affect the future women reproduction.

scholarly journals TO STUDY THE ONSET AND PROGRESSION OF AIRWAY ABNORMALITY IN TERMS OF ALTERATION IN PFT IN ASYMPTOMATIC SMOKERS.

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Hitesh Kumar Solanki ◽  
Dr. Omnath P Yadav ◽  
Dr. Anita J Gojiya
Keyword(s):  
Lung Function ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
Significant Difference ◽  
History Of ◽  
Young Smokers ◽  
The Mean ◽  
Group Ii

The study was conducted in department of physiology, B J Medical College, Ahmedabad from Mar. 2012 to Feb. 2013. This was a cross-sectional study to evaluate the effect of smoking on lung   function and serum lipids in asymptomatic smokers   and comparable non   smokers. The mean of the various spirometric parameters were calculated of the subjects for both the groups. The mean FVC in group I and group II was 2.60 ± 0.62 L and 4.10 ± 0.64L respectively. The mean FEV1 in group I was 1.91 ± 0.57L and     3.19 ± 0.77L in group II Group I had mean FEF25% - 75% and PEFR of 1.98 ± 0.67L/sec and 4.50 ± 1.57L/sec respectively. Group II had mean FEF25 – 75% of 4.22 ± 1.23L/sec and a mean PEFR of 7.22 ± 1.42L/sec. In young smokers and asymptomatic, still the spirometric values were significantly deranged as compared to controls. Even smokers with history of less pack years of smoking also had significant abnormalities of lung function. All he spirometric values in the two groups had statistically highly significant difference and were higher in non-smokers as compared to smokers. The spirometric values were reduced in smokers with history of smoking for as low as two pack years. Keywords: Progression, PFT, Asymptomatic & Smokers

Prevalence of subclinical synovitis of the hand in patients with systemic lupus erythematosus

Lupus ◽  
2020 ◽  
Vol 29 (11) ◽  
pp. 1423-1429
Author(s):  
Carlos A Guillén-Astete ◽  
Marcelino Revenga-Martinez ◽  
Antonio Zea-Mendoza ◽  
Elia Brito-Brito
Keyword(s):  
Lupus Erythematosus ◽  
Structural Damage ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Eular Recommendations ◽  
Group I ◽  
Joint Symptoms ◽  
Different Levels ◽  
Subclinical Synovitis

Objectives To determine the prevalence of subclinical synovitis in Lupus patients without peripheral joint symptoms, in those with arthralgias without arthritis and those with episodic arthritis but without radiological structural damage. Methods We conducted a multicentre cross-sectional study. Patients with lupus from those three categories were recruited to take part in a greyscale ultrasound scan performed by an expert blinded rheumatologist. Data from a historical control group from a previous study was also included for comparisons. Images were assessed separately in order to determine the presence and level of synovitis following Eular recommendations. Results Ninety-six patients (88.5% female) with an average age of 40 ± 6.2 years old, were included. SLICC/ACR score was 0.6 ± 0.3 in the group without joint symptoms (group 0), 0.8 ± 0.3 in the group with arthralgias (group I) and 1.1 ± 0.4 in the group with episodic arthritis. The global prevalence of subclinical synovitis was 38.5%. In group 0, that prevalence was 30%. The time since onset of symptoms of patients with subclinical synovitis was longer than the rest of the patients (9.4 ± 2.2 vs 6.5 ± 4.0 years, P < 0.001). No other remarkable association was founded with clinical features of the disease. Conclusions This is the first study focused on subclinical synovitis in patients with lupus. Other previous studies had included patients with different levels of arthropathy. Subclinical synovitis does exist in lupus patients in over a third of patients. Its meaning remains unclear and must be a topic of further studies.

scholarly journals COMPARATIVE STUDY BETWEEN THE EFFECT OF HISTAMINE RECEPTOR ANTAGONISTS OF TYPE II (FAMOTIDINE) AND PROTON PUMP INHIBITORS (OMEPRAZOLE) ON THE EFFICACY OF CALCIUM CARBONATE AS PHOSPHATE BINDER IN HAEMODIALYSIS PATIENT

2017 ◽  
Vol 9 (8) ◽  
pp. 10
Author(s):  
Hossam Aboelyazeed ◽  
Sahar El-haggar ◽  
Kamal Okasha
Keyword(s):  
Calcium Carbonate ◽  
Serum Calcium ◽  
Phosphate Binder ◽  
Renal Dialysis ◽  
University Hospital ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Pre Treatment

Objective: The purpose of this study was to compare the effect of famotidine versus omeprazole on the efficacy of calcium carbonate as a phosphate binder in the hemodialysis patient.Methods: From February 2014 to June 2014 a total number of 64 patients of both sexes were recruited from the department of renal dialysis, Tanta University Hospital, Egypt. Patients categorized into 3 groups. Group I (control group) consisted of 20 Patients (10) females and (10) males take calcium carbonate (caco3) (2.5–4 g/d) only, Group II consisted of 21 Patients (13) females and (8) males take the same dose of caco3 with famotidine 10 mg/d and Group III consisted of 23 Patients (8) females and (15) male take the same dose caco3 with omeprazole 20 mg/d.Results: All data are expressed as the mean±SD. Group II showed a significant increase (p<0.05) in serum phosphorus at 3rd mo with significant decreased (p<0.05) in serum calcium comparing with pre-treatment. Group III showed no significant change (p>0.05) in serum calcium, phosphorus and parathyroid hormone (PTH) comparing with pre-treatment. Both groups (II and III) showed a significant decrease in alkaline phosphatase (ALP) (p<0.05).Conclusion: Co-administration of famotidine with calcium carbonate aggravates hyperphosphatemia and this may increase the incidence of complications. The efficacy of calcium carbonate as a phosphate binder was not affected by co-administration of omeprazole.

scholarly journals Effect of maternal BMI on labor outcomes in primigravida pregnant women

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eissa Khalifa ◽  
Alaa El-Sateh ◽  
Mohamed Zeeneldin ◽  
Ahmed M. Abdelghany ◽  
Mahmoud Hosni ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Active Phase ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Group Iii ◽  
Second Stage Of Labor ◽  
Group I ◽  
Increased Risk ◽  
Group Ii ◽  
Labor Outcomes

Abstract Background This study aims to detect the effects of increased BMI on labor outcomes in primigravida pregnant women. Methods A cross-sectional study involved 600 full-term singleton primigravida pregnant women who presented in the active phase of labor to the labor ward. They were divided according to BMI into three equals groups; women with normal BMI (group I), overweight women (group II), and women with class I obesity (group III). Results We found that high BMI was associated with a significantly increased risk of Caesarean section (C.S.) (13% in group I, 18% in group II and 40% in group III). Women with higher BMI and delivered vaginally had a significantly prolonged first and second stage of labor, consequently increased the need for oxytocin augmentation as well as the oxytocin dose. Regarding the maternal and fetal outcomes, there are significantly increased risks of postpartum sepsis, perineal tears, wound infection, as well as significantly increased birth weight and longer neonatal stay in the neonatal unit (NNU). Conclusion Obese primigravida pregnant women were at higher risk of suboptimal outcomes. Besides, prolonged first and second stages of labor and the incidence of C.S. have also been increased.

scholarly journals Degree Of Proteinuria In Post-Icteric State Of Hepatitis E Virus (Hev) Infected Patients

2012 ◽  
Vol 7 (2) ◽  
pp. 37-39
Author(s):  
W Nargis ◽  
BU Ahamed ◽  
S Zabeen ◽  
F Alam ◽  
MA Wahab ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Cross Sectional Study ◽  
Urinary Protein ◽  
Age Group ◽  
Cross Sectional ◽  
Group I ◽  
Significant Difference ◽  
The Mean ◽  
Group Ii

Introduction: Nephropathies, as one of the multiple extrahepatic features of Hepatitis E virus (HEV) infection, can occur in clinically improved HEV hepatitis patients which in majority of the cases remain clinically silent for a long period. By the time these are reported, patients have already developed renal insufficiency which may even lead to renal replacement therapy. Proteinuria, a simple test in practice, can be a useful tool for early detection of the underlying renal impairment. Objective: The aim of this study was to detect the presence of proteinuria and to evaluate the degree of proteinuria in HEV- hepatitis patients during post-icteric state. Materials and Methods: This cross sectional study was conducted on 50 diagnosed patients of clinically improved HEV-hepatitis at the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU) with active cooperation of the Department of Hepatology, BSMMU, between July 2006 and June 2007. Cases were chosen carefully, to exclude the acute state of illness and the patients of HEV were selected during their third or fourth follow-up, in their post-icteric phase. The study subjects were grouped according to equal age ranges in group-I (18-26 year) and group-II (27-35 year). Depending on the level of spot urinary protein (mg/dl) the subjects were also categorized as having trace, mild and moderate proteinuria. Results: The mean age of HEV infected subjects was 24.72±2.59 years. The mean spot urinary protein in age group-II patients was raised compared to age group-I and the difference was highly significant (p<0.001). Moreover, there was no significant difference (p>0.05) of spot urinary protein of male and female. Majority of HEV patients (42%) presented with mild proteinuria and mostly (53.3%) was of age group-I. Conclusion: Spot urinary protein concentration should be checked in every HEV- hepatitis patient to detect the presence and level of proteinuria. DOI: http://dx.doi.org/10.3329/jafmc.v7i2.10395 JAFMC 2011; 7(2): 37-39

scholarly journals PERBEDAAN RERATA RASIO KALSIUM MAGNESIUM DAN RERATA RASIO NATRIUM KALIUM SERUM

2019 ◽  
Vol 1 (1) ◽  
pp. 22-29
Author(s):  
Joserizal Serudji ◽  
Helga Helga ◽  
Hafni Bachtiar
Keyword(s):  
District Hospital ◽  
Atomic Absorption Spectrophotometry ◽  
Cross Sectional Study ◽  
Maternal Serum ◽  
Severe Preeclampsia ◽  
Cross Sectional ◽  
Sodium Potassium ◽  
Smooth Muscle Function ◽  
Calcium Magnesium ◽  
The Mean

The high incidence of preeclampsia and eclampsia causes the importance of early detection especially eclampsia which is the main cause of maternal morbidity and mortality and bad perinatal outcome. The etiology was unknown, but is related to changes in electrolyte status. Electrolytes such as calcium (Ca2+), Magnesium (Mg2+), sodium (Na+) and potassium (K+) play an important role in pre-eclampsia and eclampsia because they contribute significantly in vascular smooth muscle function. This study was done to analyze the differences in mean levels of calcium magnesium ratio and sodium potassium ratio of maternal serum in severe preeclampsia and eclampsia. We performed an observasional comparative with cross sectional study on 16 women with severe preeclampsia and 16 women with eclampsia who met the inclusion criteria and there were no exclusion criteria. The samples were recruited in Dr. M Djamil general hospital Padang, Solok District Hospital, and Pariaman District Hospital from May 2015 to January 2016. The levels of calcium serum were examined by atomic absorption spectrophotometry (AAS), magnesium levels were examined by enzymatic metode, sodium and potassium levels were examined by ion selection electrode (ISE). The differences in mean levels of calcium magnesium ratio and sodium potassium ratio between the two groups was analyzed by using independent t test. The mean levels of calcium magnesium ratio in severe preeclampsia was significantly higher than eclampsia. The mean levels of sodium potassium ratio in severe preeclampsia was significantly lower than eclampsia.Keywords: Calcium magnesium ratio, sodium potassium ratio, severe preeclampsia, eclampsia

Forensic Implications of Carpal Tunnel Syndrome in Relation to Neurological, Radiological and Orthopedic Assessments

2021 ◽  
Vol 15 (8) ◽  
pp. 2169-2171
Author(s):  
Muhammad Faheem Ashraf ◽  
Tanveer Haider ◽  
Shams Munir ◽  
Muhammad Imran Khan ◽  
Uzma Zaheen ◽  
...  
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Control Group ◽  
Sectional Area ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
Tunnel Syndrome ◽  
Forensic Implications ◽  
Group Ii

Objective: To determine forensic implications of carpel tunnel syndrome in relation to neurological, radiological and orthopedic assessments. Study Design: Prospective Place and Duration of Study: Department of Forensic Medicine in collaboration with Radiology and Orthopaedic Departments, Govt. Khawaja Muhamamd Safdar Medical College Sialkot from 1st March 2020 to 28th February 2021. Methodology: One hundred and fifty patients of both genders were enrolled and age between 15-70 years. Details demographics age, sex and body mass index of all patients were recorded after taking written consent. Patients were divided into 2 groups. Group I had 75 patients with carpal tunnel syndrome and group II had 75 patients without carpal tunnel syndrome. Patients were undergone for ultrasonography and ultradiagnostic test used to diagnose the carpal tunnel syndrome. The carpal tunnel and proximal levels of the median nerve's CSA were measured, delta cross-sectional area (CSA) was determined for each wrist based on the differences between CSAc and CSAp. Sensitivity and specificity in wrists among both groups were identified. Results: There were 15 (20%) males and 60 (80%) females in group I with 90 wrists while in group II 17 (22.7%) males and 58 (77.3%) females in group II with 100 wrists. Mean age in group I was 49.68±9.66 years with mean BMI 26.47±9.54 kg/m2 and in group II mean age was 51.68±9.66 years with mean BMI 25.47±9.54 kg/m2. Mean CSAc in affected wrists group I was 17.11±6.44 greater than group II 08.17±6.58 mm2. Mean delta CSA in healthier wrists was lower 1.01±2.11 than group I 8.44±9.55 mm2. It was shown that the delta-CSA threshold of 2 mm2 had the maximum sensitivity (98.7%) and specificity (100%) in group I than control group. Conclusion: As compared to CSAc, the CSA is more accurate in diagnosing carpal tunnel syndrome. Keywords: Carpel tunnel syndrome (CTS), CSA, Wrists, Specificity, Sensitivity, Ultrasonography

Efficacy and safety of sofosbuvir plus daclatasvir with or without ribavirin in treatment of Egyptian patients infected with chronic HCV (Single Centre Study)

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohammed Shaker ◽  
Heba Abdella ◽  
Zeinab hefny
Keyword(s):  
General Hospital ◽  
Cross Sectional Study ◽  
World Health ◽  
Combination Regimen ◽  
Efficacy And Safety ◽  
Cross Sectional ◽  
Group I ◽  
Egyptian Patients ◽  
Group Ii ◽  
Chronic Hcv

Abstract Background and aim As indicated by the World Health Organization (WHO), Egypt is positioned as the country with the world’s highest prevalence of Hepatitis C virus (HCV). The current study was designed to describe the efficacy and safety of Sofosbuvir plus Daclatasvir with or without Ribavirin in treatment of chronic HCV in a cohort of Egyptian patients who were referred to the viral hepatitis unit in El -Fayoum general hospital. Methods This is a prospective descriptive cross sectional study that describes the effect of 12 weeks of daily Sofosbuvir (SOF) 400 mg plus Daclatasvir (DCV) 60 mg with or without ribavirin (RBV) with dose adjustment if indicated. It included 200 patients that fulfilled the inclusion and exclusion criteria and treated in El -Fayoum general hospital, El-Fayoum, Egypt. Results In the current study, concerning viral response, SVR12 rate was achieved by 92.5% in the overall patients (185/200); by 98% (98/100) in group I, and by 87% (87/100) in group II. Concerning safety and tolerability, The main adverse effects recorded during and after 12 weeks of treatments were fatigue (46%), (66%); headache (24%), (40%); gastrointestinal upset (15%), (43%); and nausea (10%), (15%) in group 1 and group 2, respectively. Only one female patient in group II developed HCC. All patients completed treatment till the end of course. Conclusion The current study suggested that treatment of SOF plus DCV with/without RBV for chronic HCV patients in Egypt was generally safe, well tolerated, and of high efficacy, reflecting the antiviral potency and high resistance barrier of the combination regimen.

scholarly journals Antidepressants-a possibly risk factor for cataract development: a cross-sectional study

2017 ◽  
Vol 6 (5) ◽  
pp. 1095
Author(s):  
Rajnish Raj ◽  
Anuradha Raj ◽  
Rohit Garg
Keyword(s):  
Therapeutic Dose ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Mild Depression ◽  
Cross Sectional ◽  
Group I ◽  
Increased Risk ◽  
Cataract Development ◽  
Antidepressant Use ◽  
Group Ii

Background: Few studies have reported the role of antidepressants as cataractogenic in humans.Methods: It’s a hospital based descriptive, cross-sectional study. 45 Patients were screened for antidepressant use and diminution of vision, 6 were dropped out. 39 patients with 78 eyes were finally enrolled. They were divided into two goups i.e., Group-I, with cataract (N=53) and Group-II, without cataract (N=25). Three clusters of antidepressants were assessed e.g., SSRI, SNRI and TCA with therapeutic dose (TD) and non-therapeutic dose (NTD) range. Psychiatric illness was diagnosed on DSM-5 and severity of depression on HAM-D. Best corrected visual acuity (BCVA) was converted from Snellen units to logarithm of minimal angle of resolution (log MAR) for statistical analysis. Cataract changes in eyes were seen on slit-lamp and classified on Lens opacities classification system-III (LOCS-III) criteria.Results: A total 78 eyes of thirty-nine (39) patients were evaluated. Thirty (38.46%) and forty-eight (61.53%) eyes belonged to males and females, respectively. Mean age of males (n=7) was 41.8±2.3 years and females (n=32) 40.2±1.0 years. In Group-I, out of (N=53) eyes that developed cataract 33 were females (62.26%) as compared to males 20 (37.7%). Group -II, out of (N=25) eyes, females without cataract were 15 (60%) as compared to males 10 (40%).  Therapeutic dose (TD) of antidepressants (AD) in Group-I had more cataract 37 (69.81%) as compared to non-therapeutic dose (NTD) 16 (30.1%). Most of the eyes with cataract 35 (66.03%) had AD exposure of more than 1 year that was possibly associated with increased risk of cataract development (OR 2.10; 95% CI, 0.79-5.55). Amongst users of antidepressants, SSRI was associated with increased risk of cataract development (OR 2.4; 95% CI, 0.72–7.94) with a female preponderance (OR 1.1; 95% CI, 0.41–2.91). Maximum number of eyes 34 (64.15%) that developed cataract had BCVA of ≥6/12 and minimum of 2 (3.77%) eyes had BCVA of ≤6/36. LOCS-III revealed 38 (71.69%) eyes (71.69%) having peripheral cortical cataract and 15 (28.30%) posterior sub-capsular cataract.Conclusions: There is a possible risk of association of cataract amongst user of antidepressants. The AD use of more than 1 year or longer had increased risk for development of cataract with a female preponderance. The highest risk was observed in the users of SSRI as compared to SNRI and TCA. Treatment exposure with antidepressant was longer for mild depression having more than two episodes.

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