scholarly journals Antitumor Activity of Diospyros peregrina on Ehrlich Ascites Carcinoma in Mice

2011 ◽  
Vol 3 (2) ◽  
pp. 413-419 ◽  
Author(s):  
A. B. Raju ◽  
Venu Gopal Y ◽  
Ravindranath A ◽  
Kalpana G ◽  
Prabhakar Reddy V
Keyword(s):  
Antitumor Activity ◽  
Life Span ◽  
Tumor Volume ◽  
Methanol Extract ◽  
Viable Cell ◽  
Ehrlich Ascites Carcinoma ◽  
Tumor Inoculation ◽  
Tumor Bearing ◽  
Hematological Profile ◽  
Ehrlich Ascites

The methanol extract of Diospyros peregrina (Ebenaceae) bark (MEDP) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing swiss albino mice. The extract was administered at the doses of 200 and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MEDP on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile  MEDP caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MEDP exhibited significant antitumor activity in EAC-bearing mice. Keywords: Diospyros peregrina; Ehrlich ascites carcinoma; Antitumor. © 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi:10.3329/jsr.v3i2.6787                J. Sci. Res. 3 (2), 413-419 (2011)

scholarly journals Antitumor potential of Citrus limetta fruit peel in Ehrlich ascites carcinoma bearing Swiss albino mice

2012 ◽  
Vol 2 (1) ◽  
pp. 10 ◽  
Author(s):  
Sriparna Kundusen ◽  
Asis Bala ◽  
Biswakanth Kar ◽  
Sanjib Bhattacharya ◽  
Upal K. Mazumder ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Cell ◽  
Life Span ◽  
Blood Cells ◽  
Tumor Volume ◽  
Ehrlich Ascites Carcinoma ◽  
Viable Tumor Cell ◽  
Fruit Peel ◽  
Ehrlich Ascites ◽  
Citrus Limetta

<em>Citrus limetta </em>Risso (Rutaceae), commonly known as sweet lime in English and <em>Mousambi</em> in India, has been traditionally used for several medicinal purposes. This study explored the relationship between <em>Citrus limetta </em>fruit peel and its antitumor activity against Ehrlich ascites carcinoma (EAC) bearing mice. The antitumor activity of methanol extract of peel of <em>Citrus limetta</em> fruits (MECL) was evaluated against EAC cell line in Swiss albino mice. Twenty-four hours after intraperitoneal inoculation of tumor EAC cells in mice, MECL was administered at 200 and 400 mg/kg body weight i.p. daily for nine consecutive days. On the 10th day, half of the mice were sacrificed for the estimation of tumor growth (tumor volume, viable and non-viable tumor cell counts), and hematologic parameters (red blood cells, white blood cells and hemoglobin). The rest were kept alive for assessment of survival parameters, <em>i.e. </em>median survival time and percentage increase in life span of EAC bearing mice. Intraperitoneal administration of MECL at the doses of 200 and 400 mg/kg for nine days to the carcinoma induced mice demonstrated a significant (P&lt;0.001) decrease in tumor volume, viable tumor cell count, tumor weight and a significant (P&lt;0.001) improvement in hematological parameters and life span as compared to the EAC control mice. The present study establishes marked and dose dependant anti-tumor effect of <em>C. limetta </em>fruit peel against Ehrlich ascites carcinoma bearing Swiss mice.

scholarly journals EVALUATION OF ANTICANCER ACTIVITY OF PARKINSONIA ACULEATA LEAVES EXTRACT ON EHRLICH’S ASCITES CARCINOMA-INDUCED MICE.

2018 ◽  
Vol 11 (1) ◽  
pp. 390
Author(s):  
Prameela Rani A ◽  
Agarjuna Babu E ◽  
Prem Madhur S ◽  
Ravi Chandra Sekhara Reddy D ◽  
Phani Kumar K
Keyword(s):  
Cell Count ◽  
Anticancer Activity ◽  
Tumor Volume ◽  
Hematological Parameters ◽  
Ethanolic Extract ◽  
Viable Cell ◽  
Ehrlich Ascites Carcinoma ◽  
Parkinsonia Aculeata ◽  
Tumor Weight ◽  
Ehrlich Ascites

 Objective: The objective of the study was to investigate the anticancer activity of the ethanolic extract of Parkinsonia aculeata (EEPA) leaves. Methods: Anticancer activity of P. aculeata (EEPA) of leaf extract was evaluated in Swiss albino mice against Ehrlich ascites carcinoma (EAC) cell line at the doses of 200 and 400 mg/kg body weight orally. The extracts were administered for 14 consecutive days. 24 h of the last dose and 18 h of fasting, the mice were sacrificed, and the anticancer effect of EEPA was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight, hematological parameters, and biochemical parameters of EAC bearing mice.Results: P. aculeata extracts showed a significant decrease in (p<0.01) tumor volume, viable cell count, tumor weight, and elevated the life span of EAC bearing mice. Hematological profile such as red blood cell, hemoglobin count reverted to normal level in EEPA treated mice. The extracts significantly (p<0.05) decreased the levels of lipid peroxidation and significantly (p<0.05) increased the levels of reduced glutathione, superoxide dismutase and catalase.Conclusion: The results showed that the EEPA was effective in inhibiting the tumor growth in ascitic models and that is comparable to 5-fluorouracil. 

scholarly journals EVALUATION OF ANTICANCER ACTIVITY OF ETHANOLIC EXTRACT OF CYPERUS KYLLINGIA ENDL. IN EHRLICH ASCITES CARCINOMA-INDUCED SWISS ALBINO MICE

2018 ◽  
Vol 11 (10) ◽  
pp. 482
Author(s):  
Amites Gangopadhyay ◽  
Mainak Chakraborty ◽  
Pallab Kanti Haldar ◽  
Nitai Chand Chaulya ◽  
Amitava Ghosh
Keyword(s):  
Life Span ◽  
Cell Count ◽  
Tumor Volume ◽  
Antioxidant Properties ◽  
Ethanolic Extract ◽  
Ehrlich Ascites Carcinoma ◽  
Active Principle ◽  
Dependent Manner ◽  
Tumor Weight ◽  
Ehrlich Ascites

Objective: The purpose of the study was to evaluate the antitumor and antioxidant status of ethanolic extract of Cyperus kyllingia Endl. on Ehrlich ascites carcinoma (EAC)-treated mice.Methods: The determination of in vivo antitumor activity was performed using EAC cells inoculated mice groups (n=12). The groups were treated for 9 consecutive days with ethanolic extract of C. kyllingia (EECK) at the doses of 20 and 40 mg/kg b.w., respectively. After 24 h of the last dose, half of the mice were sacrificed and the rest were kept alive for assessment of increase in life span. The antitumor potential of EECK was assessed by evaluating tumor volume, viable and non-viable tumor cell count, tumor weight, hematological parameters, and biochemical estimations. Furthermore, antioxidant parameters were assayed by estimating liver tissue enzymes.Results: EECK showed direct cytotoxicity on EAC cell line in a dose-dependent manner. EECK exhibited significant (p<0.05) decrease in the tumor volume, viable cell count, tumor weight, and elevated the life span of EAC tumor-bearing mice. The hematological profile, biochemical estimations, and tissue antioxidant assay were reverted to normal level in EECK-treated mice.Conclusion: Experimental results revealed that EECK possesses potent antitumor and antioxidant properties. Further, research is going on to find out the active principle(s) of EECK for better understanding of mechanism of its antitumor and antioxidant activity.

scholarly journals Synthesis and Evaluation of the Antitumor Activity of (E)-3-((2-(5-(4-chlorophenyl) thiazol-2-yl) hydrazono) methyl) benzene-1,2-diol “In vitro and In vivo Study”

2019 ◽  
pp. 1-16
Author(s):  
Faten Z. Mohamed ◽  
Mohamed S. Elghreeb ◽  
Moustafa S. Abdelhamid ◽  
Hazem A. Elbaz
Keyword(s):  
Antitumor Activity ◽  
Life Span ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites ◽  
Liver And Kidney

Background: Thiazole nucleus–containing compounds have an antitumor efficiency against various types of cancer. Purpose: The present study was designed to determine the cytotoxic effect of newly synthesized thiazole derivative (TD1) on human cancer cell lines, in addition to evaluate its antitumor activity against Ehrlich ascites carcinoma (EAC) in mice. Materials and Methods: TD1 was synthesized and investigated for its cytotoxic effect on HCT116 (colon cancer), HepG2 (liver cancer), PC3 (prostate cancer) and MCF7 (breast cancer). The effect of TD1 on cell viability, tumor volume, and percent of increase in life span (% ILS) in Ehrlich–bearing mice was studied. Hematological parameters, liver and kidney function tests were evaluated. The activity of superoxide dismutase (SOD) and catalase (CAT), as well as malondialdehyde (MDA) and reduced glutathione levels were determined in liver and kidney tissues. The expression of P53 in EAC was analyzed by flow cytometry. Results: TD1 demonstrated an inhibitory effect on both cancer cell lines in vitro and Ehrlich ascites cells in vivo. TD1 increased in life span of Ehrlich–bearing mice compared to control. Cell cycle and flow cytometric analysis revealed that TD1 directed Ehrlich cells toward apoptosis by increasing of P53 expression. Conclusion: It was concluded that TD1 have a potent antitumor activity against Ehrlich ascites carcinoma in mice beside a cytotoxic effect on MCF-7, PC3, HepG2 and HCT-116.

scholarly journals Antitumor activity of Pogostemon benghalensis Linn. on ehrlich ascites carcinoma tumor bearing mice

2014 ◽  
Vol 10 (4) ◽  
pp. 1071 ◽  
Author(s):  
ManishS Patel ◽  
BhaveshV Antala ◽  
Ena Dowerah ◽  
Raju Senthilkumar ◽  
Mangala Lahkar
Keyword(s):  
Antitumor Activity ◽  
Ehrlich Ascites Carcinoma ◽  
Tumor Bearing ◽  
Ehrlich Ascites ◽  
Carcinoma Tumor

scholarly journals EVALUATION OF ANTICANCER ACTIVITY OF PARKINSONIA ACULEATA LEAVES EXTRACT ON EHRLICH’S ASCITES CARCINOMA-INDUCED MICE.

2018 ◽  
Vol 11 (1) ◽  
pp. 390
Author(s):  
Prameela Rani A ◽  
Agarjuna Babu E ◽  
Prem Madhur S ◽  
Ravi Chandra Sekhara Reddy D ◽  
Phani Kumar K
Keyword(s):  
Cell Count ◽  
Anticancer Activity ◽  
Tumor Volume ◽  
Hematological Parameters ◽  
Ethanolic Extract ◽  
Viable Cell ◽  
Ehrlich Ascites Carcinoma ◽  
Parkinsonia Aculeata ◽  
Tumor Weight ◽  
Ehrlich Ascites

 Objective: The objective of the study was to investigate the anticancer activity of the ethanolic extract of Parkinsonia aculeata (EEPA) leaves. Methods: Anticancer activity of P. aculeata (EEPA) of leaf extract was evaluated in Swiss albino mice against Ehrlich ascites carcinoma (EAC) cell line at the doses of 200 and 400 mg/kg body weight orally. The extracts were administered for 14 consecutive days. 24 h of the last dose and 18 h of fasting, the mice were sacrificed, and the anticancer effect of EEPA was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight, hematological parameters, and biochemical parameters of EAC bearing mice.Results: P. aculeata extracts showed a significant decrease in (p<0.01) tumor volume, viable cell count, tumor weight, and elevated the life span of EAC bearing mice. Hematological profile such as red blood cell, hemoglobin count reverted to normal level in EEPA treated mice. The extracts significantly (p<0.05) decreased the levels of lipid peroxidation and significantly (p<0.05) increased the levels of reduced glutathione, superoxide dismutase and catalase.Conclusion: The results showed that the EEPA was effective in inhibiting the tumor growth in ascitic models and that is comparable to 5-fluorouracil. 

scholarly journals Antitumour evaluation of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea L. flower / Evaluacija antitumorskog djelovanja di-(2-etilheksil)-ftalata (DEHP) izoliranog iz cvjetova Calotropis gigantea L.

2012 ◽  
Vol 62 (4) ◽  
pp. 607-615 ◽  
Author(s):  
Muhammad Rowshanul Habib ◽  
Muhammad Rezaul Karim
Keyword(s):  
Antitumour Activity ◽  
Viable Cell ◽  
Mass Gain ◽  
Ehrlich Ascites Carcinoma ◽  
Differential Count ◽  
Calotropis Gigantea ◽  
Ehrlich Ascites ◽  
Ethylhexyl Phthalate ◽  
Dose Dependent

The objective of the study is to explore the anticancer activity of di-(2-ethylhexyl) phthalate (DEHP) isolated from Calotropis gigantea flower against Ehrlich ascites carcinoma cells (EAC) in Swiss albino mice. The activity of DEHP was evaluated at doses of 10, 20 and 40 mg kg-1 body mass applied intraperitoneally. DEHP showed a significant decrease in viable cell count (p < 0.05), mass gain (due to tumour burden) and elevated the life span of EAC cell bearing mice. Altered hematological profiles such as RBC, hemoglobin, WBC and differential count were reverted to normal levels in DEHP-treated mice. DEHP also brought back altered biochemical parameters (glucose, cholesterol, triglycerides, blood urea, SALP and SGOT) to normal level. Results of this study indicate that DEHP show potent dose dependent antitumour activity against EAC in vivo.

In vitro anticancer activity of Astaxanthin

2021 ◽  
Vol 5 (3) ◽  
pp. 033-037
Author(s):  
Uma Nath U ◽  
Ravi. R ◽  
Sundara Ganapathy ◽  
Lal Prasanth
Keyword(s):  
Anticancer Activity ◽  
Tumor Volume ◽  
Hematological Parameters ◽  
Ehrlich Ascites Carcinoma ◽  
High Dose ◽  
Ehrlich Ascites ◽  
Shrimp Shell ◽  
Shrimp Shell Waste ◽  
Wbc Count

This study was designed to determine the in vitro anticancer potential of the Astaxanthin isolated from shrimp shell waste (ETC) against Ehrlich Ascites Carcinoma (EAC) induced cancer in swiss albino mice. The anticancer activity was assessed using in vitro cytotoxicAity, mean survival time, tumor volume and hematological studies. The reliable criteria for evaluating the potential of any anticancer agent is the prolongation of lifespan of the animal and decrease in WBC count of blood. The high dose of ETC (200 mg/kg, orally) significantly reduced the tumor growth which was demonstrated by increased lifespan of the mice and restoration of hematological parameters. ETC was also found to be cytotoxic in the in vitro parameter which shows that ETC possesses significant anticancer potential.

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