scholarly journals Hereditary Haemoglobin Disorders of Anaemic Patients Attending in a Rural Tertiary Level Hospital

KYAMC Journal ◽  
2017 ◽  
Vol 6 (1) ◽  
pp. 545-549
Author(s):  
Md Shahadat Hossain ◽  
Md Mahbur Rashid Sarker ◽  
Faisal Kabir

Background: Regularly patients attending in the hospital with severe illness for medical treatment. A large number of patients came with features of anaemia. Many of them show hereditary haemoglobin disorders.Objective: This study was done to find out the pattern of hereditary haemoglobin disorders of anaemic patients attending in the hospital for medical treatment in a tertiary level rural hospital.Method: This descriptive type of retrospective study was performed with 151 cases of anaemic patients whose whole blood show abnormality in haemolobin on capillary haemoglobin electrophoresis. Haemoglobin as well as haematocrit and red blood cells indices were performed by using fully automated haematology lab automation (Sysmex XN-1000). Then haemoglobin electrophoresis was performed to see haemoglobin disorder by using Capillary-2 Haemoglobin Electrophoresis, Sebia, France.Results: All of the 151 cases of hereditary haemoglobin disorders were categorized into four groups. Of those Haemoglobin-E ß thalassaemia was 64.90%, ß thalassaemia minor was 17.22%, Haemoglobin-E haemoglobinopathies was 11.92% and ß thalassaemia major was 5.96% of cases. Among 151 patients; 106 (70.20%) patients were severely anaemic, 30 (19.87%) patients were moderately anaemic and 15 (9.93%) patients were mildly anaemic. Among 98 patients of haemoglobin-E ß thalassaemia, 87 (88.76%) patients were severely anaemic.Conclusion: All anaemic patients especially who suffers from anaemia for a long period of time should be checked for haemoglobin disorders by routine haematological investigation and peripheral blood film examination. The patients with persistent anaemia and whose blood shows hypochromic microcytic anaemia should be advised for haemoglobin electrophoresis.KYAMC Journal Vol. 6, No.-1, Jul 2015, Page 545-549

2020 ◽  
Vol 14 (2) ◽  
pp. 200-202
Author(s):  
Feroz Ahmed Sohel ◽  
Sanzida Jahan ◽  
Saifullah Russel ◽  
Farzana Zafreen

Introduction: Abortion in Bangladesh is illegal under most situations, but menstrual regulation is often used as a substitute. Abortion can be legally performed by a physician in a hospital if it is necessary to save the life of the mother. A person, who performs an abortion under any other circumstances, including a woman who self-aborts, can be punished by a fine and imprisonment. Objective: To assess the socio-demographic profile of abortion cases attending a tertiary level hospital of Bangladesh. Materials and Methods: This cross-sectional descriptive type of study was carried out among 80 patients at the Gynae ward and out patient department of Dhaka Medical College Hospital from March 2012 to June 2012. The study population was women attending the selected hospital for an abortion or abortion-related complications. Results: Most of the respondents 35(43.8%) were below 25 years of age and all patients were housewives. The maximum number of patients 63(78.8%) had spontaneous abortion, low socio-economic status and majority were multigravidas. It was also found that patients with abortion were mostly in their second (43.8%) and third (21.3%) decade of life. Conclusion: In this study, the commonest reason for termination of pregnancy was unplanned pregnancy. Creating awareness and timely intervention might decrease the number of abortion cases. Journal of Armed Forces Medical College Bangladesh Vol.14 (2) 2018: 200-202


2011 ◽  
Vol 24 (1) ◽  
pp. 34-37
Author(s):  
MR Khan ◽  
MS Uddin Shah ◽  
MA Aziz ◽  
MMR Khan ◽  
M Khalilur Rahman ◽  
...  

HbE is the most common abnormal hemoglobin of Southeast Asia and is almost limited to this region. It is estimated that 30 million people are heterozygous for HbE and that 1 million are homozygous. Aim of this study was to know the number of homozygous for haemoglobin E condition (Hb E disease) patients among patients suspected of having hereditary haemoglobin disorders referred to the regional laboratory, in Rajshahi. From April 2009 to March 2012, anaemic patients suspected of having hereditary haemoglobin disorder (haemoglobinopathy or thalassemia) were referred to the divisional laboratory, Rajshahi for hemoglobin electrophoresis from the physicians of different areas of Rajshahi division and part of Khulna division. Patient’s age ranging from 01 to 85 yrs of both sexes. Two to three milliliter blood was collected in tubes containing EDTA for complete blood count (CBC) and analysis of hemoglobin variants. CBC was measured by the Erma PC 604 particle counter. Peripheral blood film were examined after staining with Wright’s stain.9 Hemoglobin electrophoresis was carried out on cellulose acetate using TEB buffer, pH 8.6.9. Of 707 anaemic patients suspected of having hereditary haemoglobin disorder (haemoglobinopathy or thalassemia) 333 (47%) were abnormal. Of this abnormal patients 35 (11%) revealed a thalassemia-like disorder, 53 ( 17%) patients revealed haemglobin E disease, 46 ( 14%) patients haemglobin E trait and 188 ( 57%) patients having double heterozygous (Hb E/β thalassemia) disorder. The birth incidence for homozygous babies and or Eβ thalassemia would be increases per year. Population groups with higher frequencies require screening programmes and facilities for antenatal diagnosis. Future comprehensive study are require to know the actual prevalence. TAJ 2011; 24(1): 34-37


Author(s):  
Harmeet Pal Singh Dhooria ◽  
Sandeep Kaur ◽  
Gurdeep Singh Dhooria ◽  
Dinesh Gupta ◽  
Bhawna Garg

Aims: The etiological spectrum and clinical profile of admitted patients presenting with pancytopenia were studied. Study Design: This was a prospective study conducted on 200 patients presenting to the Department of Medicine, Department of Oncology and the Allied Specialities of Medicine, Dayan and Medical College and Hospital, Ludhiana and were found to have pancytopenia during hospital stay. Results: Mean age of the patients was 45.69 ± 17.05 years with maximum number of patients (23%) in the age group of 51-60 years and 119 patients were males and 81 patients were females. Most common physical finding was pallor (95%), followed by splenomegaly (22%) and hepatomegaly (17%). Total of 107 patients were vegetarians (53.5%) and 93 patients (46.5%) were non-vegetarians. Mean hemoglobin was 7.16 ± 2.04 g/dl, mean total leucocyte count was 2.51 ± 1.02 x 103/cu. mm, mean platelet count was 54885.37 x 103/ul ± 40320.96 and mean the absolute neutrophil count was 1.59 x 103 /cu.mm ± 0.84. Ten patients of pancytopenia were because of tropical fever which included 4 cases of dengue, 3 cases of malaria, 2 cases of enteric fever and 1case of mixed infection (malaria + scrub typhus). Viral markers were positive in 14 out of the 63 patients tested. Out of these 14 patients, 4 were HBsAg reactive, 7 were HCV +ve and 3 were HIV +ve. Most common red blood cell picture on peripheral blood film was normocytic normochromic (34.5%), followed by mixed morphology (33.5%). Macrocytic and microcytic morphology was seen in 19.5% and 12.5% of the patients respectively. Hypercellular marrow was seen in 82 patients (42.9%), normocellular marrow was seen in 58 patients (30.3%) and hypocellular marrow was seen in 51 patients (26.7%). The most common cause of pancytopenia in this study was megaloblastic anemia in 59 patients (29.5%), the 2nd common cause was leukemias in 28 patients (14%) and the 3rd cause was aplastic anemia in 22 patients (11%). Drug induced pancytopenia was seen in 21 patients (10.5%) and hypersplenism in 9 cases (4.5%). Conclusion: This study has helped us in knowing the various etiologies of pancytopeniain this hospital. Megaloblastic anemia was the most common etiology in this study followed by leukemiasand aplastic anemia. The study helped us in understanding of the age and gender distribution, the hematological parameters, the peripheral blood film in pancytopenia and the bone marrow picture in these patients.


2019 ◽  
Vol 31 (2) ◽  
pp. 131

In Myanmar, the main challenge to provide quality healthcare by Universal Health Care approach is documented as low health services coverage with substantial wealth-based inequality. To achieve the effective health care system, strong medical care system is essential. Understanding on challenges and needs in provision of medical services among patients and health care providers is critical to provide quality care with desirable outcomes. The aim of the study was to explore the patients’ and health care providers’ perceptions on the challenges in provision of medical services at the Mandalay General Hospital. This was a qualitative study conducted at the tertiary level hospital (Mandalay General Hospital). The data was collected by using focus group discussions and in-depth interviews with hospitalized patients or attendants, healthcare providers such as medical doctors, nurses, laboratory scientists and hospital administrators in March 2017. The qualitative data was analyzed using themes by themes matrix analysis. Most patients were satisfied with the care provided by the doctors because they believed that they received quality care. However, some patients complained about long waiting time for elective operation, congested conditions in the ward, burden for investigations outside the hospital for urgent needs and impolite manners of general workers. Healthcare providers reported that they had heavy workload due to limited human and financial resources in the hospital, poor compliances with hospital rules and regulation among patients and attendants, and inefficient referral practices from other health facilities. Other challenges experienced by healthcare providers were lack of ongoing training to improve knowledge and skills, limited health infrastructure and inadequate medicinal supplies. The findings highlighted the areas needed to be improved to provide quality health care at the tertiary level hospital. The challenges and problems encountered in this hospital can be improved by allocating adequate financial and human resources. The systematic referral system and hospital management guidelines are needed to reduce workload of health staff.


Author(s):  
MSI Tipu Chowdhury ◽  
Khaled Md. Iqbal ◽  
Zahidul Mostafa ◽  
Md. Fakhrul Islam Khaled ◽  
Sadia Sultana ◽  
...  

2021 ◽  
Vol 29 (1) ◽  
pp. 230949902098821
Author(s):  
Md Kamrul Ahsan ◽  
Md Sariful Hasan ◽  
Md Shahidul Islam Khan ◽  
Najmus Sakeb

Purpose: To perform retrospective analysis of 75 post-operative disc space infections after open lumbar discectomy (OLD) and to assess the outcome of their medical and surgical management in a tertiary-level hospital. Methods: Records of 50 men and 25 women aged 26–65 (mean, 42.53) years who underwent treatment for post-operative discitis (POD) after single level OLD at L3–4 (n = 8), L4–5 (n = 42), L5–S1 (n = 25) level. The POD was diagnosed according to specific clinical signs, laboratory and radiographic investigations and all of them received initial intravenous antibiotics (IVA) for at least 4–6 weeks followed by oral ones. Successful responders (n = 55) were considered in Group-C and remainder [Group-S (n = 20)] were operated at least after 4 weeks of failure. Demographic data, clinical variables, hospital stay, duration of antibiotic treatment and post-treatment complications were collected from the hospital record and assessment before and after treatment were done by using visual analogue scale (VAS) and Japanese Orthopaedic Association (JOA) score. Comprehensive outcome was evaluated by modified criteria of Kirkaldy-Willis. Results: The mean follows up was 36.38 months. Significant improvement of mean VAS and JOA score was achieved in both conservative (76.36% satisfactory) and operative (90% satisfactory) groups although the difference was statistically insignificant. Conclusion: Although insignificant, early surgical intervention provided better results (e.g. functional outcomes, length of hospital stay and duration of antibiotic treatment therapy) than conventional conservative treatment in post-operative discitis.


1968 ◽  
Vol 21 (6) ◽  
pp. 788-788
Author(s):  
A. G. Signy

2021 ◽  
pp. 57-59
Author(s):  
Hakimuddin Malvi ◽  
Syed Maqsood Husain

Background: India has been recognized as the diabetes capital of the world by the year of 2025 Hypertension is a signicant danger factor for cardiovascular infection, stroke and ischemic coronary illness. Objective: The aim of this paper is prevalence of hypertension amid patients with type 2 diabetes mellitus- at a tertiary level hospital in central India. Methods: Present work is hospital based cross-sectional study was conduct in Chirayu Medical College & Hospital, Bhopal. The study population consisted of total 300 subjects. Data obtained directly from patients and patients medical les, and the following data were included in the study . Results: The results showed that the after using chi-square test we found that hypertension was signicantly higher p value(<0.05) among female patients (69%),patients with long duration diabetes (77%)10 years and more, also it was signicantly higher among patients with current smokers (69%). Conclusion: In this study the prevalence of hypertension is increasing in patient with T2DM. Hypertension was the most danger factor for micro vascular and macro vascular confusion of T2DM.


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