scholarly journals Role of Cortisol and Growth Hormone in the Development of Ketosis Resistance in Malnutrition Related Diabetic Mellitus

1970 ◽  
Vol 18 (1) ◽  
pp. 5-9
Author(s):  
MA Rayhan Khandakar ◽  
M Suhrab Ali ◽  
M Obaidullah ◽  
Liaquat Ali
Keyword(s):  
Diabetes Mellitus ◽  
Growth Hormone ◽  
Serum Cortisol ◽  
Diabetic Control ◽  
Serum Growth Hormone ◽  
Cross Sectional ◽  
Control Subjects ◽  
And Control ◽  
Niddm Patients

Malnutrition Related Diabetes Mellitus (MRDM), a separate clinical class of diabetes mellitus recognized by WHO Study Group on Diabetes Mellitus in 1985 exhibits peculiar metabolic characteristic of ketosis resistance. To explore the role of cortisol and growth hormone in the development of ketosis resistance, a cross sectional study was carried out involving 21 newly diagnosed MRDM patients, 19 NIDDM patients, and 16 age matched non-diabetic control at BIRDEM, Dhaka. MRDM patients presented with significantly lower Body Mass Index (P<0.001) and significantly higher level of serum glucose (P<0.001) in comparison to NIDDM and control subjects. The mean serum cortisol was significantly higher in MRDM and NIDDM subjects compared to that of control (P<0.05). Therefore, regarding cortisol, MRDM patients behave exactly like NIDDM patients The serum growth hormone levels were similar in MRDM, NIDDM and control subjects. So it can be suggested from the study that cortisol and growth hormone may not play any significant role in the development of ketosis resistance in MRDM patients.    doi: 10.3329/taj.v18i1.3295 TAJ 2005; 18(1): 5-9

scholarly journals Novel Metabolomic Profile of Subjects with Non-classic Apparent Mineralocorticoid Excess

2020 ◽  
Author(s):  
Alejandra Tapia-Castillo ◽  
Cristian Carvajal ◽  
Andrea Vecchiola ◽  
Carlos Fardella
Keyword(s):  
Principal Component ◽  
Plasma Renin ◽  
Fractional Excretion ◽  
Serum Cortisol ◽  
High Serum ◽  
Serum Samples ◽  
Cross Sectional ◽  
Control Subjects ◽  
Apparent Mineralocorticoid Excess ◽  
And Control

Abstract Nonclassic apparent mineralocorticoid excess (NC-AME) is proposed as a novel clinical condition with a mild phenotypic spectrum that ranges from normotension to severe hypertension. This condition is mainly characterized by a high serum cortisol to cortisone ratio (F/E) and concomitant low cortisone (E), however further metabolic changes in NC-AME have not been studied. A cross-sectional study was performed in a primary-care cohort of 396 Chilean subjects, which were classified in two groups: NC-AME (n=28) and healthy controls (n=27). An untargeted metabolomics assay in serum samples from both groups was performed by UPLC-Q-TOF/MS. Global metabolic variations were assayed by principal component analysis (PCA) and further compared by orthogonal partial least-squares discriminant analysis (OPLS-DA). NC-AME subjects exhibited higher values of blood pressure, fractional excretion of potassium, and lower plasma renin activity and urinary sodium to potassium ratio. Metabolomic analyses showed 36 differentially regulated metabolites between NC-AME and control subjects. The ROC curve analyses identified eight metabolites with high discriminatory capacity between NC-AME and control subjects. Moreover, gamma-L-glutamyl-L-methionine sulfoxide and 5-sulfoxymethylfurfural (SMF), exhibited significant association with cortisone, which are potential biomarkers of NCAME, however further assays should elucidate its biological role in setup and progression of this phenotype.

scholarly journals Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alejandra Tapia-Castillo ◽  
Cristian A. Carvajal ◽  
Xaviera López-Cortés ◽  
Andrea Vecchiola ◽  
Carlos E. Fardella
Keyword(s):  
Principal Component ◽  
Plasma Renin ◽  
Fractional Excretion ◽  
Serum Cortisol ◽  
High Serum ◽  
Serum Samples ◽  
Cross Sectional ◽  
Control Subjects ◽  
Apparent Mineralocorticoid Excess ◽  
And Control

AbstractNonclassic apparent mineralocorticoid excess (NC-AME) is proposed as a novel clinical condition with a mild phenotypic spectrum that ranges from normotension to severe hypertension. This condition is mainly characterized by a high serum cortisol to cortisone ratio (F/E) and concomitant low cortisone (E), however further metabolic changes in NC-AME have not been studied. A cross-sectional study was performed in a primary-care cohort of 396 Chilean subjects, which were classified in two groups: NC-AME (n = 28) and healthy controls (n = 27). A discovery study based in untargeted metabolomics assay in serum samples from both groups was performed by UPLC-Q-TOF/MS. Global metabolomic variations were assayed by principal component analysis and further compared by orthogonal partial least-squares discriminant analysis (OPLS-DA). NC-AME subjects exhibited higher values of blood pressure, fractional excretion of potassium, and lower plasma renin activity and urinary sodium to potassium ratio. Metabolomic analyses showed 36 differentially regulated metabolites between NC-AME and control subjects. A ROC curve analyses identified eight metabolites with high discriminatory capacity between NC-AME and control subjects. Moreover, gamma-l-glutamyl-l-methionine sulfoxide and 5-sulfoxymethylfurfural, exhibited significant association with cortisone, which are potential biomarkers of NC-AME, however further assays should elucidate its biological role in setup and progression of this phenotype.

Tests for Platelet Changes, Acute Phase Reactants and Serum Lipids in Diabetes mellitus and Peripheral Vascular Disease

1982 ◽  
Vol 48 (03) ◽  
pp. 289-293 ◽  
Author(s):  
B A van Oost ◽  
B F E Veldhuyzen ◽  
H C van Houwelingen ◽  
A P M Timmermans ◽  
J J Sixma
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Acute Phase ◽  
Serum Lipids ◽  
Diabetic Patients ◽  
Peripheral Vascular ◽  
Acute Phase Reactants ◽  
Control Subjects ◽  
And Control

SummaryPlatelets tests, acute phase reactants and serum lipids were measured in patients with diabetes mellitus and patients with peripheral vascular disease. Patients frequently had abnormal platelet tests and significantly increased acute phase reactants and serum lipids, compared to young healthy control subjects. These differences were compared with multidiscriminant analysis. Patients could be separated in part from the control subjects with variables derived from the measurement of acute phase proteins and serum lipids. Platelet test results improved the separation between diabetics and control subjects, but not between patients with peripheral vascular disease and control subjects. Diabetic patients with severe retinopathy frequently had evidence of platelet activation. They also had increased acute phase reactants and serum lipids compared to diabetics with absent or nonproliferative retinopathy. In patients with peripheral vascular disease, only the fibrinogen concentration was related to the degree of vessel damage by arteriography.

scholarly journals Prevalence, awareness, treatment, and control of dyslipidemia among diabetes mellitus patients and predictors of optimal dyslipidemia control: results from the Korea National Health and Nutrition Examination Survey

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Seung Jae Kim ◽  
Oh. Deog Kwon ◽  
Kyung-Soo Kim
Keyword(s):  
Diabetes Mellitus ◽  
Optimal Control ◽  
National Health ◽  
Age Groups ◽  
Density Lipoprotein ◽  
Nutrition Examination Survey ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Factors Influencing ◽  
And Control

Abstract Background This study aimed to investigate the prevalence, awareness, treatment, and control rates of dyslipidemia and identify the predictors of optimal control (low-density lipoprotein cholesterol < 100 mg/dL) among patients with diabetes mellitus (DM). Methods A cross-sectional study was conducted using the representative Korea National Health and Nutrition Examination Survey (2014–2018). Overall, 4311 patients with DM, aged ≥19 years, and without cardiovascular diseases were selected, and the prevalence, awareness, treatment, and control rates of dyslipidemia were calculated. Univariate and multivariate logistic regression analyses were conducted to evaluate the factors influencing the optimal control of dyslipidemia. Results Dyslipidemia was prevalent in 83.3% of patients with DM, but the awareness and treatment rates were 36.5 and 26.9%, respectively. The control rate among all patients with dyslipidemia was 18.8%, whereas it was 61.1% among those being treated. Prevalence and awareness rates were also significantly higher in women than in men. Dyslipidemia was most prevalent in those aged 19–39 years, but the rates of awareness, treatment, and control among all patients with dyslipidemia in this age group were significantly lower than those in other age groups. The predictors of optimal control were age ≥ 40 years [range 40–49 years: adjusted odds ratio (aOR) 3.73, 95% confidence interval (CI) 1.43–9.72; 50–59 years: aOR 6.25, 95% CI 2.50–15.65; 60–69 years: aOR 6.96, 95% CI 2.77–17.44; 70–79 years: aOR 9.21, 95% CI 3.58–23.74; and ≥ 80 years: aOR 4.43, 95% CI 1.60–12.27]; urban living (aOR 1.44, 95% CI 1.15–1.80); higher body mass index (aOR 1.27, 95% CI 1.13–1.42); lower glycated hemoglobin levels (aOR 0.71, 95% CI 0.67–0.76); hypertension (aOR 1.53, 95% CI 1.22–1.92); poorer self-rated health status (aOR 0.72, 95% CI 0.62–0.84); and receiving regular health check-ups (aOR 1.58, 95% CI 1.25–2.00). Conclusions Most patients with DM were diagnosed with dyslipidemia, but many were unaware of or untreated for their condition. Therefore, their control rate was suboptimal. Thus, by understanding factors influencing optimal control of dyslipidemia, physicians should make more effort to encourage patients to undergo treatment and thus, adequately control their dyslipidemia.

scholarly journals Comparison between Widefield Optical Coherence Tomography Devices in Eyes with High Myopia

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 658
Author(s):  
Federico Corvi ◽  
Federico Zicarelli ◽  
Matteo Airaldi ◽  
Salvatore Parrulli ◽  
Mariano Cozzi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Myopia ◽  
Cross Sectional Study ◽  
Horizontal Line ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Image Artifact ◽  
Control Subjects ◽  
And Control

Background: To compare four different optical coherence tomography (OCT) devices for visualization of retinal and subretinal layers in highly myopic eyes. Methods: In this prospective, observational, cross-sectional study, consecutive patients with high myopia and control subjects were imaged by four OCT devices: Spectralis OCT2, PlexElite 2.0 100 kHz, PlexElite 2.0 200 kHz and the Canon Xephilio OCT-S1. The acquisition protocol for comparison consisted of single vertical and horizontal line scans centered on the fovea. Comparison between the devices in the extent of visible retina, presence of conjugate image or mirror artifacts, visibility of the sclerochoroidal interface and retrobulbar tissue. Results: 30 eyes with high myopia and 30 control subjects were analyzed. The visualized RPE length was significantly different between the OCT devices with Xephilio OCT-S1 imaging the largest extent (p < 0.0001). The proportion of eyes with conjugate image artifact was significantly higher with the Spectralis OCT (p < 0.0001), and lower with the PlexElite 200 kHz (p < 0.0001). No difference in visibility of the sclerochoroidal interface was noted among instruments. The retrobulbar tissue was visible in a higher proportion of eyes using swept-source PlexElite 100 kHz and 200 kHz (p < 0.007) compared to the other devices. Conclusions: In highly myopic eyes, the four OCT devices demonstrated significant differences in the extent of the retina imaged, in the prevalence of conjugate image artifact, and in the visualization of the retrobulbar tissue.

Temperature, Mitochondria, and Reye's Syndrome

PEDIATRICS ◽  
1983 ◽  
Vol 71 (6) ◽  
pp. 985-986
Author(s):  
R. DON BROWN ◽  
JOHN T. WILSON
Keyword(s):  
Mitochondrial Damage ◽  
Reye's Syndrome ◽  
Enhancing Effect ◽  
Control Subjects ◽  
Epidemiologic Data ◽  
Higher Temperature ◽  
And Control

In Reply.— El-Mallakh raises hypothetical questions about an enhancing effect of fever on mitochondrial damage associated with Reye's syndrome. Our article on aspirin and Reye's syndrome1 emphasized the role of prodromal illness in use of aspirin. Fever was only one of several [See table in the PDF] prodormal illness events that were different in patients as compared with control subjects. Results of our analysis of the epidemiologic data from the Ohio study reveal a statistically significant higher temperature in those children which Reye's syndrome as compared with unmatched control subjects (Table) as well as in patients and control subjects matched for record temperatures.1

Diabetic neuropathy: Epidemiological, pathogenetic, and clinical aspects with special emphasis on type 2 diabetes mellitus

1983 ◽  
Vol 104 (4_Suppl) ◽  
pp. S89-S94
Author(s):  
E. Matikainen ◽  
J. Juntunen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Diabetic Control ◽  
Clinical Aspects ◽  
Type 2 Diabetics ◽  
Insulin Dependent

ABSTRACT. Peripheral neuropathy is a frequent complication of diabetes mellitus. Alterations of the peripheral nervous system in diabetics have been studied in numerous investigations. There are many factors known to participate in the development of this complication, e.g. the age of the patient, duration of the diabetes, quality of the diabetic control etc. The role of different types of diabetes in development of neuropathy is still largely unclear since investigations on this aspect are few. It seems, however, that peripheral neuropathy in type 2 (non-insulin dependent) diabetes is common but often mild. The differential diagnosis of the peripheral neuropathy in type 2 diabetics is more difficult than in type 1 (insulin dependent) diabetics, since these patients tend to be older and also may have other concomitant disorders. In this paper the clinical features and pathogenetic mechanisms of neuropathy in type 2 diabetes are briefly discussed.

scholarly journals Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Laura Bordoni ◽  
Joanna J. Samulak ◽  
Angelika K. Sawicka ◽  
Iwona Pelikant-Malecka ◽  
Adrianna Radulska ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Transfer Protein ◽  
Control Subjects ◽  
Atherosclerotic Lesions ◽  
Complex Picture ◽  
Artery Disease ◽  
Genetically Determined ◽  
And Control

Abstract The early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the role of trimethylamine N-oxide (TMAO) in development of cardiovascular disease (CVD). The current study aimed to investigate the association between TMAO and CETP polymorphisms (rs12720922 and rs247616), previously identified as a genetic determinant of circulating CETP, in a population of coronary artery disease (CAD) patients (n = 394) and control subjects (n = 153). We also considered age, sex, trimethylamine (TMA) levels and glomerular filtration rate (GFR) as other factors that can potentially play a role in this complex picture. We found no association of TMAO with genetically determined CETP in a population of CAD patients and control subjects. Moreover, we noticed no differences between CAD patients and control subjects in plasma TMAO levels. On the contrary, lower levels of TMA in CAD patients respect to controls were observed. Our results indicated a significant correlation between GFR and TMAO, but not TMA. The debate whether TMAO can be a harmful, diagnostic or protective marker in CVD needs to be continued.

Sign in / Sign up

Export Citation Format

Share Document