scholarly journals Medical Ozone: The Pharmacological Mechanisms Accounting for its Effectiveness against COVID-19/SARS-COV-2

2021 ◽  
Vol 5 (3) ◽  
pp. 1-5
Author(s):  
Olga S. León Fernández ◽  
Gabriel Takon Oru ◽  
Renate Viebhan Hansler ◽  
Gilberto López Cabreja ◽  
Irainis Serrano Espinosa ◽  
...  
Keyword(s):  
Positive Response ◽  
Vascular Complications ◽  
Clinical Effectiveness ◽  
Innate Immune ◽  
Patient Response ◽  
Safety And Efficacy ◽  
Pharmacological Mechanism ◽  
Nuclear Transcription Factor ◽  
Regulatory Effects ◽  
Medical Ozone

Introduction: Medical ozone has been used with safety and efficacy in different diseases of oxidative etiology, for the most part involving autoimmune diseases. Methods: An analysis of the pharmacological mechanism of action of ozone was carried out to explain its clinical effectiveness and its positive response in clinical patients to COVID-19. This was done in the context of the different therapeutic targets that have been demonstrated for ozone in other diseases (autoimmune and hypoxia status). Results: Based on the intestine/lung functional axis, the necessity of rectal insufflation as route of application with the aim of attaining improved results using medical ozone against COVID 19 is demonstrated. It was possible to identify at least nine adverse events/molecules which were targets of regulation through medical ozone in other diseases, including innate immune response, nuclear transcription factor NF-kB, “cytokine storm”, inflammation, severe acute respiratory syndrome and coagulopathy. Some of them lead to multi organ failure. Finally, a brief analysis is undertaken to show the regulatory effects of ozone versus the comorbidities contributing to virus lethality, including hyperglycemia and its vascular complications. Conclusions: Medical ozone is effective against COVID-19/SARS-CoV-2: due to the multiple targets it is able to regulate and thereby achieve a positive patient response.

scholarly journals Safety and Efficacy of Coil Embolization in Treating Vascular Complications of Pancreatitis

2016 ◽  
Vol 15 (08) ◽  
pp. 113-116
Author(s):  
Dr. Prajwaleet Gour ◽  
Dr. Jawahar Rathod ◽  
Dr. Dharmik Bhuva ◽  
Dr. Dyaneshwar Shinde ◽  
Dr. Ashwini Bakade
Keyword(s):  
Coil Embolization ◽  
Vascular Complications ◽  
Safety And Efficacy

scholarly journals Transcatheter Mitral Edge-to-Edge Repair in Patients with Primary or Secondary Mitral Regurgitation

2021 ◽  
Vol 1 (10) ◽  
Author(s):  
Kwakye Peprah ◽  
Holly Gunn ◽  
Melissa Walter
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Mitral Valve Repair ◽  
Pacemaker Implantation ◽  
Vascular Complications ◽  
Kidney Injury ◽  
Clinical Effectiveness ◽  
Valve Repair ◽  
Significant Difference ◽  
Secondary Mitral Regurgitation

Four systematic reviews (SRs) and 6 retrospective cohort studies provided evidence for the clinical effectiveness of transcatheter mitral valve repair (TMVR) versus open heart conventional surgical mitral valve repair or replacement (SMVR) in patients with primary or secondary mitral regurgitation (MR). No relevant evidence regarding the cost-effectiveness of TMVR versus SMVR in patients with primary or secondary MR was identified; therefore, no summary can be provided. There was evidence indicating a statistically significant difference in favour of TMVR over SMVR regarding the odds of post-procedure bleeding, need for permanent pacemaker implantation, 30-day readmission, and a shorter duration of hospitalization. There was evidence suggesting a statistically significant difference in favour of SMVR over TMVR regarding the odds of recurrent MR, the need for reoperation, and mortality rate (i.e., during hospitalization, at 1 year, and > 3 years). Also, compared with TMVR, the likelihood of residual MR grade > 2 or freedom from MR grade ≥ 2 or ≥ 3 at 4 years was statistically significantly lower or higher, respectively, with SMVR. Evidence regarding the comparative clinical effectiveness of TMVR versus SMVR concerning stroke, acute kidney injury (AKI), cardiogenic shock, and death during hospitalization was conflicting and inconclusive. There was no evidence of a significant difference between the 2 interventions regarding overall mortality or mortality at 5 years, overall survival, freedom from cardiac death at 4 years, cardiac arrest, acute myocardial infarction (MI), and respiratory or vascular complications. A major limitation of the evidence was that it derives from studies of low or unknown quality and risk of bias, Furthermore, all the findings are confounded by differences in patient selection, which reflect the approved indications for the interventions but prevent a direct comparison between the TMVR and SMVR groups.

scholarly journals One Single Site Clinical Study: To Evaluate the Safety and Efficacy of Immunotherapy With Autologous Dendritic Cells, Cytokine-Induced Killer Cells in Primary Hepatocellular Carcinoma Patients

2020 ◽  
Vol 10 ◽  
Author(s):  
Kaiyue Xu ◽  
Zhengjie Meng ◽  
Xiaoxin Mu ◽  
Beicheng Sun ◽  
Yi Chai
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dendritic Cells ◽  
Survival Rates ◽  
Clinical Effectiveness ◽  
Radical Resection ◽  
Primary Hepatocellular Carcinoma ◽  
Safety And Efficacy ◽  
Cik Cells ◽  
Relapse Time

Dendritic cells (DCs) and cytokine-induced killer (CIK) cells play an important role in the anti-tumor immune response. In this study, we evaluated the clinical effectiveness of DC/CIK-CD24 immunotherapies to primary hepatocellular carcinoma patients who received radical resection. 36 resected primary hepatocellular carcinoma (HCC) patients were enrolled from August 2014 to December 2015. All patients received two or four times of DC/CIK immunotherapy after radical resection. 1–4 years patients’ survival rates were evaluated during the follow-up. The 4-year survival rate of patients who received two times of immunotherapy was 47.1%, and the rate of those who received four times of immunotherapies was 52.6%. Compared to baseline, after receiving the DC/CIK-CD24 autotransfusion, the serum Treg concentration of the patients decreased, while CD3+, CD4+, CD56+ increased slightly. The adverse effect of immunotherapy was I–II° transient fever and could be tolerable. DC/CIK-CD24 immunotherapy can delay the relapse time.

scholarly journals Use of medical ozone in fail back surgery syndrome: a systematic review.

2021 ◽  
Vol 4 (5) ◽  
pp. 64
Author(s):  
Jose Baeza-Noci ◽  
Rosa Maria Pinto-Bonilla
Keyword(s):  
Systematic Review ◽  
Treatment Option ◽  
Potential Role ◽  
Lumbar Disc ◽  
Spinal Diseases ◽  
Antiinflammatory Action ◽  
Safety And Efficacy ◽  
Back Surgery ◽  
Medical Ozone

The safety and efficacy of ozone injections in the spine for lumbar disc herniation has been proved in two systematic reviews with one metaanalysis. Many other papers with lower evidence level were published before encouraging its use for this pathology and other degenerative spinal diseases. Fail back surgery syndrome (FBSS) is a terrible situation with no clear treatment option presently. Some authors have dared to use ozone injections in these patients, based on its antiinflammatory action and its highly save portfolio. Due to the great disability and dramatic situation of FBSS patients, a systematic review is mandatory in order to clarify the potential role of ozone in this pathology.

scholarly journals Lantus, the first peakless basal insulin analogue: 10 years of clinical experience in children and adolescents

2014 ◽  
Vol 17 (2) ◽  
pp. 105-115
Author(s):  
Tamara Leonidovna Kuraeva
Keyword(s):  
Glycemic Control ◽  
Children And Adolescents ◽  
Insulin Analogue ◽  
Vascular Complications ◽  
Clinical Use ◽  
Age Group ◽  
Safety And Efficacy ◽  
Glycemic Profile

This review analyses existing literature, including authors' own data, describing the results of clinical trials which assess safety and efficacy of insulin Glargine (Lantus?) in children and adolescents, as well as peculiar features of T1D management in this age group, including the challenge of reducing the rate of hypoglycemia while maintaining adequate glycemic control. The article also discusses various issues in T1D management in children and adolescents, including the role of glycemic control in development of vascular complications, hypoglycemia and the variability of glycemia. The data confirm the high efficacy of Lantus insulin in respect to metabolic control, including the decrease in the incidence of hypoglycemia and in variability of glycemic profile, the safety of its clinical use in treatment of children, including young children, and adolescents, as well as its ability to improve the quality of life for patients and their parents.

Patient Response to Psychiatric Consultation in a General Hospital

1973 ◽  
Vol 7 (4) ◽  
pp. 279-282 ◽  
Author(s):  
Bernard Hughson ◽  
Robert Lyons
Keyword(s):  
General Hospital ◽  
Drug Dependence ◽  
Positive Response ◽  
Psychiatric Consultation ◽  
Patient Response ◽  
Direct Benefit

Inpatients referred for psychiatric consultation were evaluated during and after the consultation to determine their response to this event. A majority saw the consultation as relevant and/or helpful. The presence of anxiety or depression was associated with a positive response. Patients without a disturbance of mood responded negatively, obtained no direct benefit from consultation, and were likely to have had a diagnosis of psychogenic regional pain, alcoholism or drug dependence.

scholarly journals Preliminary Study on the Safety and Efficacy of One-Stop Treatment of Percutaneous LAAO Combined with Coronary Intervention for Higher Risk of Bleeding in Patients with AF Complicated with CHD

2021 ◽  
Vol 24 (3) ◽  
pp. E474-E478
Author(s):  
Xiaofei Jiang ◽  
Jie Zeng, ◽  
Lintao Zhong ◽  
Weimin Zhu ◽  
Jun Li
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Heart Function ◽  
Clinical Manifestations ◽  
Vascular Complications ◽  
Coronary Intervention ◽  
Atrial Appendage ◽  
Nonvalvular Atrial Fibrillation ◽  
Safety And Efficacy

Aims: To explore the feasibility, safety, and efficacy of 1-stop treatment of percutaneous left atrial appendage occlusion (LAAO) combined with coronary intervention for patients with nonvalvular atrial fibrillation (AF) complicated with coronary heart disease (CHD). Methods and Results: We retrospectively analyzed the clinical data of 6 patients with AF combined with CHD admitted from Zhuhai People’s Hospital from April 2017 to June 2018. After the operation, all patients were treated with aspirin (100 mg qd) and clopidogrel (75 mg qd) for 1 year, which is considered long-term use of aspirin/clopidogrel. The effects of LAAO and coronary intervention were evaluated immediately. The location of the left atrial appendage occluder, thrombosis, residual leak, and clinical manifestations were observed during the 90-day follow-up. The patients were implanted with Watchman™ devices and coronary stents. After the operation, the immediate sealing effect was satisfactory. The Watchman occluder was used in accordance with the PASS principle (position, anchor, size, seal), and the coronary intervention was satisfactory. During the operation, there were no device-related thrombosis, tamponade, or vascular complications. Follow-up results showed that in the 6 patients, there were no hemorrhagic strokes, worsening heart function, residual leakage, device-related thrombosis, angina pectoris, myocardial infarction, skin ecchymosis, gastrointestinal bleeding, or cerebral hemorrhage. Conclusion: For patients with nonvalvular AF combined with CHD, the safety and feasibility of 1-stop treatment with left atrial appendage and coronary intervention are reliable, and the curative effects were also satisfactory at short- and medium-term follow-up.

Abstract 4590: Safety and Efficacy of Prolonged Use of Unfractionated Heparin After Percuatneous Coronary Intervention: A Meta-Analysis

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Param P Singh ◽  
Sarabjeet Singh ◽  
Janos Molnar ◽  
Rohit Arora
Keyword(s):  
Unfractionated Heparin ◽  
Meta Analysis ◽  
Vascular Complications ◽  
Coronary Intervention ◽  
Fixed Effect Model ◽  
Vascular Complication ◽  
Safety And Efficacy ◽  
Repeat Revascularization ◽  
Ischemic Complications ◽  
Venous Fistula

The current guidelines for percutaneous coronary intervention (PCI) do not address the prolonged post-procedural use of unfractionated heparin (UFH) to prevent acute occlusion. However, recently published small studies have yielded mixed results, leaving the question unanswered. Hence a meta-analysis was performed to evaluate safety and efficacy of prolonged use of UFH after PCI. A systematic review of literature revealed 7 studies (Juergens et al, Rabah et al, Garachemani et al, Pizzulli et al, Freidman et al, Tanajura et al and Ellis et al) involving 2412 patients. End points analyzed were ischemic complications (acute closure, myocardial infarction and repeat revascularization) and major vascular complications (hematoma, arterio-venous fistula, pseudo-aneurysm and retroperitoneal bleed). Since the studies were homogenous for outcomes, combined relative risks (RR) across all the studies and the 95% confidence intervals were computed using the Mantel-Haenszel fixed-effect model. A two-sided alpha error < 0.05 was considered to be statistically significant. There were no significant differences in patient demographics between both groups. Compared with placebo the risk of major vascular complication was significantly higher in patients getting post-procedural UFH for prolonged hours (RR: 2.24, CI: 1.68 – 3.48; p=0.001). However, the risk of ischemic complications was similar in both groups (RR: 0.95, CI: 0.46 – 1.96; p=0.89). The meta-analysis suggests that prolonged use of UFH after PCI may result in increased major vascular complications, even though the incidence of ischemic complications may not decrease.

scholarly journals Cigarette Smoke Modulates NOD1 Signal Pathway and Human ß Defensins Expression in Human Oral Mucosa

2015 ◽  
Vol 36 (2) ◽  
pp. 457-473 ◽  
Author(s):  
Ya-jie Qian ◽  
Xiang Wang ◽  
Ya-fan Gao ◽  
Ning Duan ◽  
Xiao-feng Huang ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Oral Mucosa ◽  
Western Blotting ◽  
Signal Pathway ◽  
Innate Immune ◽  
Mrna Levels ◽  
Interacting Protein ◽  
Normal Oral Mucosa ◽  
Regulatory Effects ◽  
Tissue Specimens

Background/Aims: Nucleotide binding oligomerization domain 1 (NOD1) signal pathway and human ß defensins (hBDs) play crucial roles in innate immune. Cigarette smoke has been confirmed to dampen innate immune in some human tissues, such as oral mucosa. The aim of this study was to evaluate potential effects of smoking on NOD1 signaling and hBDs expression in oral mucosa. Methods: Tissue specimens of normal oral mucosa were collected from donors undergoing routine surgical treatment. All 20 participants were classified equally as two groups: non-smokers and smokers. By using Western blotting and immunohistochemistry, we investigated differential expression of crucial molecules in NOD1 signal pathway, hBD-1, -2, and -3 in oral mucosa tissues between non-smokers and smokers. Immortalized human oral mucosal epithelial (Leuk-1) cells were treated with various concentrations of cigarette smoke extract (CSE) for 24h. Western blotting and immunofluorescence assays were performed to study CSE-induced alteration of protein expression. Leuk-1 cells were treated with 4% CSE, iE-DAP (NOD1 agonist), CSE + iE-DAP, BAY 11-7082 (NF-κB inhibitor), 4% CSE + BAY 11-7082, respectively. Real-time PCR and ELISA were performed to detect the mRNA levels and secretion of hBD-1, -2, and -3, respectively. Results: The levels of NOD1, NF-κB, hBD-1 and hBD-3 significantly reduced in oral mucosa tissues of smokers compared with non-smokers. The levels of RIP2 (receptor-interacting protein 2), phospho-NF-κB (P-NF-κB) and hBD-2 remarkably enhanced in oral mucosal tissues of smokers. CSE treatment suppressed NOD1 and NF-κB expression and activated RIP2 and P-NF-κB expression in Leuk-1 cells. The mRNA and secretory levels of hBD-1 and -3 were down-regulated by CSE, while the mRNA and secretory level of hBD-2 were up-regulated by CSE. The iE-DAP or BAY 11-7082 treatment reversed the regulatory effects of CSE on levels of hBDs. Conclusion: The present study indicated that cigarette smoke could potentially modulate the expression of crucial molecules of NOD1 signal pathway and hBDs in human oral mucosal epithelium. NOD1 signal pathway could play an important role in the regulatory effects of CSE on hBDs levels in oral mucosal epithelial cells.

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