Uterine artery hemodynamics in female dogs with open- and closed-cervix pyometra

Although pyometra is a common disease, the mechanisms that determine cervical opening remain unknown. Knowing that the vascular structures are crucial in pathophysiology, it was observed need for hemodynamic studies assessing uterine artery of female dogs with pyometra and its relation to the neck opening. Thirty-five female dogs were selected and separate into three groups: control group (CG) (n = 12), open-cervix pyometra group (OCG) (n = 11) and closed-cervix pyometra group (CCG) (n = 12), with the objective of evaluating and comparing the hemodynamic changes of the uterine artery [peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI)] in female dogs with open- and closed-cervix pyometra and correlate them with measurements of uterine diameter (UD) and endometrial thickness (ET). The correlation analysis showed that, with the exception of PSV, the hemodynamics indices were associated with UD and ET, presenting a moderate and positive correlation between UD and EDV (r = 0.62; P<0.01), a moderate and negative correlation between UD and RI (r =-0.68; P<0.01) and also moderate and negative correlation between ET and RI (r = -0.62; P<0.01). These results suggest that alterations of uterine artery hemodynamics are similar in dog females with open- or closed-cervix pyometra, although the UD and the ET can influence in the uterine perfusion.

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Developmental changes in hemodynamics of uterine artery, utero- and umbilicoplacental, and vitelline circulations in mouse throughout gestation

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00031.2006 ◽

2006 ◽

Vol 291 (3) ◽

pp. H1421-H1428 ◽

Cited By ~ 87

Author(s):

Junwu Mu ◽

S. Lee Adamson

Keyword(s):

Uterine Artery ◽

Umbilical Artery ◽

Resistance Index ◽

Peak Systolic Velocity ◽

Normal Pregnancy ◽

Ultrasound Biomicroscopy ◽

Placental Development ◽

Diastolic Velocity ◽

Early Onset Preeclampsia ◽

Arterial Canal

In human pregnancy, abnormal placental hemodynamics likely contribute to the etiology of early-onset preeclampsia and fetal intrauterine growth restriction. The mouse is increasingly being deployed to study normal and abnormal mammalian placental development, yet the placental hemodynamics in normal pregnancy in mice is currently unknown. We used ultrasound biomicroscopy to noninvasively image and record Doppler blood velocity waveforms from the maternal and embryonic placental circulations in mice throughout gestation. In the uterine artery, peak systolic velocity (PSV) increased significantly from 23 ± 2 (SE) to 59 ± 3 cm/s, and end-diastolic velocity (EDV) increased from 7 ± 1 to 28 ± 2 cm/s in nonpregnant versus full-term females so that the uterine arterial resistance index (RI) decreased from 0.70 ± 0.02 to 0.53 ± 0.02. Velocities in the maternal arterial canal in the placenta were low and nearly steady and increased from 0.9 ± 0.03 cm/s at embryonic day 10.5 (E10.5) to 2.4 ± 0.07 cm/s at E18.5. PSV in the umbilical artery increased steadily from 0.8 ± 0.1 cm/s at E8.5 to 15 ± 0.6 cm/s at E18.5, whereas PSV in the vitelline artery increased from 0.6 ± 0.1 cm/s at E8.5 to 4 ± 0.2 cm/s at E13.5 and then remained stable to term. In the umbilical artery, the EDV detection rate was 0% at ≤E14.5 and 94% at E18.5, and the RI decreased from 1 to 0.82 ± 0.01 during this interval. We conclude that ultrasound biomicroscopy can be used to monitor placental hemodynamics during pregnancy in mice. These results provide novel information concerning the development of the vitelline and placental circulations in mice and reveal strong similarities in placental hemodynamics between mice and humans.

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Post-exercise pulsatility index indicates treatment effects in peripheral arterial occlusive disease (PAOD)

Wiener klinische Wochenschrift ◽

10.1007/s00508-021-01818-x ◽

2021 ◽

Author(s):

Andrej Udelnow ◽

Maria Hawemann ◽

Ivo Buschmann ◽

Frank Meyer ◽

Zuhir Halloul

Keyword(s):

Repeated Measures ◽

Pulsatility Index ◽

Treatment Effects ◽

Resistance Index ◽

Peak Systolic Velocity ◽

Arterial Tree ◽

Post Exercise ◽

Diastolic Velocity ◽

Before And After ◽

Healthy Persons

Summary Background Hypothesis: Post-exercise measurements better discriminate PAOD-patients from healthy persons and they more sensitively detect hemodynamic improvements after treatment procedures than resting measurements. Methods A total of 19 healthy volunteers and 23 consecutive PAOD-patients underwent measurements of peak systolic velocity (PSV), end-diastolic velocity (EDV), minimal diastolic velocity (MDV), time-averaged maximum velocities (TAMAX), resistance index (RI) and pulsatility index (PI) before and after a standard exercise test (at 1, 2, 3, 4 and 5 min) before and after treatment (incl. epidemiological data, PAOD risk factors and comorbidities). Results In resting values, healthy persons and PAOD-patients did not differ significantly in any of the hemodynamic parameters. PSV increased after treatment in PAOD-patients by 5 cm/s (paired t‑test, p: 0.025); however, when the amplitude of autoregulatory changes related to the resting values were calculated, PAOD-patients showed clearly less hemodynamic changes after exercise than healthy persons (p: 0.04; 0.002; <0.001 for PSV, TAMAX and PI, resp.). The time course after exercise was compared by repeated measures of ANOVA. Healthy persons differed significantly in PI, RI and PSV from PAOD patients before and after treatment (p<0.001 each). The PAOD-patients revealed a significantly improved PI after treatment (p: 0.042). The only factor contributing significantly to PI independently from grouping was direct arterial vascularization as compared to discontinuous effects by an obstructed arterial tree. Conclusion Healthy persons cannot be well differentiated from PAOD-patients solely by hemodynamics at rest but by characteristic changes after standard exercise. Treatment effects are reflected by higher PI-values after exercise.

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195 Are the Spectral Doppler Indices of the Ovarian Arteries Predictive of Ovulatory Responses and Embryo Yields in Superovulated Ewes?

Reproduction Fertility and Development ◽

10.1071/rdv30n1ab195 ◽

2018 ◽

Vol 30 (1) ◽

pp. 238

Author(s):

M. E. F. Oliveira ◽

Y. Tarasevych ◽

W. R. R. Vicente ◽

P. M. Bartlewski

Keyword(s):

Resistance Index ◽

Peak Systolic Velocity ◽

Ovarian Response ◽

Embryo Viability ◽

Mean Velocity ◽

Ovarian Artery ◽

Diastolic Velocity ◽

Spectral Doppler ◽

Left And Right ◽

Doppler Indices

Increased uterine and ovarian blood flow seems to be related to the effectiveness of ovarian response to hormonal superstimulation in mares (Witt et al. 2012 Theriogenology 77, 1406-1414). Similar studies do not exist for sheep. Nineteen Santa Inês ewes were subjected to a 9-day CIDR® priming and superovulatory (SOV) treatment with 200 mg of porcine (p)FSH per ewe given twice daily for 4 consecutive days in decreasing doses and initiated 6 days after CIDR® insertion. Ten ewes received an IM injection of oestradiol benzoate (EB, 350 μg) at the time of CIDR® insertion (group E); the remaining animals served as controls (group C). The ewes were placed in a pen with rams for 3 days after CIDR® removal. The embryos were recovered surgically 6 days after the CIDR® removal. Transrectal ultrasonographic examinations (Doppler mode) using MyLab VET 30 scanner (Esaote, Genoa, Italy) equipped with a linear-array (6- to 8-MHz) transducer were performed once a day throughout the SOV treatment (Days 1 to 4) to determine the velocimetric indices of the left and right ovarian arteries: flow velocity integral (FVI); peak systolic velocity (SVp); mean velocity (Vm); end-diastolic velocity (EDV); vascular resistance index [RI = (SVp – EDV)/SVp]; and pulsatility index [PI = (SVp – EDV)/Vm]. All spectral data were obtained from a longitudinal subovarian segment of the ovarian artery using a gate ranging from 2 to 3 mm (~two-thirds of the vessel’s diameter) and insonation angle ≤60°. There were no differences (P > 0.05) in ovarian responses and embryo yields/quality between left and right ovaries/uterine horns flashed or between EB-treated and control ewes. Mean EDV and Vm were greater (P < 0.05) in group C compared with group E on Days 1 and 2, and mean Vp was greater (P < 0.05) in group C ewes on Day 3 of the SOV treatment. In group E, there were 5 significant correlations between the spectral Doppler indices (RI, PI, and EDV) of the ovarian arteries recorded on Days 2 and 4 and SOV responses (numbers of degenerated embryos, unfertilized eggs, and luteinized unovulated follicles characterised by a lack of ovulatory stigmata). In group C, 7 significant correlations were found between Vp, EDV, Vm, and RI on Days 1, 2, and 3 and numbers/percentages of degenerated embryos, numbers of prematurely regressed luteal structures (pale, ≤5 mm in diameter), and embryo viability rates (percentage of transferrable quality embryos). When ultrasonographic and SOV data were analysed separately for the left and right ovarian artery/uterine horn, multiple significant correlations were found between the velocimetric indices and SOV responses but they varied among days, the 2 ovaries, and the 2 groups of animals studied. These results may be interpreted to suggest that intrinsic gonadal factors remain a significant barrier precluding the prediction of SOV outcomes from haemodynamic changes in ovine ovarian arteries. Velocimetric indices determined in the ovarian arteries appear to have limited prognostic value during the application of different SOV protocols in ewes.

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298 Effects of parity on late gestational uterine blood flow and hemodynamics in beef cattle

Journal of Animal Science ◽

10.1093/jas/skz258.281 ◽

2019 ◽

Vol 97 (Supplement_3) ◽

pp. 137-138

Author(s):

Allison M Meyer ◽

Natalie B Duncan ◽

Katy S Stoecklein ◽

Emma L Stephenson

Keyword(s):

Heart Rate ◽

Blood Flow ◽

Birth Weight ◽

Pulsatility Index ◽

Uterine Artery ◽

Color Doppler ◽

Peak Systolic Velocity ◽

Late Gestation ◽

Artery Blood Flow ◽

Diastolic Velocity

Abstract To determine parity effects on late gestational uteroplacental blood flow, uterine artery hemodynamics were measured in 13 primiparous and 11 multiparous (parity 3 and 4) non-lactating, fall-calving crossbred females beginning 109 d prepartum. Females were nutritionally managed as one group to meet or exceed nutrient requirements. Transrectal color Doppler ultrasonography of the both uterine arteries was conducted 3 to 6 times per female across late gestation, ending at approximately 20 d prepartum. Data were analyzed with parity (primiparous vs. multiparous), day prior to calving, and their interaction in the model; day was a repeated effect. Dam BW was greater (P < 0.001) for multiparous than primiparous females, and increased (P = 0.004) as gestation progressed. Calf birth weight was unaffected (P = 0.87) by parity. The parity x day interaction tended to affect (P = 0.06) ipsilateral uterine artery blood flow (L/min), where multiparous cows had a greater increase per day. Total and contralateral uterine artery blood flow were unaffected (P ≥ 0.11) by parity, but increased (P < 0.001) with day of gestation. When expressed relative to dam BW, total and contralateral blood flow were greater (P ≤ 0.04) in primiparous than multiparous females; ipsilateral blood flow was unaffected (P ≥ 0.13) by parity, however. Ipsilateral pulsatility index and both resistance indices were unaffected (P ≥ 0.28) by parity and day, but day tended to affect (P = 0.07) contralateral pulsatility index. Parity did not affect (P ≥ 0.11) cross-sectional area, mean velocity, peak systolic velocity, and end diastolic velocity of either uterine artery, but all increased (P < 0.001) as gestation progressed. Heart rate was greater (P = 0.03) in primiparous than multiparous females. Data suggest that uterine artery blood flow and heart rate may be altered in primiparous females, even when birth weight is unaffected by parity.

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Increasing Maternal Blood Pressure with Ephedrine Increases Uterine Artery Blood Flow Velocity during Uterine Contraction

Anesthesiology ◽

10.1097/00000542-200203000-00017 ◽

2002 ◽

Vol 96 (3) ◽

pp. 612-616 ◽

Cited By ~ 18

Author(s):

Laurent Ducros ◽

Philippe Bonnin ◽

Bernard P. Cholley ◽

Eric Vicaut ◽

Moncef Benayed ◽

...

Keyword(s):

Blood Flow ◽

Flow Velocity ◽

Uterine Artery ◽

Uterine Contraction ◽

Perfusion Pressure ◽

Resistance Index ◽

Hemodynamic Parameters ◽

Uterine Blood Flow ◽

Uterine Contractions ◽

Uterine Perfusion

Background During labor, ephedrine is widely used to prevent or to treat maternal arterial hypotension and restore uterine perfusion pressure to avoid intrapartum fetal asphyxia. However, the effects of ephedrine on uterine blood flow have not been studied during uterine contractions. The purpose of the study was to assess the effects of ephedrine on uterine artery velocities and resistance index using the Doppler technique during the active phase of labor. Methods Ten normotensive, healthy parturients with uncomplicated pregnancies at term received intravenous ephedrine during labor to increase mean arterial pressure up to a maximum of 20% above their baseline pressure. Peak systolic and end-diastolic Doppler flow velocities and resistance indices were measured in the uterine artery before and immediately after administration of bolus intravenous ephedrine and after ephedrine washout. Umbilical and fetal middle cerebral arterial resistance indices and fetal heart rate were also calculated. Results After ephedrine administration, mean arterial pressure increased by 17 +/- 4%. End-diastolic flow velocity in the uterine artery at peak amplitude of uterine contraction was restored to 74% of the value observed in the absence of contraction. The systolic velocity was totally restored, and the uterine resistance index was significantly decreased, compared with the values in the absence of contraction. Between uterine contractions, ephedrine induced similar but less marked effects. Fetal hemodynamic parameters were not altered by ephedrine administration. Conclusions Bolus administration of intravenous ephedrine reversed the dramatic decrease in diastolic uteroplacental blood flow velocity and the increase in resistance index during uterine contraction, without altering fetal hemodynamic parameters. This suggests that the increase in uterine perfusion pressure during labor could in part restore uterine blood flow to the placenta during uterine contraction.

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Outcome of vaginal sildinafil in assisted reproductive technology cycles

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20210306 ◽

2021 ◽

Vol 10 (2) ◽

pp. 575

Author(s):

Avnika Kapoor ◽

Garima Sharma ◽

Rita Bakshi

Keyword(s):

Uterine Artery ◽

Endometrial Thickness ◽

Study Groups ◽

Control Group ◽

P Value ◽

Surrogate Mothers ◽

Endometrial Pattern ◽

Study Population ◽

Pre Treatment ◽

And Control

Background: The present study assessed the role of sildenafil in endometrial blood flow and successful pregnancy in IVF done in surrogate mothers.Methods: In the present study surrogate mothers were included. Thirty patients were randomized to receive sildenafil 25 mg thrice a day vaginally in addition to standard drugs and technique and another 30 were not given sildenafil.Results: Mean age, anthropometry, duration of infertility and pre-treatment endometrial thickness was similar in the two study groups. After treatment completion, it was observed that the endometrial pattern in ultrasound was similar in the two study groups (p value=0.58). Heterogenic endometrial pattern was observed in 6.7% of the Sildenafil patients and 3.3% in the control patients, while echogenic pattern was seen in 10% of the sildenafil patients and 6.7% of the control patients. Similarly, endometrial thickness was 10.2±1.7 and 9.7±1.8 mm in sildenafil and control group respectively, p value=0.62. Using doppler ultrasound, uterine artery PI was significantly lower in Sildenafil group patients as compared to control group patients. Similarly, we found uterine artery RI was also significantly lower in the Sildenafil group patients as compared to control group patients. We followed the patients and found that clinical pregnancy rate was significantly higher among Sildenafil group (60%) as compared to control group (26.6%), p value<0.05.Conclusions: Vaginal sildenafil resulted in significantly higher pregnancy rates in our study population. The uterine artery PI and RI were significantly lower in patients taking sildenafil.

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Effect of nitric oxide donors on uterine and sub-endometrial blood flow in patients with unexplained infertility: a randomized controlled trial

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20212144 ◽

2021 ◽

Vol 10 (6) ◽

pp. 2178

Author(s):

Mohamed A. Abdel Hafeez ◽

Ashraf M. F. Kortam ◽

Alaa M. A. Youssef ◽

Ahmed Reda ◽

Rehab M. Abdelrahman

Keyword(s):

Blood Flow ◽

Uterine Artery ◽

Endometrial Thickness ◽

Controlled Trial ◽

Unexplained Infertility ◽

Control Group ◽

Artery Blood Flow ◽

Randomized Controlled ◽

Endometrial Blood Flow ◽

Fertile Women

Background: Impaired sub-endometrial perfusion might reduce endometrial receptivity and possibly contribute to unexplained infertility. A favorable effect on sub-endometrial blood flow has been demonstrated with nitric oxide.Methods: This randomized controlled trial evaluated the effect of nitroglycerine on uterine and sub-endometrial blood flow in women with unexplained infertility. Sixty women were randomized into 2 equal groups. The study group received 5mg nitroglycerine patch daily from day 2 of the cycle till the evaluation day and the control group received no treatment. Independent of the study arms, 30 parous women were included as the fertile group. Six to eight days after detecting luteinizing hormone surge, women were assessed for endometrial thickness, uterine artery blood flow with color Doppler and sub-endometrial blood flow with three-dimensional power Doppler.Results: Compared to fertile women, cases with unexplained infertility (control group) had a significantly thinner endometrium, higher uterine artery Doppler indices and lower sub-endometrial blood flow. Women who received nitroglycerin showed a significant improvement in sub-endometrial blood flow while uterine artery blood flow did not show a significant difference; however, the values were also comparable to fertile women. In addition, no effect on endometrial thickness was found with nitroglycerin treatment. Nitroglycerin treatment side effects were headache, blurring of vision and hypotension. These adverse effects were not significant compared to controls.Conclusions: In women with unexplained infertility, nitroglycerin significantly improved the sub-endometrial blood flow but did not affect the endometrial thickness.

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Comparison of liver hemodynamics according to doppler ultrasonography in alcoholic patients subtyped by Cloninger classification and non-alcoholic healthy subjects

Acta Neuropsychiatrica ◽

10.1111/j.0924-2708.2006.00111.x ◽

2006 ◽

Vol 18 (1) ◽

pp. 7-14

Author(s):

Z. Sumru Cosar ◽

Behcet Cosar ◽

Suna Oktar ◽

Zehra Arikan ◽

Hakan Özdemir ◽

...

Keyword(s):

Portal Vein ◽

Superior Mesenteric Artery ◽

Hepatic Artery ◽

Mesenteric Artery ◽

Healthy Subjects ◽

Peak Systolic Velocity ◽

Control Group ◽

Cross Sectional ◽

Diastolic Velocity ◽

Significant Difference

Background:The aim of this study was to search for morphological and hemodynamic changes in hepatic and splanchnic vasculature in alcoholic patients without the signs of hepatic damage and subtyped by Cloninger classification by means of sonography, and compare the subtypes among themselves and with nonalcoholic healthy subjects.Methods:Thirty alcohol dependent patients and 30 healthy subjects with no alcohol problem or hepatic impairment were included in the study. Patients were subtyped by Cloninger classification and all patients were evaluated by gray-scale and spectral Doppler ultrasound. The diameter of the portal vein, portal venous velocity, peak systolic and end diastolic velocities of hepatic and superior mesenteric arteries were assessed. RI, PI and systolic/diastolic velocity ratios were also calculated.Results:Portal vein diameter (PV diameter), portal vein cross sectional area (PV area), portal vein velocity (PV PSV), hepatic artery peak systolic velocity (HA PSV), hepatic artery end diastolic velocity (HA EDV), hepatic artery resistive index (HA RI), hepatic artery pulsatility index (HA PI), and systolic/diastolic velocity ratios (HA S/D), superior mesenteric artery peak systolic velocity (SMA PSV), superior mesenteric artery end diastolic velocity (SMA EDV), superior mesenteric artery resistive indices (SMA RI), pulsatility index (SMA PI), and systolic/diastolic velocity rates (SMA S/D) showed no significant difference among the groups (P > 0.01). Although there is no significant difference in PV PSV, HA PSV, SMA PSV, SMA EDV values between the groups, mean values of Type II alcoholics is greater than other groups. Portal vein cross-sectional area was greater in alcoholic patients (Type I, II and III) compared to the control group (P = 0.000). Portal vein velocity, hepatic artery peak systolic and end diastolic velocity, superior mesenteric artery peak systolic and end diastolic velocity were significantly greater in alcoholic patients than in the control group (P < 0.001). No statistical difference was detected between other parameters evaluated.Conclusion:In alcohol dependent patients, some hemodynamic and morphologic changes occur in hepatic and splanchnic circulation, even before the signs of hepatic damage develop, which can be detected by means of Doppler and gray-scale sonography. But as there is no significant difference between the Doppler ultrasonographic findings among alcoholics subtyped by a Cloninger classification, which is a clinical classification, it suggests that psychiatric classification doesn't show any correlation with biological parameters, and because of this Cloninger classification a psychiatric classification cannot be considered as a characteristic determinative factor in the prognosis of hepatic disorder due to alcohol use. However, higher values of Type II alcoholics can be attributed to the longer alcohol intake of this subtype.

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Effects of Yoga on Utero-Fetal-Placental Circulation in High-Risk Pregnancy: A Randomized Controlled Trial

Advances in Preventive Medicine ◽

10.1155/2015/373041 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 14

Author(s):

Abbas Rakhshani ◽

Raghuram Nagarathna ◽

Rita Mhaskar ◽

Arun Mhaskar ◽

Annamma Thomas ◽

...

Keyword(s):

High Risk ◽

Standard Care ◽

Uterine Artery ◽

Controlled Trial ◽

Resistance Index ◽

High Risk Pregnancy ◽

Trophoblast Invasion ◽

Control Group ◽

Risk Pregnancy ◽

Yoga Group

Introduction. Impaired placentation and inadequate trophoblast invasion have been associated with the etiology of many pregnancy complications and have been correlated with the first trimester uterine artery resistance. Previous studies have shown the benefits of yoga in improving pregnancy outcomes and those of yogic visualization in revitalizing the human tissues.Methods. 59 high-risk pregnant women were randomized into yoga (n= 27) and control (n= 32) groups. The yoga group received standard care plus yoga sessions (1 hour/day, 3 times/week), from 12th to 28th week of gestation. The control group received standard care plus conventional antenatal exercises (walking). Measurements were assessed at 12th, 20th, and 28th weeks of gestation.Results. RM-ANOVA showed significantly higher values in the yoga group (28th week) for biparietal diameter (P= 0.001), head circumference (P= 0.002), femur length (P= 0.005), and estimated fetal weight (P= 0.019). The resistance index in the right uterine artery (P= 0.01), umbilical artery (P= 0.011), and fetal middle cerebral artery (P= 0.048) showed significantly lower impedance in the yoga group.Conclusion. The results of this first randomized study of yoga in high-risk pregnancy suggest that guided yogic practices and visualization can improve the intrauterine fetal growth and the utero-fetal-placental circulation.

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MRI CSF flowmetry in evaluation of different neurological diseases

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-021-00429-w ◽

2021 ◽

Vol 52 (1) ◽

Author(s):

Nermin Ahmad ◽

Dina Salama ◽

Mohammad Al-Haggar

Keyword(s):

Neurological Diseases ◽

Therapeutic Option ◽

Peak Systolic Velocity ◽

Maximum Velocity ◽

Invasive Technique ◽

Control Group ◽

Type I ◽

Csf Flow ◽

Non Invasive ◽

Diastolic Velocity

Abstract Background Phase contrast MR imaging is a rapid and non-invasive technique which is sensitive in diagnosis and follow-up of different neurological diseases that cause CSF flow abnormality. MRI CSF flowmetry will be currently assessed in different neurological diseases that may cause CSF flow abnormalities. Results This study includes 39 patients with their ages ranging from 1 to 65 years; they were referred from the neurology department, with nine individuals of matched age and sex as a control group. Based on clinical history and conventional MRI, patients were subdivided into five subgroups; normal pressure hydrocephalus (NPH), hydrocephalus, idiopathic intracranial hypertension (IIH), brain atrophy (BA), and Chiari malformation type I (CM-I). All patients and control were subjected to MRI CSF flowmetry evaluation with stress on peak diastolic velocity (PDV), peak systolic velocity (PSV), stroke volume (SV), and maximum velocity (Vmax). PDV, PSV, and SV were found significantly higher in NPH, CM-I, and hydrocephalus compared to control (4.2, 4.96, and 83.23 for NPH; 3.95, 4.93, and 37.38 for CM-I; and 4.2, 5.6, and 125 in hydrocephalus versus 2.11, 2.73, and 75.33 in control, respectively; P = 0.0004, 0.0008, and 0.0009 for NPH; 0.03, 0.003, and 0.06 for CM-I; and 0.0005, 0.0002, and 0.0003, respectively). On the other hand, patients with BA showed significantly lower values (1.37, 1.66, and 1.53, respectively) compared to control (P = 0.001, 0.001, and 0.004, respectively). Conclusion MRI CSF flowmetry provides an easy, accurate, and non-invasive method for diagnosis of different neurological diseases that cause CSF flow abnormality. Moreover, this diagnostic modality could be helpful in selecting the therapeutic option.

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