Resistência a carbapenêmicos por Acinetobacter spp. reportados ao GLASS de acordo com o nível de renda dos países

Paulo Monteiro Araujo; Carina da Costa Braúna; Susan Catherine Lima Lemos; Duanne Mendes Gomes; Veridiana Rebelo dos Santos; Savio Freire da Silva; Luciano da Silva Lopes

doi:10.33448/rsd-v10i17.24115

Resistência a carbapenêmicos por Acinetobacter spp. reportados ao GLASS de acordo com o nível de renda dos países

Research Society and Development ◽

10.33448/rsd-v10i17.24115 ◽

2021 ◽

Vol 10 (17) ◽

pp. e116101724115

Author(s):

Paulo Monteiro Araujo ◽

Carina da Costa Braúna ◽

Susan Catherine Lima Lemos ◽

Duanne Mendes Gomes ◽

Veridiana Rebelo dos Santos ◽

...

Keyword(s):

Antimicrobial Resistance ◽

Surveillance System ◽

Acinetobacter Spp ◽

Per Capita

Este trabalho tem por objetivo avaliar a resistência a carbapenêmicos da Acinetobacter spp. reportada ao GLASS (Global Antimicrobial Resistance and Use Surveillance System), estratificando esses dados por faixa de renda per capita. Foi conduzido um estudo observacional retrospectivo sobre a sensibilidade a carbapenêmicos da Acinetobacter spp., reportada ao GLASS, fora incluído todos os dados disponíveis no momento da coleta, fevereiro de 2021, estratificando esses achados pelo nível de renda de cada país e a quantidade de testes de sensibilidade a carbapenêmicos realizados. Os países de maior renda tiveram a menor não-suscetibilidade relatada, contudo dentro deles existem exemplos que apresentam uma alta incidência de não-suscetibilidade. Para todos os quatro grupos de renda existiu uma alta variância do desvio padrão para a média dos testes de sensibilidade a carbapenêmicos, assim revelando pontos de inconsistência. Os dados trabalhados neste artigo mostram um nível preocupante de resistência a carbapenêmicos observados no GLASS. Dentro mesmo dos países ricos há aqueles que possuem níveis alarmantes de não-susceptibilidade e, para os países mais pobres, destaca-se uma escassez de dados mais completos, pois naqueles com os níveis mais preocupantes de não-susceptibilidade já são encontradas cepas de Acinetobacter spp. com fenótipo de multirresistência.

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Susceptibility of Escherichia coli to fluoroquinolones and 3rd-generation cephalosporins by age group and gender – results from the German antimicrobial resistance surveillance system 2014

10.26226/morressier.56d5ba26d462b80296c94b13 ◽

2016 ◽

Author(s):

Ines Noll

Keyword(s):

Escherichia Coli ◽

Antimicrobial Resistance ◽

Surveillance System ◽

Age Group ◽

Antimicrobial Resistance Surveillance ◽

And Gender

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Quality Assessment of an Antimicrobial Resistance Surveillance System in a Province of Nepal

Tropical Medicine and Infectious Disease ◽

10.3390/tropicalmed6020060 ◽

2021 ◽

Vol 6 (2) ◽

pp. 60

Author(s):

Jyoti Acharya ◽

Maria Zolfo ◽

Wendemagegn Enbiale ◽

Khine Wut Yee Kyaw ◽

Meika Bhattachan ◽

...

Keyword(s):

Antimicrobial Resistance ◽

Surveillance System ◽

Surveillance Data ◽

World Health ◽

Cross Sectional ◽

Antimicrobial Resistance Surveillance ◽

Data Collection Process ◽

Data Compilation ◽

Site Variation ◽

Health Organization

Antimicrobial resistance (AMR) is a global problem, and Nepal is no exception. Countries are expected to report annually to the World Health Organization on their AMR surveillance progress through a Global Antimicrobial Resistance Surveillance System, in which Nepal enrolled in 2017. We assessed the quality of AMR surveillance data during 2019–2020 at nine surveillance sites in Province 3 of Nepal for completeness, consistency, and timeliness and examined barriers for non-reporting sites. Here, we present the results of this cross-sectional descriptive study of secondary AMR data from five reporting sites and barriers identified through a structured questionnaire completed by representatives at the five reporting and four non-reporting sites. Among the 1584 records from the reporting sites assessed for consistency and completeness, 77–92% were consistent and 88–100% were complete, with inter-site variation. Data from two sites were received by the 15th day of the following month, whereas receipt was delayed by a mean of 175 days at three other sites. All four non-reporting sites lacked dedicated data personnel, and two lacked computers. The AMR surveillance data collection process needs improvement in completeness, consistency, and timeliness. Non-reporting sites need support to meet the specific requirements for data compilation and sharing.

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1439. High Rates of Drug Resistance in Escherichia coli from a Pilot Antimicrobial Resistance Surveillance System in Cambodia

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.1620 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S723-S724

Author(s):

Vandarith Nov ◽

Darapheak Chau ◽

Chhorvann Chhea

Keyword(s):

Public Health ◽

Escherichia Coli ◽

Staphylococcus Aureus ◽

Antimicrobial Resistance ◽

Blood Culture ◽

Klebsiella Pneumoniae ◽

Surveillance System ◽

Methicillin Resistance ◽

Salmonella Typhi ◽

Blood Samples

Abstract Background Antimicrobial resistance (AMR) is a major and growing global public health problem. The Cambodia Ministry of Health established a pilot laboratory-based AMR surveillance system for blood specimens in 2017. The objective of this study is to characterize AMR among pathogenic isolates from blood samples. Methods A retrospective analysis was performed using one year of data from a pilot AMR Surveillance system in Cambodia. Four blood culture isolate pathogens were included: Escherichia coli, Klebsiella pneumoniae, Salmonella Typhi /Salmonella Paratyphi A and Staphylococcus aureus. Blood culture isolates that were referred from eleven sentinel sites were analyzed at the National Public Health Laboratory for identification. Antibiotic susceptibility testing (AST) was done using disk diffusion, minimum inhibitory concentration method following Clinical Laboratory Standard Institute (CLSI) guidelines. Results Among 214 pathogenic isolates from blood samples, E.coli was the most common (56.1%), followed by Salmonella Typhi/Salmonella Paratyphi A (18.7%), Staphylococcus aureus (13.5%), and Klebsiella pneumoniae (11.7%). Methicillin Resistance Staphylococcus aureus (MRSA) was detected in half of the isolates. E.coli was resistant to ampicillin (94.4%), trimethoprim-sulfamethoxazole (84.5%), and ceftriaxone (79.2%). Salmonella Typhi was resistant to ampicillin (73.3%) and trimethoprim-sulfamethoxazole (60.0%) and Salmonella Paratyphi A were resistant to fluoroquinolones (91.7%). For last resort antibiotics, E.coli was resistant to carbapenem groups (3.2% for imipenem, 4.9% for meropenem, and 5.0% for ertapenem). Klebsiella pneumoniae was not resistant to any groups. Conclusion E.coli was found at high rates in blood samples and was resistant to common antibiotics used in Cambodia. These pilot data show the importance of establishing a national AMR surveillance system in Cambodia to monitor AMR trends following GLASS guidelines. Disclosures All Authors: No reported disclosures

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Establishment of the South Korean national antimicrobial resistance surveillance system, Kor-GLASS, in 2016

Eurosurveillance ◽

10.2807/1560-7917.es.2018.23.42.1700734 ◽

2018 ◽

Vol 23 (42) ◽

Cited By ~ 12

Author(s):

Hyukmin Lee ◽

Eun-Jeong Yoon ◽

Dokyun Kim ◽

Seok Hoon Jeong ◽

Jong Hee Shin ◽

...

Keyword(s):

Antimicrobial Resistance ◽

Surveillance System ◽

Action Plan ◽

World Health ◽

Surveillance Systems ◽

The South ◽

South Korean ◽

Antimicrobial Resistance Surveillance ◽

The Status ◽

Health Organization

Surveillance plays a pivotal role in overcoming antimicrobial resistance (AMR) in bacterial pathogens, and a variety of surveillance systems have been set up and employed in many countries. In 2015, the World Health Organization launched the Global Antimicrobial Resistance Surveillance System (GLASS) as a part of the global action plan to enhance national and global surveillance and research. The aims of GLASS are to foster development of national surveillance systems and to enable collection, analysis and sharing of standardised, comparable and validated data on AMR between different countries. The South Korean AMR surveillance system, Kor-GLASS, is compatible with the GLASS platform and was established in 2016 and based on the principles of representativeness, specialisation, harmonisation and localisation. In this report, we summarise principles and processes in order to share our experiences with other countries planning to establish a national AMR surveillance system. The pilot operation of Kor-GLASS allowed us to understand the national burden of specific infectious diseases and the status of bacterial AMR. Issues pertaining to high costs and labour-intensive operation were raised during the pilot, and improvements are being made.

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Antimicrobial resistance profiles of microorganisms isolated from hospitalized patients in Dominican Republic

Revista Panamericana de Salud Pública ◽

10.26633/rpsp.2020.36 ◽

2020 ◽

Vol 44 ◽

pp. 1

Author(s):

David de Luna ◽

José Javier Sánchez ◽

Miguel Peguero ◽

Wilmary García ◽

Sylmari Liciaga ◽

...

Keyword(s):

Antimicrobial Resistance ◽

Dominican Republic ◽

Methicillin Resistance ◽

Carbapenem Resistance ◽

Generation Cephalosporin ◽

Cross Sectional Study ◽

Hospitalized Patients ◽

Coagulase Negative Staphylococci ◽

Cross Sectional ◽

Acinetobacter Spp

Objective. To define the antimicrobial resistance profiles of the microorganisms most commonly isolated from hospitalized adult patients in Dominican Republic (DR). Methods. A retrospective, cross-sectional study of phenotypic antimicrobial susceptibility patterns was conducted using data from 3 802 clinical microbiology reports specifying positive bacterial cultures in samples collected from patients admitted to the clinical, surgery, and intensive care units (ICU) at three tertiary-level care hospitals in the city of Santiago de los Caballeros from 1 January 2016 – 31 December 2017. Descriptive statistics and chi-square test (P ≤ 0.05) were used to analyze the qualitative variables. Results. At the three hospitals, there were 932, 1 090, and 1 780 microbiology reports analyzed. Of the total, 1274 were from the ICU, 1 042 from the surgery unit, and 1 486 from the clinical unit. Methicillin resistance was found in 57.3% of the Staphylococcus aureus isolates and 75.3% of the coagulase-negative staphylococci. Third-generation cephalosporin resistance was detected in 54.4% of isolates identified as members of the Enterobacteriaceae family, 67.3% of the Acinetobacter spp., and 91.7% of the Pseudomonas, while carbapenem resistance was shown by 8.0%, 23.8%, and 51.0% of these, respectively. Most of the resistant Acinetobacter spp. isolates were found in just one hospital and the prevalence of Enterobacteriaceae resistant to carbapenems was highest in the ICU. Conclusion. Antimicrobial resistance levels are high among hospitalized patients in Dominican Republic and may cause enhanced risk factors that impact clinical outcomes. Urgent measures are needed to address antimicrobial resistance in DR.

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