Repercussão de dietas inflamatórias nas desordens endócrinas de pacientes com diabetes mellitus

Introdução: O diabetes mellitus é uma doença crônica não transmissível em que há desordens endócrinas e metabólicas, como estresse oxidativo e processos inflamatórios em decorrência da hiperglicemia. Esses processos inflamatórios têm origem multifatorial, dentre eles, a alimentação inadequada. Neste sentido, o objetivo dessa revisão foi discutir as desordens endócrinas do diabetes mellitus e sua relação com o índice inflamatório da dieta. Metodologia: Foi realizada uma revisão narrativa a partir da busca de artigos publicados nas bases de dados Pubmed, Science Direct, SciELO e Cochrane Library, utilizando os descritores “Diabetes Mellitus”, “Inflammation”, “Insulin Resistence”, “Oxidative Stress” e “Inflammatory Diet”. Resultado: Estudos científicos sugerem que alguns componentes da dieta causem estresse oxidativo e inflamação, o que por sua vez repercute no quadro clínico de indivíduos com diabetes. É possível detectar que dietas baseadas no estilo de vida ocidental, com uma alimentação rica em carne vermelha, açúcares refinados, bebidas industrializadas e alimentos processados, são considerados estimuladores positivos da elevação dos níveis de biomarcadores inflamatórios, a exemplo da PCR, TNF-α e interleucinas. Conclusão: existe uma possível relação entre a presença do diabetes mellitus e uma alimentação pró-inflamatória, sendo necessário mais estudos acerca do tema abordado.

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Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

Endocrine Connections ◽

10.1530/ec-20-0466 ◽

2020 ◽

Author(s):

Zhiwei Zhang ◽

Hui Zhao ◽

Aixia Wang

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Body Weight ◽

Blood Glucose ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Signaling Pathway ◽

Hepatic Glycogen ◽

Ampk Signaling ◽

Tnf Α

Background: Gestational diabetes mellitus (GDM) has a high incidence rate among pregnant women. The objective of the study was to assess the effect of plant-derived oleuropein in attenuating inflammatory and oxidative stress of GDM. Methods: Oleuropein was administered to GDM mice at the doses of 5 or 10 mg/kg/day. Body weight, blood glucose, insulin and hepatic glycogen levels were recorded. To evaluate the effect of oleuropein in reducing oxidative stress, enzyme-linked immunosorbent assay (ELISA) was used to measure the hepatic oxidative stress markers. The inflammation levels of GDM mice were evaluated by measuring serum levels of IL-6 and TNF-α by ELISA, and mRNA levels of IL-1β, TNF-α and IL-6 by real-time PCR (RT-PCR). The AMP-activated protein kinase (AMPK) signaling pathway was assessed by Western blot. Gestational outcome was analyzed through comparing litter size and birth weight. Results: Oleuropein attenuated the elevated body weight of GDM mice, and efficiently reduced blood glucose, insulin and hepatic glycogen levels. Oxidative stress and inflammation were alleviated by oleuropein treatment. The AMPK signaling was activated by oleuropein in GDM mice. Gestational outcome was markedly improved by oleuropein treatment. Conclusions: Our study suggests that oleuropein is effective in alleviating symptoms of GDM and improving gestational outcome in the mouse model. This effect is achieved by attenuating oxidative stress and inflammation, which is mediated by the activation of the AMPK signaling pathway.

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The Role of Oxidative Stress, Inflammation, and Advanced Glycation End Product in Skin Manifestations of Diabetes Mellitus

Current Diabetes Reviews ◽

10.2174/1573399817666210920102318 ◽

2021 ◽

Vol 17 ◽

Author(s):

Lili Legiawati

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Adhesion Molecule ◽

Intercellular Adhesion Molecule ◽

Skin Disorders ◽

Intercellular Adhesion Molecule 1 ◽

Tnf Α ◽

Mitogen Activated Protein ◽

High Level ◽

Factor Α

: Diabetes mellitus is a metabolic disorder caused by an increase in insulin resistance, a decrease in insulin production, or both of them, resulting in a high level of blood glucose or hyperglycemia. An uncontrolled state of DM may cause complications, namely skin disorder. One or more skin disorders are found amongst 74% of T2DM patients, with the highest percentage is dry skin (47%), followed by infection (10%), diabetic hand (5%), hair loss and diabetic dermopathy (each 4%). In DM, the state of hyperglycemia and production of advanced glycaemic end-products (AGEs) profoundly impact skin changes. In the pathological pathway, AGEs induce oxidative stress and inflammation. Nonetheless, AGEs level is higher in T2DM patients compared to non-T2DM people. This is caused by hyperglycemia and oxidative stress. Binding between AGEs and receptor of AGEs (RAGE) promotes pathway of oxidative stress and inflammation cascade via mitogen-activated protein kinases (MAPK), nuclear factor-k-light-chain-enhancer of activated β cells (NF-kβ), interleukin- 6 (IL-6), tumor necrosis factor-α (TNF-α), expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 2 (VCAM-2) pathway which furtherly effectuates DM complication including skin disorders.

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PHYSICAL TRAINING ON GLYCEMIA AND OXIDATIVE STRESS IN TYPE 2 DIABETES: A SYSTEMATIC REVIEW

Revista Brasileira de Medicina do Esporte ◽

10.1590/1517-869220202601187572 ◽

2020 ◽

Vol 26 (1) ◽

pp. 70-76

Author(s):

Ediléa Monteiro de Oliveira ◽

Andressa Karoline Pinto de Lima Ribeiro ◽

Dayse Danielle de Oliveira Silva ◽

Erica Feio Carneiro Nunes ◽

Gisely Santiago Santos ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Systematic Review ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Oxidative Damage ◽

Physical Training ◽

Cochrane Library ◽

And Oxidative Stress

ABSTRACT Introduction: Diabetes mellitus is accompanied by increased formation of reactive oxygen species (ROS) and decreased antioxidant capacity, leading to oxidative damage to cellular components. There is evidence to suggest that regular physical training positively changes oxidative homeostasis in the cells and tissues by lowering basal levels of oxidative damage, increasing resistance to oxidative stress. Objective: To verify the possible effects of aerobic physical training and resistance on glycemia and oxidative metabolism, and to determine whether there is any difference in outcomes resulting from different types of training in sedentary people with Type 2 Diabetes Mellitus (T2DM). Methods: A systematic review of controlled and randomized trials based on PRISMA. The databases LILACS, IBECS, Pubmed/MEDLINE, Cochrane Library, SciELO, PEDro, ScienceDirect and BIREME were searched, combining the descriptors type 2 diabetes mellitus, resistance training, aerobic exercise and oxidative stress in Portuguese, English and Spanish. The methodological quality of the papers was assessed by the PEDro scale. The data were read, analyzed, extracted and summarized. Results: Of the 1386 papers retrieved, only five met the inclusion criteria. The five selected papers, consisting of controlled and randomized clinical trials, were summarized. Conclusion: There have been many published studies reporting on exercises and diabetes. However, there is limitation when it comes to comparing their results. The variability of research methods and measurement instruments used makes it difficult to draw conclusions as to which physical training modality is most effective in reducing glycemic levels and oxidative stress in sedentary individuals with T2DM, considering that in each study analyzed in this review, the response to these variables is different. In future research, it would be important to standardize exercise modality, intensity, training time and evaluation parameters. Level of evidence I; Systematic review of RCTs (Randomized controlled trials).

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Asperulosidic Acid, a Bioactive Iridoid, Alleviates Placental Oxidative Stress and Inflammatory Responses in Gestational Diabetes Mellitus by Suppressing NF-κB and MAPK Signaling Pathways

Pharmacology ◽

10.1159/000521080 ◽

2022 ◽

pp. 1-9

Author(s):

Qian Wu ◽

Shukun Gai ◽

Huijie Zhang

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Blood Glucose ◽

Gestational Diabetes ◽

Inflammatory Responses ◽

Serum Insulin ◽

Mapk Signaling ◽

Tnf Α ◽

Mapk Signaling Pathways ◽

Placental Oxidative Stress

Background: Asperulosidic acid (ASP) is a bioactive iridoid exerting broad pharmacological and medicinal properties. However, it is still unknown if ASP has therapeutical effects on gestational diabetes mellitus (GDM). This study aims to evaluate the effects of ASP on GDM as well as its underlying mechanism. Methods: A mouse model of GDM was established and orally administrated ASP (10, 20, and 40 mg/kg) on gestation day (GD) 0. The mice were sacrificed on GD 18. Results: Blood glucose and serum insulin were then determined. The inflammatory cytokines including IL-6 and TNF-α and oxidative stress biomarkers including MDA, SOD, GSH, and GPx were determined by using specific ELISAs. In addition, the expressions of NF-κB and MAPK signaling pathway-related proteins were determined by using Western blotting. Treatment with ASP decreased blood glucose in the mouse model of GDM. Besides, ASP also increased serum insulin and attenuated β-cell function. Treatment with ASP suppressed IL-6 and TNF-α and regulated oxidative stress-related biomarkers. Western blotting analysis showed that treatment with ASP suppressed phosphorylation of NF-κB p65, ERK1/2, and p38 in placental tissues. Conclusion: ASP alleviates placental oxidative stress and inflammatory responses in GDM by the inhibition of the NF-κB and MAPK signaling pathways.

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Comparisons of the oxidative stress biomarkers levels in gestational diabetes mellitus (GDM) and non-GDM among Thai population: cohort study

Endocrine Connections ◽

10.1530/ec-18-0093 ◽

2018 ◽

Vol 7 (5) ◽

pp. 681-687 ◽

Cited By ~ 16

Author(s):

Hathairat Rueangdetnarong ◽

Rattanaporn Sekararithi ◽

Thidarat Jaiwongkam ◽

Sirinart Kumfu ◽

Nipon Chattipakorn ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Glycemic Control ◽

Cord Blood ◽

Inflammatory Marker ◽

Oxidative Stress Biomarkers ◽

Good Glycemic Control ◽

Stress Biomarkers ◽

Tnf Α ◽

Maternal And Neonatal Outcomes

Objective The primary objective of this study was to compare the levels of oxidative stress biomarkers between pregnancies with gestational diabetes mellitus (GDM) and normoglycemic pregnancies. Materials and methods A prospective study was conducted on pregnant women at average risk for GDM. The participants were screened for GDM with glucose challenge test and confirmed by 100 g, 3-h oral glucose tolerance test and categorized into the control (non-GDM) and GDM groups. Maternal blood was collected from all participants at gestational age (GA) 24–28 weeks and early labor and fetal cord blood was collected for measurements of 8 Isoprostane (8Isop) (oxidative stress marker), TNF-α (inflammatory marker) and IL-10 (anti-inflammatory marker) and were followed up for maternal and neonatal outcomes. Result A total of 62 women, 30 in GDM and 32 in control group, met the inclusion criteria. At 24–28 weeks of gestation, maternal serum 8Isop and TNF-α levels were significantly higher in GDM group (P = 0.032 and P = 0.047), in spite of good glycemic control. At early labor, maternal 8Isop levels were significantly higher in GDM (P = 0.001). The biomarkers in the cord blood as well as maternal and neonatal outcomes in both groups were not significantly different. Conclusion GDM is significantly associated with inflammatory process when compared to normal pregnancy, as indicated by higher oxidative stress and apoptosis markers. However, such levels were not correlated with the pregnancy outcomes. An increase in oxidative stress could not be prevented by good glycemic control. Cord blood biomarker levels in pregnancy with GDM were not changed, suggesting that the placenta could be the barrier for the oxidative stress and cytokines.

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The Effect Of Sea Cucumber Powder And Hyperbaric Oxygen Therapy On The Expression Of Tumor Necrosis Factor Alfa In Rats With Diabetes Mellitus Induced By Porphyromonas gingivalis

DENTA ◽

10.30649/denta.v10i1.40 ◽

2016 ◽

Vol 10 (1) ◽

pp. 79

Author(s):

Caroline Prajnaparamitha Anggraini ◽

Kristanti Parisihni ◽

Widyastuti W

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Sea Cucumber ◽

Oxygen Therapy ◽

Positive Control ◽

Negative Control ◽

Tnf Α ◽

Immunohistochemistry Stain

Background: Periodontitis have a bidirectional relationship with diabetes mellitus, both can increase oxidative stress that trigger an increase of pro-inflammatory cytokines, such as TNF-α. Sea cucumbers have anti-inflammatory component that act to inhibit the release of inflammatory mediators. Hyperbaric oxygen therapy reduce oxidative stress. Purpose: The aim of this study is to investigate the effect of the sea cucumber powder and hyperbaric oxygen therapy on the expression of TNF-α in rats with diabetes mellitus induced by P.gingivalis bacteria. Materials and Methods: The study was an experimental laboratories research with factorial design. Twenty wistar rats were divided into 5 groups. K0 negative control, K1 positive control. K1-K4 groups were induced with streptozotocin for diabetes condition and P.gingivalis bacteria for periodontitis condition. K2 group was treated with sea cucumber 3% for 7 days, K3 with OHB 2.4 ATA 3 x 30’ interval 5’ for 7 days, and K4 group was treated with combination of sea cucumber and OHB. At the 51st day all rats were sacrified, then the expression of TNF-α on periodontal macrophages were examined by immunohistochemistry stain. Data were analized by Kruskal Wallis followed by Mann-whitney. Result: Expression of TNF-α were increased in K1 (11.50±1.291) compare K0 (p<0.05). Sea cucumber treatment, OHB, and combination treatment decreased expression of TNF-α significantly in amount of 2.50±0.577 (K2), 8.25±2.217 (K3), 3.00±0.816 (K4). Conclusion: Sea cucumber powder and OHB therapy affected the expression of TNF-α in rats with diabetes mellitus induced by P. gingivalis bacteria.

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The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus

BMC Endocrine Disorders ◽

10.1186/s12902-021-00712-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Dandan Li ◽

Zixin Cai ◽

Zhenhong Pan ◽

Yan Yang ◽

Jingjing Zhang

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Glycemic Control ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Meta Analysis ◽

Cochrane Library ◽

Mineral Supplementation ◽

Vitamin And Mineral Supplementation ◽

And Oxidative Stress

Abstract Background The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus (GDM) have not been well established. We conduct a meta-analysis to evaluate the effects of vitamin and mineral supplementation on glycemic control, inflammation and oxidative stress for women with GDM. Methods A systematic search of randomized controlled trials (RCTs) was conducted from PubMed, Embase, Web of Science and Cochrane Library up to July, 2020. Various results were pooled by using Review manager 5.3 and Stata 12.0. Mean difference (MD) with 95% confidence interval (CI) was estimated. Heterogeneity between studies was assessed by I-squared (I2) tests. Results Six hundred ninety-eight patients from 12 trials were included in our meta-analysis. Magnesium, zinc, selenium, calcium, vitamin D and E (alone or in combination) were found to significantly improve glycemic control in women with GDM compared to those receiving placebos: fasting plasma glucose (FPG) (MD = - 9.02; 95% CI: - 12.09, - 5.96; P < 0.00001), serum insulin (MD = - 4.33; 95% CI: - 5.35, - 3.32; P < 0.00001), homeostasis model assessment-insulin resistance (HOMA-IR) (MD = - 1.34; 95% CI: - 1.60, - 1.07; P < 0.00001), and homeostasis model of assessment for β cell function (HOMA-B) (MD = - 15.58; 95% CI: - 23.70, - 7.46; P = 0.0002). Vitamin and mineral supplementation was found to attenuated inflammation and oxidative stress through decreasing high-sensitivity C-reactive protein (hs-CRP) (MD = - 1.29; 95% CI: - 1.82, - 0.76; P < 0.00001), malondialdehyde (MDA) (MD = - 0.71; 95% CI: - 0.97, - 0.45; P < 0.00001), and increasing total antioxidant capacity (TAC) (MD = 45.55; 95% CI: 22.02, 69.08; P = 0.0001). Conclusions This meta-analysis shows that vitamin and mineral supplementation significantly improved glycemic control, attenuated inflammation and oxidative stress in women with GDM.

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