scholarly journals Effects of Organophosphate Insecticides on Mechanical Properties of Rat Aorta

2011 ◽  
pp. 39-46 ◽  
Author(s):  
B. GUVENC TUNA ◽  
N. OZTURK ◽  
U. COMELEKOGLU ◽  
B. C. YILMAZ
Keyword(s):  
Mechanical Properties ◽  
Elastic Modulus ◽  
Thoracic Aorta ◽  
High Stress ◽  
Chronic Administration ◽  
Female Rats ◽  
Control Group ◽  
Stress Strain ◽  
High Stress Region ◽  
Stress Region

The present study was carried out to search whether organophosphate pesticides affect the mechanical properties of the thoracic aorta. Wistar female rats (aged 6-8 weeks) were assigned randomly to a control group and groups treated with either dichlorvos or chlorpyriphos for 90 days at a dose of 5 mg/kg/day. After that period, animals were killed and thoracic aorta strips in longitudinal direction were isolated. The stress, strain and elastic modulus were obtained from the strips. Our results showed that chronic administration of chlorpyriphos and dichlorvos caused downward shift of the stress-strain relations compared to the control curve. The elastic modulus-stress curve revealed distinct characteristics in the low and high stress regions. A power function was used to simulate the low stress region while a line was fit to the high stress region. Curve fitting procedure illustrated that both pesticides influenced mainly the high stress region, but they had diverse effects at the low stress region. The results also imply that chlorpyriphos and dichlorvos decrease the strength of the aorta and therefore might influence the response of the aorta to mechanical loading induced by blood pressure.

The Effect of Adhesive for Fillet on Stress in Weld-Bonded Joints

2010 ◽  
Vol 450 ◽  
pp. 502-505 ◽  
Author(s):  
Min You ◽  
Jia Ling Yan ◽  
Xiao Ling Zheng ◽  
Nan Feng Xiong ◽  
Ding Feng Zhu
Keyword(s):  
Elastic Modulus ◽  
High Stress ◽  
Bonded Joints ◽  
Longitudinal Stress ◽  
Lap Joint ◽  
Load Bearing Capacity ◽  
High Stress Region ◽  
Single Lap Joint ◽  
Stress Region ◽  
Peak Value

The influence of the fillet with different elastic modulus on the stress distributed in weld-bonded aluminum alloy single lap joint was investigated using elasto-plastic finite element method. The results show that the peak values of the stress along the mid-bondline at the points near the fillet edge were increased as the elastic modulus of the fillet increased. But at points near the both ends of the adherend in over lap zone as well as in the region of the nugget the peak stresses were decreased except longitudinal stress Sx. The peak value of Seqv decreased first, and then it increased again as the elastic modulus in fillet increased. The load-bearing capacity of the whole weld-bonded joints may be improved for the fillet with Adhesive B (825 MPa) for the relative high stress region in nugget was wider and the stress distribution in overlap zone was more uniform.

Hypothalamic regulation of reproduction under the chronic influence of toluene and melatonin

2021 ◽  
Vol 50 (2) ◽  
pp. 42-46
Author(s):  
G. O. Kerkeshko
Keyword(s):  
Biogenic Amines ◽  
Preoptic Area ◽  
Chronic Administration ◽  
Female Rats ◽  
Control Group ◽  
Simultaneous Administration ◽  
Chronic Effect ◽  
Circadian Variations ◽  
Hypothalamic Regulation ◽  
Maximal Permissible Concentration

Experiments on chronic administration of melatonin with and without chronic inhalation of toluene dosed at both maximal permissible concentration (50 mg/ml) and limited chronical range (500 mg/m3) have been carried out on female rats to discover their effects on biogenic amines system in hypothalamic structures related to gonadoliberin synthesis and secretion - preoptic area (PA) and median eminence (ME). Contents of biogenic amines in ME and especially in PA have been shown to have circadian variations with maximum in the morning in control group of rats.The chronic effect of synchronizing agent melatonin (administered dissolved in drinking water in concentration of 10 pg/m l, at night during 2 months) on neotransmitters and their circadian variations in both hypothalamic structures proved surprisingly to be much alike the effect of toluene. Both chemicals cause the disturbances of normal circadian variations o f norepinephrine, dopamine and serotonine in PA and dopamine in ME. The simultaneous administration of toluene and melatonin showed likewise no synchronizing ability of the latter under the conditions described.

scholarly journals Determinants of mechanical properties in the developing ovine thoracic aorta

1999 ◽  
Vol 277 (4) ◽  
pp. H1385-H1391 ◽  
Author(s):  
Sarah M. Wells ◽  
B. Lowell Langille ◽  
J. Michael Lee ◽  
S. Lee Adamson
Keyword(s):  
Mechanical Properties ◽  
Elastic Modulus ◽  
Tensile Stress ◽  
Thoracic Aorta ◽  
Adult Life ◽  
Perinatal Period ◽  
Developmental Changes ◽  
Cross Linking ◽  
Postnatal Life ◽  
Collagen Cross Linking

We previously reported changes in mechanical properties and collagen cross-linking of the ovine thoracic aorta during perinatal development and postnatal maturation, and we now report changes in biochemical composition (elastin, collagen, and DNA contents per mg wet wt) over the same developmental intervals. A comparison of results from the present and previous studies has yielded novel and important observations concerning the relationship between aortic mechanics and composition during maturation. Developmental changes in aortic incremental elastic modulus at low tensile stress ( E low) closely followed changes in relative elastin content (i.e., per mg wet wt). An 89% increase in E low during the perinatal period was associated with a 69% increase in relative elastin content, whereas neither variable changed during postnatal life. Incremental elastic modulus at high tensile stress ( E high) did not change during the perinatal period but increased 88% during postnatal life. This pattern closely paralleled changes in collagen cross-linking index, which did not change perinatally but almost doubled postnatally. In contrast, relative collagen content (per mg wet wt) increased only slightly from fetal to adult life, a trend that was unrelated to aortic mechanics. Substantial, progressive decreases in measures of wall viscosity (pressure wave attenuation coefficient and viscoelastic phase angle) from fetal to adult life followed the pattern observed for relative DNA (smooth muscle cell) content (per mg wet wt). Our findings suggest that accumulation of elastin per milligram wet weight contributes most to developmental changes in E low, change in collagen cross-linking is the primary determinant of developmental changes in E high, and cell accumulation contributes most to developmental changes in wall viscosity.

The Crack Arrest Capability of 9-Percent Ni Steels (ASTM 553, Type 1) LNG Storage Tanks

1991 ◽  
Vol 113 (3) ◽  
pp. 380-384
Author(s):  
P. B. Crosley ◽  
E. J. Ripling
Keyword(s):  
Fracture Toughness ◽  
Residual Stress ◽  
High Stress ◽  
Crack Arrest ◽  
Storage Tanks ◽  
Membrane Stress ◽  
High Stress Region ◽  
Fast Running ◽  
Stress Region

Safety of structures can be assured, even if cracks initiate in localized regions of abnormally low toughness, and/or abnormally high stress (LT/HS), if the materials from which they are fabricated have a high enough crack arrest fracture toughness. When this requirement is met, fast-running cracks that initiate in LT/HS regions arrest when their tip encounters material having normal toughness and stresses. The work described in this paper was carried out to determine the crack arrest capability of LNG storage tanks by determining the longest LT/HS region in which a crack could initiate and still arrest when it leaves this region. The determination consisted of relating a fracture analysis with the measured full-thickness crack arrest fracture toughness of three 9-percent Ni plates which were reported in reference [1]. The calculations used a residual stress pattern, produced by welding, superimposed on a typical membrane stress. The residual stress was selected as an example of a localized high stress region. It was found that tanks built from the poorest of the three tested plates could arrest cracks about 3/4 m long, while tanks built from the two tougher plates could arrest cracks almost 2 m long.

scholarly journals The mechanical properties of fin whale arteries are explained by novel connective tissue designs.

1996 ◽  
Vol 199 (4) ◽  
pp. 985-997 ◽  
Author(s):  
J M Gosline ◽  
R E Shadwick
Keyword(s):  
Mechanical Properties ◽  
Elastic Modulus ◽  
Aortic Arch ◽  
Thoracic Aorta ◽  
Collagen Fibre ◽  
External Diameter ◽  
Collagen Fibres ◽  
Descending Aorta ◽  
Fin Whale ◽  
Terrestrial Mammals

The aortic arch and the descending aorta in the fin whale (Balaenoptera physalus) are structurally and mechanically very different from comparable vessels in other mammals. Although the external diameter of the whale's descending thoracic aorta (approximately 12 cm) is similar to that predicted by scaling relationships for terrestrial mammals, the wall thickness:diameter ratio in the whale (0.015) is much smaller than the characteristic value for other mammals (0.05). In addition, the elastic modulus of the thoracic aorta (12 MPa at 13 kPa blood pressure) is about 30 times higher than in other mammals. In contrast, the whale's aortic arch has a wall thickness/diameter ratio (0.055) and an elastic modulus (0.4 MPa) that are essentially identical to those for other mammals. However, the aortic arch is unusual in that it can be deformed biaxially to very large strains without entering a region of high stiffness caused by the recruitment of fully extended collagen fibres. Chemical composition studies indicate that the elastin:collagen ratio is high in the aortic arch (approximately 2:1) and that this ratio falls in the thoracic (approximately 1:2) and abdominal (approximately 1:3) aortas, but the magnitude of the change in composition does not account for the dramatic difference in mechanical properties. This suggests that there are differences in the elastin and collagen fibre architecture of these vessels. The descending aorta contains dense bands of tendon-like, wavy collagen fibres that run in the plane of the arterial wall, forming a fibre-lattice that runs in parallel to the elastin lamellae and reinforces the wall, making it very stiff. The aortic arch contains a very different collagen fibre-lattice in which fibres appear to have a component of orientation that runs through the thickness of the artery wall. This suggests that the collagen fibres may be arranged in series with elastin-containing elements, a difference in tissue architecture that could account for both the lower stiffness and the extreme extensibility of the whale's aortic arch. Thus, both the structure and the mechanical behaviour of the lamellar units in the aortic arch and aorta of the whale have presumably been modified to produce the unusual mechanical and haemodynamic properties of the whale circulation.

scholarly journals MECHANICAL PROPERTIES OF SANDSTONE SUBJECTED TO COUPLING OF TEMPERATURE–SEEPAGE–STRESS

10.6036/10055 ◽  
2021 ◽  
Vol 96 (3) ◽  
pp. 309-315
Author(s):  
Lijie Long ◽  
Dongyan Liu ◽  
Dong Wang ◽  
Jin Li
Keyword(s):  
Mechanical Properties ◽  
Plastic Deformation ◽  
Rock Mass ◽  
Elastic Modulus ◽  
Plastic Zone ◽  
Residual Strength ◽  
Confining Pressure ◽  
Peak Strength ◽  
Hydraulic Pressure ◽  
Stress Strain

ABSTRACT: The deformation and fracture of rock mass in deep rock mass engineering are affected by the coupling of temperature, seepage, and stress. A test and a calculation model for sandstone under thermal–hydrological–mechanical (THM) coupling were proposed to reveal the mechanical properties of sandstone. The law of coupling for mechanical indicators of sandstone was established by laboratory tests and numerical simulations. The permeability, peak strength, peak strain, residual strength, elastic modulus, plastic deformation area, and stress–strain cloud diagram were analyzed by the steady state seepage method and THM coupling principle, and the accuracy of the model was verified. Results demonstrate that: (1) As the temperature rises and the peak deformation increases, the sample slowly drops to the residual strength level after the peak stress. (2) The main factor that affects peak strength is confining pressure. In the temperature range of 25 °C–50 °C, the maximum peak strength and peak deformation are increased by heating, and the increases in confining pressure and temperature reduce the reduction coefficient of the residual strength. Moreover, the elastic modulus increases with the increase in confining pressure, but it shows a downward trend when the temperature increases. (3) The plastic deformation zone and stress–strain cloud diagram indicated that when the temperature and osmotic pressure increase, the specimen enters the plastic zone earlier, the effective plastic zone increases, the stress increases, and the deformation is intensified. The proposed method provides a certain reference for the permeability and stability evaluation of rock mass under the conditions of “three-high” (high confining pressure, high hydraulic pressure, and high stress) engineering. Keywords: temperature–seepage–stress coupling, sandstone, mechanical properties

scholarly journals Mechanical Properties of Laser-Sintered 3D-Printed Cobalt Chromium and Soft-Milled Cobalt Chromium

Prosthesis ◽  
2020 ◽  
Vol 2 (4) ◽  
pp. 313-320
Author(s):  
Abdullah Barazanchi ◽  
Kai Chun Li ◽  
Basil Al-Amleh ◽  
Karl Lyons ◽  
J. Neil Waddell
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Elastic Modulus ◽  
Ultimate Tensile Strength ◽  
High Stress ◽  
Uniform Structure ◽  
Cobalt Chromium ◽  
Proof Stress ◽  
Fracture Surfaces ◽  
3D Printed

Purpose: To compare the mechanical properties and fracture behaviour of laser-sintered/3D-printed cobalt chromium (LS CoCr) with soft-milled cobalt chromium (SM CoCr) to assess their suitability for use in high-stress areas in the oral cavity. Material and Method: Two computer-aided manufacturing methods were used to fabricate dumbbell specimens in accordance with the ASTM standard E8. Specimens were fractured using tensile testing and elastic modulus, and proof stress and ultimate tensile strength were calculated. Fracture surfaces were examined using scanning electron microscopy. Plate specimens were also fabricated for the examination of hardness and elastic modulus using nanoindentation. Unpaired t-test was used to evaluate statistical significance. Results: LS CoCr specimens were found to have significantly higher ultimate tensile strength (UTS) and proof stress (PS) (p < 0.05) but not a significantly higher elastic modulus (p > 0.05). Examination of the dumbbell fracture surfaces showed uniform structure for the LS CoCr specimens whilst the SM CoCr specimens were perforated with porosities; neither showed an obvious point of fracture. Nanoindentation also showed that LS CoCr specimens possessed higher hardness compared with SM CoCr specimens. Conclusion: LS CoCr and SM CoCr specimens were both found to exhibit uniformly dense structure; although porosities were noted in the SM CoCr specimens. LS CoCr specimens were found to have superior tensile properties, likely due to lack of porosities, however both had mean values higher than those reported in the literature for cast CoCr. Uniformity of structure and high tensile strength indicates that LS CoCr and SM CoCr fabricated alloys are suitable for long-span metallic frameworks for use in the field of prosthodontics.

EFFECTS OF CULTURE PERIODS AND LOADING ON BIOMECHANICAL PROPERTIES OF SHEEP COLLAGEN FASCICLES

2014 ◽  
Vol 14 (06) ◽  
pp. 1440010
Author(s):  
AHMET C. CILINGIR
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Soft Tissues ◽  
Culture Media ◽  
Experimental Studies ◽  
Biomechanical Properties ◽  
Collagen Fibrils ◽  
Tangent Modulus ◽  
Control Group ◽  
Stress Strain

Soft tissues (e.g., tendon, skin, cartilage) change their dimensions and properties in response to applied mechanical stress/strain, which is called remodeling. Experimental studies using tissue cultures were performed to understand the biomechanical properties of collagen fascicles under mechanical loads. Collagen fascicles were dissected from sheep Achilles tendons and loaded under 1, 2, and 3 kg for 2, 4, and 6 days under culture. The mechanical properties of collagen fascicles after being loaded into the culture media were determined using tensile tester, and resultant stress–strain curves, tangent modulus, tensile strength, and strain at failure values were compared with those in a non-loaded and non-cultured control group of fascicles. The tangent modulus and tensile strength of the collagen fascicles increased with the increasing remodeling load after two days of culture. However, these values gradually decreased with the increasing culture period compared with the control group. According to the results obtained in this study, the mechanical properties of collagen fascicles were improved by loading at two days of culture, most likely due to the remodeling of collagen fibers. However, after a period of remodeling, local strains on the collagen fibrils increased, and finally, the collagen fibrils broke down, decreasing the mechanical properties of the tissue.

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