Effect of Feeding Rat on the Biochemical Profile of Blood and Liver Morphology

The nature of nutrition modifies the metabolism of substances and ensures either normal functioning or contributes to metabolic disorders and the development of pathologies. A study was made of the effect of different feeding diets (lipid, carbohydrate and protein) on the blood biochemical profile of adult sexually mature rats. The work was performed on 28 white laboratory male rats weighing 180–250 g, which were 4 groups: the first (1) group (n=7) was fed exclusively with lipids (fat tail fat), the second (2, n=7) — carbohydrates (sugar), the third (3, n=7) — proteins, and the fourth (4, n=7) — standard food. The levels of glucose, cholesterol, total protein and albumin were determined by the colorimetric method. It was revealed that when taking lipid food in the blood, levels of cholesterol, glucose, total protein and albumin increased; when consuming carbohydrate feed — the content of glucose and lipids; when consuming a protein diet — total protein, albumin and lipids. The concentration of cholesterol increased with the use of all types of diet, especially significantly with lipid. Thus, glucose concentration increased with carbohydrate and lipid diets; total protein — with protein; glucose equally — with lipid and carbohydrate. The highest concentration of albumin is observed with a lipid diet, the lowest — with a carbohydrate.

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BLOOD BIOCHEMICAL PROFILE IN DOGS AND CATS UNDER DIFFERENT FEEDING DIETS

Archives of Veterinary Science ◽

10.5380/avs.v8i1.4012 ◽

2003 ◽

Vol 8 (1) ◽

Cited By ~ 1

Author(s):

F.H.D. GONZÁLEZ ◽

V. CARVALHO ◽

V. MÖLLER ◽

F.R. DUARTE

Keyword(s):

Caloric Intake ◽

Blood Chemistry ◽

Blood Levels ◽

Biochemical Profile ◽

Blood Biochemical ◽

Calcium Phosphorus ◽

Healthy Dogs ◽

Low Levels ◽

Feeding Diets ◽

Effect Of Feeding

Foram determinados os parâmetros de bioquímica sanguínea em 50 cães e 25 gatos sadios submetidos a três regimes alimentares: ração comercial, comida caseira e alimentação mista (ração e caseira). Os cães e os gatos alimentados com regime misto apresentaram níveis sanguíneos elevados de glicose e de colesterol, sugerindo um consumo de alimentos calóricos acima dos requerimentos e um maior risco de obesidade. A ingestão de proteínas na alimentação caseira parece ser restrita, considerando-se as baixas concentrações de albumina e/ou uréia sanguíneas nos cães e nos gatos. Baixos teores de cálcio foram encontrados nos cães de alimentação não concentrada. Os gatos com alimentação caseira podem estar consumindo quantidades baixas de minerais revelado pelos menores teores sanguíneos de cálcio, fósforo e magnésio. Abstract The aim of the present work was to carry out a study on the variation of the blood chemistry constituents of dogs and cats subjected to different feeding diets. Blood samples from 50 healthy dogs and 25 cats were used to study the effect of feeding diets with commercial ration, homemade or mixed (concentrate and homemade) on their blood biochemical profile. Both, dogs and cats, fed with mixed rations showed higher glucose and cholesterol blood levels, which could be suggestive of a high caloric intake and a risk of obesity. Intake of proteins in animals with homemade feed seems to be low considering concentrations of plasma albumin and/or urea in dogs and cats. Low levels of calcium were found in dogs with non-concentrated feed. Cats with homemade feed could have low intake of minerals considering the lower levels of calcium, phosphorus and magnesium observed.

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A Comparative Study on the Effects of Using Hydroalcoholic Extracts of Linum Usitatissimum and Rosa Damascena on Liver Function in Adult Male Rats

Quarterly of Horizon of Medical Sciences ◽

10.32598/hms.26.1.3116.1 ◽

2020 ◽

Vol 26 (1) ◽

pp. 54-67

Author(s):

Mohammad Mehdi Padam ◽

◽

Ameneh Khoshvaghti ◽

Keyword(s):

Liver Function ◽

Total Protein ◽

Linum Usitatissimum ◽

Colorimetric Method ◽

Serum Glucose ◽

Male Rats ◽

Control Group ◽

Rosa Damascena ◽

Glucose Levels ◽

Significant Difference

Aims: Damage to liver tissue and its dysfunction is very important and if left untreated, it can cause serious problems and even death. In this study, we aimed to investigate the effects of the hydroalcoholic extracts of Linum usitatissimum and Rosa damascena on liver enzymes, total protein, bilirubin, albumin, and serum glucose levels. Materials and Methods: This is a non-randomized clinical trial conducted on 42 male rats divided into 6 groups; control group (group 1) received only sufficient water and food, groups 1 and 2 received 300 and 500 mg/ kgB.W Linum usitatissimum extract, groups 3 and 4 received 500 and 1000 mg/ kgB.W Rosa damascena, and group 6 received 100 mg/ kgB.W Linum usitatissimum plus 250 mg/ kgB.W Rosa damascena extracts intraperitoneally for 28 days. After the last injection, the rats were weighed and their blood samples were collected. The study parameters were measured using a colorimetric method by a spectrophotometer, and then were analyzed using ANOVA and Tukey’s test in SPSS V. 25 at a significance level of P<0.05. Findings: There was no significant difference between alanine aminotransferase, alkaline phosphatase, total and direct bilirubin levels in the control group in comparison with other groups (P>0.05). In the groups received Rosa damascena extract, there was a significant difference between total protein and albumin levels compared to the control group (P<0.05). Moreover, there was a significant difference between serum glucose and aspartate aminotransferase in the control group compared to other groups (P<0.05). Conclusion: Linum usitatissimum and Rosa damascena have no negative effect on the liver function. The probability of diarrhea occurrence and the possible effects on the total protein and serum albumin after using Rosa damascena, and the effects of different doses of Linum usitatissimum on the glucose levels should be taken into account.

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Effect of feeding cotton seed cake (CSC) on growth performance and blood biochemical profile in Mehsana buffalo calves

Indian Journal of Animal Research ◽

10.18805/ijar.b-3558 ◽

2018 ◽

Author(s):

Deepandita Barman ◽

K. B. Prajapati ◽

M. M. Pawar ◽

Hemen Das ◽

C. Kotresh Prasad ◽

...

Keyword(s):

Body Weight ◽

Cotton Seed ◽

Monthly Interval ◽

Biochemical Profile ◽

Buffalo Calves ◽

Seed Cake ◽

Blood Biochemical ◽

Group I ◽

G Ratio ◽

Effect Of Feeding

The present study was conducted in 20 growing female Mehsana buffalo calves to study the effect of feeding cotton seed cake with the objective to increase growth and blood biochemical profile. Mehsana buffalo calves of 3-6 months of age were randomly divided in two groups on the basis of body weight and age. Group I was control (T1) fed Banasdan (concentrate mixture) whereas, group II (T2) was fed with cottonseed cake @ 700g, 850g and 960g for 1st, 2nd and 3rd month of treatment, respectively in addition to concentrate feed. Both the groups fed green fodder @ 3kg and dry fodder @ 1kg per day throughout the experiment. Body weights of individual calves were recorded at the commencement of the experiment and followed by monthly interval. Blood- biochemical constituents were recorded on day 1 and thereafter on day 90 of experiment period to analyze the changes in blood constituents in T1 and T2 groups. Average daily body weight gain of calves during the experimental period was higher (P less than 0.01) in T2 group as compared to T1 group. The serum glucose level was higher (P less than 0.05) in T1 group than T2 on day 90. The values of serum cholesterol, protein, globulin, ALP, SGOT and SGPT concentration were also significantly (P less than 0.01) higher in T2 group than T1 on day 90. However, the differences for serum albumin, A/G ratio, calcium and phosphorus on day 90 were found to be non-significant whereas metabolic hormone level T3 and T4 were significantly (P less than 0.01) higher in T2 than T1 on day 90. The results are indicative of supplementation of cotton seed cake in addition to Banasdan accelerated the growth, blood biochemical parameters and hormonal levels.

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Hepatoprotective and antioxidant effects of Mexidol-Vet® in an experiment on rats

Russian veterinary journal ◽

10.32416/2500-4379-2020-5-38-42 ◽

2020 ◽

Vol 2020 (5) ◽

pp. 38-42

Author(s):

Dmitriy Gildikov

Keyword(s):

Toxic Hepatitis ◽

Free Radical Oxidation ◽

Antioxidant Effect ◽

Male Rats ◽

Histological Changes ◽

Radical Oxidation ◽

Blood Biochemical ◽

Adaptive Capabilities ◽

First Time ◽

Sexually Mature

The aim of the work was to establish the hepatoprotective and antioxidant effect of Mexidol-Vet® in rats with toxic hepatitis. We have reproduced the toxic hepatitis in sexually mature male rats (n = 90) by a single intragastric injection of carbon tetrachloride. For 30 days, we studied reactivity, variations in blood biochemical parameters, the intensity of iron-induced chemiluminescence of homogenates and histological changes in the liver. The experiment confirmed the antioxidant effect and for the first time established the hepatoprotective effect of Mexidol-Vet®. The use of Mexidol-Vet® in rats with tetrachloromethane hepatitis increases reactivity and adaptive capabilities, correction of carbohydrate (lactate dehydrogenase) and protein metabolism (total protein, aspartate aminotransferase and alanine aminotransferase), inhibition of free radical oxidation and the development of oxidative stress.

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