Diseases of cardiovascular system in patients with severe and moderatesevere forms of psoriasis

2021 ◽  
pp. 21-23
Author(s):  
A. A. Hotko ◽  
M. Yu. Pomazanova ◽  
Y. V. Kozyr
Keyword(s):  
Skin Lesions ◽  
Pathological Process ◽  
Practical Significance ◽  
Case Histories ◽  
Cardiac Pathology ◽  
Coronary Syndrome ◽  
Organ Systems ◽  
Body Organ ◽  
Krasnodar Region ◽  
Medical Histories

Psoriasis is one of the most common chronic recurrent dermatoses, which is not limited to skin lesions, leading to a violation of the functions of various body organ systems. The article presents the results of the analysis of the medical histories of patients of Clinical dermatovenerologic dispensary (Krasnodar Region of Russia) with moderate-severe and severe forms of psoriasis and concomitant cardiological pathology. The article presents data from 70 case histories of patients with moderate to severe psoriasis, the analysis of which shows the clinical and practical significance of comorbidity of psoriasis. From the analysis, we conclude that there is a direct relationship between the severity of the course of the cutaneous pathological process and the aggravation of the cardiological diagnosis. The higher the severity of psoriasis, the higher the risk of developing acute coronary syndrome, myocardial infarction and other cardiac pathology.

scholarly journals Anaplastic Large Cell Lymphoma with Generalized Skin Lesion in Childhood: Clinical Case

2020 ◽  
Vol 19 (6) ◽  
pp. 477-482
Author(s):  
Timur T. Valiev ◽  
Tatyana S. Belysheva ◽  
Svetlana R. Varfolomeeva
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Clinical Case ◽  
Clinical Laboratory ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Skin Lesions ◽  
Pathological Process ◽  
Practical Significance ◽  
Disease Manifestation ◽  
Large Cell Lymphoma

Background. Anaplastic large cell lymphoma (ALCL) represents 15% of all non-Hodgkin lymphomas (NHL) in children, and it is characterized by aggressive course and involvement of various organs and systems (including skin) in the pathological process. Skin tumors at NHL in childhood are rare. Thus, cases of skin localization are more oftenly diagnosed at ALCL among all morphoimmunologic variants of NHLs. The description of any new case of skin lesions in patients with ALCL has undeniable interest and scientific and practical significance due to its extremely rare frequency.Clinical Case Description. Patient G., 11 years old, has firstly noted inflammatory nodes on the skin of scrotum. The generalization of skin lesions on tibia, face, lymph nodes and bones was recorded due to late admission to the hospital. The inflammatory-necrotic process has been revealed at skin histological examination. Local antiseptic and antibacterial therapies were ineffective. The ALCL was diagnosed on morphoimmunologic re-examination of the skin. Life expectancy after disease manifestation to patient’s death was 6 months.Conclusion. Rare cases of skin involvement at ALCL require mandatory histological and immunohistochemical examinations. Second biopsy with reconsideration of histological preparations in the reference center may be necessary due to clinical-laboratory picture of the inflammatory process accompanying the tumor itself.

Diseases of cardiovascular system in patients with moderate-to-severe and severe forms of psoriasis

2021 ◽  
pp. 35-38
Author(s):  
A. A. Hotko ◽  
M. Yu. Pomazanova ◽  
M. V. Durleshter
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Direct Relationship ◽  
Skin Diseases ◽  
Inflammatory Diseases ◽  
Pathological Process ◽  
Practical Significance ◽  
Case Histories ◽  
Immune Mediated ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Psoriasis is one of the most common chronic immune-mediated skin diseases. One of the widely discussed gastroenterological comorbidities of psoriasis is chronic inflammatory diseases of the gastrointestinal tract. The article presents the results of the analysis of the case histories of patients with moderate-to-severe and severe forms of psoriasis and concomitant pathology – inflammatory bowel diseases (Clinical Dermatovenerologic Dispensary, Krasnodar, Russia). The analysis of 16 case histories of patients with moderate-to-severe and severe psoriasis has been carried out, where one can see the clinical and practical significance of the combined pathology – psoriasis and inflammatory bowel diseases. From the analysis, one can conclude that there is a direct relationship between the severity of the course of the skin pathological process and the development of intestinal diseases, as well as the influence of ustekinumab on the course of combined pathology – psoriasis, ulcerative colitis and Crohn’s disease.

Renal Manifestations of Tuberous Sclerosis Complex

2020 ◽  
Vol 7 (3) ◽  
pp. 5-19
Author(s):  
Nikhil Nair ◽  
Ronith Chakraborty ◽  
Zubin Mahajan ◽  
Aditya Sharma ◽  
Sidarth Sethi ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Gene Disruption ◽  
Treatment Guidelines ◽  
Renal Cysts ◽  
Skin Lesions ◽  
Multiple Organ ◽  
Tsc2 Gene ◽  
Genetic Condition ◽  
Organ Systems

Tuberous sclerosis complex (TSC) is a genetic condition caused by a mutation in either the TSC1 or TSC2 gene. Disruption of either of these genes leads to impaired production of hamartin or tuberin proteins, leading to the manifestation of skin lesions, tumors and seizures. TSC can manifests in multiple organ systems with the cutaneous and renal systems being the most commonly affected. These manifestations can secondarily lead to the development of hypertension, chronic kidney disease, and neurocognitive declines. The renal pathologies most commonly seen in TSC are angiomyolipoma, renal cysts and less commonly, oncocytomas. In this review, we highlight the current understanding on the renal manifestations of TSC along with current diagnosis and treatment guidelines.

scholarly journals ANALYSIS OF DATA FROM MINOCA PATIENTS BASED ON COMPARISON OF TOTAL REGISTER OF ACUTE CORONARY SYNDROME IN THE KRASNODAR REGION WITH FOREIGN REGISTERS

2019 ◽  
Vol 33 (4) ◽  
pp. 38-43
Author(s):  
S. V. Kruchinova ◽  
E. D. Kosmacheva ◽  
S. A. Raff ◽  
V. A. Porkhanov
Keyword(s):  
Myocardial Infarction ◽  
Acute Coronary Syndrome ◽  
Comparative Analysis ◽  
Coronary Arteries ◽  
Krasnodar Krai ◽  
Coronary Syndrome ◽  
Krasnodar Region

The review presents a comparative analysis of data from patients with myocardial infarction with non-obstructive coronary arteries. Data were obtained from the total register of acute coronary syndrome in the Krasnodar Krai and were compared with data of foreign registers.

Ultrasound examination of pregnant women in diagnosing fetal cardiac pathology

2020 ◽  
Vol 69 (2) ◽  
pp. 43-50
Author(s):  
Viktoria A. Lim
Keyword(s):  
Pregnant Women ◽  
Fetal Heart ◽  
Fetal Echocardiography ◽  
Heart Defects ◽  
Care Service ◽  
Ultrasound Screening ◽  
Atrioventricular Canal ◽  
Cardiac Pathology ◽  
Organ Systems ◽  
Atrioventricular Canal Defect

Hypothesis/aims of study. Fetal heart defects are the most common malformations causing infant mortality. The task of the obstetric care service is to make a timely diagnosis, which includes high-quality ultrasound screening and, if necessary, fetal echocardiography. This study aimed to compare fetal echocardiography with postpartum echocardiography. Study design, materials and methods. 101 pregnant women with both isolated fetal heart defects and combined pathology were examined for the period 20172019. Results. The greatest number of heart defects was detected at 2331 weeks of gestation. The structure of the malformations is diverse, the most common one being a complete form of the atrioventricular canal defect. In multiple pregnancies, complex heart defects were often combined with abnormalities in other organ systems. Conclusion. It is recommended to describe the heart structure in detail from 2122 weeks of pregnancy. If cardiac pathology is detected in utero, it is mandatory to conduct an examination of other fetal organs.

scholarly journals Treatment of Established Human Graft-Versus-Host Disease by Antithymocyte Globulin

Blood ◽  
1974 ◽  
Vol 44 (1) ◽  
pp. 57-75 ◽  
Author(s):  
R. Storb ◽  
E. Gluckman ◽  
E. D. Thomas ◽  
C. D. Buckner ◽  
R. A. Cliff ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Interstitial Pneumonitis ◽  
Bacterial Infections ◽  
Antithymocyte Globulin ◽  
Relative Effectiveness ◽  
Skin Lesions ◽  
Host Disease ◽  
Graft Versus Host ◽  
Organ Systems ◽  
Long Term Survivors

Abstract Forty successful marrow grafts have been carried out since April 1972 for the treatment of severe refractory aplastic anemia or acute leukemia. All patients were HL-A identical and nonreactive in mixed leukocyte culture tests with the marrow donor. Nineteen of the patients developed moderately severe to severe graft-versus-host disease (GVHD) and were treated with rabbit or goat antihuman antithymocyte globulin (ATG). Under ATG therapy, 12 of the 19 showed complete resolution of GVHD, five showed improvement of most organ systems involved, and two showed no change except for improvement in skin lesions. Six of the 19 became long-term survivors. Five of the six are alive between 276 and 629 days after grafting, and one died on day 346 with chronic respiratory failure. Of the remaining 13 patients, 11 died with interstitial pneumonitis of predominantly viral etiology, and two died with fungal and bacterial infections. In conclusion, the present study demonstrates the relative effectiveness of ATG in reversing human GVHD. Death with interstitial pneumonitis was the single most serious impediment to successful treatment of GVHD by ATG.

scholarly journals CLINICAL AND METABOLIC ANALYSIS OF DISORDERS IN PSORIATIC PATIENTS

2019 ◽  
Vol 72 (7) ◽  
pp. 1304-1309 ◽  
Author(s):  
Uljana Fedorova ◽  
Orysya Syzon ◽  
Igor Gajduchok ◽  
Kostjantyn Ischejkin ◽  
Marianna Dashko
Keyword(s):  
Age Groups ◽  
Pathological Process ◽  
Blood Analysis ◽  
Stress Factors ◽  
Practical Significance ◽  
Individual Treatment ◽  
Psoriatic Disease ◽  
Literary Sources ◽  
Inflammatory Processes ◽  
Analysis Of Results

Introduction: Elucidation of the primary nature of biochemical shifts in psoriatic disease and prediction of interconnected subsequent changes in metabolic and inflammatory processes are important in foreseeing the dynamic development of pathological process and the choice of individual treatment. The aim of the research was to assess the disorders and correlations between main indicators of protein, fat, hydrocarbon and pigment metabolism and specifics of inflammatory processes in psoriatic patients against the clinical course of dermatosis. Materials and methods: We analysed the results of clinical and laboratory examinations conducted in 62 psoriatic patients. All these patients have been analysed as per their age, sex, prevalence and the type of skin rash as well as per the clinical disease form. Biochemical examinations were conducted using appropriate sets of reagents. To establish the possible correlation between the indicators of biochemical blood analysis, we calculated the correlation coefficient, which determines the nature of correlation between the studied variables. Results: The analysis of results received upon examining psoriatic patients indicated that microbial-viral associations, stress factors and genetic predisposition were the most frequent trigger factors of psoriatic disease, which corresponds to the data from literary sources. We detected that the duration of psoriaric disease up to 5 years was the most common, and relapses were manifested in its limited form against the background of the disease advanced stage; the prevalent psoriasis was more common at the hospital stage. Our study justifies that metabolic changes occurred in the overwhelming majority of examined patients of different age groups. At that, abnormalities of a number of indicators of protein, lipid, hydrocarbon and enzyme metabolism have been established. In addition, the expressiveness of corresponding changes correlated with the prevalence of skin psoriatic process and the duration of dermatosis course as well as the presence of pathology of a number of internal organs, in particular of gastrointestinal tract, hepatobiliary and cardiovascular systems, that suggest the presence of systemic disorders at psoriasis. Conclusions: The identification of independent mechanisms existing between some changes in metabolic process parameters in psoriasis has a theoretical and practical significance in dermatology, which involves the use of medications to regulate the detected disorders, the possibility to restore correlations, and it will inevitably contribute to the achievement of clinical and preventive effect.

scholarly journals Comparative assessment of the hospital letality structure during severe mechanical injury for 2005–2006 and 2014–2015 years

2020 ◽  
Vol 17 (2) ◽  
pp. 152-157
Author(s):  
E. V. Romanovskiy ◽  
A. N. Voloshenyuk ◽  
N. S. Serdiuchenko ◽  
N. V. Zavada ◽  
I. N. Ladutsko
Keyword(s):  
Comparative Assessment ◽  
Mechanical Injury ◽  
Mechanical Trauma ◽  
Case Histories ◽  
Trauma Unit ◽  
Structure And Dynamics ◽  
Medical Histories ◽  
The City ◽  
Combined Injuries ◽  
Clinical Emergency

The article provides a comparative assessment of data from 131 medical histories and autopsy protocols for those who died from severe mechanical trauma in 2005–2006 in the combined trauma unit of the medical institution “9th City Clinical Hospital” in Minsk with data on 133 case histories and autopsy reports of dead from severe mechanical injury in 2014–2015 in the combined trauma unit of the “City Clinical Emergency Hospital in Minsk”. During the study, general patterns and differences in the structure and dynamics of mortality in combined injuries were determined, which allows us to scientifically substantiate organizational measures to improve medical care for severe mechanical injuries in order to improve the results of diagnosis and treatment of victims at an early hospital stage.

scholarly journals Renal Manifestations of Tuberous Sclerosis Complex

2020 ◽  
Vol 7 (3) ◽  
pp. 5-19
Author(s):  
Nikhil Nair ◽  
Ronith Chakraborty ◽  
Zubin Mahajan ◽  
Aditya Sharma ◽  
Sidharth K. Sethi ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Gene Disruption ◽  
Treatment Guidelines ◽  
Renal Cysts ◽  
Skin Lesions ◽  
Multiple Organ ◽  
Tsc2 Gene ◽  
Genetic Condition ◽  
Organ Systems

Tuberous sclerosis complex (TSC) is a genetic condition caused by a mutation in either the TSC1 or TSC2 gene. Disruption of either of these genes leads to impaired production of hamartin or tuberin proteins, leading to the manifestation of skin lesions, tumors, and seizures. TSC can manifest in multiple organ systems with the cutaneous and renal systems being the most commonly affected. These manifestations can secondarily lead to the development of hypertension, chronic kidney disease, and neurocognitive declines. The renal pathologies most commonly seen in TSC are angiomyolipoma, renal cysts, and less commonly, oncocytomas. In this review, we highlight the current understanding on the renal manifestations of TSC along with current diagnosis and treatment guidelines.

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