CLINICAL AND METABOLIC ANALYSIS OF DISORDERS IN PSORIATIC PATIENTS

Introduction: Elucidation of the primary nature of biochemical shifts in psoriatic disease and prediction of interconnected subsequent changes in metabolic and inflammatory processes are important in foreseeing the dynamic development of pathological process and the choice of individual treatment. The aim of the research was to assess the disorders and correlations between main indicators of protein, fat, hydrocarbon and pigment metabolism and specifics of inflammatory processes in psoriatic patients against the clinical course of dermatosis. Materials and methods: We analysed the results of clinical and laboratory examinations conducted in 62 psoriatic patients. All these patients have been analysed as per their age, sex, prevalence and the type of skin rash as well as per the clinical disease form. Biochemical examinations were conducted using appropriate sets of reagents. To establish the possible correlation between the indicators of biochemical blood analysis, we calculated the correlation coefficient, which determines the nature of correlation between the studied variables. Results: The analysis of results received upon examining psoriatic patients indicated that microbial-viral associations, stress factors and genetic predisposition were the most frequent trigger factors of psoriatic disease, which corresponds to the data from literary sources. We detected that the duration of psoriaric disease up to 5 years was the most common, and relapses were manifested in its limited form against the background of the disease advanced stage; the prevalent psoriasis was more common at the hospital stage. Our study justifies that metabolic changes occurred in the overwhelming majority of examined patients of different age groups. At that, abnormalities of a number of indicators of protein, lipid, hydrocarbon and enzyme metabolism have been established. In addition, the expressiveness of corresponding changes correlated with the prevalence of skin psoriatic process and the duration of dermatosis course as well as the presence of pathology of a number of internal organs, in particular of gastrointestinal tract, hepatobiliary and cardiovascular systems, that suggest the presence of systemic disorders at psoriasis. Conclusions: The identification of independent mechanisms existing between some changes in metabolic process parameters in psoriasis has a theoretical and practical significance in dermatology, which involves the use of medications to regulate the detected disorders, the possibility to restore correlations, and it will inevitably contribute to the achievement of clinical and preventive effect.

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FEATURES OF THE COEFFICIENT OF VARIATION OF HEMATOLOGICAL INDICATORS IN PERSONS OF MIDDLE, ELDERLY AND SENILE AGE WITH PNEUMONIA

Успехи геронтологии ◽

10.34922/ae.2021.34.1.014 ◽

2021 ◽

pp. 102-106

Author(s):

С. А. Рукавишникова ◽

Т. А. Ахмедов ◽

А.С. Пушкин ◽

У.Р. Сагинбаев ◽

Д.П. Пискунов ◽

...

Keyword(s):

Retrospective Study ◽

Older Persons ◽

Risk Group ◽

Age Groups ◽

Biological Variation ◽

The Body ◽

Blood Analysis ◽

Internal Environment ◽

Severity Of The Disease ◽

Hematological Indicators

Пневмония занимает лидирующие позиции по смертности среди всех инфекционных заболеваний. Установлено, что к достоверной группе риска по уровню заболеваемости и смертности от данной нозологической формы относятся лица старше 60 лет, причем с возрастом тяжесть протекания заболевания только возрастает. Согласно литературным данным, одной из причин снижения адаптационных возможностей лиц пожилого возраста является феномен «возрастного десинхроноза», проявляющийся значительными колебаниями параметров внутренней среды организма. Цель работы - сравнительный анализ коэффициентов внутри-и межиндивидуальной биологической вариации. Для этого проведено ретроспективное исследование клинического анализа крови у пациентов, страдающих пневмонией неуточненной этиологии, в разрезе трех возрастных групп - средней, пожилой и старческой. Обнаружены особенности биологической вариации в зависимости от возраста, выявленные отличия были обоснованы в соответствии с имеющимися теориями. Pneumonia is the leading mortality rate among all infectious diseases. It has been established that the reliable risk group for morbidity and mortality from this nosology includes persons over 60 years of age, and with age the severity of the disease only increases. According to literary data, one of the reasons for the decline in adaptation capabilities of older persons is the phenomenon of «age desinhronosis», which manifests itself in significant fluctuations in the parameters of the internal environment of the body. The purpose of this work was to compare the coefficients of intra- and interindividual biological variation. For this purpose, a retrospective study of clinical blood analysis in patients suffering from pneumonia of unspecified etiology was carried out in terms of three age groups: medium, elderly and senile. Features of biological variation depending on age have been found, the differences identified have been justified according to available theories.

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Investigation of the relationship between theoretical and actual turning radii of a tracked vehicle using mathematical modeling

Izvestiya MGTU MAMI ◽

10.31992/2074-0530-2020-46-4-80-91 ◽

2020 ◽

Vol 1 (4) ◽

pp. 80-91

Author(s):

A.A. Stadukhin ◽

Keyword(s):

Center Of Mass ◽

Weight Ratio ◽

Traction Force ◽

Plane Motion ◽

Practical Significance ◽

Tracked Vehicle ◽

Literary Sources ◽

Active Safety Systems ◽

Turning Radius ◽

Safety Systems

Introduction. Determination of the traction force and power required in a turn by a tracked ve-hicle is based on analytical dependencies given in classical literary sources. In this case, the de-pendence of the theoretical and actual turning radius is usually not described accurately enough. Subject of study. A study of the dependence of the theoretical and actual turning radius and the influence of the parameters of the undercarriage of the tracked vehicle, the characteristics of the support base and the mode of movement on it was made. Methodology and methods. The study was carried out using a specially developed stationary rotation tracked vehicle (TV) model, which differs by taking into account the redistribution of nor-mal reactions and implementation, allowing one to quickly carry out multifactorial experiments. The rotation of the TV in the model is described as a plane motion of a rigid body. In contrast to the classical approaches, the model allows one to study the rotation of the TV at a speed close to the critical drift. Results and scientific novelty. During computational experiments, the parameters of the chassis of the TV, the properties of the support base, as well as the speed of movement and the actual turn-ing radius were varied. It was found that the classical dependences of the actual and theoretical turning radius need to be refined when driving at a speed close to the critical drift, while the form of the dependence is determined by the height of the center of mass of the TV. Practical significance. These features should be taken into account both when assessing the speed of the vehicle and determining the required thrust-to-weight ratio, and when working on the development of active safety systems for tracked vehicles.

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Microbial profile of grain liquid of dogs of different age groups

The Agrarian Scientific Journal ◽

10.28983/asj.y2019i8pp41-46 ◽

2019 ◽

pp. 41-46

Author(s):

Aleksandr Vladimirovich Krasnikov ◽

Ekaterina Sergeevna Krasnikova ◽

Tatiana Antonovna Chistyakova ◽

Daria Dmitrievna Morozova

Keyword(s):

Risk Factors ◽

Age Groups ◽

Practical Significance ◽

Microbial Composition ◽

Periodontal Tissues ◽

Microbial Profile ◽

Gingival Fluid

The article presents the results of a comparison of the microbial composition of the gingival fluid of dogs of different age groups. The practical significance of the work lies in the fact that the data obtained during the study allow us to predict the risk factors for damage to periodontal tissues, as well as to determine the choice of antiseptic and antibiotic, the duration of the course of their use.

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Visualization of Lesions of Metaphyses and Epiphyses of Bones in Newborns and Young Children

Radiology - Practice ◽

10.52560/2713-0118-2021-5-82-90 ◽

2021 ◽

pp. 82-90

Author(s):

N. A. Sholokhova

Keyword(s):

Young Children ◽

False Negative ◽

Age Groups ◽

High Sensitivity ◽

Negative Results ◽

False Negative Results ◽

Inflammatory Processes ◽

Group 5 ◽

Magnetic Resonance Imaging Mri ◽

Diagnostic Capabilities

The aim of this study was to determine the diagnostic capabilities of various methods of radiological diagnostics for lesions of the metaphyses and epiphyses of bones in newborns and young children.The study involved 108 children in the age group 5 days – 12 months with pathological changes in the pineal gland and bone metaphysis. The possibilities and advantages of standard radiography (СR), ultrasound examination (US) and magnetic resonance imaging (MRI) in the early and differential diagnosis of the osteomyelitis process and epiphyseolysis have been determined. High sensitivity (98 %), specificity (99 %) and accuracy (98 %) for ultrasound and sensitivity (94 %), specificity (89 %) and accuracy (95 %) of MRI in diagnosing osteomyelitis in patients of this age groups. At the same time, the possibilities of standard radiography at the stages of early diagnosis of inflammatory processes in the distal parts of the bones were limited due to a number of factors. The use of diagnostic algorithms greatly facilitates the work of a radiologist and reduces the number of false negative results during the initial treatment of patients.

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Microbiological aspects in conservative treatment of generalized periodontitis using autotrombocytic mass

International Journal on Integrated Education ◽

10.31149/ijie.v3i12.919 ◽

2020 ◽

Vol 3 (11) ◽

pp. 206-209

Author(s):

Turaeva F.A.

Keyword(s):

Conservative Treatment ◽

Oral Cavity ◽

Immune Status ◽

Pathological Process ◽

The Body ◽

Primary Factor ◽

Normal Microflora ◽

Inflammatory Processes ◽

Microbiological Aspects

The primary factor causing periodontal damage is plaque bacteria. The etiological structure of infectious processes in the last decade has changed significantly, due to the constant evolution of microbes and the involvement of opportunistic microbes in the pathological process, which can act as commensals in the normal microflora and manifest their pathogenicity with a decrease in the body's immune status. Inflammatory processes in the oral cavity are sometimes an endogenous infection caused by the resident flora of not only the oral cavity, but also other ecosystems of the body.

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Closed Fractures of the Distal Part of the Shin Bones. Different Types and Methods of the Treatment in Adolescence. Short Period Results

Physical and rehabilitation medicine, medical rehabilitation ◽

10.36425/rehab63615 ◽

2021 ◽

Vol 3 (1) ◽

pp. 11-23

Author(s):

Alexander I. Dorokhin ◽

Alexander I. Krupatkin ◽

Anastasia A. Adrianova ◽

Vladimir I. Khudik ◽

Dmitriy S. Sorokin ◽

...

Keyword(s):

Distal Part ◽

Clinical Investigation ◽

Morphological Changes ◽

Treatment Algorithm ◽

Age Groups ◽

Growth Zone ◽

Difficult Problem ◽

Pathological Process ◽

X Rays ◽

Short Period

Background.Fractures of the distal leg bones in children, due to the peculiarities of localization, the presence of a growth zone, the proximity of the joint and the involvement of the ligamentous apparatus in the pathological process, present a difficult problem in the choice of treatment and rehabilitation.Aims:In order to our aims we create the diagnostic and treatment algorithm in the system of early rehabilitation after fractures in the distal part of the shin bone in adolescence.Methods.Our clinical investigation based on the treatment of 56 patients in the age 817 years. Cohort of patients consist from three age groups: 811 years (n=13), 1214 years (n=28) and 1517 years (n=15). Examination was done with X-rays, CT and Ultrasound, specialy in the cases where the damage of ligamentous apparatus was suspicious. The main method of treatment was surgical osteosynthesis by pins, plates and screws. In the rehabilitation period the legs were immobilized by Plaster of Paris for 46 weeks.Results.In majority of cases the outcomes in the period of 68 weeks after trauma were good and satisfactory. The method of laser Doppler fluometry was performed in 16 cases in follow up period after trauma for examination of the regional blood circulation as a argumentation of regeneration process.Conclusion.The different choice in treatment of compound fractures of the distal part of the shin bones according to morphological changes in adolescence permits to aid good results in majority of caces.

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FEATURES OF MANUFACTURE OF ADVANCED PROVISIONAL BRIDGE-BASED PROSTHESES

Art of Medicine ◽

10.21802/artm.2021.1.17.33. ◽

2021 ◽

pp. 33-37

Author(s):

А. В. Kostyshyn

Keyword(s):

High Efficiency ◽

Age Groups ◽

Masticatory Muscles ◽

Pathological Process ◽

Muscle Group ◽

Control Group ◽

Masticatory Muscle ◽

Orthopedic Treatment ◽

Group 2 ◽

Reinforcement Model

Abstract. The relevance of the topic is related to the need to improve methods of preparation of dentitions for orthopedic treatment, taking into account the defects of dentitions in patients with reduced occlusion height, taking into account the condition of the masticatory muscles and temporary use of plastic dentures, which provide gradual lifting of occlusion to normalize the masticatory group muscles and reorganization of myostatic reflexes. The aim of the research. Improving the effectiveness of preparation for orthopedic treatment of patients with partial tooth loss, with reduced occlusion height, by improving the design of a temporary bridge-based prosthesis. Materials and methods of research. We examined, treated and conducted clinical observation of 93 patients, who were divided into three groups according to the height of the reduction in occlusion, to achieve this goal and solve problems during the dissertation. Group 1 consisted of 32 patients with included dentition defects with reduced occlusion height up to 2 mm (n=32), group 2 - patients with included dentition defects with reduced occlusion height up to 2-4 mm (n=31), group 3 - these are patients with included dentition defects with reduced occlusion height up to 4-6 mm (n=30). All patients of the main groups belonged to the second and third age groups according to the WHO, aged 35-55 years. The control group (n=30) are young people who belonged to the 1st age group according to the WHO with intact dentition, without concomitant somatic and dental pathology, were admitted in one visit. Also, 123 fiberglass-reinforced plastic prostheses were made. Research results. When drawing up a plan for orthopedic treatment of patients with reduced occlusion height, we took into account possible complications, which are characterized by chipping of the facing material, pathological changes in the temporomandibular joint and masticatory muscle group. We have improved the method of manufacturing non-removable temporary plastic orthopedic constructions by reinforcing with fiberglass tapes and beams, to prevent them and gradually raise the bite. Expanded data on the dynamics of changes in myostatic reflexes and the effectiveness of the use of fixed orthopedic constructions, depending on the pathological process, the timing of adaptation of the masticatory muscle group to orthopedic constructions, according to the degree of reduction in occlusion height. The absence of complaints of breakage and other technical defects of the proposed temporary orthopedic constructions in 100% of cases, successfully allows to use it in the clinic of orthopedic dentistry. A new method of preparing patients for permanent orthopedic treatment by combined reinforcement of temporary non-removable bridge constructions with fiberglass tapes and beams is proposed, which differ in that after preliminary modeling of the frame of the bridge constructions, the technology of double reinforcement, model two support platforms with a step-like transition between them, in which fiberglass tapes and beams are fitted with dental tweezers, after which they are polymerized by the generally accepted method with a photopolymer lamp. Complete the modeling of the constructions and polymerize the prosthesis in the pneumopolymerizer with subsequent grinding and polymerize the prosthesis. Conclusion. The results of the research revealed the high efficiency of the improved method of manufacturing non-removable makeshift plastic of orthopedic constructions.

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USAGE OF HISTOLOGICAL METHODS IN DETERMINING THE PRESCRIPTION OF KIDNEY INJURIES IN FORENSIC MEDICAL PRACTICE

Wiadomości Lekarskie ◽

10.36740/wlek201905206 ◽

2019 ◽

Vol 72 (5) ◽

pp. 988-992

Author(s):

Olena P. Babkina ◽

Volodymyr V. Zosimenko ◽

Svitlana I. Danylchenko ◽

Andriy A. Chernozub ◽

Illia I. Vako ◽

...

Keyword(s):

Statistical Analysis ◽

Medical Practice ◽

Alcohol Intoxication ◽

Mechanical Injury ◽

Mechanical Trauma ◽

Histological Changes ◽

Literary Sources ◽

Analysis Of Results ◽

Males And Females ◽

The Moment

Introduction: The article presents data from literary sources and a statistical analysis of our own research on the nature, mechanism and prescription of kidneys injury in case of mechanical trauma and the absence of alcohol intoxication. The aim: To study the dynamics of changes in the histological parameters of the kidneys injured tissues in case of mechanical trauma depending on the prescription of injury. Materials and methods: The material of the study was the kidneys tissue of 48 males and females aged from 20-60 who died at known and unknown time in the presence and absence of alcohol in the blood. We used histological, histochemical methods, and carried out the analysis of results. Results: The obtained results showed that during the mechanical injury of kidneys there often developed a capsule and a parenchyma with hematoma in the area of injury. Our records showed that during the first 6 hours after injury, there appeared a hematoma in the center of the injury. Hemolysis of the erythrocyte particles was observed in the center of the hematoma. There were also isolated leukocytes and fibrin tissues closer to the edge of the hematoma. Conclusions: The obtained results indicate that there are several histological changes in the damaged kidneys tissues area which directly depend on the time which passed from the moment of injury.

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Psychological training of fire service employees

XXI century Technosphere Safety ◽

10.21285/2500-1582-2021-4-379-386 ◽

2022 ◽

Vol 6 (4) ◽

pp. 379-386

Author(s):

G. I. Savina ◽

Yu. V. Kalegina

Keyword(s):

Training Programs ◽

Fire Service ◽

Stress Factors ◽

Practical Significance ◽

Training Center ◽

Service Employees ◽

Emergency Situations ◽

Psychological Service ◽

Professional Stress ◽

Chelyabinsk Region

The problem of premature professional burnout among employees, including firefighters is of scientific and practical significance. The article describes the nature and types of professional stress, as well as activities of the Training Center of the Federal Fire Service in Chelyabinsk Region. It aims to identify guidelines in the normative labor functions of rescuers of the Ministry of Emergency Situations of Russia and firefighters for training programs to prepare fire service employees for stressful activities. To achieve this goal, labor functions of rescuers of the Ministry of Emergency Situations of Russia and firefighters were analyzed; training programs developed by the Training Center of the Federal Fire Service in Chelyabinsk region were assessed. The methods of comparative analysis and conversation with experts were used to identify pedagogical aspects of labor functions of fire service employees associated with their willingness to work under stress. The article established a relationship between the training programs and the development of readiness to perform labor functions under stress. The condition required for the training program to be efficient was determined. It involves attracting the psychological service of the Ministry of Emergency Situations to hold methodical meetings and seminars. The positive result of this training is an adequate response to stress factors. The research results may be used by teachers of training centers and universities and methodologists.

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Diseases of cardiovascular system in patients with severe and moderatesevere forms of psoriasis

Medical alphabet ◽

10.33667/2078-5631-2021-9-21-23 ◽

2021 ◽

pp. 21-23

Author(s):

A. A. Hotko ◽

M. Yu. Pomazanova ◽

Y. V. Kozyr

Keyword(s):

Skin Lesions ◽

Pathological Process ◽

Practical Significance ◽

Case Histories ◽

Cardiac Pathology ◽

Coronary Syndrome ◽

Organ Systems ◽

Body Organ ◽

Krasnodar Region ◽

Medical Histories

Psoriasis is one of the most common chronic recurrent dermatoses, which is not limited to skin lesions, leading to a violation of the functions of various body organ systems. The article presents the results of the analysis of the medical histories of patients of Clinical dermatovenerologic dispensary (Krasnodar Region of Russia) with moderate-severe and severe forms of psoriasis and concomitant cardiological pathology. The article presents data from 70 case histories of patients with moderate to severe psoriasis, the analysis of which shows the clinical and practical significance of comorbidity of psoriasis. From the analysis, we conclude that there is a direct relationship between the severity of the course of the cutaneous pathological process and the aggravation of the cardiological diagnosis. The higher the severity of psoriasis, the higher the risk of developing acute coronary syndrome, myocardial infarction and other cardiac pathology.

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