scholarly journals Another coronavirus, Another challenge

JMS SKIMS ◽  
2020 ◽  
Vol 23 (1) ◽  
pp. 1-2
Author(s):  
Rafi A Jan ◽  
Arif Rehman Sheikh
Keyword(s):  
Animal Species ◽  
Large Family ◽  
Animal Origin ◽  
Chinese Isolate ◽  
Wuhan City ◽  
Animal Reservoir ◽  
The World ◽  
Enteric Infections ◽  
The Many ◽  
Novel Coronavirus

The world is yet again challenged by the outbreak of a new coronavirus, named SARS-CoV-2; disease caused by this virus, now termed as COVID-19,was first reported in Wuhan City, Hubei Province China in the last week of December 2019. As of march 5, WHO reports a total of 80,430 cases of COVID-19 with 3013 deaths from China. The disease has been now reported in all the continents of the world except Antarctica –around 15,053 cases in 85 countries with 273 deaths. Although many cases have been reported in India, whether it going to touch this part of the country too, only time will tell.  It is very likely that by the time this editorial goes in print, the numbers would have changed significantly. It is because of this developing outbreak situation that has engulfed the entire world and has the potential to turn into a pandemic, I decided to focus on this new disease than to comment on one of the many well written papers in this issue of the journal. Understanding of this novel coronavirus, SARS-CoV-2, is evolving. This virus belongs to a large family of viruses known as coronaviridae family which are enveloped positive stranded RNA viruses causing respiratory and enteric infections affecting both animals and humans. The animal species infected by various coronaviruses include camels, cattle, cats and bats. Although very uncommon, coronaviruses of animal origin can infect humans and then spread from person to person, sometimes with devastating morbidity and mortality as is the case with MERS-CoV. The other two animal coronaviruses infecting people are SARS-CoV and SARS-CoV-2. All these three viruses are betacoronaviruses and have their origin in bats1. Sequences from SARS-CoV-2 generated from patients outside China are similar to the original Chinese isolate suggesting a likely single emergence of SARS-CoV-2 from an animal reservoir. In the coming months we expect to learn more about the evolution and other pathogenetic aspects of the disease caused by SARS-CoV-2

scholarly journals An Overview of SARS‐CoV‐2 and Animal Infection

2020 ◽  
Author(s):  
Mohamed Mahdy
Keyword(s):  
Animal Species ◽  
Short Review ◽  
World Health ◽  
Zoonotic Infection ◽  
Wholesale Market ◽  
Wuhan City ◽  
Animal Reservoir ◽  
Animal Infection ◽  
Novel Coronavirus ◽  
Health Organization

A novel coronavirus has been reported as the causative pathogen of the Coronavirus disease 2019 (COVID-19) outbreak Wuhan city, China in December 2019. Due to the rapid spreading of COVID-19 worldwide, it has been announced as a pandemic by the World Health Organization (WHO). Hospitalized patients in Wuhan are associated with the Huanan seafood wholesale market where live animals, such as poultry, bats, snakes, frogs, rabbits, marmots, and hedgehogs are sold in that market which suggests a possible zoonotic infection. Therefore, it is essential to identify the potential animal reservoir, and the possibility of infection for other animal species. This short review aims to provide an overview on the relation between severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection and animals.

scholarly journals An Overview of SARS‐CoV‐2 and Animal Infection

2020 ◽  
Author(s):  
Mohamed Mahdy
Keyword(s):  
Animal Species ◽  
Short Review ◽  
World Health ◽  
Zoonotic Infection ◽  
Wholesale Market ◽  
Wuhan City ◽  
Animal Reservoir ◽  
Animal Infection ◽  
Novel Coronavirus ◽  
Health Organization

A novel coronavirus has been reported as the causative pathogen of the Coronavirus disease 2019 (COVID-19) outbreak Wuhan city, China in December 2019. Due to the rapid spreading of COVID-19 worldwide, it has been announced as a pandemic by the World Health Organization (WHO). Hospitalized patients in Wuhan are associated with the Huanan seafood wholesale market where live animals, such as poultry, bats, snakes, frogs, rabbits, marmots, and hedgehogs are sold in that market which suggests a possible zoonotic infection. Therefore, it is essential to identify the potential animal reservoir, and the possibility of infection for other animal species. This short review aims to provide an overview on the relation between severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection and animals.

Treatment Options in COVID-19: The Role of Bioavailable Antiviral Ribonucleoside Analog on NHC in vitro

2020 ◽  
Author(s):  
Lara Bittmann
Keyword(s):  
World Health Organization ◽  
Clinical Picture ◽  
Treatment Options ◽  
World Health ◽  
Wuhan City ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

On December 31, 2019, WHO was informed of cases of pneumonia of unknown cause in Wuhan City, China. A novel coronavirus was identified as the cause by Chinese authorities on January 7, 2020 and was provisionally named "2019-nCoV". This new Coronavirus causes a clinical picture which has received now the name COVID-19. The virus has spread subsequently worldwide and was explained on the 11th of March, 2020 by the World Health Organization to the pandemic.

The Pandemic of Novel Coronavirus Disease 2019 (COVID-19): Need for an Immediate Action (Preprint)

2020 ◽  
Author(s):  
Mujib Ullah
Keyword(s):  
World Health Organization ◽  
Large Family ◽  
Current Treatment ◽  
World Health ◽  
New Disease ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

UNSTRUCTURED Coronaviruses belong to a large family of viruses. Coronavirus also called COVID-19 is a new disease that has not been previously identified in humans. The World Health Organization has announced that COVID-19 is a pandemic. Currently there is no specific vaccine or treatment for COVID-19. Current treatment for COVID-19 is only supportive (treating the symptoms). There are no antiviral or vaccine options at this time. Therefore, it is time to bring collective efforts to treat or prevent a rapidly evolving pandemic of COVID-19.

scholarly journals Early epidemiological assessment of the transmission potential and virulence of coronavirus disease 2019 (COVID-19) in Wuhan City: China, January-February, 2020

2020 ◽  
Author(s):  
Kenji Mizumoto ◽  
Katsushi Kagaya ◽  
Gerardo Chowell
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Public Health Intervention ◽  
Ecological Modelling ◽  
The Novel ◽  
Wuhan City ◽  
Transmission Potential ◽  
The World ◽  
Novel Coronavirus ◽  
Epidemiological Parameters

AbstractBackgroundSince the first cluster of cases was identified in Wuhan City, China, in December, 2019, coronavirus disease 2019 (COVID-19) rapidly spread around the world. Despite the scarcity of publicly available data, scientists around the world have made strides in estimating the magnitude of the epidemic, the basic reproduction number, and transmission patterns. Accumulating evidence suggests that a substantial fraction of the infected individuals with the novel coronavirus show little if any symptoms, which highlights the need to reassess the transmission potential of this emerging disease. In this study, we derive estimates of the transmissibility and virulence of COVID-19 in Wuhan City, China, by reconstructing the underlying transmission dynamics using multiple data sources.MethodsWe employ statistical methods and publicly available epidemiological datasets to jointly derive estimates of transmissibility and severity associated with the novel coronavirus. For this purpose, the daily series of laboratory–confirmed COVID-19 cases and deaths in Wuhan City together with epidemiological data of Japanese repatriated from Wuhan City on board government–chartered flights were integrated into our analysis.ResultsOur posterior estimates of basic reproduction number (R) in Wuhan City, China in 2019–2020 reached values at 3.49 (95%CrI: 3.39–3.62) with a mean serial interval of 6.0 days, and the enhanced public health intervention after January 23rd in 2020 was associated with a significantly reduced R at 0.84 (95%CrI: 0.81–0.88), with the total number of infections (i.e. cumulative infections) estimated at 1906634 (95%CrI: 1373500–2651124) in Wuhan City, elevating the overall proportion of infected individuals to 19.1% (95%CrI: 13.5–26.6%). We also estimated the most recent crude infection fatality ratio (IFR) and time–delay adjusted IFR at 0.04% (95% CrI: 0.03%–0.06%) and 0.12% (95%CrI: 0.08–0.17%), respectively, estimates that are several orders of magnitude smaller than the crude CFR estimated at 4.06%ConclusionsWe have estimated key epidemiological parameters of the transmissibility and virulence of COVID-19 in Wuhan, China during January-February, 2020 using an ecological modelling approach. The power of this approach lies in the ability to infer epidemiological parameters with quantified uncertainty from partial observations collected by surveillance systems.

scholarly journals Molecular Docking Study of the Potential Relevance of the Natural Compounds Isoflavone and Myricetin to COVID-19

2021 ◽  
Vol 25 (3) ◽  
pp. 271-282
Author(s):  
Didik Priyandoko ◽  
◽  
Wahyu Widowati ◽  
Mawar Subangkit ◽  
Diana Jasaputra ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Severe Acute Respiratory Syndrome ◽  
Active Sites ◽  
Docking Study ◽  
Binding Mode ◽  
Molecular Docking Study ◽  
Wuhan City ◽  
The World ◽  
Novel Coronavirus ◽  
Proteins Interactions

The 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly from its origin in Wuhan City, Hubei Province, China, to the rest of the world. The efficacy of herbal treatment in the control of contagious disease was demonstrated during the 2003 outbreak of severe acute respiratory syndrome (SARS). Natural compound used for this study were isoflavone and myricetin. Molecular docking was performed to analyze binding mode of the compounds towards 12 proteins related to COVID-19. The prediction shows that isoflavone and myricetin have moderate probability of antiviral activity. All of the docked compounds occupied the active sites of the proteins related to COVID-19. Based on QSAR and molecular docking, interactions were predicted with 10 out of 12 potential COVID-19 proteins for myricetin and with 9 out of 12 proteins interactions for isoflavone. A potential disease alleviating action is suggested for isoflavone and myricetin in the context of COVID-19 infection.

COVID-19: Pakistan’s Preparedness and response

2021 ◽  
Vol 1 (4) ◽  
pp. e207
Author(s):  
Sahrish Khan ◽  
Atiq ur Rahman ◽  
Muhammad Imran
Keyword(s):  
Preventive Measures ◽  
Awareness Campaign ◽  
Wuhan City ◽  
The World ◽  
Novel Coronavirus

At the end of December 2019 in the Wuhan City of China, a novel coronavirus (Covid-19) outbreak has been proclaimed. Several cases have arisen in other cities of China. It spread simultaneously worldwide in 209 countries of Europe, Australia, America, Asia, and Pakistan. Mortality is high; millions of people have been affected while cases are rapidly increasing in the world. Different controlling strategies have been adopted for COVID-19. Pakistan took rigorous measures like the hospital, specific laboratories for testing, centres for quarantine, awareness campaign, Ehsaas Emergency Cash Programme and lockdown for controlling this virus. There is no antiviral and vaccine based treatment only preventive measures are taken.

scholarly journals WHAT IS CORONAVIRUS, THEIR PREVENTION AND TREATMENTS AND SOME GOVERNMNET POLICIES IN INDIA

2021 ◽  
Vol 9 (06) ◽  
pp. 816-821
Author(s):  
Babita a ◽  
◽  
Rajat b ◽  
Nivedan Bhardwaj ◽  
Nivedita c ◽  
...  
Keyword(s):  
Human Population ◽  
Animal Species ◽  
Human Beings ◽  
The World ◽  
Clinical Interest ◽  
Incubation Duration ◽  
New Form ◽  
Novel Coronavirus

The name “coronavirus” comes from the crown- like spike that cowl the surfaces of coronaviridae family. The 2019 novel coronavirus is getting plenty of interest now due to the fact it's miles a brand new form of coronavirus. We have now no longer visible amongst human before. The idea is that it is able to have jumped from an animal species into the human population, after which all started spreading. We have visible a few human beings which have died of this ailment, and we recognize that there are already thousands of cases. So human beings are concerned, due to the fact we do now no longer but recognize precisely how intense the ailment may be or how a long way it's going to unfold. Also, don't forget that coronavirus has an incubation duration of up to fourteen days, and also you ought to are seeking for clinical interest if the signs persist or get worse past 7 to ten days. PM Modi recites shloka to stress on collective strength against coronavirus: “Utsaho balavanarya nastyutsahat param balam | Uthsaharambhamatrena jayante sarvasampadah. Meaning there is no force greater than our enthusiasm and spirit in this world. There is nothing in the world that cannot be achieved with this force.

SARS-CoV-2: Origin, pathogenesis and Therapeutic Interventions

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Ipsita G Kundu ◽  
NNV Radharani ◽  
Amit S Yadav ◽  
Srinivas Patnaik ◽  
Gopal C Kundu
Keyword(s):  
Large Population ◽  
Supportive Therapy ◽  
Therapeutic Interventions ◽  
Personal Hygiene ◽  
Therapeutic Approaches ◽  
Wuhan City ◽  
Comprehensive Information ◽  
The World ◽  
Novel Coronavirus ◽  
Different Parts

: In December, 2019 a novel coronavirus named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) rapidly infected a large population in Wuhan city, Hubei province, China. Since then it has been spread all over the world causing a pandemic termed as Coronavirus Disease 2019 or COVID-19. It has infected over 32 million people and caused more than nine lakhs casualties worldwide till date. Till now there is no specific drug or vaccine has been developed to prevent the spread of SARS-CoV-2. WHO has announced that personal hygiene and social distancing are the best available options against COVID-19 till now. Various experimental and re-purposed drugs are being used as preventive and supportive therapy in different parts of world. Comprehensive information about SARS-CoV-2 is required to develop therapeutic approaches for prevention of COVID-19. In this article, we have comprehensively reviewed the origin, structure and infection mechanism of SARS-CoV-2. We have also discussed the pathology of COVID-19 and various therapeutic interventions which are being used for drug development against COVID-19.

scholarly journals A Community Based Collaborative Research Model to Fight Coronavirus Disease (Covid-19). A Report on Nairobi, Kenya Covd19 Efforts

2020 ◽  
pp. 1-2
Author(s):  
Samson Chama ◽  
◽  
Enouce Ndeche ◽  
Keyword(s):  
Human Disease ◽  
Collaborative Research ◽  
World Health ◽  
Research Model ◽  
Community Based ◽  
Wuhan City ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

The first cases of COVID-19 pneumonia were identified in Wuhan City, China, in December 2019. In January 2020, a novel coronavirus, known as SARS-CoV-2, was identified as the cause of this outbreak. The virus, and the human disease it causes, have evolved into a global pandemic. As of April 29, 2020, according to the World Health Organization, cases have been confirmed in 213 countries, areas, or territories, with 3,090,445 confirmed cases so far, and 217,769 confirmed deaths [1].

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