scholarly journals Combating Leishmaniasis through Awareness Campaigning: A Mathematical Study on Media Efficiency

2016 ◽  
Vol 1 (3) ◽  
pp. 139-149 ◽  
Author(s):  
Dibyendu Biswas ◽  
Abhirup Datta ◽  
Priti Kumar Roy
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Disease Prevalence ◽  
Sand Fly ◽  
Mathematical Study ◽  
Complex Vector ◽  
Awareness Campaign ◽  
Infected Female ◽  
Vector Borne ◽  
Awareness Programme ◽  
Genus Leishmania

Leishmaniasis is a complex vector-borne disease that is originated by protozoa of the genus Leishmania. The disease is transmitted to human or animals through bites of infected female Phlebotominae sand-fly. Awareness campaign plays a significant role to restrict the spreading of disease cutaneous leishmaniasis. Here, we have considered a mathematical model of cutaneous leishmaniasis (CL) consisting susceptible and infected population of human and vector. Increase in growth of aware population impulsively leading to reduction of incompetence for environmental factors. Our analytical and numerical results reveal that circulating of the campaigning periodically minimizes the disease prevalence. The efficiency of the awareness programme contributes a better regime on the system moving towards healthy and hygienic environment.

Sand fly fauna (Diptera: Psychodidae) from Serra da Mocidade Nacional Park: report of vectors and putative vectors of American cutaneous leishmaniasis and new records for the state of Roraima, Brazil

Zootaxa ◽  
2018 ◽  
Vol 4500 (2) ◽  
pp. 289
Author(s):  
WALKYRIA RODRIGUES RAMOS ◽  
ARLEY FARIA JOSÉ DE OLIVEIRA ◽  
RUI ALVES DE FREITAS ◽  
VERACILDA RIBEIRO ALVES ◽  
DANILO PACHECO CORDEIRO
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Rural Areas ◽  
Urban Environments ◽  
The State ◽  
Sand Fly ◽  
Sand Flies ◽  
Infected Female ◽  
Phlebotomine Sand Flies ◽  
The Past ◽  
The North

Phlebotomine sand flies are insects of medical importance, as they are vectors of viruses, bacteria and trypanosomatids of the genus Leishmania Ross, the causative agent of leishmaniasis (Forattini 1973). During the past 20 years approximately 500,000 cases of leishmaniasis have been reported in Brazil. Most of these cases were reported in the North and Northeast regions. In the State of Roraima, almost 2,000 cases, including both cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL), have been reported during the past three years (SINAN 2017). Usually the transmission by infected female sand flies occurs in wild or rural areas, but there have also been recorded cases and vector captures in urban environments. Some sand fly species are known to enter houses in search of resting places and blood meal sources; as a result of this behavior, they are remarkably adaptable to new environments (Carvalhoet al. 2010). 

scholarly journals The Cutaneous Leishmaniasis and the Sand Fly: Knowledge and Beliefs of the Population in Central Morocco (El Hajeb)

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Karima El-Mouhdi ◽  
Abdelkader Chahlaoui ◽  
Mohammed Fekhaoui
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Public Awareness ◽  
Public Health Problem ◽  
Epidemiological Data ◽  
Sand Fly ◽  
Infected Female ◽  
Scientific Terminology ◽  
Knowledge And Beliefs ◽  
Individual Knowledge ◽  
And Control

Background. Cutaneous leishmaniasis is a neglected parasitic dermal disease transmitted to humans through the bite of an infected female sand fly. Morocco hopes to eliminate all forms of leishmaniasis by 2030. These dermatoses pose a real public health problem in the country. Although the information is available on the disease, individual knowledge of cutaneous leishmaniasis and sand fly is not yet developed. Exploring people’s beliefs and popular behaviours about cutaneous leishmaniasis and its vector allows health officials to know the sociocultural aspects of the disease and to improve prevention and control actions. Objectives. To identify the knowledge of cutaneous leishmaniasis and its vector in the population in central Morocco. Methods. Based on the epidemiological data of leishmaniases in the province of El Hajeb, we conducted a field survey and personal interviews in April and May 2019, among 281 persons belonging to the localities where leishmaniases were registered. Results. Our results show that the participants use the concept of “Chniwla” (61.6%) for sand fly and the concept of “Hboub Chniwla” (50.8%) for cutaneous leishmaniasis; 24.6% of the respondents do not know how the disease is transmitted to humans and 43.7% use traditional treatments and home remedies to cure themselves. 44% of participants believe that sand fly does not transmit the disease to humans and only 6.4% were aware of their responsibility in vector control. Conclusions. The study concluded that there is a need to simplify the scientific terminology in the health education of citizens regarding these dermatoses and their vector by integrating the popular concepts obtained in this study to raise public awareness and facilitate their involvement as active actors in the prevention of cutaneous leishmaniasis.

scholarly journals Distribution and Diversity of Sand Fly Species (Diptera: Psychodidae, Phlebotominae) in Two Geoclimatic Zones of Chad

2021 ◽  
Author(s):  
Israel DEMBA KODINDO ◽  
Demba Kodindo Israël ◽  
Cheick Amadou Coulibaly ◽  
Ibrahim Moussa Sissoko ◽  
Bourama Traoré ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Vector Competence ◽  
Abundant Species ◽  
Morphological Characters ◽  
Sand Fly ◽  
Canine Leishmaniasis ◽  
Phlebotomus Duboscqi ◽  
Vector Borne ◽  
Study Sites ◽  
Health Districts

Abstract Introduction: Leishmaniasis transmitted by sandflies is an important vector-borne disease. In Chad, information on sandflies is outdated, and so this study was designed to update the sandfly fauna. Methods: Sandflies were collected in five health districts representing two geoclimatic zones using sticky traps and pyrethrum sprays in indoor and peridomestic habitats between September 2019 and December 2020. All collected sandfly specimens were identified based on species-level morphological characters. Results: A total of 2,015 specimens belonging to 13 species of sandflies (one Phlebotomus and twelve Sergentomyia) were collected and identified. The vector of human cutaneous leishmaniasis, Phlebotomus duboscqi, represents 0.65% of all collected sandflies and is the only representative of the Phlebotomus genus to be collected predominantly inside human dwellings. Phlebotomus orientalis, the vector of visceral leishmaniasis previously collected in Chad in 1976 was not found in this study. Sergentomyia clydei, Sergentomyia schwetzi, Sergentomyia antennata and Sergentomyia africana were the most abundant species collected with 44.71%; 22.73%; 16.03% and 11.17%, respectively. Sergentomyia schwetzi and Sergentomyia dubia, the two species involved in the transmission of canine leishmaniasis, were found in five and four study sites respectively. Conclusion: According to our results, the sandfly fauna of the two geoclimatic zones of Chad is comprised of 13 species. Our data showed that, unlike P. orientalis which was not found, P. duboscqi is present in four of the five sites surveyed. Therefore, these areas are at risk and remain potential foci of cutaneous leishmaniasis. However, the need for further studies such as vector species detection, their seasonal fluctuations and their vector competence.

scholarly journals Identification of Sand Flies (Diptera: Psychodidae) Collected from Cutaneous Leishmaniasis Endemic Focus in the Ho Municipality, Ghana

2020 ◽  
Vol 10 (1) ◽  
pp. 33-44
Author(s):  
Edna Dzifa Doe ◽  
Godwin Kwakye-Nuako ◽  
Seth Offei Addo ◽  
Alexander Egyir-Yawson
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Sand Fly ◽  
Coi Gene ◽  
Morphological Identification ◽  
Correct Identification ◽  
Sand Flies ◽  
Oxidase Gene ◽  
Infected Female ◽  
Molecular Weights ◽  
Endemic Focus

Leishmaniasis, is a vector-borne disease transmitted to humans through the bite of infected female sand flies. Active and continuous monitoring of the sand fly is an important aspect of disease control. Thus, the correct identification of its vectors is paramount in this regard. Objective: The study was conducted to morphologically and molecularly identify female sand fly species in a cutaneous leishmaniasis endemic focus collected in three villages in the Ho Municipality of the Volta region based on taxonomic keys. CDC light traps and sticky paper traps was used for the collection of the sand flies. The morphologically identified sand flies was molecularly confirmed by running PCR with the mitochondrial cytochrome c oxidase gene subunit I (COI) primers and DNA sequenced. A total of 537 sand flies was collected, made up of 363 females and 174 males.  Eleven different species of sand flies was morphologically identified – one Phlebotomus species and ten Sergentomyia species. The PCR amplified products showed bands of molecular weights 658 base pairs for the primers. The molecular identification using the 658-bp fragment of the (COI) gene was congruent with the morphological identification.

Evaluation of CO2 laser efficacy in the treatment of cutaneous leishmaniasis in a group of 10 Sudanese patients

2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Ali M. Osman ◽  
Nafie A. Almuslet
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Skin Ulcer ◽  
Sand Fly ◽  
Infected Female ◽  
Mucosal Disease ◽  
Good Improvement ◽  
Chronic Skin ◽  
Present Case Study

AbstractCutaneous leishmaniasis (CL) is a protozoal skin disease, transmitted by the bite of an infected female sand fly. The result of infection can vary from a chronic skin ulcer to erosive mucosal disease. The disease is endemic in Sudan, persists for longer periods and heals with disfiguring scars. The use of lasers has not been extensively tried out in the treatment of this disease. The present case study aimed to evaluate the efficacy of a fractional COThe ulcers of 10 randomly selected Sudanese patients, diagnosed as CL patients, were ablated using a 10,600 nm COThe majority of the patients (8 out of 10) had either a complete or very good improvement by the end of follow-up. Pain occurred post-operatively in all patients, while edema, infection and hypo/hyperpigmentation occurred in only two patients. These side effects were trivial and disappeared a few days after treatment.The fractional CO

Prevalence of Leishmania major Yakimoff and Schokhor (Kinetoplastida: Trypanosomatidae) in Sandflies in Iran: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Hamid Reza Shoraka ◽  
Moslem Taheri Soodejani ◽  
Ehsan Allah Kalteh ◽  
Maryam Chegeni ◽  
Marzieh Mahmudimanesh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Leishmania Major ◽  
Meta Analysis ◽  
Sand Fly ◽  
Sand Flies ◽  
Infected Female ◽  
Cochrane Reviews ◽  
Pooled Prevalence ◽  
Vector Borne

Abstract Cutaneous leishmaniasis is an important parasitic and vector-borne disease in Iran and can be transmitted to humans and animals through bites of infected female sand flies. The present study aimed to determine the pooled prevalence of Leishmania major in sand flies in Iran. A systematic review and meta-analysis was performed in the present study, so that databases, namely PubMed, Web of Sciences, Science Direct, ProQuest, Embase, Cochrane Reviews, and Scopus as well as IranDoc, SID, Elmnet, and Magiran were searched for finding Persian articles. Inclusion criteria of study contained the study in Iran and investigation of L. major parasite in sand flies. The quality of studies was examined by Joanna Briggs Institute Critical Appraisal Checklist for studies that reported prevalence data; and the data were analyzed by Stata 14 software. In total, 42 studies were evaluated, all of which had investigated the infection of Phlebotomus papatasi Scopoli (Diptera: Psychodidae). The infection of Phlebotomus caucasicus group was investigated in 13 studies, Phlebotomus ansarii Lewis in four studies, Phlebotomus salehi Mesghali and Rashti in five studies, and the infection of other species of sandflies in seven studies. According to the meta-analysis, the pooled prevalence of Ph. papatasi, Ph. caucasicus group, Ph. salehi, and Ph. ansarii were equal to 2.4, 6.2, 1.6, and 9.2%, respectively, with 95% confidence interval. According to reports of different rates of sand fly infection in different regions, all studies should have certain and standard forms and formats to determine the pooled prevalence of sand fly infection.

scholarly journals Cutaneous leishmaniasis

2017 ◽  
Vol 7 (2) ◽  
pp. 1212-1217 ◽  
Author(s):  
Ram Chandra Adhikari ◽  
Mahesh Shah
Keyword(s):  
Cell Carcinoma ◽  
Cutaneous Leishmaniasis ◽  
Skin Diseases ◽  
Protozoan Parasite ◽  
Skin Tumor ◽  
Common Disease ◽  
Lupus Vulgaris ◽  
Infected Female ◽  
Genus Leishmania ◽  
Sodium Antimony Gluconate

ABSTRACTLeishmaniasis is considered to be zoonotic disease, caused by a protozoan parasite of the genus Leishmania, and transmitted by a bite of infected female sandfly. Primary cutaneous leishmaniasis is not common disease in Nepal, however, there were cases reported from Terai region of Nepal. The patients with cutaneous leishmaniasis present with a papule or nodule at the site of inoculation, followed by formation of crusts. Differential diagnoses of cutaneous leishmaniasis include variety of skin diseases, inflammatory like impetigo, eczema, or granulomatous like sarcoidosis, lupus vulgaris, to skin tumor like basal cell carcinoma & squamous cell carcinoma. There are various procedures and laboratory techniques used to diagnose leishmaniasis. Punch skin biopsy is widely used & popular technique to diagnose cutaneous leishmaniasis. Different drugs like sodium stibogluconate, sodium antimony gluconate, Amphotericin B and Miltefosine: are used for its treatment. No vaccines are available for prevention. 

scholarly journals Distribution and Diversity of Sand Fly Species (Diptera: Psychodidae, Phlebotominae) in Two Geoclimatic Zones of Chad

2022 ◽  
Vol 2 ◽  
Author(s):  
Demba Kodindo Israël ◽  
Cheick Amadou Coulibaly ◽  
Ibrahim Moussa Sissoko ◽  
Bourama Traoré ◽  
André B. B. Wilke ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Vector Competence ◽  
Abundant Species ◽  
Morphological Characters ◽  
Sand Fly ◽  
Canine Leishmaniasis ◽  
Phlebotomus Duboscqi ◽  
Vector Borne ◽  
Study Sites ◽  
Health Districts

Leishmaniasis transmitted by sandflies is an important vector-borne disease. In Chad, information on sandflies is outdated, and so this study was designed to update the sandfly fauna. Sandflies were collected in five health districts representing two geoclimatic zones using sticky traps and pyrethrum sprays in indoor and peridomestic habitats between September 2019 and December 2020. All collected sandfly specimens were identified based on species-level morphological characters. A total of 2,015 specimens belonging to 13 species of sandflies (one Phlebotomus and twelve Sergentomyia) were collected and identified. The vector of human cutaneous leishmaniasis, Phlebotomus duboscqi, represents 0.65% of all collected sandflies and is the only representative of the Phlebotomus genus to be collected predominantly inside human dwellings. Phlebotomus orientalis, the vector of visceral leishmaniasis previously collected in Chad in 1976 was not found in this study. Sergentomyia clydei, Sergentomyia schwetzi, Sergentomyia antennata and Sergentomyia africana were the most abundant species collected with 44.71%; 22.73%; 16.03% and 11.17%, respectively. Sergentomyia schwetzi and Sergentomyia dubia, the two species involved in the transmission of canine leishmaniasis, were found in five and four study sites respectively. According to our results, the sandfly fauna of the two geoclimatic zones of Chad is comprised of 13 species. Our data showed that, unlike P. orientalis which was not found, P. duboscqi is present in four of the five sites surveyed. Therefore, these areas are at risk and remain potential foci of cutaneous leishmaniasis. However, the need for further studies such as vector species detection, their seasonal fluctuations and their vector competence.

scholarly journals Clinical and laboratory profiles of visceral leishmaniasis among adult patients admitted to Felege Hiwot Hospital, Bahir Dar, Ethiopia

2021 ◽  
Vol 9 ◽  
pp. 205031212110367
Author(s):  
Berhanu Tarekegn ◽  
Ayanaw Tamene
Keyword(s):  
Visceral Leishmaniasis ◽  
Leishmania Donovani ◽  
Clinical Presentation ◽  
Winter Season ◽  
Adult Patients ◽  
Sand Fly ◽  
Timely Initiation ◽  
Vector Borne Disease ◽  
Vector Borne ◽  
Endemic Areas

Background: Visceral leishmaniasis is a vector-borne disease caused by Leishmania donovani transmitted by sand fly species. It is the third most common vector-borne disease globally. Visceral leishmaniasis is endemic in Ethiopia with an estimated annual incidence ranging from 3700 to 7400 cases. This research aimed to assess the clinical presentations and laboratory profiles of visceral leishmaniasis for early diagnosis and timely initiation of management. Objective: To describe the clinical and laboratory manifestation and diagnostic modalities of visceral leishmaniasis among adult patients admitted to Felege Hiwot Hospital, from 1 September 2016 to 30 August 2019. Method: Institution-based retrospective cross-sectional study was conducted among 141 patients admitted to Felege Hiwot Hospital from 1 September 2016 to 30 August 2019. Descriptive statistics were used to describe the clinical presentation and laboratory profiles of patients with visceral leishmaniasis. Results: Among a total of 141 enrolled patients in the study, males were affected 13-fold. Most of them were travelers to endemic areas during the winter season for labor work. The mean duration of illness was 48 days. Common symptoms were fever (96.5%), weightless (82.5%), jaundice (18.4%), vomiting/diarrhea (13.5%), and bleeding episodes (11.3%). Splenomegaly was seen in 98.6%, ascites in 35.5%, and lymphadenopathy in 9.9%. Lymphadenopathy was seen significantly in HIV patients (40%). Anemia was seen in 95%, thrombocytopenia in 90.2%, leukopenia in 86.4%, and pancytopenia in 79.4%. Half of the patients had coinfection. Neutropenic sepsis was seen in 21.3%. The diagnosis was made by tissue aspiration in 65% of patients. Conclusion: The majority of patients who were diagnosed to have visceral leishmaniasis were young male adults who traveled to the endemic areas seasonally. Fever and splenomegaly were seen as the commonest clinical presentation. Lymphadenopathy occurred in high frequency among HIV co-infected patients. Anemia was the commonest hematologic finding.

scholarly journals A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates

2015 ◽  
Vol 7 (290) ◽  
pp. 290ra90-290ra90 ◽  
Author(s):  
Fabiano Oliveira ◽  
Edgar Rowton ◽  
Hamide Aslan ◽  
Regis Gomes ◽  
Philip A. Castrovinci ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Nonhuman Primates ◽  
Mononuclear Cells ◽  
Rhesus Macaques ◽  
Parasite Burden ◽  
Salivary Protein ◽  
Sand Fly ◽  
Protein Vaccine ◽  
Peripheral Blood Mononuclear ◽  
Phlebotomus Duboscqi

Currently, there are no commercially available human vaccines against leishmaniasis. In rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection against leishmaniasis, making them worthy targets for further exploration as vaccines. We demonstrate that nonhuman primates (NHP) exposed to Phlebotomus duboscqi uninfected sand fly bites or immunized with salivary protein PdSP15 are protected against cutaneous leishmaniasis initiated by infected bites. Uninfected sand fly–exposed and 7 of 10 PdSP15-immunized rhesus macaques displayed a significant reduction in disease and parasite burden compared to controls. Protection correlated to the early appearance of Leishmania-specific CD4+IFN-γ+ lymphocytes, suggesting that immunity to saliva or PdSP15 augments the host immune response to the parasites while maintaining minimal pathology. Notably, the 30% unprotected PdSP15-immunized NHP developed neither immunity to PdSP15 nor an accelerated Leishmania-specific immunity. Sera and peripheral blood mononuclear cells from individuals naturally exposed to P. duboscqi bites recognized PdSP15, demonstrating its immunogenicity in humans. PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis.

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