scholarly journals Biomimetic Hydrogels to Promote Wound Healing

2021 ◽  
Vol 9 ◽  
Author(s):  
Fei Fan ◽  
Sanjoy Saha ◽  
Donny Hanjaya-Putra
Keyword(s):  
Wound Healing ◽  
External Environment ◽  
Wound Management ◽  
Future Perspectives ◽  
Supporting Cells ◽  
Promote Wound Healing ◽  
Design Considerations ◽  
Cellular Events ◽  
Healing Wounds ◽  
The Ideal

Wound healing is a common physiological process which consists of a sequence of molecular and cellular events that occur following the onset of a tissue lesion in order to reconstitute barrier between body and external environment. The inherent properties of hydrogels allow the damaged tissue to heal by supporting a hydrated environment which has long been explored in wound management to aid in autolytic debridement. However, chronic non-healing wounds require added therapeutic features that can be achieved by incorporation of biomolecules and supporting cells to promote faster and better healing outcomes. In recent decades, numerous hydrogels have been developed and modified to match the time scale for distinct stages of wound healing. This review will discuss the effects of various types of hydrogels on wound pathophysiology, as well as the ideal characteristics of hydrogels for wound healing, crosslinking mechanism, fabrication techniques and design considerations of hydrogel engineering. Finally, several challenges related to adopting hydrogels to promote wound healing and future perspectives are discussed.

scholarly journals Novel formulation approaches for wound healing

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 937-948
Author(s):  
Tanaji D Nandgude ◽  
Syed Nateque Naser
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Cell Types ◽  
Wound Management ◽  
Wound Healing Process ◽  
Anatomic Structure ◽  
Tissue Integrity ◽  
Molecular Events ◽  
Acute Injuries ◽  
Healing Wounds

A wound is damage to the typical anatomic structure. Wound healing is an immediate therapeutic response to injury. It is a creation of the combined response of some cell types towards injury. Wound healing takes place by a sequence of molecular events which cooperate to fix tissue integrity and cell work. In typical healthy individual under ordinary conditions, these physiological events take place smoothly. Though sometimes, these molecular events are arrested, this brings about in struggle to heal. There is an assortment of approaches for the way toward managing and controlling both acute injuries (acute wounds) and ceaseless non-mending wounds (chronic non-healing wounds). The principal objective of these two cases is to achieve better-wound healing. Ideal formulations of wound healing should not only enhance the healing process but also reduce pain, infection and loss of electrolytes, proteins and liquids from the injury. A broad scope of items typically introduced with target various parts of the wound healing process depends on numerous types of wounds and novel polymers utilised for the conveyance of medications to both acute and ceaseless injuries. These include alginate, hydrocolloids, hydrofibers, polyurethane, and hydrogels. This article gives particular importance to different novel approaches in the management of wound healing. This review draws out the data and hopes to provide understanding into traditional, current and imminent techniques and methods for wound management.

The veterinary nurse's role in the management of wound drains

2020 ◽  
Vol 11 (6) ◽  
pp. 264-269
Author(s):  
Evie Yon
Keyword(s):  
Wound Healing ◽  
Patient Outcomes ◽  
Wound Management ◽  
Surgical Reconstruction ◽  
Normal Process ◽  
Initial Management ◽  
Accurate Knowledge ◽  
Wound Breakdown ◽  
Potential Applications ◽  
The Ideal

Wound management is an exciting and well-researched area of veterinary medicine. It is a key area for veterinary nursing involvement from initial management to possible surgical reconstruction. An essential aspect of this is provision of the ideal wound environment to encourage normal and effective wound healing, and to reduce the incidence of wound breakdown and dehiscence. Throughout this clinical review, consideration will be given to the normal process of wound healing and how this can be assisted by drain placement. The types of drain used in practice, in addition to novel drainage techniques, will be considered throughout, as well as the veterinary nurse's role in their management. Comprehensive and accurate knowledge and understanding of different drain types, in addition to their potential applications, can help to ensure more informed veterinary nursing and, in turn, better wound healing and patient outcomes.

scholarly journals Insulin-like growth factor-I and wound healing, a potential answer to non-healing wounds: A systematic review of the literature and future perspectives

2021 ◽  
Vol 15 (2) ◽  
Author(s):  
Zoe Garoufalia ◽  
Argyro Papadopetraki ◽  
Elli Karatza ◽  
Dimitrios Vardakostas ◽  
Anastassios Philippou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Future Perspectives ◽  
Review Of The Literature ◽  
Factor I ◽  
Healing Wounds ◽  
Growth Factor I

scholarly journals Wound care with traditional, complementary and alternative medicine

2012 ◽  
Vol 45 (02) ◽  
pp. 418-424 ◽  
Author(s):  
Ananda A. Dorai
Keyword(s):  
Wound Healing ◽  
Alternative Medicine ◽  
Traditional Medicine ◽  
Care Management ◽  
Wound Care ◽  
Healing Process ◽  
Wound Management ◽  
Care Practice ◽  
Wound Therapy ◽  
The Ideal

ABSTRACTWound care is constantly evolving with the advances in medicine. Search for the ideal dressing material still continues as wound care professionals are faced with several challenges. Due to the emergence of multi-resistant organisms and a decrease in newer antibiotics, wound care professionals have revisited the ancient healing methods by using traditional and alternative medicine in wound management. People′s perception towards traditional medicine has also changed and is very encouraging. The concept of moist wound healing has been well accepted and traditional medicine has also incorporated this method to fasten the healing process. Several studies using herbal and traditional medicine from different continents have been documented in wound care management. Honey has been used extensively in wound care practice with excellent results. Recent scientific evidences and clinical trials conducted using traditional and alternative medicine in wound therapy holds good promise in the future.

scholarly journals Ekek anti mikroba terapi larva

2016 ◽  
Vol 8 (1) ◽  
Author(s):  
Sunny Wangko
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Healing Process ◽  
Wound Management ◽  
Wound Healing Process ◽  
Healing Wounds ◽  
Chronic Wound Management ◽  
Very High ◽  
Anti Inflammation ◽  
Larval Therapy

Abstract: Chronic wound is still a world-wide problem that spends a very high cost related to its management and treatment. Although there are a lot of promising studies about wound healing process, the prevalence and incidence of chronic wound and its complications are still high. Conventionally, the management of chronic wound consists of surgical debridement, manual irrigation, dressing, and antimicrobial therapy (topical and/or systemic). It is accepted that microbial biofilm and its complexity play important roles in non-healing wounds. This biofilm consists of polymicrobial colonies embedded in exopolymeric matrix produced by the biofilm itself and has a high tolerance to host defence mechanisme, antibiotics, and antiseptics. Larval therapy has been approved by FDA to be used in chronic wound management. It has antimicrobial effects besides its other effects on wound healing inter alia mechanical debridement, anti-inflammation, angiogenesis, and destabilization of biofilm enzymes. Further studies are needed to explore the effects of larval therapy, especially its excretion/secretion components, so that it can be applicated more aesthetically.Keywords: chronic wound, wound healing process, biofilm, larval therapyAbstrak: Luka kronis merupakan masalah kesehatan di seluruh dunia yang telah memboroskan biaya cukup tinggi. Walaupun telah terjadi kemajuan dan pemahaman mengenai penyembuhan luka, prevalensi dan insidensi luka kronis dan komplikasinya tetap meningkat pesat. Secara konvensional, perawatan luka kronis terdiri dari debrideman, irigasi manual, dressing untuk mempertahankan kelembaban, dan terapi antimikroba (topikal dan atau sistemik). Adanya biofilm mikroba serta kompleksitasnya pada luka kronis telah disepakati sebagai salah satu kunci gagalnya penyembuhan luka. Biofilm mikroba terdiri dari koloni-koloni mikroorganisme polimikrobial terkemas dalam matriks eksopolimerik yang diproduksi olehnya sendiri dan memiliki toleransi tinggi terhadap pertahanan pejamu (host), antibiotik, dan antiseptik. Terapi larva telah diterima oleh FDA dan telah terbukti berefek antimikroba disamping efek lainnya terhadap penyembuhan luka, antara lain: debrideman mekanis, anti-inflamasi, angiogenesis, dan destabilisasi enzim biofilm pada luka. Studi lanjut diperlukan untuk mengeksplorasi efek terapi larva terutama komponen ekskresi/skresi larva terhadap penyembuhan luka agar dapat diaplikasikan secara lebih estetik.Kata kunci: luka kronis, penyembuhan luka, biofilm, terapi larva

Eliminating non-healing wounds: a review

2021 ◽  
Vol 16 (4) ◽  
pp. 391-404
Author(s):  
Damien P Kuffler
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Mechanisms Of Action ◽  
Wound Management ◽  
Cutaneous Wounds ◽  
Venous Ulcers ◽  
Metabolic Conditions ◽  
Healing Wounds ◽  
Complete Wound Healing

Non-healing cutaneous wounds, including pressure, diabetic and venous ulcers, are wounds where the skin and underlying tissues die due to ischemia, infection, metabolic conditions, immunosuppression or radiation. Some can be eliminated with relatively straightforward techniques, although they may continue to grow in diameter and depth, becoming increasingly painful and never heal. Others respond more slowly or poorly to treatment, while others are recalcitrant to treatments. This review examines the etiology of non-healing wounds and different wound management treatments. In addition, it examines the efficacy of platelet-rich plasma in promoting wound healing and its potential mechanisms of action. It is concluded that platelet-rich plasma alone, but more effectively when combined with another technique(s), has the greatest potential for promoting complete wound healing. However, further studies are required to determine whether the efficacy of wound healing induced by each of these techniques is enhanced by applying the techniques simultaneously.

scholarly journals Recent advances in topical wound care

2012 ◽  
Vol 45 (02) ◽  
pp. 379-387 ◽  
Author(s):  
Sujata Sarabahi
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Wound Care ◽  
Skin Grafting ◽  
Primary Objective ◽  
Wound Management ◽  
Accelerate Wound Healing ◽  
Constant Change ◽  
Healing Wounds ◽  
Systemic Antibiotics

ABSTRACTThere are a wide variety of dressing techniques and materials available for management of both acute wounds and chronic non-healing wounds. The primary objective in both the cases is to achieve a healed closed wound. However, in a chronic wound the dressing may be required for preparing the wound bed for further operative procedures such as skin grafting. An ideal dressing material should not only accelerate wound healing but also reduce loss of protein, electrolytes and fluid from the wound, and help to minimize pain and infection. The present dictum is to promote the concept of moist wound healing. This is in sharp contrast to the earlier practice of exposure method of wound management wherein the wound was allowed to dry. It can be quite a challenge for any physician to choose an appropriate dressing material when faced with a wound. Since wound care is undergoing a constant change and new products are being introduced into the market frequently, one needs to keep abreast of their effect on wound healing. This article emphasizes on the importance of assessment of the wound bed, the amount of drainage, depth of damage, presence of infection and location of wound. These characteristics will help any clinician decide on which product to use and where,in order to get optimal wound healing. However, there are no ′magical dressings′. Dressings are one important aspect that promotes wound healing apart from treating the underlying cause and other supportive measures like nutrition and systemic antibiotics need to be given equal attention.

scholarly journals Wound healing: cellular mechanisms and pathological outcomes

Open Biology ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 200223 ◽  
Author(s):  
Holly N. Wilkinson ◽  
Matthew J. Hardman
Keyword(s):  
Wound Healing ◽  
Tissue Repair ◽  
Wound Repair ◽  
Complex Dynamic ◽  
Cellular Mechanisms ◽  
Cellular Events ◽  
High Prevalence ◽  
Healing Wounds ◽  
Socioeconomic Burden ◽  
Healing Impairment

Wound healing is a complex, dynamic process supported by a myriad of cellular events that must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound-linked cellular behaviours, as occurs with diabetes and ageing, can lead to healing impairment and the formation of chronic, non-healing wounds. These wounds are a significant socioeconomic burden due to their high prevalence and recurrence. Thus, there is an urgent requirement for the improved biological and clinical understanding of the mechanisms that underpin wound repair. Here, we review the cellular basis of tissue repair and discuss how current and emerging understanding of wound pathology could inform future development of efficacious wound therapies.

Honey: An Effective Regenerative Medicine Product in Wound Management

2019 ◽  
Vol 26 (27) ◽  
pp. 5230-5240 ◽  
Author(s):  
Simona Martinotti ◽  
Marcela Bucekova ◽  
Juraj Majtan ◽  
Elia Ranzato
Keyword(s):  
Wound Healing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Potential Role ◽  
Wound Management ◽  
Physiological Basis ◽  
Speed Up ◽  
Healing Wounds ◽  
Medicine Product

:Honey has successfully been used in the treatment of a broad spectrum of injuries including burns and non-healing wounds. It acts as an antibacterial and anti-biofilm agent with anti/pro-inflammatory properties. However, besides these traditional properties, recent evidence suggests that honey is also an immunomodulator in wound healing and contains several bee and plant-derived components that may speed up wound healing and tissue regeneration process. Identifying their exact mechanism of action allows better understanding of honey healing properties and promotes its wider translation into clinical practice.:This review will discuss the physiological basis for the use of honey in wound management, its current clinical uses, as well as the potential role of honey bioactive compounds in dermal regenerative medicine and tissue re-modeling.

scholarly journals RESEARCH AND DEVELOPMENT IN WOUND MANAGEMENT PRODUCTS: A BRIEF REVIEW

2018 ◽  
Vol 11 (6) ◽  
pp. 17
Author(s):  
Surya Geetha V ◽  
Vishal Gupta N ◽  
Gowda Dv ◽  
Kulkarni Pk
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Wound Management ◽  
Skin Substitutes ◽  
Wound Recovery ◽  
Surgical Wounds ◽  
Wide Range ◽  
Healing Wounds ◽  
Dressing Materials ◽  
Normal Architecture

Wound can be defined as any process which leads to the disruption of the normal architecture of a tissue. They may be closed or open, for example, abrasions, lacerations, avulsions, ballistic and excised, or surgical wounds. Successful wound care includes advancing patient local and systemic conditions in conjunction with a perfect injury healing condition. Numerous wide assortments of dressing materials are accessible both for extreme and persistent non-healing wounds. A wide range of wound healing products have been produced to impact this injury condition to give a non-pathogen, ensured, and clammy region for healing to happen. A perfect injury dressing ought to limit loss of protein, electrolytes, and liquids from twisted and to diminish pain and contamination alongside wound healing. More current products are as of now being utilized to supplant or enlarge different substrates in the injury healing period. There is a sharp complexity to prior routine of wound administration, where the injury is permitted to dry, yet the present advancement was to move forward to the idea of wet injury recovering. This review of the present wounding periphery in wound recovery occurs at the most recent utilizations of silver and the employments of negative pressure wound gadgets, propelled dressings and skin substitutes, and biologic injury items including development of hydrogels and hyperbaric oxygen as an aid in wound mending. With the advancement of accessible dressings, the objective is to locate the most proper methodology or blend of modalities to optimize wound healing.

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