scholarly journals Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

2021 ◽  
Vol 9 ◽  
Author(s):  
Wuping Sun ◽  
Yixuan Luo ◽  
Fei Zhang ◽  
Shuo Tang ◽  
Tao Zhu
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Weight Control ◽  
Trp Channels ◽  
Obesity Prevalence ◽  
Brown Adipose ◽  
Promising Application ◽  
Body Weight Control ◽  
Global Health Problem ◽  
Shivering Thermogenesis

Obesity prevalence became a severe global health problem and it is caused by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major site of mammalian non-shivering thermogenesis or energy dissipation. Thus, modulation of BAT thermogenesis might be a promising application for body weight control and obesity prevention. TRP channels are non-selective calcium-permeable cation channels mainly located on the plasma membrane. As a research focus, TRP channels have been reported to be involved in the thermogenesis of adipose tissue, energy metabolism and body weight regulation. In this review, we will summarize and update the recent progress of the pathological/physiological involvement of TRP channels in adipocyte thermogenesis. Moreover, we will discuss the potential of TRP channels as future therapeutic targets for preventing and combating human obesity and related-metabolic disorders.

Melatonin and brown adipose tissue: novel insights to a complex interplay

2019 ◽  
Vol 2 (4) ◽  
pp. 25-41
Author(s):  
Ingrid Fernandes Olesçuck ◽  
Ludmilla Scodeler Camargo ◽  
Paula Vargas Versignassi Carvalho ◽  
Caroline Aparecida Pereira Souza ◽  
Camila Congentino Gallo ◽  
...  
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Weight Control ◽  
Complex Interplay ◽  
Metabolic Balance ◽  
Brown Adipose ◽  
Circannual Cycles ◽  
Body Weight Control ◽  
Shivering Thermogenesis

As a chronobiotic molecule, melatonin finely tunes a variety of physiological processes including energy metabolism, reproduction and sleep-wake cycle, collaborating for the survival of the organisms. Since its pineal production occurs exclusively during the night, melatonin is responsible for signaling the circadian and circannual cycles to the organisms. This involves different ways of action that need to be considered when analyzing its effects in a given tissue/organism. Non-shivering thermogenesis (NST) is a crucial process for homeothermic animals and increasing evidences show its importance for the energy metabolic balance due to its influence in body weight control. The highly seasonal brown adipose tissue (BAT) is the site for NST and its metabolism is importantly influenced by melatonin. This review focuses on melatonin actions over BAT and the attention should be given to the relation between this signaling molecule and such a seasonally expressed tissue.

scholarly journals Resistance to Obesity by Repression of VEGF Gene Expression through Induction of Brown-Like Adipocyte Differentiation

Endocrinology ◽  
2012 ◽  
Vol 153 (7) ◽  
pp. 3123-3132 ◽  
Author(s):  
Xiaodan Lu ◽  
Yan Ji ◽  
Luqing Zhang ◽  
Yuntao Zhang ◽  
Shuzhi Zhang ◽  
...  
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Energy Metabolism ◽  
Weight Control ◽  
Specific Gene ◽  
Fatty Acid Transport ◽  
Adipose Tissues ◽  
Genetic Mouse Model ◽  
Brown Adipose ◽  
Body Weight Control

Adipose tissues are classified into white adipose tissue (WAT) and brown adipose tissue (BAT). WAT is responsible for energy storage, and malfunction is associated with obesity. BAT, on the contrary, consumes fat to generate heat through uncoupling mitochondrial respiration and is important in body weight control. Vascular endothelial growth factor (VEGF)-A is the founding member of the VEGF family and has been found highly expressed in adipose tissue. A genetic mouse model of an inducible VEGF (VEGF-A) repression system was used to study VEGF-regulated energy metabolism in WAT. VEGF-repressed mice demonstrated lower food efficiency, lower body weight, and resistance to high-fat diet-induced obesity. Repression of VEGF expression caused morphological and molecular changes in adipose tissues. VEGF repression induced brown-like adipocyte development in WAT, up-regulation of BAT-specific genes including PRDM16, GATA-1, BMP-7, CIDEA, and UCP-1 and down-regulation of leptin, a WAT-specific gene. VEGF repression up-regulated expression of VEGF-B and its downstream fatty acid transport proteins. Relative levels of VEGF/VEGF-B may be important switches in energy metabolism and of pharmaceutical significances.

scholarly journals Thermogenesis challenges the adipostat hypothesis for body-weight control

2009 ◽  
Vol 68 (4) ◽  
pp. 401-407 ◽  
Author(s):  
Barbara Cannon ◽  
Jan Nedergaard
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Food Intake ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Weight Control ◽  
Dietary Intervention ◽  
Human Subjects ◽  
Brown Adipose ◽  
Body Weight Control

According to the adipostat hypothesis for body-weight control, alterations in body weight should always be compensated by adequate alterations in food intake and thermogenesis. Thus, increased thermogenesis should not be able to counteract obesity because food intake would be increased. However evidence is presented here that thermogenesis in different forms (through artificial uncouplers, exercise, cold exposure) may counteract obesity and is not always fully compensated by increased food intake. Correspondingly, a decreased capacity for metaboloregulatory thermogenesis (i.e. non-functional brown adipose tissue) may in itself lead to obesity. This is evident in mice and may be valid for human subjects, as a substantial proportion of adults possess brown adipose tissue, and those with less or without brown adipose tissue would seem to be more prone to obesity. Thus, increased thermogenesis may counteract obesity, without dietary intervention.

scholarly journals The Hypothalamic Preoptic Area and Body Weight Control

2017 ◽  
Vol 106 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Sangho Yu ◽  
Marie François ◽  
Clara Huesing ◽  
Heike Münzberg
Keyword(s):  
Body Weight ◽  
Temperature Change ◽  
Weight Control ◽  
Energy Homeostasis ◽  
Preoptic Area ◽  
Scientific Basis ◽  
Main Function ◽  
Humoral Factors ◽  
Brown Adipose ◽  
Body Weight Control

The preoptic area (POA) of the hypothalamus is involved in many physiological and behavioral processes thanks to its interconnections to many brain areas and ability to respond to diverse humoral factors. One main function of the POA is to manage body temperature homeostasis, e.g. in response to ambient temperature change, which is achieved in part by controlling brown adipose tissue thermogenesis. The POA is also importantly involved in modulating food intake in response to temperature change, thus making it relevant for body weight homeostasis and obesity research. POA function in body weight control is highly unexplored, and a better understanding of POA circuits and their integration into classic hypothalamic circuits that regulate energy homeostasis is expected to provide new opportunities for the scientific basis and treatment of obesity and comorbidities.

Non-shivering Thermogenesis and Brown Adipose Tissue in the Human New-born Infant

Nature ◽  
1965 ◽  
Vol 206 (4980) ◽  
pp. 201-202 ◽  
Author(s):  
M. J. R. DAWKINS ◽  
J. W. SCOPES
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
New Born ◽  
Born Infant ◽  
Brown Adipose ◽  
Shivering Thermogenesis

scholarly journals Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Carmen P. Wong ◽  
Urszula T. Iwaniec ◽  
Russell T. Turner
Keyword(s):  
Adipose Tissue ◽  
Differential Expression ◽  
International Space Station ◽  
Space Station ◽  
Interscapular Brown Adipose Tissue ◽  
International Space ◽  
Expression Of Genes ◽  
Brown Adipose ◽  
Differential Expression Of Genes ◽  
Shivering Thermogenesis

AbstractSixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in differential expression of genes in BAT consistent with increased non-shivering thermogenesis and differential expression of genes in WAT consistent with increased glucose uptake and metabolism, adipogenesis, and β-oxidation.

Sign in / Sign up

Export Citation Format

Share Document