scholarly journals Enhancing the Stability and Photothermal Conversion Efficiency of ICG by Pillar[5]arene-Based Host-Guest Interaction

2021 ◽  
Vol 9 ◽  
Author(s):  
Yue Ding ◽  
Chenwei Wang ◽  
Bing Lu ◽  
Yong Yao
Keyword(s):  
Conversion Efficiency ◽  
Near Infrared ◽  
Treatment Time ◽  
Weak Acid ◽  
Water Soluble ◽  
Photothermal Conversion ◽  
New Type ◽  
The Stability ◽  
Neutral Conditions

Indocyanine green (ICG) is a classical near-infrared (NIR) photothermal reagent that can be employed in clinical medical detection. Under neutral conditions, ICG can adsorb NIR light effectively for photothermal (PTT) and photodynamic (PDT) therapy. However, ICG is easily degraded in weak acid environments, which seriously restricts its application. In this work, a cationic water-soluble pillar[5]arene (WP5) was selected as the stabilizing agent for ICG. Thanks to the host-guest interaction between WP5 and alkyl sulfonate, the stability and the photothermal conversion efficiency of ICG increased remarkably upon addition of WP5 as investigated by UV-vis spectrum and photothermal studies. Furthermore, an in vitro study showed higher efficiency of WP5&ICG in killing cancer cells in a shorter treatment time than the free ICG. Hence, it is hopeful that WP5 can be a new type of supramolecular host in enhancing the stability and photothermal conversion efficiency of photosensitizers.

scholarly journals A Semimetal-Like Molybdenum Carbide Quantum Dots Photoacoustic Imaging and Photothermal Agent with High Photothermal Conversion Efficiency

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1776 ◽  
Author(s):  
Wenhao Dai ◽  
Haifeng Dong ◽  
Xueji Zhang
Keyword(s):  
Quantum Dots ◽  
Conversion Efficiency ◽  
Molybdenum Carbide ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Therapeutic Interventions ◽  
High Concentration ◽  
Photothermal Conversion

Theranostic platforms integrating imaging diagnostic and therapeutic interventions into a single nanoplatform have attracted considerable attention for cancer-individualized therapies. However, their uncertain stability, complex pharmacokinetics, and intrinsic toxicology of multiple components hinder their practical application in clinical research. In this paper, stable and high-concentration molybdenum carbide quantum dots (Mo2C QDs) with a diameter of approximately 6 nm and a topographic height of about 1.5 nm were synthesized using a facile sonication-assisted liquid-phase exfoliation approach. The prepared Mo2C QDs exhibited a strong near-infrared (NIR) absorbance with a high molar extinction coefficient of 4.424 Lg−1cm−1 at 808 nm, a high photothermal conversion efficiency of 42.9%, and showed excellent performance on photoacoustic imaging. The Mo2C QDs had high stability and highly biocompatibility, with low cytotoxicity. Under NIR irradiation, a remarkable in vitro and in vivo therapeutic effect was obtained. Such a stable and biocompatible all-in-one theranostic nanoagent generated by facile synthesis that combines promising imaging guidance and effective tumor ablation properties may hold great potential for theranostic nanomedicine.

Comparison of Gold Nanospheres, Nanorods, Nanocages and Nanoflowers for Combined Photothermal-Radiotherapy of Cancer

NANO ◽  
2021 ◽  
pp. 2150037
Author(s):  
Lijie Yang ◽  
Jinhua Wang ◽  
Liying Sun ◽  
Yisi Zhang ◽  
Peng Huang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Conversion Efficiency ◽  
Near Infrared ◽  
Enhancement Effect ◽  
Gold Nanospheres ◽  
Photothermal Conversion ◽  
Uptake Efficiency ◽  
Gold Nanoflowers

Gold nanoparticles are promising dual agents for combined photothermal-radiotherapy of cancer. Nevertheless, the shape effects of gold nanoparticles on photothermal conversion efficiency and radiosensitization have not been completely revealed. To address this knowledge gap, different shapes of gold nanoparticles including gold nanospheres (GNSs), gold nanorods (GNRs), gold nanocages (GNCs) and gold nanoflowers (GNFs) were synthesized. Despite being subjected to the same modification with poly (ethylene glycol) (PEG), these gold nanoparticles showed different cellular uptake efficiencies: GNFs[Formula: see text][Formula: see text][Formula: see text]GNSs[Formula: see text][Formula: see text][Formula: see text]GNCs[Formula: see text][Formula: see text][Formula: see text]GNRs. Moreover, GNRs, GNCs and GNFs could convert near-infrared (NIR) light to heat and GNFs displayed the highest photothermal conversion efficiency, whereas GNSs showed poor photothermal effects due to the weak NIR absorption. The highest uptake efficiency as well as the best photothermal conversion ability led to GNFs to exhibit the best photothermal therapeutic effect. Furthermore, all the gold nanoparticles could be used as radiosensitizers to improve radiotherapeutic effect. Among these nanoparticles, GNFs showed the best radiation enhancement effect because of their highest uptake efficiency. Furthermore, a higher accumulation of GNFs in tumor tissues was observed than those of other shaped gold nanoparticles. Importantly, our in vitro and in vivo comparative studies revealed that GNFs possessed the strongest anticancer effect in combined photothermal-radiotherapy. Hence, compared to gold nanoparticles with other shapes, the GNFs might be more desirable dual agents for highly efficient combined photothermal-radiotherapy.

Rapid evaluation of pasture quality for a critically endangered mammal, the northern hairy-nosed wombat (Lasiorhinus krefftii)

2002 ◽  
Vol 29 (1) ◽  
pp. 91 ◽  
Author(s):  
Andrew P. Woolnough ◽  
William J. Foley
Keyword(s):  
Large Scale ◽  
Nutritive Value ◽  
Near Infrared ◽  
Nitrogen Concentration ◽  
Water Soluble ◽  
Critically Endangered ◽  
Soluble Carbohydrates ◽  
Dry Matter Digestibility ◽  
Acid Detergent Fibre

Near-infrared spectroscopy (NIRS) was used to predict the nutritive value of forage species available to the critically endangered northern hairy-nosed wombat (Lasiorhinus krefftii). Nutritive attributes of the forage successfully estimated included total nitrogen concentration, fibre (including neutral detergent fibre, acid detergent fibre and acid lignin), organic matter, water soluble carbohydrates and in vitro dry matter digestibility. The reported results demonstrate the seasonal variability of the forage resource available to L. krefftii in its tropical savanna habitat. Multivariate modelling of the spectra enabled the nutritive value of forage samples to be estimated with coefficients of determination (r2) of 0.770–0.995 and standard errors of the cross-validation of 0.070–2.850 using a modified partial least-squares analysis technique. The standard error of the laboratory was 0.02–1.42. This study demonstrates that broad-based NIRS predictive equations can be used to predict the nutritive value of a number of plant types available to a herbivore over time. By using NIRS the analyst can rapidly analyse large numbers of samples with limited reduction of precision, thereby enabling large-scale ecological applications that may have previously been impeded by time and costs.

Effect of Heat-Treatment Time on Microstructure and Mechanical Properties of Mg-5Gd-2Y-2Zn-0.5Zr Alloy

2012 ◽  
Vol 482-484 ◽  
pp. 1384-1389 ◽  
Author(s):  
Ling Gang Meng ◽  
Can Feng Fang ◽  
Peng Peng ◽  
Nai Pu Li ◽  
Qiong Zhu ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Grain Boundary ◽  
Treatment Time ◽  
Time Range ◽  
Lpso Phase ◽  
High Temperature Heat Treatment ◽  
Lpso Structure ◽  
The Matrix ◽  
New Type ◽  
The Stability

Microstructure evolution of Mg-5Gd-2Y-2Zn-0.5Zr alloy during high temperature heat-treatment at 500°C in the time range 10-70h was investigated. The results show that after adding the element Y, the as-cast Mg-5Gd-2Y-2Zn-0.5Zr alloy forms the Mg12Zn(Y,Gd) phase with 18R-LPSO structure at the grain boundary. During heat-treatment at 500°C, the stability of 18R-LPSO structure is weakened by Gd atoms, parts of LPSO phases dissolve gradually into the matrix with time prolonged and a new type Mg(Y,Gd)Zn phase come into being. LPSO phase in the grain boundary can ensure the ultimate tensile strength and elongation of the alloy, and effect of dissevering on the LPSO phase by Mg(Gd,Y)Zn phase results the decrease of UTS and elongation.

Ag functionalized SnS2 with enhanced photothermal activity for safe and efficient wound disinfection

2021 ◽  
Author(s):  
Jun Yang ◽  
Lin Sun ◽  
Shuhan Hui ◽  
Peng Zhang ◽  
Jian Li ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Antibacterial Effect ◽  
Photothermal Conversion ◽  
New Type ◽  
Nir Laser

A new type of Ag@SnS2 was established with Ag decorated on SnS2 surface for improved photothermal conversion capability. Ag@SnS2 exhibited a robust in vitro antibacterial effect and in vivo wound disinfection under NIR laser irradiation.

Shape tunable gallium nanorods mediated tumor enhanced ablation through near-infrared photothermal therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 2655-2667 ◽  
Author(s):  
Xuyang Sun ◽  
Mengmeng Sun ◽  
Miaomiao Liu ◽  
Bo Yuan ◽  
Weiping Gao ◽  
...  
Keyword(s):  
Liquid Metal ◽  
Metal Nanoparticles ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Photothermal Conversion

Shape tunable liquid metal nanoparticles were fabricated with characterization of biocompatibility, favorable photothermal conversion efficiency and tumor targeting capability for photothermal therapy.

A Novel pH-Sensitive Microsphere Composed of CM-Chitosan and Alginate for Sulforaphane Delivery

2011 ◽  
Vol 687 ◽  
pp. 539-547 ◽  
Author(s):  
Hui Wang ◽  
Hao Liang ◽  
Qi Peng Yuan ◽  
Tian Xin Wang
Keyword(s):  
Sodium Sulfate ◽  
Anticancer Agent ◽  
Ph Sensitive ◽  
Water Soluble ◽  
Ph Values ◽  
Swelling Studies ◽  
The Stability ◽  
Carboxymethylated Chitosan

Sulforaphane (SF) has been proved to be an effective anticancer agent according to its experiments bothin vitroandin vivo. To date, there is few reported method to deliver SF for increasing its bioactivity and stability. In this study, a novel pH-sensitive microsphere composed of water-soluble carboxymethylated chitosan (CMCS) and alginate mixed with sodium sulfate was developed for SF delivery. Swelling studies and release characteristics under different pH values of microspheres were investigated. Then, the release of SF from test microspheres was studied in simulated gastric and segmented intestinal media. It has been found that the SF cumulated release in 5h was increased from 55.89% to 76.73% when the microspheres mixed with sodium sulfate. In addition, the stability of SF embedded in CMCS/alginate microspheres was also significantly improved. Under pH 7.4, free SF had a severe degradation of approximate 100% within 210 min, whereas the change of the SF in microspheres was only a decrease of about 10%. The results suggested that the microspheres of CMCS and alginate could be a suitable pH-sensitive carrier to increase the stability of SF in the segmented intestine.

Regulating morphologies and near-infrared photothermal conversion of perylene bisimide via sequence-dependent peptide self-assembly

2018 ◽  
Vol 54 (18) ◽  
pp. 2208-2211 ◽  
Author(s):  
Lingyun Cui ◽  
Yang Jiao ◽  
Anhe Wang ◽  
Luyang Zhao ◽  
Qianqian Dong ◽  
...  
Keyword(s):  
Conversion Efficiency ◽  
Self Assembly ◽  
Near Infrared ◽  
Aqueous Media ◽  
Radical Anions ◽  
Photothermal Conversion ◽  
Perylene Bisimide ◽  
Sequence Dependent

The behavior of PBI self-assembly can be precisely organised by the conjugation of sequence dependent dipeptides in aqueous media resulting in different assembled nanostructures with improved radical anions yield and enhanced photothermal conversion efficiency.

Water-Soluble Germanium(0) Nanocrystals: Cell Recognition and Near-Infrared Photothermal Conversion Properties

Small ◽  
2007 ◽  
Vol 3 (4) ◽  
pp. 691-699 ◽  
Author(s):  
Timothy N. Lambert ◽  
Nicholas L. Andrews ◽  
Henry Gerung ◽  
Timothy J. Boyle ◽  
Janet M. Oliver ◽  
...  
Keyword(s):  
Near Infrared ◽  
Water Soluble ◽  
Cell Recognition ◽  
Photothermal Conversion
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