scholarly journals Incidence, Risk Factors and Outcomes of Postoperative Headache After Stanford Type a Acute Aortic Dissection Surgery

2021 ◽  
Vol 8 ◽  
Author(s):  
Dashuai Wang ◽  
Sheng Le ◽  
Jingjing Luo ◽  
Xing Chen ◽  
Rui Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Practice ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Prediction Models ◽  
Multivariate Logistic Regression Analysis ◽  
Type A ◽  
Smoking History ◽  
Incidence Risk ◽  
Postoperative Headache

Background: Postoperative headache (POH) is common in clinical practice, however, no studies about POH after Stanford type A acute aortic dissection surgery (AADS) exist. This study aims to describe the incidence, risk factors and outcomes of POH after AADS, and to construct two prediction models.Methods: Adults who underwent AADS from 2016 to 2020 in four tertiary hospitals were enrolled. Training and validation sets were randomly assigned according to a 7:3 ratio. Risk factors were identified by univariate and multivariate logistic regression analysis. Nomograms were constructed and validated on the basis of independent predictors.Results: POH developed in 380 of the 1,476 included patients (25.7%). Poorer outcomes were observed in patients with POH. Eight independent predictors for POH after AADS were identified when both preoperative and intraoperative variables were analyzed, including younger age, female sex, smoking history, chronic headache history, cerebrovascular disease, use of deep hypothermic circulatory arrest, more blood transfusion, and longer cardiopulmonary bypass time. White blood cell and platelet count were also identified as significant predictors when intraoperative variables were excluded from the multivariate analysis. A full nomogram and a preoperative nomogram were constructed based on these independent predictors, both demonstrating good discrimination, calibration, clinical usefulness, and were well validated. Risk stratification was performed and three risk intervals were defined based on the full nomogram and clinical practice.Conclusions: POH was common after AADS, portending poorer outcomes. Two nomograms predicting POH were developed and validated, which may have clinical utility in risk evaluation, early prevention, and doctor-patient communication.

scholarly journals Frank's sign with acute aortic dissection

2021 ◽  
Author(s):  
Hironobu Nishiori ◽  
Yuichi Hirano ◽  
Masayoshi Otsu ◽  
Hiroyuki Watanabe
Keyword(s):  
Computed Tomography ◽  
Back Pain ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Young Patients ◽  
Type A ◽  
Aortic Disease ◽  
Atherosclerotic Disease ◽  
Smoking History

A 59-year-old man with a long smoking history presented with sudden back pain. Frank’s sign was noticed in his bilateral ears, and computed tomography revealed Stanford type A acute aortic dissection. If young patients have Frank’s sign, attention should be paid to atherosclerotic disease including aortic disease.

scholarly journals Characteristics and outcomes of Stanford type A aortic dissection patients with post-operation severe hyperbilirubinemia: a retrospective cohort study

2020 ◽  
Author(s):  
Xiaolan Chen ◽  
Ming Bai ◽  
Lijuan Zhao ◽  
Yangping Li ◽  
Yan Yu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Transfusion ◽  
Aortic Dissection ◽  
Hospital Mortality ◽  
Multivariate Logistic Regression Analysis ◽  
Kidney Injury ◽  
Type A ◽  
Type A Aortic Dissection ◽  
Post Operation ◽  
Severe Hyperbilirubinemia

Abstract Background Hyperbilirubinemia is one of the common complications after cardiac surgery and is associated with increased mortality. However, to the best of our knowledge, the report on clinical significance of postoperative severe hyperbilirubinemia in Stanford type A aortic dissection (AAD) patients is limited. Methods Patients who underwent surgical treatment for AAD in our center between January 2015 and December 2018 were retrospectively screened. In-hospital mortality, long-term mortality, acute kidney injury (AKI), and the requirement of continuous renal replacement therapy (CRRT) were assessed as endpoints. Univariate and multivariate regression models were employed to identify the risk factors of these endpoints. Results 271 (12.3%) patients were included. Of the included patients, 222 (81.9%) experienced postoperative AKI, and 50 (18.5%) received CRRT. In-hospital mortality was 30.3%. The 1-year, 2-year, and 3-year cumulative mortality were 32.9%, 33.9%, and 35.3%, respectively. Multivariate Logistic regression analysis indicated that age (P < 0.033), AKI stage 3 (P < 0.001), the amount of blood transfusion after surgery (P = 0.019), mean arterial pressure (MAP) in the first postoperative day (P = 0.012), the use of extracorporeal membrane oxygenation (ECMO) (P = 0.02), and the peak total bilirubin (TB) concentration (P = 0.023) were independent risk factors of in-hospital mortality. The optimal cut-off value of peak TB on predicting in-hospital mortality was 121.2 µmol/l. Survival analysis showed significantly decreased survival for patients who developed severe, rather than mild, hyperbilirubinemia. Conclusions Post-operation severe hyperbilirubinemia is a common clinical presentation in AAD surgery patients. Post-operation severe hyperbilirubinemia AAD patients with older age, lower MAP, increased blood transfusion, stage 3 AKI, the use of ECMO, and the increased peak TB had higher risk of in-hospital mortality.

scholarly journals Lower body ischaemic time is a risk factor for acute kidney injury after surgery for type A acute aortic dissection

2019 ◽  
Vol 30 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Kentaro Amano ◽  
Yoshiyuki Takami ◽  
Hiroshi Ishikawa ◽  
Michiko Ishida ◽  
Masato Tochii ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Surgical Repair ◽  
Kidney Injury ◽  
Type A ◽  
Hospital Death ◽  
Lower Body ◽  
Postoperative Aki

Abstract OBJECTIVES Postoperative acute kidney injury (AKI) is known as a risk factor for death after surgery for Stanford type A acute aortic dissection under hypothermic circulatory arrest. It may also adversely affect long-term survival. We searched for modifiable risk factors for postoperative AKI, focusing on lower body ischaemic time. METHODS We reviewed 191 patients undergoing surgical repair for Stanford type A acute aortic dissection. The distal anastomosis depended on excluding the primary tear location, resulting in ascending/hemiarch (n = 119), partial arch (n = 18) and total arch replacement (n = 54). We defined an increase in the serum creatinine level to ≧2 times the baseline level as AKI. The incidence of AKI was investigated with multivariate analysis of its risk factors. RESULTS Postoperative AKI was observed in 49 patients (26%), 31% of whom required renal replacement therapy. The overall hospital mortality rate was 8.5%. Postoperative AKI, preoperative shock and organ malperfusion were predictors of hospital death. Multivariate stepwise logistic regression analysis identified age, body mass index, preoperative chronic kidney disease and lower body ischaemic time as risk factors for postoperative AKI. CONCLUSIONS Although surgical repair for Stanford type A acute aortic dissection showed favourable results, the incidence of postoperative AKI is still high, closely associated with hospital death. Lower body ischaemic time should be recognized specifically as a modifiable surgical risk factor for postoperative AKI.

Incidence and risk factors of recurrent pain in acute aortic dissection and in-hospital mortality

VASA ◽  
2018 ◽  
Vol 47 (4) ◽  
pp. 301-310
Author(s):  
Dilixiati Siti ◽  
Asiya Abudesimu ◽  
Xiaojie Ma ◽  
Lei Yang ◽  
Xiang Ma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Aortic Dissection ◽  
Hospital Mortality ◽  
Acute Aortic Dissection ◽  
Emergency Operation ◽  
Type A ◽  
Type B ◽  
Recurrent Pain ◽  
Group I ◽  
Group Ii

Abstract. Background: We investigated the prevalence of recurrent pain and its relationship with in-hospital mortality in acute aortic dissection (AAD). Patients and methods: Between 2011 and 2016, 234 AAD patients were selected. Recurrent pain was defined as a mean of VAS > 3, within 48 hours following hospital admission or before emergency operation. Patients with and without recurrent pain were divided into group I and group II, respectively into type A AAD and type B AAD patients. Our primary outcome was in-hospital mortality. Results: The incidence of recurrent pain was 24.4 % in AAD patients. Incidence of recurrent pain was higher in type A AAD patients than type B AAD patients (48.9 vs. 9.6 %). Overall in-hospital mortality was 25.6 %. Type A AAD had a higher in-hospital mortality than type B AAD patients (47.7 vs. 12.3 %). Group I had significantly higher in-hospital mortality than group II (type A: 79.1 vs. 17.8 %; type B: 57.1 vs. 7.6 %, all P < 0.001), as was the case with medical managed patients (type A: 72.1 vs. 13.3 %; type B: 35.7 vs. 2.3 %, all P < 0.001). Logistic regression analysis showed that use of one drug alone and waist pain were predictive factors for recurrent pain in type A AAD and type A AAD patients, respectively (OR 3.686, 95 % CI: 1.103~12.316, P = 0.034 and OR 14.010, 95 % CI: 2.481~79.103, P = 0.003). Recurrent pains were the risk factors (type A: OR 11.096, 95 % CI: 3.057~40.280, P < 0.001; type B: OR 14.412, 95 % CI: 3.662~56.723, P < 0.001), while invasive interventions were protective (type A: OR 0.133, 95 % CI: 0.035~0.507, P < 0.001; type B: OR 0.334, 95 % CI: 0.120~0.929, P = 0.036) for in-hospital mortality in AAD patients. Conclusions: Approximately one-fourth of AAD patients presented with recurrent pains, which might increase in-hospital mortality. Thus, interventional strategies at early stages are important.

P1825The characteristics of type A acute aortic dissection in patients with out-of-hospital cardiopulmonary arrest analyzed by computed tomography

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Takeuchi ◽  
H Yoshino ◽  
Y Yamaguchi ◽  
K Soejima
Keyword(s):  
Pericardial Effusion ◽  
Aortic Dissection ◽  
Acute Phase ◽  
Acute Aortic Dissection ◽  
Cardiopulmonary Arrest ◽  
Multivariate Logistic Regression Analysis ◽  
Type A ◽  
High Morbidity ◽  
Survival Group ◽  
Ct Findings

Abstract Background/Introduction Acute aortic dissection (AAD) is a life-threatening condition associated with high morbidity and mortality rates, and is reported to have a 1–2% fatality rate per hour after onset. Therefore, many cases with AAD are considered to be included in patients with out-of-hospital cardiopulmonary arrest (OHCPA). However at this time, there is a lack of documentation of these cases. Purpose In this study, we investigated the characteristics of Stanford type A AAD (TAAD) cases between OHCPA cases and survival cases using acute phase CT. Methods An acute phase CT scanning was performed on consecutive patients with OHCPA transported to our hospital in order to estimate the causes of cardiopulmonary arrest (CPA). Based on our emergency outpatient databases, we retrospectively reviewed the acute phase CT findings of OHCPA TAAD cases and survival TAAD cases diagnosed at our hospital during the same period. Results Of 1,011 consecutive patients with OHCPA, except for exogenous death from 1 January 2015 to 31 December 2017, 934 patients underwent CT examination in the acute phase. Based on the clinical course and CT findings, 71 of the 934 patients (7.6%) were diagnosed with AAD. Out of 71 AAD patients, 66 were TAAD patients, and all of these patients were enrolled in the OHCPA group. On the other hand, 41 patients were registered as the survival group during the same period. These patients were diagnosed as TAAD and were admitted to our hospital without falling into CPA. Increased Age (78±8 years old vs 69±13 years old, P<0.01), visible intimal flap (63.6% vs 41.5%, P=0.043), bloody pericardial effusion (72.7% vs 26.8%, P<0.01), hemothorax (24.2% vs 0%, P<0.01) were significant in patients with the OHCPA group compared with the survival group. In addition, 56 patients with OHCPA (84.8%) had at least one of massive bloody pericardial effusion or massive hemothorax. Using multivariate logistic regression analysis, increased age and bloody pericardial effusion were both found to be independent factors related to OHCPA. Conclusion In this study, it is thought that the main characteristics of the CT findings with OHCPA due to TAAD are a rupture of the aorta into the pericardial cavity or thoracic cavity.

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