scholarly journals Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Zijing Ran ◽  
Xiaomei Xue ◽  
Lin Han ◽  
Robert Terkeltaub ◽  
Tony R. Merriman ◽  
...  

ObjectiveTo clarify the relationship between serum urate (SU) decrease and visceral fat area (VFA) reduction in patients with gout.MethodsWe retrospectively analyzed 237 male gout patients who had two sets of body composition and metabolic measurements within 6 months. Subjects included had all been treated with urate-lowering therapy (ULT) (febuxostat 20–80 mg/day or benzbromarone 25–50 mg/day, validated by the medical record). All patients were from the specialty gout clinic of The Affiliated Hospital of Qingdao University. The multiple linear regression model evaluated the relationship between change in SU [ΔSU, (baseline SU) – (final visit SU)] and change in VFA [ΔVFA, (baseline VFA) – (final visit VFA)].ResultsULT resulted in a mean (standard deviation) decrease in SU level (464.22 ± 110.21 μmol/L at baseline, 360.93 ± 91.66 μmol/L at the final visit, p <0.001) accompanied by a decrease in median (interquartile range) VFA [97.30 (81.15–118.55) at baseline, 90.90 (75.85–110.05) at the final visit, p < 0.001]. By multiple regression model, ΔSU was identified to be a significant determinant variable of decrease in VFA (beta, 0.302; p = 0.001).ConclusionsThe decrease in SU level is positively associated with reduced VFA. This finding provides a rationale for clinical trials to affirm whether ULT promotes loss of visceral fat in patients with gout.

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 912
Author(s):  
Mai Matsumoto ◽  
Hiroyuki Suganuma ◽  
Naoki Ozato ◽  
Sunao Shimizu ◽  
Mitsuhiro Katashima ◽  
...  

Consumption of fruits and vegetables rich in carotenoids has been widely reported to prevent cardiovascular diseases. However, the relationship between serum carotenoid concentrations and visceral fat area (VFA), which is considered a better predictor of cardiovascular diseases than the body-mass index (BMI) and waist circumference, remains unclear. Therefore, we examined the relationship in healthy individuals in their 20s or older, stratified by sex and age, to compare the relationship between serum carotenoid concentrations and VFA and BMI. The study was conducted on 805 people, the residents in Hirosaki city, Aomori prefecture, who underwent a health checkup. An inverse relationship between serum carotenoid concentrations and VFA and BMI was observed only in women. In addition, the results were independent of the intake of dietary fiber, which is mainly supplied from vegetables as well as carotenoids. This suggests that consumption of a diet rich in carotenoids (especially lutein and beta-carotene) is associated with lower VFA, which is a good predictor of cardiovascular disease, especially in women. This study is the first to comprehensively evaluate the association between serum carotenoid levels and VFA in healthy individuals.


2014 ◽  
Vol 43 (1) ◽  
pp. 139-148 ◽  
Author(s):  
Helena Moreira ◽  
Betânia Passos ◽  
Josiane Rocha ◽  
Vivianne Reis ◽  
André Carneiro ◽  
...  

Abstract The object of the study was to analyze the relationship between aerobic fitness and body composition in postmenopausal women. We hypothesized that postmenopausal women that had higher adiposity had lower cardiorespiratory capacity, regardless of the characteristics of menopause. The sample included 208 women (57.57 ± 6.62 years), whose body composition and the basal metabolic rate were evaluated by octopolar bioimpedance (InBody 720) and the oxygen uptake by the modified Bruce protocol. Most of the sample showed obesity and a high visceral fat area. The visceral fat area and the basal metabolic rate explained 30% of the variation of oxygen uptake, regardless of age, time, nature or hormone therapy. The values of the latter variables were reduced in the presence of high central adiposity (-6.16 ml/kg/min) and the basal metabolic rate of less than 1238 kcal/day (-0.18 ml/kg/min). The women with oxygen uptake above 30.94 ml/kg/min showed lower values of total and central adiposity when compared with other groups. With an increase of aerobic fitness, there was a growing tendency of the average values of the soft lean mass index, with differences between the groups low-high and moderate-high. These results suggest worsening of the cardiorespiratory condition with an increase of central adiposity and a decrease of the BMR, regardless of age and menopause characteristics.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Mahdi Salehi ◽  
Hassan Mohammadzadeh Moghadam ◽  
Zohreh Hajiha

Purpose The present study aims to investigate the relationship between intellectual capital and the readability of financial statements with the mediating role of management characteristics of companies listed on the Tehran Stock Exchange. In other words, this research tries to find the answer to whether intellectual capital can positively affect the readability of financial statements. Design/methodology/approach A multivariate regression model was used to test the hypotheses for this purpose. The research hypotheses were tested using a sample of 1,309 observations listed on the Tehran Stock Exchange from 2012 to 2018 and a multiple regression model based on panel data and fixed-effects models. Findings The results indicate that intellectual capital has a positive and significant relationship with the readability of financial statements, which means that with increasing intellectual capital in companies, financial statements’ readability also increases. Based on the hypothesis test results, it has been determined that narcissism, accrual and real earnings management have a negative effect on the relationship between intellectual capital and the readability of financial statements. Originality/value Since the present study examines such an issue in emerging markets, it provides users, analysts and legal entities with useful information about management’s inherent and acquired characteristics that significantly impact the purchase of audit opinion. This study’s results also contribute to developing science and knowledge in this field and close the literature gap.


2019 ◽  
Vol 18 (1) ◽  
pp. 199-222 ◽  
Author(s):  
Mahdi Salehi ◽  
Fariba Jahanbin ◽  
Mohammad Sadegh Adibian

Purpose The expectation gap between auditors and users has recently been the topic of many controversies. This paper aims to evaluate the relationship between auditor’s characteristics and audit expectation gap among information users in listed companies on the Tehran stock exchange market. In other words, the study attempts to find whether there is a significant relationship between audit components and the audit expectation gap or not. Design/methodology/approach The multiple regression model is used to test the hypotheses. Research hypotheses are tested using a sample of 78 listed companies on the Tehran stock exchange during 2012-2016, by using integrated data technique of the multiple regression model. Findings The findings show that standard audit fees are not significantly associated with the audit expectation gap. Furthermore, audit fees are negatively associated with the audit expectation gap, which provides that allocated audit price in financial statements gives useful information for external and internal individuals. Predictably, it is recommended that audit opinion significantly determines the level of the audit expectation gap. The authors also find that the independence of the director boards and audit committee members fulfill the expectation gap of individual users. Moreover, finding the negative impact of audit firms ranking on the expectation gap, supports the idea of higher ranked audit firms provide high quality services, and consequently, more reliable information. Finally, the results show that the audit record is positively associated with the audit expectation gap. Originality/value As all recent studies on the expectation gap were qualitative, the present study is the first paper, which measures the expectation gap quantitatively through the statistical method.


2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Kazuyuki Okada ◽  
Tatsuto Nishigori ◽  
Kazutaka Obama ◽  
Shigeru Tsunoda ◽  
Koya Hida ◽  
...  

Background. Visceral obesity is a risk factor for complications after gastrectomy in patients with gastric cancer. However, it is unclear whether postoperative complications decrease with preoperative reduction of visceral fat without the achievement of a nonobese state. This is because previous studies have performed categorical comparisons of obesity and nonobesity. The current study was performed to estimate the impact of the preoperative visceral fat area (VFA) as a continuous variable on postoperative complications after gastrectomy. Methods. Consecutive patients with gastric cancer who underwent curative gastrectomy between June 2006 and August 2017 at the Kyoto University Hospital were included in this retrospective study. The VFA at the level of the umbilicus was measured using preoperative computed tomography. The relationship between postoperative complications and VFA was investigated with univariate and multivariate analyses. Results. total of 566 patients were included in the study. Their mean VFA was 110 ± 58 cm2, and postoperative complications occurred in 121 patients (21.4%). The larger the VFA (<50, 50–99, 100–149, and ≥150 cm2), the higher the incidence of postoperative complications (11%, 14%, 21%, and 38%, respectively, P<0.001). Multivariate logistic regression analyses showed that the VFA was associated with postoperative complications (odds ratio: 1.009, 95% confidence interval (CI): 1.004–1.013, P<0.001), with an incidence of postoperative complications that was 9% (95% CI: 4%–12%) higher for every 10 cm2 increase in the VFA. Conclusion. The incidence of postoperative complications after gastrectomy increases in proportion to an increase in the preoperative VFA.


Author(s):  
Fauzhia Rahmasari

AbstractEfforts to manage the recycling of paper waste into new paper have been carried out in recent times. It takes a tool or machine that is able to effectively and efficiently recycle used paper into new paper. There are several factors that affect the effectiveness of paper recycling machines, one of which is the paper thickness. One method that can be used to analyze the factors that influence paper thickness in the paper production process using a paper recycling machine is regression analysis. Regression analysis is data analysis techniques in statistics that is used to examine the relationship between several independent variables and dependent variable. However, if we want to examine the relationship or effect of two or more independent variables on a dependent variable, the regression model used is a multiple linear regression model. This study purposes are to analyze the factors that influence paper thickness using a paper recycling machine using multiple linear regression and to inform the modeling about that. The results showed that the factors that affect the paper thickness optimization are destruction and press phase. AbstractUpaya pengelolaan daur ulang sampah kertas menjadi kertas baru telah banyak dilakukan pada jaman sekarang. Dibutuhkan suatu alat atau mesin yang mampu secara efektif dan efisien dalam mendaur ulang kertas bekas menjadi kertas baru. Terdapat beberapa faktor yang mempengaruhi tingkat efektifitas mesin daur ulang kertas diantaranya adalah ketebalan kertas. Salah satu metode yang dapat digunakan untuk menganalisis faktor-faktor yang mempengaruhi ketebalan kertas pada proses produksi kertas menggunakan mesin daur ulang kertas adalah analisis regresi. Analisis regresi merupakan teknik analisis data dalam statistika yang digunakan untuk mengkaji hubungan antara beberapa variabel bebas dengan variabel tidak bebas. Namun, jika ingin mengkaji hubungan atau pengaruh dua atau lebih variabel bebas terhadap satu variabel tidak bebas, maka model regresi yang digunakan adalah model regresi linier berganda. Tujuan dalam penelitian ini yaitu menganalisis faktor-faktor yang mempengaruhi ketebalan kertas menggunakan mesin daur ulang kertas menggunakan regresi linier berganda serta memberikan informasi pemodelan mengenai hal tersebut. Hasil penelitian menunjukkan bahwa faktor yang mempengaruhi keoptimalan ketebalan kertas adalah fase penghancuran dan pemadatan kertas


2018 ◽  
Author(s):  
Muhammad Syukri

The purpose of this study is to determine the effect of locally-generated revenue (PAD), balancing funds and Foreign Direct Investment (FDI) to Progress Regions Level districts and cities in South Sulawesi Province either simultaneously or partially. Type of research used is applied research with quantitative data. The data used obtained from the Statistics Central Institution (BPS), which covers 24 districts and cities of South Sulawesi Province in 2016 in the form of thousands of rupiah. The research procedure is (1) Descriptive Analysis. (2) Establish multiple regression model. (3) Partial test and simultaneous test, and (4) determine the coefficient determination. Based on the simultaneous test of multiple linear regression model that PAD (X1), Balance Funds (X2) and FDI (X3) have significant effect to regional progress level (Y). And partial model testing, only PAD (X1) and fund balancing (X2) which significantly influence to regional progress level (Y). Meanwhile, FDI (X3) has no significant effect on regional progress level (Y). Therefore, the cultivation of FDI should be targeted and can provide direct benefits for the community in improving their welfare that will impact on improving regional progress. The suggestions needed in the development of further research that is required addition of other variables that can affect the level of regional progress.


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